Gene: ENSG00000137275 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000137275
Transcript Identifier
ENST00000380409
Gene Type
Coding gene
Location
6 : 3076824-3113339 : positive

Family Information

Homologous gene family
HOM02SEM000002
(1733 genes in 25 species)
specific family

Descriptions

gene_descr
receptor (TNFRSF)-interacting serine-threonine kinase 1

Identifiers

Type Value
pidENSP00000369773
HGNC10019
UniprotQ13546
UniprotA0A024QZU0
RefSeq_mRNANM_003804.3
EMBLCHEMBL5464
EMBLAB208926
EMBLAK304701
EMBLAK314176
EMBLAL031963
EMBLAY682848
EMBLBC126254
EMBLBC126256
EMBLCH471087
EMBLU25994
EMBLU50062

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2001240
IEA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001238
IMP
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway
GO:2001238
IMP
Gene Ontologypositive regulation of extrinsic apoptotic signaling pathway1 2
GO:2001237
IMP
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway
GO:2001237
IMP
Gene Ontologynegative regulation of extrinsic apoptotic signaling pathway1
GO:2000379
TAS
Genome Projectpositive regulation of reactive oxygen species metabolic process
GO:2000379
TAS
Gene Ontologypositive regulation of reactive oxygen species metabolic process3
GO:1990000
IMP
Genome Projectamyloid fibril formation
GO:1990000
IMP
Gene Ontologyamyloid fibril formation4
GO:1905206
IMP
Genome Projectpositive regulation of hydrogen peroxide-induced cell death
GO:1905206
IMP
Gene Ontologypositive regulation of hydrogen peroxide-induced cell death5
GO:1902042
TAS
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042
TAS
Gene Ontologynegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902041
TAS
Genome Projectregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902041
TAS
Gene Ontologyregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1901026
IBA
Genome Projectripoptosome assembly involved in necroptotic process
GO:0097527
IMP
ISS
Genome Projectnecroptotic signaling pathway
GO:0097527
IMP
ISS
Gene Ontologynecroptotic signaling pathway6 7
GO:0097343
IMP
Genome Projectripoptosome assembly
GO:0097343
IMP
Gene Ontologyripoptosome assembly8
GO:0097296
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097191
IDA, IMP
Genome Projectextrinsic apoptotic signaling pathway
GO:0097191
IDA, IMP
Gene Ontologyextrinsic apoptotic signaling pathway9 10 11
GO:0097190
TAS
Genome Projectapoptotic signaling pathway
GO:0097190
TAS
Gene Ontologyapoptotic signaling pathway
GO:0071550
TAS
Genome Projectdeath-inducing signaling complex assembly
GO:0071550
TAS
Gene Ontologydeath-inducing signaling complex assembly
GO:0071363
IEA
Genome Projectcellular response to growth factor stimulus
GO:0071356
IDA
Genome Projectcellular response to tumor necrosis factor
GO:0071356
IDA
Gene Ontologycellular response to tumor necrosis factor12
GO:0070926
IMP
Genome Projectregulation of ATP:ADP antiporter activity
GO:0070926
IMP
Gene Ontologyregulation of ATP:ADP antiporter activity7
GO:0070266
IMP
TAS
Genome Projectnecroptotic process
GO:0070266
IMP
ISS
TAS
Gene Ontologynecroptotic process8 13 14
GO:0070231
ISS
Genome ProjectT cell apoptotic process
GO:0070231
ISS
Gene OntologyT cell apoptotic process
GO:0060545
IMP
Genome Projectpositive regulation of necroptotic process
GO:0060545
IMP
Gene Ontologypositive regulation of necroptotic process2 4 15
GO:0060544
TAS
Genome Projectregulation of necroptotic process
GO:0051291
IMP
Genome Projectprotein heterooligomerization
GO:0051291
IMP
Gene Ontologyprotein heterooligomerization4
GO:0051260
IDA
Genome Projectprotein homooligomerization
GO:0051260
IDA
Gene Ontologyprotein homooligomerization4
GO:0051092
IMP
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051092
IMP
Gene Ontologypositive regulation of NF-kappaB transcription factor activity10 11 16
GO:0046777
IDA
Genome Projectprotein autophosphorylation
GO:0046777
IDA
Gene Ontologyprotein autophosphorylation10
GO:0046330
IDA
Genome Projectpositive regulation of JNK cascade
GO:0046330
IDA
Gene Ontologypositive regulation of JNK cascade12
GO:0045944
IDA
Genome Projectpositive regulation of transcription by RNA polymerase II
GO:0045944
IDA
Gene Ontologypositive regulation of transcription by RNA polymerase II12 17
GO:0045651
IMP
Genome Projectpositive regulation of macrophage differentiation
GO:0045651
IMP
Gene Ontologypositive regulation of macrophage differentiation18
GO:0044257
IDA
Genome Projectcellular protein catabolic process
GO:0044257
IDA
Gene Ontologycellular protein catabolic process12
GO:0043124
IMP
Genome Projectnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124
IMP
Gene Ontologynegative regulation of I-kappaB kinase/NF-kappaB signaling18
GO:0043123
IDA, IEP
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123
IDA, IEP
Gene Ontologypositive regulation of I-kappaB kinase/NF-kappaB signaling12 19
GO:0043068
IMP
Genome Projectpositive regulation of programmed cell death
GO:0043068
IMP
Gene Ontologypositive regulation of programmed cell death20
GO:0043065
IDA, IMP
Genome Projectpositive regulation of apoptotic process
GO:0043065
IDA, IMP
Gene Ontologypositive regulation of apoptotic process10 12 21
GO:0036289
IDA
Genome Projectpeptidyl-serine autophosphorylation
GO:0036289
IDA
Gene Ontologypeptidyl-serine autophosphorylation22
GO:0035666
TAS
Genome ProjectTRIF-dependent toll-like receptor signaling pathway
GO:0035666
TAS
Gene OntologyTRIF-dependent toll-like receptor signaling pathway
GO:0034612
IMP
Genome Projectresponse to tumor necrosis factor
GO:0034612
IMP
Gene Ontologyresponse to tumor necrosis factor11
GO:0033209
TAS, IC
Genome Projecttumor necrosis factor-mediated signaling pathway
GO:0033209
TAS, IC
Gene Ontologytumor necrosis factor-mediated signaling pathway10
GO:0032760
IDA
Genome Projectpositive regulation of tumor necrosis factor production
GO:0032760
IDA
Gene Ontologypositive regulation of tumor necrosis factor production17
GO:0032757
IDA
Genome Projectpositive regulation of interleukin-8 production
GO:0032757
IDA
Gene Ontologypositive regulation of interleukin-8 production17
GO:0016579
TAS
Genome Projectprotein deubiquitination
GO:0016579
TAS
Gene Ontologyprotein deubiquitination
GO:0010940
IMP
Genome Projectpositive regulation of necrotic cell death
GO:0010940
IMP
Gene Ontologypositive regulation of necrotic cell death5
GO:0010803
TAS
Genome Projectregulation of tumor necrosis factor-mediated signaling pathway
GO:0010803
TAS
Gene Ontologyregulation of tumor necrosis factor-mediated signaling pathway
GO:0007257
TAS
Genome Projectactivation of JUN kinase activity
GO:0007257
TAS
Gene Ontologyactivation of JUN kinase activity3
GO:0007249
TAS
Genome ProjectI-kappaB kinase/NF-kappaB signaling
GO:0007249
TAS
Gene OntologyI-kappaB kinase/NF-kappaB signaling
GO:0006919
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
TAS
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915
IMP
Genome Projectapoptotic process
GO:0006915
IMP
Gene Ontologyapoptotic process8 23
GO:0001934
IMP
Genome Projectpositive regulation of protein phosphorylation
GO:0001934
IMP
Gene Ontologypositive regulation of protein phosphorylation12
GO:0034138
TAS
Gene Ontologytoll-like receptor 3 signaling pathway
GO:0002756
TAS
Gene OntologyMyD88-independent toll-like receptor signaling pathway
GO:0035303
IEA
PLAZA Integrative Orthologyregulation of dephosphorylation ENSG00000129465
GO:0016311
IEA
PLAZA Integrative Orthologydephosphorylation ENSG00000129465
GO:0010921
IEA
PLAZA Integrative Orthologyregulation of phosphatase activity ENSG00000129465
GO:0035306
IEA
PLAZA Integrative Orthologypositive regulation of dephosphorylation ENSG00000129465
GO:0002009
IEA
PLAZA Integrative Orthologymorphogenesis of an epithelium ENSG00000183421
GO:0010922
IEA
PLAZA Integrative Orthologypositive regulation of phosphatase activity ENSG00000129465
GO:0009888
IEA
PLAZA Integrative Orthologytissue development ENSG00000183421
GO:0060429
IEA
PLAZA Integrative Orthologyepithelium development ENSG00000183421
GO:0009653
IEA
PLAZA Integrative Orthologyanatomical structure morphogenesis ENSG00000183421
GO:0048729
IEA
PLAZA Integrative Orthologytissue morphogenesis ENSG00000183421

