Gene: ENSG00000135018 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000135018
Transcript Identifier
ENST00000376395
Gene Type
Coding gene
Location
9 : 83661787-83707679 : negative

Family Information

Homologous gene family
HOM02SEM009252
(10 genes in 5 species)
specific family

Descriptions

gene_descr
ubiquilin 1

Identifiers

Type Value
pidENSP00000365576
HGNC12508
UniprotQ9UMX0
UniprotA0A024R284
RefSeq_mRNANM_013438.4
EMBLCH471089

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1903071
IMP
Genome Projectpositive regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:1903071
IMP
Gene Ontologypositive regulation of ER-associated ubiquitin-dependent protein catabolic process1
GO:1902175
IMP
Genome Projectregulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902175
IMP
Gene Ontologyregulation of oxidative stress-induced intrinsic apoptotic signaling pathway2
GO:1901340
IMP
Genome Projectnegative regulation of store-operated calcium channel activity
GO:1901340
IMP
Gene Ontologynegative regulation of store-operated calcium channel activity3
GO:0097352
IMP
Genome Projectautophagosome maturation
GO:0097352
IMP
Gene Ontologyautophagosome maturation4
GO:0071456
IMP
Genome Projectcellular response to hypoxia
GO:0071456
IMP
Gene Ontologycellular response to hypoxia2
GO:0035973
IDA
Genome Projectaggrephagy
GO:0035973
IDA
Gene Ontologyaggrephagy5
GO:0034976
IMP
Genome Projectresponse to endoplasmic reticulum stress
GO:0034976
IMP
Gene Ontologyresponse to endoplasmic reticulum stress2
GO:0034140
IEA
Genome Projectnegative regulation of toll-like receptor 3 signaling pathway
GO:0031398
IDA
Genome Projectpositive regulation of protein ubiquitination
GO:0031398
IDA
Gene Ontologypositive regulation of protein ubiquitination3
GO:0031396
IDA
Genome Projectregulation of protein ubiquitination
GO:0031396
IDA
Gene Ontologyregulation of protein ubiquitination6
GO:0030433
IMP
Genome Projectubiquitin-dependent ERAD pathway
GO:0030433
IMP
Gene Ontologyubiquitin-dependent ERAD pathway7
GO:0016236
IMP
Genome Projectmacroautophagy
GO:0016236
IMP
Gene Ontologymacroautophagy8
GO:0000045
IMP
Genome Projectautophagosome assembly
GO:0000045
IMP
Gene Ontologyautophagosome assembly8
GO:0045806
IEA
PLAZA Integrative Orthologynegative regulation of endocytosis ENSG00000188021
GO:0070727
IEA
PLAZA Integrative Orthologycellular macromolecule localization YMR276W
GO:0007010
IEA
PLAZA Integrative Orthologycytoskeleton organization YMR276W
GO:0022402
IEA
PLAZA Integrative Orthologycell cycle process YMR276W
GO:0008104
IEA
PLAZA Integrative Orthologyprotein localization YMR276W
GO:0043620
IEA
PLAZA Integrative Orthologyregulation of DNA-templated transcription in response to stress WBGene00008852
GO:0023058
IEA
PLAZA Integrative Orthologyadaptation of signaling pathway ENSG00000188021
GO:0007017
IEA
PLAZA Integrative Orthologymicrotubule-based process YMR276W
GO:0022401
IEA
PLAZA Integrative Orthologynegative adaptation of signaling pathway ENSG00000188021
GO:0072583
IEA
PLAZA Integrative Orthologyclathrin-dependent endocytosis ENSG00000188021
GO:0051641
IEA
PLAZA Integrative Orthologycellular localization YMR276W
GO:0045893
IEA
PLAZA Integrative Orthologypositive regulation of transcription, DNA-templated WBGene00008852
GO:2000112
IEA
PLAZA Integrative Orthologyregulation of cellular macromolecule biosynthetic process WBGene00008852
GO:0051129
IEA
PLAZA Integrative Orthologynegative regulation of cellular component organization ENSG00000188021
GO:0051128
IEA
PLAZA Integrative Orthologyregulation of cellular component organization ENSG00000188021
GO:1902680
IEA
PLAZA Integrative Orthologypositive regulation of RNA biosynthetic process WBGene00008852
GO:0036003
IEA
PLAZA Integrative Orthologypositive regulation of transcription from RNA polymerase II promoter in response to stress WBGene00008852
GO:0045935
IEA
PLAZA Integrative Orthologypositive regulation of nucleobase-containing compound metabolic process WBGene00008852
GO:0002090
IEA
PLAZA Integrative Orthologyregulation of receptor internalization ENSG00000188021
GO:0002091
IEA
PLAZA Integrative Orthologynegative regulation of receptor internalization ENSG00000188021
GO:0043112
IEA
PLAZA Integrative Orthologyreceptor metabolic process ENSG00000188021
GO:0000226
IEA
PLAZA Integrative Orthologymicrotubule cytoskeleton organization YMR276W
GO:0009967
IEA
