Gene: ENSG00000138083 (Homo sapiens)

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Gene Identifier
ENSG00000138083
Transcript Identifier
ENST00000260653
Gene Type
Coding gene
Location
2 : 44942105-44944760 : positive

Family Information

Homologous gene family
HOM02SEM006454
(13 genes in 3 species)
specific family
Orthologous gene family
ORTHO02SEM010033
(7 genes in 3 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
SIX homeobox 3

Identifiers

Type Value
pidENSP00000260653
HGNC10889
UniprotO95343
RefSeq_mRNANM_005413.3
EMBLAC012354
EMBLAF049339
EMBLAF083891
EMBLAF092047
EMBLAJ012611
EMBLCH471053

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2000177
ISS
Genome Projectregulation of neural precursor cell proliferation
GO:2000177
ISS
Gene Ontologyregulation of neural precursor cell proliferation
GO:1990086
ISS
Genome Projectlens fiber cell apoptotic process
GO:1990086
ISS
Gene Ontologylens fiber cell apoptotic process
GO:1902742
ISS
Genome Projectapoptotic process involved in development
GO:1902742
ISS
Gene Ontologyapoptotic process involved in development
GO:1902692
ISS
Genome Projectregulation of neuroblast proliferation
GO:1902692
ISS
Gene Ontologyregulation of neuroblast proliferation
GO:1901987
ISS
Genome Projectregulation of cell cycle phase transition
GO:1901987
ISS
Gene Ontologyregulation of cell cycle phase transition
GO:0097402
ISS
Genome Projectneuroblast migration
GO:0097402
ISS
Gene Ontologyneuroblast migration
GO:0070306
ISS
Genome Projectlens fiber cell differentiation
GO:0070306
ISS
Gene Ontologylens fiber cell differentiation
GO:0061074
ISS
Genome Projectregulation of neural retina development
GO:0061074
ISS
Gene Ontologyregulation of neural retina development
GO:0060235
IEA
Genome Projectlens induction in camera-type eye
GO:0048512
IEA
Genome Projectcircadian behavior
GO:0045944
IEA
Genome Projectpositive regulation of transcription by RNA polymerase II
GO:0045892
IDA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045892
IDA
Gene Ontologynegative regulation of transcription, DNA-templated1
GO:0045665
ISS
Genome Projectnegative regulation of neuron differentiation
GO:0045665
ISS
Gene Ontologynegative regulation of neuron differentiation
GO:0042127
ISS
Genome Projectregulation of cell proliferation
GO:0042127
ISS
Gene Ontologyregulation of cell proliferation
GO:0030178
IEA
Genome Projectnegative regulation of Wnt signaling pathway
GO:0021983
ISS
Genome Projectpituitary gland development
GO:0021983
ISS
Gene Ontologypituitary gland development
GO:0021978
ISS
Genome Projecttelencephalon regionalization
GO:0021978
ISS
Gene Ontologytelencephalon regionalization
GO:0021846
ISS
Genome Projectcell proliferation in forebrain
GO:0021846
ISS
Gene Ontologycell proliferation in forebrain
GO:0021798
IDA
Genome Projectforebrain dorsal/ventral pattern formation
GO:0021798
IDA
Gene Ontologyforebrain dorsal/ventral pattern formation1
GO:0021797
IEA
Genome Projectforebrain anterior/posterior pattern specification
GO:0021537
ISS
Genome Projecttelencephalon development
GO:0021537
ISS
Gene Ontologytelencephalon development
GO:0014016
ISS
Genome Projectneuroblast differentiation
GO:0014016
ISS
Gene Ontologyneuroblast differentiation
GO:0009946
ISS
Genome Projectproximal/distal axis specification
GO:0009946
ISS
Gene Ontologyproximal/distal axis specification
GO:0007601
TAS
Genome Projectvisual perception
GO:0007601
TAS
Gene Ontologyvisual perception2
GO:0007420
TAS
Genome Projectbrain development
GO:0006366
IEA
Genome Projecttranscription by RNA polymerase II
GO:0003404
ISS
Genome Projectoptic vesicle morphogenesis
GO:0003404
ISS
Gene Ontologyoptic vesicle morphogenesis
GO:0002088
ISS
Genome Projectlens development in camera-type eye
GO:0002088
ISS
Gene Ontologylens development in camera-type eye
GO:0002070
ISS
Genome Projectepithelial cell maturation
