Gene: ENSG00000134758 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000134758
Transcript Identifier
ENST00000261593
Gene Type
Coding gene
Location
18 : 32092777-32129187 : positive

Family Information

Homologous gene family
HOM02SEM017130
(5 genes in 1 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
ring finger protein 138, E3 ubiquitin protein ligase

Identifiers

Type Value
pidENSP00000261593
HGNC17765
UniprotQ8WVD3
RefSeq_mRNANM_001191324.1
RefSeq_mRNANM_016271.4

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0032436
IBA
Genome Projectpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0016567
IMP
Genome Projectprotein ubiquitination
GO:0016567
IMP
Gene Ontologyprotein ubiquitination1 2
GO:0016055
IEA
Genome ProjectWnt signaling pathway
GO:0010792
IMP
Genome ProjectDNA double-strand break processing involved in repair via single-strand annealing
GO:0010792
IMP
Gene OntologyDNA double-strand break processing involved in repair via single-strand annealing2
GO:0000724
IMP
Genome Projectdouble-strand break repair via homologous recombination
GO:0000724
IMP
Gene Ontologydouble-strand break repair via homologous recombination1 2
GO:0000209
IBA
Genome Projectprotein polyubiquitination
GO:0039528
IEA
PLAZA Integrative Orthologycytoplasmic pattern recognition receptor signaling pathway in response to virus ENSG00000101695
GO:0051239
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal process ENSG00000101695
GO:0039529
IEA
PLAZA Integrative OrthologyRIG-I signaling pathway ENSG00000101695
GO:0045088
IEA
PLAZA Integrative Orthologyregulation of innate immune response ENSG00000101695
GO:0045087
IEA
PLAZA Integrative Orthologyinnate immune response ENSG00000101695
GO:0045089
IEA
PLAZA Integrative Orthologypositive regulation of innate immune response ENSG00000101695
GO:0039531
IEA
PLAZA Integrative Orthologyregulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway ENSG00000101695
GO:0039535
IEA
PLAZA Integrative Orthologyregulation of RIG-I signaling pathway ENSG00000101695
GO:0039532
IEA
PLAZA Integrative Orthologynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway ENSG00000101695
GO:0032501
IEA
PLAZA Integrative Orthologymulticellular organismal process ENSG00000101695
GO:0050776
IEA
PLAZA Integrative Orthologyregulation of immune response ENSG00000101695
GO:0050778
IEA
PLAZA Integrative Orthologypositive regulation of immune response ENSG00000101695
GO:0039536
IEA
PLAZA Integrative Orthologynegative regulation of RIG-I signaling pathway ENSG00000101695
GO:0032101
IEA
PLAZA Integrative Orthologyregulation of response to external stimulus ENSG00000101695
GO:0032102
IEA
PLAZA Integrative Orthologynegative regulation of response to external stimulus ENSG00000101695
GO:0048585
IEA
PLAZA Integrative Orthologynegative regulation of response to stimulus ENSG00000101695
GO:0009968
IEA
PLAZA Integrative Orthologynegative regulation of signal transduction ENSG00000101695
GO:0009605
IEA
PLAZA Integrative Orthologyresponse to external stimulus ENSG00000101695
GO:0009607
IEA
PLAZA Integrative Orthologyresponse to biotic stimulus ENSG00000101695
GO:0048583
IEA
PLAZA Integrative Orthologyregulation of response to stimulus ENSG00000101695
GO:0048584
IEA
PLAZA Integrative Orthologypositive regulation of response to stimulus ENSG00000101695
GO:0009615
IEA
PLAZA Integrative Orthologyresponse to virus ENSG00000101695
GO:1902532
IEA
PLAZA Integrative Orthologynegative regulation of intracellular signal transduction ENSG00000101695
GO:1902531
IEA
PLAZA Integrative Orthologyregulation of intracellular signal transduction ENSG00000101695
GO:0043207
IEA
PLAZA Integrative Orthologyresponse to external biotic stimulus ENSG00000101695
GO:0032479
IEA
PLAZA Integrative Orthologyregulation of type I interferon production ENSG00000101695
GO:0098542
IEA
PLAZA Integrative Orthologydefense response to other organism ENSG00000101695
GO:0044764
IEA
PLAZA Integrative Orthologymulti-organism cellular process ENSG00000101695
GO:0032480
IEA
PLAZA Integrative Orthologynegative regulation of type I interferon production ENSG00000101695
GO:0051607
IEA
PLAZA Integrative Orthologydefense response to virus ENSG00000101695
GO:0002832
IEA
PLAZA Integrative Orthologynegative regulation of response to biotic stimulus ENSG00000101695