PLAZA Integrative Orthologypositive regulation of signal transduction ENSG00000188021
GO:0006725
IEA
PLAZA Integrative Orthologycellular aromatic compound metabolic process WBGene00008852
GO:0023056
IEA
PLAZA Integrative Orthologypositive regulation of signaling ENSG00000188021
GO:0051254
IEA
PLAZA Integrative Orthologypositive regulation of RNA metabolic process WBGene00008852
GO:0043242
IEA
PLAZA Integrative Orthologynegative regulation of protein complex disassembly ENSG00000160803
GO:0051252
IEA
PLAZA Integrative Orthologyregulation of RNA metabolic process WBGene00008852
GO:0016241
IEA
PLAZA Integrative Orthologyregulation of macroautophagy ENSG00000188021
GO:0016242
IEA
PLAZA Integrative Orthologynegative regulation of macroautophagy ENSG00000160803
GO:0033365
IEA
PLAZA Integrative Orthologyprotein localization to organelle YMR276W
GO:0097659
IEA
PLAZA Integrative Orthologynucleic acid-templated transcription WBGene00008852
GO:0031623
IEA
PLAZA Integrative Orthologyreceptor internalization ENSG00000188021
GO:2000369
IEA
PLAZA Integrative Orthologyregulation of clathrin-dependent endocytosis ENSG00000188021
GO:0034613
IEA
PLAZA Integrative Orthologycellular protein localization YMR276W
GO:0019219
IEA
PLAZA Integrative Orthologyregulation of nucleobase-containing compound metabolic process WBGene00008852
GO:1901360
IEA
PLAZA Integrative Orthologyorganic cyclic compound metabolic process WBGene00008852
GO:0009892
IEA
PLAZA Integrative Orthologynegative regulation of metabolic process ENSG00000188021
GO:1901362
IEA
PLAZA Integrative Orthologyorganic cyclic compound biosynthetic process WBGene00008852
GO:0009891
IEA
PLAZA Integrative Orthologypositive regulation of biosynthetic process WBGene00008852
GO:0043244
IEA
PLAZA Integrative Orthologyregulation of protein complex disassembly ENSG00000160803
GO:0009895
IEA
PLAZA Integrative Orthologynegative regulation of catabolic process ENSG00000160803
GO:0048259
IEA
PLAZA Integrative Orthologyregulation of receptor-mediated endocytosis ENSG00000188021
GO:0045944
IEA
PLAZA Integrative Orthologypositive regulation of transcription by RNA polymerase II WBGene00008852
GO:0046483
IEA
PLAZA Integrative Orthologyheterocycle metabolic process WBGene00008852
GO:0016070
IEA
PLAZA Integrative OrthologyRNA metabolic process WBGene00008852
GO:0051300
IEA
PLAZA Integrative Orthologyspindle pole body organization YMR276W
GO:0016192
IEA
PLAZA Integrative Orthologyvesicle-mediated transport ENSG00000188021
GO:0018130
IEA
PLAZA Integrative Orthologyheterocycle biosynthetic process WBGene00008852
GO:0031330
IEA
PLAZA Integrative Orthologynegative regulation of cellular catabolic process ENSG00000160803
GO:0048261
IEA
PLAZA Integrative Orthologynegative regulation of receptor-mediated endocytosis ENSG00000188021
GO:1901097
IEA
PLAZA Integrative Orthologynegative regulation of autophagosome maturation ENSG00000160803
GO:1901096
IEA
PLAZA Integrative Orthologyregulation of autophagosome maturation ENSG00000160803
GO:1990440
IEA
PLAZA Integrative Orthologypositive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress WBGene00008852
GO:0031328
IEA
PLAZA Integrative Orthologypositive regulation of cellular biosynthetic process WBGene00008852
GO:0010647
IEA
PLAZA Integrative Orthologypositive regulation of cell communication ENSG00000188021
GO:2000785
IEA
PLAZA Integrative Orthologyregulation of autophagosome assembly ENSG00000188021
GO:0032774
IEA
PLAZA Integrative OrthologyRNA biosynthetic process WBGene00008852
GO:0030474
IEA
PLAZA Integrative Orthologyspindle pole body duplication YMR276W
GO:0031326
IEA
PLAZA Integrative Orthologyregulation of cellular biosynthetic process WBGene00008852
GO:0031324
IEA
PLAZA Integrative Orthologynegative regulation of cellular metabolic process ENSG00000188021
GO:0006366
IEA
PLAZA Integrative Orthologytranscription by RNA polymerase II WBGene00008852
GO:1902115
IEA
PLAZA Integrative Orthologyregulation of organelle assembly ENSG00000188021
GO:0044087
IEA
PLAZA Integrative Orthologyregulation of cellular component biogenesis ENSG00000188021
GO:0098657
IEA
PLAZA Integrative Orthologyimport into cell ENSG00000188021
GO:0044088
IEA
PLAZA Integrative Orthologyregulation of vacuole organization ENSG00000188021
GO:0072665
IEA
PLAZA Integrative Orthologyprotein localization to vacuole YMR276W
GO:0030100
IEA
PLAZA Integrative Orthologyregulation of endocytosis ENSG00000188021
GO:0090304
