Gene: ENSG00000135679 (Homo sapiens)

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Gene Identifier
ENSG00000135679
Transcript Identifier
ENST00000258149
Gene Type
Coding gene
Location
12 : 68808478-68839849 : positive

Family Information

Homologous gene family
HOM02SEM005056
(16 genes in 11 species)
specific family

Descriptions

gene_descr
MDM2 proto-oncogene, E3 ubiquitin protein ligase

Identifiers

Type Value
pidENSP00000258149
HGNC6973
UniprotQ00987
RefSeq_mRNANM_002392.5

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1990785
IEA
Genome Projectresponse to water-immersion restraint stress
GO:1990000
IMP
Genome Projectamyloid fibril formation
GO:1990000
IMP
Gene Ontologyamyloid fibril formation1
GO:1904754
IEA
Genome Projectpositive regulation of vascular associated smooth muscle cell migration
GO:1904707
IEA
Genome Projectpositive regulation of vascular smooth muscle cell proliferation
GO:1904404
IEA
Genome Projectresponse to formaldehyde
GO:1902254
IMP
Genome Projectnegative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1902254
IMP
Gene Ontologynegative regulation of intrinsic apoptotic signaling pathway by p53 class mediator2
GO:1901797
IDA
Genome Projectnegative regulation of signal transduction by p53 class mediator
GO:1901797
IDA
Gene Ontologynegative regulation of signal transduction by p53 class mediator3
GO:1901796
TAS
Genome Projectregulation of signal transduction by p53 class mediator
GO:1901796
TAS
Gene Ontologyregulation of signal transduction by p53 class mediator
GO:0072717
IDA
Genome Projectcellular response to actinomycin D
GO:0072717
IDA
Gene Ontologycellular response to actinomycin D4
GO:0071494
IEA
Genome Projectcellular response to UV-C
GO:0071480
IDA
Genome Projectcellular response to gamma radiation
GO:0071480
IDA
Gene Ontologycellular response to gamma radiation5
GO:0071456
IEP
Genome Projectcellular response to hypoxia
GO:0071456
IEP
Gene Ontologycellular response to hypoxia6
GO:0071391
IEA
Genome Projectcellular response to estrogen stimulus
GO:0071375
IEA
Genome Projectcellular response to peptide hormone stimulus
GO:0071363
IEA
Genome Projectcellular response to growth factor stimulus
GO:0071312
IEA
Genome Projectcellular response to alkaloid
GO:0071301
IEA
Genome Projectcellular response to vitamin B1
GO:0071157
IDA
Genome Projectnegative regulation of cell cycle arrest
GO:0071157
IDA
Gene Ontologynegative regulation of cell cycle arrest7
GO:0070301
IEA
Genome Projectcellular response to hydrogen peroxide
GO:0060411
IEA
Genome Projectcardiac septum morphogenesis
GO:0051865
IMP
Genome Projectprotein autoubiquitination
GO:0051865
IMP
Gene Ontologyprotein autoubiquitination8 9
GO:0051603
IMP
Genome Projectproteolysis involved in cellular protein catabolic process
GO:0051603
IMP
Gene Ontologyproteolysis involved in cellular protein catabolic process10
GO:0048545
IEA
Genome Projectresponse to steroid hormone
GO:0046827
IEA
Genome Projectpositive regulation of protein export from nucleus
GO:0046677
IEP
Genome Projectresponse to antibiotic
GO:0046677
IEP
Gene Ontologyresponse to antibiotic6
GO:0045931
IMP
Genome Projectpositive regulation of mitotic cell cycle
GO:0045931
IMP
Gene Ontologypositive regulation of mitotic cell cycle11
GO:0045892
IDA, IMP
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045892
IDA, IMP
Gene Ontologynegative regulation of transcription, DNA-templated8 10 12
GO:0045472
IEA
Genome Projectresponse to ether
GO:0045184
IDA
Genome Projectestablishment of protein localization
GO:0045184
IDA
Gene Ontologyestablishment of protein localization13