GO:0002831
IEA
PLAZA Integrative Orthologyregulation of response to biotic stimulus ENSG00000101695
GO:0002684
IEA
PLAZA Integrative Orthologypositive regulation of immune system process ENSG00000101695
GO:0002683
IEA
PLAZA Integrative Orthologynegative regulation of immune system process ENSG00000101695
GO:0002682
IEA
PLAZA Integrative Orthologyregulation of immune system process ENSG00000101695
GO:0001819
IEA
PLAZA Integrative Orthologypositive regulation of cytokine production ENSG00000101695
GO:0001818
IEA
PLAZA Integrative Orthologynegative regulation of cytokine production ENSG00000101695
GO:0001817
IEA
PLAZA Integrative Orthologyregulation of cytokine production ENSG00000101695
GO:0010646
IEA
PLAZA Integrative Orthologyregulation of cell communication ENSG00000101695
GO:0001816
IEA
PLAZA Integrative Orthologycytokine production ENSG00000101695
GO:0010648
IEA
PLAZA Integrative Orthologynegative regulation of cell communication ENSG00000101695
GO:0006952
IEA
PLAZA Integrative Orthologydefense response ENSG00000101695
GO:0030522
IEA
PLAZA Integrative Orthologyintracellular receptor signaling pathway ENSG00000101695
GO:0051704
IEA
PLAZA Integrative Orthologymulti-organism process ENSG00000101695
GO:0002218
IEA
PLAZA Integrative Orthologyactivation of innate immune response ENSG00000101695
GO:0002698
IEA
PLAZA Integrative Orthologynegative regulation of immune effector process ENSG00000101695
GO:0002697
IEA
PLAZA Integrative Orthologyregulation of immune effector process ENSG00000101695
GO:0002221
IEA
PLAZA Integrative Orthologypattern recognition receptor signaling pathway ENSG00000101695
GO:0051707
IEA
PLAZA Integrative Orthologyresponse to other organism ENSG00000101695
GO:0050688
IEA
PLAZA Integrative Orthologyregulation of defense response to virus ENSG00000101695
GO:0050687
IEA
PLAZA Integrative Orthologynegative regulation of defense response to virus ENSG00000101695
GO:0031348
IEA
PLAZA Integrative Orthologynegative regulation of defense response ENSG00000101695
GO:0031347
IEA
PLAZA Integrative Orthologyregulation of defense response ENSG00000101695
GO:0023051
IEA
PLAZA Integrative Orthologyregulation of signaling ENSG00000101695
GO:0031349
IEA
PLAZA Integrative Orthologypositive regulation of defense response ENSG00000101695
GO:0023057
IEA
PLAZA Integrative Orthologynegative regulation of signaling ENSG00000101695
GO:0002764
IEA
PLAZA Integrative Orthologyimmune response-regulating signaling pathway ENSG00000101695
GO:0098586
IEA
PLAZA Integrative Orthologycellular response to virus ENSG00000101695
GO:0002376
IEA
PLAZA Integrative Orthologyimmune system process ENSG00000101695
GO:0009966
IEA
PLAZA Integrative Orthologyregulation of signal transduction ENSG00000101695
GO:0002253
IEA
PLAZA Integrative Orthologyactivation of immune response ENSG00000101695
GO:0048523
IEA
PLAZA Integrative Orthologynegative regulation of cellular process ENSG00000101695
GO:0002252
IEA
PLAZA Integrative Orthologyimmune effector process ENSG00000101695
GO:0035556
IEA
PLAZA Integrative Orthologyintracellular signal transduction ENSG00000101695
GO:0051241
IEA
PLAZA Integrative Orthologynegative regulation of multicellular organismal process ENSG00000101695
GO:0051240
IEA
PLAZA Integrative Orthologypositive regulation of multicellular organismal process ENSG00000101695
GO:0002758
IEA
PLAZA Integrative Orthologyinnate immune response-activating signal transduction ENSG00000101695
GO:0002757
IEA
PLAZA Integrative Orthologyimmune response-activating signal transduction ENSG00000101695
GO:0006955
IEA
PLAZA Integrative Orthologyimmune response ENSG00000101695
GO:0002753
IEA
PLAZA Integrative Orthologycytoplasmic pattern recognition receptor signaling pathway ENSG00000101695
GO:0032606
IEA
PLAZA Integrative Orthologytype I interferon production ENSG00000101695
GO:0048519
IEA
PLAZA Integrative Orthologynegative regulation of biological process ENSG00000101695
GO:0080134
IEA
PLAZA Integrative Orthologyregulation of response to stress ENSG00000101695
GO:0043900
IEA
PLAZA Integrative Orthologyregulation of multi-organism process ENSG00000101695
GO:0043901
IEA
PLAZA Integrative Orthologynegative regulation of multi-organism process ENSG00000101695

