Gene: ENSG00000133706 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000133706
Transcript Identifier
ENST00000394434
Gene Type
Coding gene
Location
5 : 146114106-146182493 : negative

Family Information

Homologous gene family
HOM02SEM001863
(33 genes in 25 species)
specific family
Orthologous gene family
ORTHO02SEM002174
(31 genes in 25 species)
specific family

Descriptions

gene_descr
leucyl-tRNA synthetase

Identifiers

Type Value
pidENSP00000377954
HGNC6512
UniprotQ9P2J5
RefSeq_mRNANM_020117.9
EMBLCHEMBL3258
EMBLAB037773
EMBLAC091887
EMBLAC091959
EMBLAK295874
EMBLAY513284
EMBLAY926480
EMBLBC131798
EMBLBC150213
EMBLBC151214
EMBLBC152422
EMBLCH471062
EMBLD84223

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1990253
IMP
Genome Projectcellular response to leucine starvation
GO:1990253
IMP
Gene Ontologycellular response to leucine starvation1
GO:1904263
IMP
Genome Projectpositive regulation of TORC1 signaling
GO:1904263
IMP
Gene Ontologypositive regulation of TORC1 signaling1
GO:0071233
IMP
Genome Projectcellular response to leucine
GO:0071233
IMP
Gene Ontologycellular response to leucine1
GO:0071230
IMP
Genome Projectcellular response to amino acid stimulus
GO:0071230
IMP
Gene Ontologycellular response to amino acid stimulus1
GO:0043547
IMP
Genome Projectpositive regulation of GTPase activity
GO:0043547
IMP
Gene Ontologypositive regulation of GTPase activity1
GO:0034198
IMP
Genome Projectcellular response to amino acid starvation
GO:0034198
IMP
Gene Ontologycellular response to amino acid starvation1
GO:0010507
IMP
Genome Projectnegative regulation of autophagy
GO:0010507
IMP
Gene Ontologynegative regulation of autophagy1
GO:0008361
IMP
Genome Projectregulation of cell size
GO:0008361
IMP
Gene Ontologyregulation of cell size1
GO:0006622
IMP
Genome Projectprotein targeting to lysosome
GO:0006622
IMP
Gene Ontologyprotein targeting to lysosome1
GO:0006450
IEA
Genome Projectregulation of translational fidelity
GO:0006438
IBA
Genome Projectvalyl-tRNA aminoacylation
GO:0006429
IBA
Genome Projectleucyl-tRNA aminoacylation
GO:0006418
TAS
Genome ProjecttRNA aminoacylation for protein translation
GO:0006418
TAS
Gene OntologytRNA aminoacylation for protein translation
GO:0006425
IDA
Gene Ontologyglutaminyl-tRNA aminoacylation2
GO:0031401
IEA
PLAZA Integrative Orthologypositive regulation of protein modification process WBGene00003073
GO:0010562
IEA
PLAZA Integrative Orthologypositive regulation of phosphorus metabolic process WBGene00003073
GO:0080090
IEA
PLAZA Integrative Orthologyregulation of primary metabolic process WBGene00003073
GO:0031326
IEA
PLAZA Integrative Orthologyregulation of cellular biosynthetic process WBGene00003073
GO:0031325
IEA
PLAZA Integrative Orthologypositive regulation of cellular metabolic process WBGene00003073
GO:0032774
IEA
PLAZA Integrative OrthologyRNA biosynthetic process WBGene00003073
GO:0010605
IEA
PLAZA Integrative Orthologynegative regulation of macromolecule metabolic process WBGene00003073
GO:0001934
IEA
PLAZA Integrative Orthologypositive regulation of protein phosphorylation WBGene00003073
GO:0001932
IEA
PLAZA Integrative Orthologyregulation of protein phosphorylation WBGene00003073
GO:0010604
IEA
PLAZA Integrative Orthologypositive regulation of macromolecule metabolic process WBGene00003073
GO:0031327
IEA
PLAZA Integrative Orthologynegative regulation of cellular biosynthetic process WBGene00003073
GO:0006357
IEA
PLAZA Integrative Orthologyregulation of transcription by RNA polymerase II WBGene00003073
GO:0042325
IEA
PLAZA Integrative Orthologyregulation of phosphorylation WBGene00003073
GO:0006796
IEA
PLAZA Integrative Orthologyphosphate-containing compound metabolic process WBGene00003073
GO:0043412
IEA
PLAZA Integrative Orthologymacromolecule modification WBGene00003073
GO:0006793
IEA
PLAZA Integrative Orthologyphosphorus metabolic process WBGene00003073
GO:0006355
IEA
PLAZA Integrative Orthologyregulation of transcription, DNA-templated WBGene00003073
GO:0006351
IEA
PLAZA Integrative Orthologytranscription, DNA-templated WBGene00003073
GO:0060255
IEA
PLAZA Integrative Orthologyregulation of macromolecule metabolic process WBGene00003073
GO:0042327
IEA