GO:0043518
IDA
Genome Projectnegative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043518
IDA
Gene Ontologynegative regulation of DNA damage response, signal transduction by p53 class mediator7 13
GO:0043278
IEA
Genome Projectresponse to morphine
GO:0043154
IEA
Genome Projectnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042220
IEA
Genome Projectresponse to cocaine
GO:0042176
IDA
Genome Projectregulation of protein catabolic process
GO:0042176
IDA
Gene Ontologyregulation of protein catabolic process14
GO:0036369
TAS
Genome Projecttranscription factor catabolic process
GO:0036369
TAS
Gene Ontologytranscription factor catabolic process15
GO:0034504
IDA
Genome Projectprotein localization to nucleus
GO:0034504
IDA
Gene Ontologyprotein localization to nucleus13
GO:0032436
IDA
Genome Projectpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032436
IDA
Gene Ontologypositive regulation of proteasomal ubiquitin-dependent protein catabolic process16
GO:0032026
IEA
Genome Projectresponse to magnesium ion
GO:0031648
IDA, IMP
Genome Projectprotein destabilization
GO:0031648
IDA, IMP
Gene Ontologyprotein destabilization4 7 8 13 17
GO:0018205
IMP
Genome Projectpeptidyl-lysine modification
GO:0018205
IMP
Gene Ontologypeptidyl-lysine modification18
GO:0016925
IEA
Genome Projectprotein sumoylation
GO:0016579
TAS
Genome Projectprotein deubiquitination
GO:0016579
TAS
Gene Ontologyprotein deubiquitination
GO:0016567
IDA
Genome Projectprotein ubiquitination
GO:0016567
IDA
Gene Ontologyprotein ubiquitination19 20 21 22
GO:0016032
IEA
Genome Projectviral process
GO:0010977
IEA
Genome Projectnegative regulation of neuron projection development
GO:0010955
IEA
Genome Projectnegative regulation of protein processing
GO:0010628
IEA
Genome Projectpositive regulation of gene expression
GO:0010039
IEA
Genome Projectresponse to iron ion
GO:0009636
IEA
Genome Projectresponse to toxic substance
GO:0008284
TAS
Genome Projectpositive regulation of cell proliferation
GO:0008284
TAS
Gene Ontologypositive regulation of cell proliferation23
GO:0007089
IEA
Genome Projecttraversing start control point of mitotic cell cycle
GO:0006977
IMP
TAS
Genome ProjectDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006977
IMP
TAS
Gene OntologyDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest24
GO:0003283
IEA
Genome Projectatrial septum development
GO:0003281
IEA
Genome Projectventricular septum development
GO:0003203
IEA
Genome Projectendocardial cushion morphogenesis
GO:0003181
IEA
Genome Projectatrioventricular valve morphogenesis
GO:0002027
IEA
Genome Projectregulation of heart rate
GO:0001974
IEA
Genome Projectblood vessel remodeling
GO:0001568
IEA
Genome Projectblood vessel development
GO:0000122
IDA
Genome Projectnegative regulation of transcription by RNA polymerase II
GO:0000122
IDA
Gene Ontologynegative regulation of transcription by RNA polymerase II2 12
GO:0065003
IDA
Gene Ontologyprotein-containing complex assembly25 26
GO:0006511
IDA, IMP, IGI
Gene Ontologyubiquitin-dependent protein catabolic process2 3 4 8 9 16 17 27
GO:0045023
IEA
PLAZA Integrative OrthologyG0 to G1 transition ENSG00000198625
GO:0008285
IEA
PLAZA Integrative Orthologynegative regulation of cell proliferation ENSG00000198625
GO:0042177
IEA
PLAZA Integrative Orthologynegative regulation of protein catabolic process ENSG00000198625
GO:0009895
IEA
PLAZA Integrative Orthologynegative regulation of catabolic process ENSG00000198625
GO:0050821
IEA
PLAZA Integrative Orthologyprotein stabilization ENSG00000198625