IEA
PLAZA Integrative Orthologynucleic acid metabolic process WBGene00008852
GO:2001141
IEA
PLAZA Integrative Orthologyregulation of RNA biosynthetic process WBGene00008852
GO:1904021
IEA
PLAZA Integrative Orthologynegative regulation of G protein-coupled receptor internalization ENSG00000188021
GO:1904020
IEA
PLAZA Integrative Orthologyregulation of G protein-coupled receptor internalization ENSG00000188021
GO:0007186
IEA
PLAZA Integrative OrthologyG protein-coupled receptor signaling pathway ENSG00000188021
GO:1900186
IEA
PLAZA Integrative Orthologynegative regulation of clathrin-dependent endocytosis ENSG00000188021
GO:0008277
IEA
PLAZA Integrative Orthologyregulation of G protein-coupled receptor signaling pathway ENSG00000188021
GO:0042982
IEA
PLAZA Integrative Orthologyamyloid precursor protein metabolic process FBgn0031057
GO:0006897
IEA
PLAZA Integrative Orthologyendocytosis ENSG00000188021
GO:0044249
IEA
PLAZA Integrative Orthologycellular biosynthetic process WBGene00008852
GO:0006898
IEA
PLAZA Integrative Orthologyreceptor-mediated endocytosis ENSG00000188021
GO:0006139
IEA
PLAZA Integrative Orthologynucleobase-containing compound metabolic process WBGene00008852
GO:0009889
IEA
PLAZA Integrative Orthologyregulation of biosynthetic process WBGene00008852
GO:0010507
IEA
PLAZA Integrative Orthologynegative regulation of autophagy ENSG00000160803
GO:0010628
IEA
PLAZA Integrative Orthologypositive regulation of gene expression WBGene00008852
GO:0010506
IEA
PLAZA Integrative Orthologyregulation of autophagy ENSG00000188021
GO:0010468
IEA
PLAZA Integrative Orthologyregulation of gene expression WBGene00008852
GO:0010467
IEA
PLAZA Integrative Orthologygene expression WBGene00008852
GO:0034654
IEA
PLAZA Integrative Orthologynucleobase-containing compound biosynthetic process WBGene00008852
GO:0031023
IEA
PLAZA Integrative Orthologymicrotubule organizing center organization YMR276W
GO:0019438
IEA
PLAZA Integrative Orthologyaromatic compound biosynthetic process WBGene00008852
GO:0033043
IEA
PLAZA Integrative Orthologyregulation of organelle organization ENSG00000188021
GO:0009059
IEA
PLAZA Integrative Orthologymacromolecule biosynthetic process WBGene00008852
GO:0060627
IEA
PLAZA Integrative Orthologyregulation of vesicle-mediated transport ENSG00000188021
GO:0009058
IEA
PLAZA Integrative Orthologybiosynthetic process WBGene00008852
GO:1903506
IEA
PLAZA Integrative Orthologyregulation of nucleic acid-templated transcription WBGene00008852
GO:0045744
IEA
PLAZA Integrative Orthologynegative regulation of G protein-coupled receptor signaling pathway ENSG00000188021
GO:0045745
IEA
PLAZA Integrative Orthologypositive regulation of G protein-coupled receptor signaling pathway ENSG00000188021
GO:0010556
IEA
PLAZA Integrative Orthologyregulation of macromolecule biosynthetic process WBGene00008852
GO:0033036
IEA
PLAZA Integrative Orthologymacromolecule localization YMR276W
GO:0034641
IEA
PLAZA Integrative Orthologycellular nitrogen compound metabolic process WBGene00008852
GO:0010557
IEA
PLAZA Integrative Orthologypositive regulation of macromolecule biosynthetic process WBGene00008852
GO:0034645
IEA
PLAZA Integrative Orthologycellular macromolecule biosynthetic process WBGene00008852
GO:0006351
IEA
PLAZA Integrative Orthologytranscription, DNA-templated WBGene00008852
GO:0043618
IEA
PLAZA Integrative Orthologyregulation of transcription from RNA polymerase II promoter in response to stress WBGene00008852
GO:1901576
IEA
PLAZA Integrative Orthologyorganic substance biosynthetic process WBGene00008852
GO:0006355
IEA
PLAZA Integrative Orthologyregulation of transcription, DNA-templated WBGene00008852
GO:0002031
IEA
PLAZA Integrative OrthologyG protein-coupled receptor internalization ENSG00000188021
GO:0007049
IEA
PLAZA Integrative Orthologycell cycle YMR276W
GO:0006357
IEA
PLAZA Integrative Orthologyregulation of transcription by RNA polymerase II WBGene00008852
GO:1903508
IEA
PLAZA Integrative Orthologypositive regulation of nucleic acid-templated transcription WBGene00008852
GO:0002029
IEA
PLAZA Integrative Orthologydesensitization of G protein-coupled receptor signaling pathway ENSG00000188021
GO:0044271
IEA
PLAZA Integrative Orthologycellular nitrogen compound biosynthetic process WBGene00008852
GO:0010605
IEA
PLAZA Integrative Orthologynegative regulation of macromolecule metabolic process ENSG00000188021