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0061630
IMP
Genome Projectubiquitin protein ligase activity
GO:0061630
IMP
Gene Ontologyubiquitin protein ligase activity1 2
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0031624
IBA
Genome Projectubiquitin conjugating enzyme binding
GO:0019901
IPI
Genome Projectprotein kinase binding
GO:0019901
IPI
Gene Ontologyprotein kinase binding3
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding1 4 5 6
GO:0003697
IDA
Genome Projectsingle-stranded DNA binding
GO:0003697
IDA
Gene Ontologysingle-stranded DNA binding1
GO:0008270
IEA
PLAZA Integrative Orthologyzinc ion binding ENSG00000101695
GO:0002039
IEA
PLAZA Integrative Orthologyp53 binding ENSG00000101695
GO:0046914
IEA
PLAZA Integrative Orthologytransition metal ion binding ENSG00000101695

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0035861
IDA
Genome Projectsite of double-strand break
GO:0035861
IDA
Gene Ontologysite of double-strand break1 2
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
Gene Ontologynucleus7
GO:0012505
IEA
PLAZA Integrative Orthologyendomembrane system ENSG00000101695
GO:0016020
IEA
PLAZA Integrative Orthologymembrane ENSG00000124226
GO:0031090
IEA
PLAZA Integrative Orthologyorganelle membrane ENSG00000101695
GO:0044425
IEA
PLAZA Integrative Orthologymembrane part ENSG00000101695
GO:0005783
IEA
PLAZA Integrative Orthologyendoplasmic reticulum ENSG00000101695
GO:0034098
IEA
PLAZA Integrative OrthologyVCP-NPL4-UFD1 AAA ATPase complex ENSG00000101695
GO:0098827
IEA
PLAZA Integrative Orthologyendoplasmic reticulum subcompartment ENSG00000101695
GO:0032991
IEA
PLAZA Integrative Orthologyprotein-containing complex ENSG00000101695
GO:0098791
IEA
PLAZA Integrative OrthologyGolgi subcompartment ENSG00000101695
GO:0005829
IEA
PLAZA Integrative Orthologycytosol ENSG00000124226
GO:0005789
IEA
PLAZA Integrative Orthologyendoplasmic reticulum membrane ENSG00000101695
GO:0000139
IEA
PLAZA Integrative OrthologyGolgi membrane ENSG00000101695
GO:0005794
IEA
PLAZA Integrative OrthologyGolgi apparatus ENSG00000101695
GO:0071944
IEA
PLAZA Integrative Orthologycell periphery ENSG00000124226
GO:0042175
IEA
PLAZA Integrative Orthologynuclear outer membrane-endoplasmic reticulum membrane network ENSG00000101695
GO:0005737
IEA
PLAZA Integrative Orthologycytoplasm ENSG00000124226
GO:0098796
IEA
PLAZA Integrative Orthologymembrane protein complex ENSG00000101695
GO:0031984
IEA
PLAZA Integrative Orthologyorganelle subcompartment ENSG00000101695
GO:0098588
IEA
PLAZA Integrative Orthologybounding membrane of organelle ENSG00000101695
GO:0005886
IEA
PLAZA Integrative Orthologyplasma membrane ENSG00000124226
GO:0044444
IEA
PLAZA Integrative Orthologycytoplasmic part ENSG00000124226
GO:0044431
IEA
PLAZA Integrative OrthologyGolgi apparatus part ENSG00000101695
GO:0044432
IEA
PLAZA Integrative Orthologyendoplasmic reticulum part ENSG00000101695

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001841Zinc finger, RING-type
IPR008598Drought induced 19 protein type, zinc-binding domain
IPR013083Zinc finger, RING/FYVE/PHD-type
IPR034734Zinc finger C2HC RNF-type

No MapMan annotations defined for this gene.
KeggID Description
K10668RNF138; E3 ubiquitin-protein ligase RNF138
No chloroplast target sequence found.