GO:0002070
ISS
Gene Ontologyepithelial cell maturation
GO:0001654
IDA
Genome Projecteye development
GO:0001654
IDA
Gene Ontologyeye development1
GO:0000060
ISS
Genome Projectprotein import into nucleus, translocation
GO:0000060
ISS
Gene Ontologyprotein import into nucleus, translocation
GO:0001655
IEA
PLAZA Integrative Orthologyurogenital system development ENSG00000170577
GO:0048232
IEA
PLAZA Integrative Orthologymale gamete generation FBgn0003460
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction FBgn0003460
GO:0048749
IEA
PLAZA Integrative Orthologycompound eye development FBgn0003460
GO:0007444
IEA
PLAZA Integrative Orthologyimaginal disc development FBgn0003460
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process FBgn0003460
GO:0035295
IEA
PLAZA Integrative Orthologytube development FBgn0003460
GO:0007283
IEA
PLAZA Integrative Orthologyspermatogenesis FBgn0003460
GO:0007560
IEA
PLAZA Integrative Orthologyimaginal disc morphogenesis FBgn0003460
GO:0048707
IEA
PLAZA Integrative Orthologyinstar larval or pupal morphogenesis FBgn0003460
GO:0044703
IEA
PLAZA Integrative Orthologymulti-organism reproductive process FBgn0003460
GO:0035214
IEA
PLAZA Integrative Orthologyeye-antennal disc development FBgn0003460
GO:0051704
IEA
PLAZA Integrative Orthologymulti-organism process FBgn0003460
GO:0072001
IEA
PLAZA Integrative Orthologyrenal system development ENSG00000170577
GO:0009605
IEA
PLAZA Integrative Orthologyresponse to external stimulus FBgn0003460
GO:0009649
IEA
PLAZA Integrative Orthologyentrainment of circadian clock FBgn0003460
GO:0032504
IEA
PLAZA Integrative Orthologymulticellular organism reproduction FBgn0003460
GO:0060788
IEA
PLAZA Integrative Orthologyectodermal placode formation FBgn0003460
GO:0042752
IEA
PLAZA Integrative Orthologyregulation of circadian rhythm FBgn0003460
GO:0007552
IEA
PLAZA Integrative Orthologymetamorphosis FBgn0003460
GO:0007276
IEA
PLAZA Integrative Orthologygamete generation FBgn0003460
GO:0055034
IEA
PLAZA Integrative OrthologyBolwig's organ development FBgn0003460
GO:0019953
IEA
PLAZA Integrative Orthologysexual reproduction FBgn0003460
GO:0002009
IEA
PLAZA Integrative Orthologymorphogenesis of an epithelium FBgn0003460
GO:0048569
IEA
PLAZA Integrative Orthologypost-embryonic animal organ development FBgn0003460
GO:0048646
IEA
PLAZA Integrative Orthologyanatomical structure formation involved in morphogenesis FBgn0003460
GO:0009886
IEA
PLAZA Integrative Orthologypost-embryonic animal morphogenesis WBGene00000453
GO:0035271
IEA
PLAZA Integrative Orthologyring gland development FBgn0003460
GO:0048609
IEA
PLAZA Integrative Orthologymulticellular organismal reproductive process FBgn0003460
GO:0071697
IEA
PLAZA Integrative Orthologyectodermal placode morphogenesis FBgn0003460
GO:0035239
IEA
PLAZA Integrative Orthologytube morphogenesis FBgn0003460
GO:0048563
IEA
PLAZA Integrative Orthologypost-embryonic animal organ morphogenesis FBgn0003460
GO:0001746
IEA
PLAZA Integrative OrthologyBolwig's organ morphogenesis FBgn0003460
GO:0001745
IEA
PLAZA Integrative Orthologycompound eye morphogenesis FBgn0003460
GO:0071696
IEA
PLAZA Integrative Orthologyectodermal placode development FBgn0003460
GO:0042063
IEA
PLAZA Integrative Orthologygliogenesis FBgn0003460
GO:0001822
IEA
PLAZA Integrative Orthologykidney development ENSG00000170577
GO:0001744
IEA
PLAZA Integrative Orthologyoptic lobe placode formation FBgn0003460
GO:0008347
IEA
PLAZA Integrative Orthologyglial cell migration FBgn0003460
GO:0002165
IEA
PLAZA Integrative Orthologyinstar larval or pupal development FBgn0003460
GO:0007455
IEA
PLAZA Integrative Orthologyeye-antennal disc morphogenesis FBgn0003460
GO:0009791
IEA
PLAZA Integrative Orthologypost-embryonic development WBGene00000453
GO:0060562
IEA
PLAZA Integrative Orthologyepithelial tube morphogenesis FBgn0003460