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042802
IPI
Gene Ontologyidentical protein binding9 10 11
GO:0031593
IDA
Genome Projectpolyubiquitin modification-dependent protein binding
GO:0031593
IDA
Gene Ontologypolyubiquitin modification-dependent protein binding12
GO:0019900
IPI
Genome Projectkinase binding
GO:0019900
IPI
Gene Ontologykinase binding13
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding1 2 3 4 5 7 9 10 11 12 14 15 16 17 18 19 20 21 22
GO:0060090
IEA
PLAZA Integrative Orthologymolecular adaptor activity YMR276W
GO:0070628
IEA
PLAZA Integrative Orthologyproteasome binding FBgn0031057
GO:0044877
IEA
PLAZA Integrative Orthologyprotein-containing complex binding FBgn0031057
GO:0030674
IEA
PLAZA Integrative Orthologyprotein binding, bridging YMR276W

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0048471
IDA
NAS
Genome Projectperinuclear region of cytoplasm
GO:0048471
IDA
NAS
Gene Ontologyperinuclear region of cytoplasm2 13
GO:0031410
IEA
Genome Projectcytoplasmic vesicle
GO:0016235
IDA
Genome Projectaggresome
GO:0016235
IDA
Gene Ontologyaggresome5 15
GO:0005886
IDA
Genome Projectplasma membrane
GO:0005886
IDA
Gene Ontologyplasma membrane5
GO:0005829
IDA
Genome Projectcytosol
GO:0005829
IDA
Gene Ontologycytosol
GO:0005783
IDA
Genome Projectendoplasmic reticulum
GO:0005783
IDA
Gene Ontologyendoplasmic reticulum2 7
GO:0005776
IDA
Genome Projectautophagosome
GO:0005776
IDA
Gene Ontologyautophagosome3 4 5 8
GO:0005737
IDA, IMP
Genome Projectcytoplasm
GO:0005737
IDA, IMP
Gene Ontologycytoplasm6 13 15
GO:0005654
IDA
Genome Projectnucleoplasm
GO:0005654
IDA
Gene Ontologynucleoplasm
GO:0000502
IEA
Genome Projectproteasome complex
GO:0032991
IDA
Gene Ontologyprotein-containing complex
GO:0031597
IEA
PLAZA Integrative Orthologycytosolic proteasome complex ENSG00000160803
GO:0031595
IEA
PLAZA Integrative Orthologynuclear proteasome complex ENSG00000160803
GO:0044445
IEA
PLAZA Integrative Orthologycytosolic part ENSG00000160803

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000626Ubiquitin domain
IPR006636Heat shock chaperonin-binding
IPR009060UBA-like superfamily
IPR015496Ubiquilin
IPR015940Ubiquitin-associated domain
IPR029071Ubiquitin-like domain superfamily

No MapMan annotations defined for this gene.
KeggID Description
K04523UBQLN, DSK2; ubiquilin
No chloroplast target sequence found.