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070513
IPI
Genome Projectdeath domain binding
GO:0070513
IPI
Gene Ontologydeath domain binding10 24
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042802
IPI
Gene Ontologyidentical protein binding4 22 25
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0031625
IPI
Gene Ontologyubiquitin protein ligase binding26
GO:0005524
IEA
Genome ProjectATP binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding1 2 4 12 13 14 16 17 18 20 21 25 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53
GO:0005123
IPI
Genome Projectdeath receptor binding
GO:0005123
IPI
Gene Ontologydeath receptor binding9
GO:0004674
IDA
Genome Projectprotein serine/threonine kinase activity
GO:0004674
IDA
Gene Ontologyprotein serine/threonine kinase activity10 22
GO:0004672
IDA, IMP
Genome Projectprotein kinase activity
GO:0004672
IDA, IMP
Gene Ontologyprotein kinase activity4 13 54
GO:0044877
IDA
Gene Ontologyprotein-containing complex binding14
GO:0140110
IEA
PLAZA Integrative Orthologytranscription regulator activity ENSG00000129465
GO:0003713
IEA
PLAZA Integrative Orthologytranscription coactivator activity ENSG00000129465
GO:0003712
IEA
PLAZA Integrative Orthologytranscription coregulator activity ENSG00000129465

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0097342
IDA
Genome Projectripoptosome
GO:0097342
IDA
Gene Ontologyripoptosome8
GO:0045121
IEA
Genome Projectmembrane raft
GO:0043235
IDA
Genome Projectreceptor complex
GO:0043235
IDA
Gene Ontologyreceptor complex10
GO:0031264
IDA
Genome Projectdeath-inducing signaling complex
GO:0031264
IDA
Gene Ontologydeath-inducing signaling complex6
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005829
IDA
TAS
Gene Ontologycytosol
GO:0005739
IDA
Genome Projectmitochondrion
GO:0005739
IDA
Gene Ontologymitochondrion7
GO:0010008
TAS
Gene Ontologyendosome membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000488Death domain
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase, catalytic domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain superfamily
IPR011029Death-like domain superfamily
IPR025735RHIM domain

No MapMan annotations defined for this gene.
KeggID Description
K02861RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
No chloroplast target sequence found.