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0042826
IEA
Genome Projecthistone deacetylase binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding3
GO:0005102
IEA
Genome Projectsignaling receptor binding
GO:0003713
ISS
Genome Projecttranscription coactivator activity
GO:0003713
ISS
Gene Ontologytranscription coactivator activity
GO:0003700
ISS
Genome ProjectDNA-binding transcription factor activity
GO:0003700
ISS
Gene OntologyDNA-binding transcription factor activity
GO:0001222
IPI
Genome Projecttranscription corepressor binding
GO:0001222
IPI
Gene Ontologytranscription corepressor binding4 5
GO:0000980
IEA
Genome ProjectRNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981
ISA, ISM
NAS
Gene OntologyDNA-binding transcription factor activity, RNA polymerase II-specific6
GO:0000987
IEA
PLAZA Integrative Orthologyproximal promoter sequence-specific DNA binding ENSG00000126778
GO:0000978
IEA
PLAZA Integrative OrthologyRNA polymerase II proximal promoter sequence-specific DNA binding ENSG00000126778

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IEA
Genome Projectnucleus
GO:0070013
IEA
PLAZA Integrative Orthologyintracellular organelle lumen ENSG00000126778
GO:0044422
IEA
PLAZA Integrative Orthologyorganelle part ENSG00000126778
GO:0044428
IEA
PLAZA Integrative Orthologynuclear part ENSG00000126778
GO:0031974
IEA
PLAZA Integrative Orthologymembrane-enclosed lumen ENSG00000126778
GO:0005730
IEA
PLAZA Integrative Orthologynucleolus ENSG00000126778
GO:0031981
IEA
PLAZA Integrative Orthologynuclear lumen ENSG00000126778
GO:0044446
IEA
PLAZA Integrative Orthologyintracellular organelle part ENSG00000126778
GO:0043232
IEA
PLAZA Integrative Orthologyintracellular non-membrane-bounded organelle ENSG00000126778
GO:0043233
IEA
PLAZA Integrative Orthologyorganelle lumen ENSG00000126778
GO:0043228
IEA
PLAZA Integrative Orthologynon-membrane-bounded organelle ENSG00000126778

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001356Homeobox domain
IPR009057Homeobox-like domain superfamily
IPR031701Homeobox protein SIX1, N-terminal SD domain
IPR032949Homeobox protein SIX3

No MapMan annotations defined for this gene.
KeggID Description
K19473SIX3_6, OPTIX; homeobox protein SIX3/6
No chloroplast target sequence found.