PLAZA Integrative Orthologypositive regulation of phosphorylation WBGene00003073
GO:0016310
IEA
PLAZA Integrative Orthologyphosphorylation WBGene00003073
GO:0010558
IEA
PLAZA Integrative Orthologynegative regulation of macromolecule biosynthetic process WBGene00003073
GO:0032268
IEA
PLAZA Integrative Orthologyregulation of cellular protein metabolic process WBGene00003073
GO:0010556
IEA
PLAZA Integrative Orthologyregulation of macromolecule biosynthetic process WBGene00003073
GO:0019220
IEA
PLAZA Integrative Orthologyregulation of phosphate metabolic process WBGene00003073
GO:0018130
IEA
PLAZA Integrative Orthologyheterocycle biosynthetic process WBGene00003073
GO:0000122
IEA
PLAZA Integrative Orthologynegative regulation of transcription by RNA polymerase II WBGene00003073
GO:1903507
IEA
PLAZA Integrative Orthologynegative regulation of nucleic acid-templated transcription WBGene00003073
GO:0006468
IEA
PLAZA Integrative Orthologyprotein phosphorylation WBGene00003073
GO:1903506
IEA
PLAZA Integrative Orthologyregulation of nucleic acid-templated transcription WBGene00003073
GO:0006464
IEA
PLAZA Integrative Orthologycellular protein modification process WBGene00003073
GO:0009890
IEA
PLAZA Integrative Orthologynegative regulation of biosynthetic process WBGene00003073
GO:1901362
IEA
PLAZA Integrative Orthologyorganic cyclic compound biosynthetic process WBGene00003073
GO:0009893
IEA
PLAZA Integrative Orthologypositive regulation of metabolic process WBGene00003073
GO:0019219
IEA
PLAZA Integrative Orthologyregulation of nucleobase-containing compound metabolic process WBGene00003073
GO:0032270
IEA
PLAZA Integrative Orthologypositive regulation of cellular protein metabolic process WBGene00003073
GO:0019438
IEA
PLAZA Integrative Orthologyaromatic compound biosynthetic process WBGene00003073
GO:0097659
IEA
PLAZA Integrative Orthologynucleic acid-templated transcription WBGene00003073
GO:0034654
IEA
PLAZA Integrative Orthologynucleobase-containing compound biosynthetic process WBGene00003073
GO:0010468
IEA
PLAZA Integrative Orthologyregulation of gene expression WBGene00003073
GO:0051252
IEA
PLAZA Integrative Orthologyregulation of RNA metabolic process WBGene00003073
GO:0051174
IEA
PLAZA Integrative Orthologyregulation of phosphorus metabolic process WBGene00003073
GO:0051253
IEA
PLAZA Integrative Orthologynegative regulation of RNA metabolic process WBGene00003073
GO:0010629
IEA
PLAZA Integrative Orthologynegative regulation of gene expression WBGene00003073
GO:0009889
IEA
PLAZA Integrative Orthologyregulation of biosynthetic process WBGene00003073
GO:0045934
IEA
PLAZA Integrative Orthologynegative regulation of nucleobase-containing compound metabolic process WBGene00003073
GO:2001141
IEA
PLAZA Integrative Orthologyregulation of RNA biosynthetic process WBGene00003073
GO:0045937
IEA
PLAZA Integrative Orthologypositive regulation of phosphate metabolic process WBGene00003073
GO:0031399
IEA
PLAZA Integrative Orthologyregulation of protein modification process WBGene00003073
GO:2000112
IEA
PLAZA Integrative Orthologyregulation of cellular macromolecule biosynthetic process WBGene00003073
GO:2000113
IEA
PLAZA Integrative Orthologynegative regulation of cellular macromolecule biosynthetic process WBGene00003073
GO:0045892
IEA
PLAZA Integrative Orthologynegative regulation of transcription, DNA-templated WBGene00003073
GO:0051247
IEA
PLAZA Integrative Orthologypositive regulation of protein metabolic process WBGene00003073
GO:0051246
IEA
PLAZA Integrative Orthologyregulation of protein metabolic process WBGene00003073
GO:1902679
IEA
PLAZA Integrative Orthologynegative regulation of RNA biosynthetic process WBGene00003073
GO:0051171
IEA
PLAZA Integrative Orthologyregulation of nitrogen compound metabolic process WBGene00003073
GO:0051173
IEA
PLAZA Integrative Orthologypositive regulation of nitrogen compound metabolic process WBGene00003073
GO:0006366
IEA
PLAZA Integrative Orthologytranscription by RNA polymerase II WBGene00003073
GO:0051172
IEA
PLAZA Integrative Orthologynegative regulation of nitrogen compound metabolic process WBGene00003073
GO:0036211
IEA
PLAZA Integrative Orthologyprotein modification process WBGene00003073

