Gene: ENSG00000136986 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000136986
Transcript Identifier
ENST00000259512
Gene Type
Coding gene
Location
8 : 123015447-123042122 : negative

Family Information

Homologous gene family
HOM02SEM000733
(60 genes in 25 species)
specific family

Descriptions

gene_descr
derlin 1

Identifiers

Type Value
pidENSP00000259512
HGNC28454
UniprotQ9BUN8
UniprotA0A024R9G3
RefSeq_mRNANM_024295.5
EMBLAC104316
EMBLAK124086
EMBLAY358818
EMBLBC002457
EMBLCH471060

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0071712
IMP
Genome ProjectER-associated misfolded protein catabolic process
GO:0071712
IMP
Gene OntologyER-associated misfolded protein catabolic process1
GO:0055085
TAS
Genome Projecttransmembrane transport
GO:0055085
TAS
Gene Ontologytransmembrane transport
GO:0051260
IDA
Genome Projectprotein homooligomerization
GO:0051260
IDA
Gene Ontologyprotein homooligomerization2
GO:0045184
TAS
Genome Projectestablishment of protein localization
GO:0045184
TAS
Gene Ontologyestablishment of protein localization3
GO:0036503
IMP
Genome ProjectERAD pathway
GO:0036503
IMP
Gene OntologyERAD pathway4
GO:0032092
IMP
Genome Projectpositive regulation of protein binding
GO:0032092
IMP
Gene Ontologypositive regulation of protein binding1
GO:0031648
IMP
Genome Projectprotein destabilization
GO:0031648
IMP
Gene Ontologyprotein destabilization4
GO:0031398
IDA
Genome Projectpositive regulation of protein ubiquitination
GO:0031398
IDA
Gene Ontologypositive regulation of protein ubiquitination1
GO:0030970
IDA, IMP
Genome Projectretrograde protein transport, ER to cytosol
GO:0030970
IDA, IMP
Gene Ontologyretrograde protein transport, ER to cytosol3 5 6
GO:0030968
IDA
Genome Projectendoplasmic reticulum unfolded protein response
GO:0030968
IDA
Gene Ontologyendoplasmic reticulum unfolded protein response3
GO:0030433
IDA, IMP
TAS
Genome Projectubiquitin-dependent ERAD pathway
GO:0030433
IDA, IMP
TAS
Gene Ontologyubiquitin-dependent ERAD pathway3 7 8 9
GO:0019060
TAS
Genome Projectintracellular transport of viral protein in host cell
GO:0016567
TAS
Genome Projectprotein ubiquitination
GO:0016567
TAS
Gene Ontologyprotein ubiquitination
GO:0006986
IMP
Genome Projectresponse to unfolded protein
GO:0006986
IMP
Gene Ontologyresponse to unfolded protein5
GO:0006457
TAS
Genome Projectprotein folding
GO:0006457
TAS
Gene Ontologyprotein folding
GO:0006897
IEA
PLAZA Integrative Orthologyendocytosis WBGene00000843
GO:0016192
IEA
PLAZA Integrative Orthologyvesicle-mediated transport WBGene00000843
GO:0098657
IEA
PLAZA Integrative Orthologyimport into cell WBGene00000843

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1990381
IPI
Genome Projectubiquitin-specific protease binding
GO:1990381
IPI
Gene Ontologyubiquitin-specific protease binding10
GO:0051117
IPI
Genome ProjectATPase binding
GO:0051117
IPI
Gene OntologyATPase binding1 2
GO:0042288
IDA
Genome ProjectMHC class I protein binding
GO:0042288
IDA
Gene OntologyMHC class I protein binding5
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0031625
IPI
Gene Ontologyubiquitin protein ligase binding11
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding1 3 4 7 8 12 13 14 15 16 17
GO:0004252
IEA
Genome Projectserine-type endopeptidase activity
GO:0002020
IPI
Genome Projectprotease binding
GO:0002020
IPI
Gene Ontologyprotease binding4
GO:0038023
NAS
Gene Ontologysignaling receptor activity3

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0048500
IDA
Genome Projectsignal recognition particle
GO:0048500
IDA
Gene Ontologysignal recognition particle18
GO:0034098
TAS
Genome ProjectVCP-NPL4-UFD1 AAA ATPase complex
GO:0034098
TAS
Gene OntologyVCP-NPL4-UFD1 AAA ATPase complex2
GO:0005785
IDA
Genome Projectsignal recognition particle receptor complex
GO:0005785
IDA
Gene Ontologysignal recognition particle receptor complex18
GO:0043657
IEA
Genome Projecthost cell
GO:0036513
IDA
Genome ProjectDerlin-1 retrotranslocation complex
GO:0036513
IDA
Gene OntologyDerlin-1 retrotranslocation complex3 4 7
GO:0036502
IDA
Genome ProjectDerlin-1-VIMP complex
GO:0036502
IDA
Gene OntologyDerlin-1-VIMP complex3
GO:0030176
IDA
Genome Projectintegral component of endoplasmic reticulum membrane
GO:0030176
IDA
Gene Ontologyintegral component of endoplasmic reticulum membrane3
GO:0016021
IDA
Genome Projectintegral component of membrane
GO:0016021
IDA
Gene Ontologyintegral component of membrane5
GO:0016020
IDA
Genome Projectmembrane
GO:0016020
Gene Ontologymembrane19
GO:0005789
TAS
Genome Projectendoplasmic reticulum membrane
GO:0005789
TAS
Gene Ontologyendoplasmic reticulum membrane
GO:0005783
IDA, IMP
Genome Projectendoplasmic reticulum
GO:0005783
IDA, IMP
Gene Ontologyendoplasmic reticulum2 5 20
GO:0005770
IEA
Genome Projectlate endosome
GO:0005769
IEA
Genome Projectearly endosome
GO:1902494
IEA
PLAZA Integrative Orthologycatalytic complex YDR411C
GO:0000839
IEA
PLAZA Integrative OrthologyHrd1p ubiquitin ligase ERAD-L complex YDR411C
GO:0000837
IEA
PLAZA Integrative OrthologyDoa10p ubiquitin ligase complex YDR411C
GO:0000836
IEA
PLAZA Integrative OrthologyHrd1p ubiquitin ligase complex YDR411C
GO:0000835
IEA
PLAZA Integrative OrthologyER ubiquitin ligase complex YDR411C
GO:0000153
IEA
PLAZA Integrative Orthologycytoplasmic ubiquitin ligase complex YDR411C
GO:1990234
IEA
PLAZA Integrative Orthologytransferase complex YDR411C
GO:0048471
IEA
PLAZA Integrative Orthologyperinuclear region of cytoplasm WBGene00000843
GO:0000151
IEA
PLAZA Integrative Orthologyubiquitin ligase complex YDR411C
GO:0097038
IEA
PLAZA Integrative Orthologyperinuclear endoplasmic reticulum WBGene00000843

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR007599Derlin
IPR022764Peptidase S54, rhomboid domain

No MapMan annotations defined for this gene.
KeggID Description
K11519DERL1; Derlin-1
No chloroplast target sequence found.