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0097718
IPI
Genome Projectdisordered domain specific binding
GO:0097718
IPI
Gene Ontologydisordered domain specific binding1
GO:0097110
IEA
Genome Projectscaffold protein binding
GO:0061663
IMP
Genome ProjectNEDD8 ligase activity
GO:0061663
IMP
Gene OntologyNEDD8 ligase activity17
GO:0061630
IDA, IMP
TAS
Genome Projectubiquitin protein ligase activity
GO:0061630
IDA, IMP
TAS
Gene Ontologyubiquitin protein ligase activity2 4 8 17 18
GO:0047485
IPI
Genome Projectprotein N-terminus binding
GO:0047485
IPI
Gene Ontologyprotein N-terminus binding28
GO:0042975
IEA
Genome Projectperoxisome proliferator activated receptor binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042802
IPI
Gene Ontologyidentical protein binding29 30 31
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0031625
IPI
Gene Ontologyubiquitin protein ligase binding32 33
GO:0019899
IPI
Genome Projectenzyme binding
GO:0019899
IPI
Gene Ontologyenzyme binding11 34 35 36
GO:0019789
EXP
Genome ProjectSUMO transferase activity
GO:0019789
EXP
Gene OntologySUMO transferase activity37
GO:0016874
IDA
Genome Projectligase activity
GO:0016874
IDA
Gene Ontologyligase activity38
GO:0008270
IDA
Genome Projectzinc ion binding
GO:0008270
IDA
Gene Ontologyzinc ion binding39
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding2 3 4 7 9 11 12 15 17 18 20 21 23 24 25 26 29 30 31 35 36 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125
GO:0004842
IDA, IMP
Genome Projectubiquitin-protein transferase activity
GO:0004842
IDA, IMP
Gene Ontologyubiquitin-protein transferase activity19 36
GO:0002039
IPI
Genome Projectp53 binding
GO:0002039
IPI
Gene Ontologyp53 binding7 10 36 126
GO:0043130
IDA
Gene Ontologyubiquitin binding33
GO:0043021
IDA
Gene Ontologyribonucleoprotein complex binding127
GO:0019904
IPI
Gene Ontologyprotein domain specific binding8
GO:0008097
IDA
Gene Ontology5S rRNA binding127

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0016604
IDA
Genome Projectnuclear body
GO:0016604
IDA
Gene Ontologynuclear body13
GO:0045202
IEA
Genome Projectsynapse
GO:0030666
TAS
Genome Projectendocytic vesicle membrane
GO:0030666
TAS
Gene Ontologyendocytic vesicle membrane
GO:0005886
TAS
Genome Projectplasma membrane
GO:0005886
TAS
Gene Ontologyplasma membrane
GO:0005829
TAS
Genome Projectcytosol
GO:0005829
TAS
Gene Ontologycytosol
GO:0005737
IMP
Genome Projectcytoplasm
GO:0005737
IMP
Gene Ontologycytoplasm4 24
GO:0005730
IDA, IMP
Genome Projectnucleolus
GO:0005730
IDA, IMP
Gene Ontologynucleolus28 115 128
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005654
IDA
TAS
Gene Ontologynucleoplasm26 128
GO:0005634
IDA, IMP
Genome Projectnucleus
GO:0005634
IDA, IMP
Gene Ontologynucleus4 13 24 33
GO:0032991
IDA, IMP
Gene Ontologyprotein-containing complex2 4 7 8 28

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001841Zinc finger, RING-type
IPR001876Zinc finger, RanBP2-type
IPR003121SWIB/MDM2 domain
IPR013083Zinc finger, RING/FYVE/PHD-type
IPR015459Ubiquitin-protein ligase E3 MDM2
IPR016495p53 negative regulator Mdm2/Mdm4
IPR028340E3 ubiquitin-protein ligase Mdm2

No MapMan annotations defined for this gene.
KeggID Description
K06643MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
No chloroplast target sequence found.