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005524
IEA
Genome ProjectATP binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding1 3
GO:0005096
IMP
Genome ProjectGTPase activator activity
GO:0005096
IMP
Gene OntologyGTPase activator activity1
GO:0004832
IBA
Genome Projectvaline-tRNA ligase activity
GO:0004823
IBA
TAS
Genome Projectleucine-tRNA ligase activity
GO:0004823
TAS
Gene Ontologyleucine-tRNA ligase activity
GO:0002161
IEA
Genome Projectaminoacyl-tRNA editing activity
GO:0004819
IDA
Gene Ontologyglutamine-tRNA ligase activity2

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005829
IDA
IBA
TAS
Genome Projectcytosol
GO:0005829
IDA
TAS
Gene Ontologycytosol4
GO:0017101
IEA
Genome Projectaminoacyl-tRNA synthetase multienzyme complex
GO:0017101
IDA
Gene Ontologyaminoacyl-tRNA synthetase multienzyme complex5
GO:0016604
IDA
Genome Projectnuclear body
GO:0016604
IDA
Gene Ontologynuclear body
GO:0012505
IDA
Genome Projectendomembrane system
GO:0012505
IDA
Gene Ontologyendomembrane system1
GO:0005783
IDA
Genome Projectendoplasmic reticulum
GO:0005783
IDA
Gene Ontologyendoplasmic reticulum1
GO:0005764
IMP
Genome Projectlysosome
GO:0005764
IMP
Gene Ontologylysosome1
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm1
GO:0055044
IEA
PLAZA Integrative Orthologysymplast AT1G09620
GO:0009536
IEA
PLAZA Integrative Orthologyplastid AT1G09620
GO:0030054
IEA
PLAZA Integrative Orthologycell junction AT1G09620
GO:0005911
IEA
PLAZA Integrative Orthologycell-cell junction AT1G09620
GO:0009506
IEA
PLAZA Integrative Orthologyplasmodesma AT1G09620
GO:0009507
IEA
PLAZA Integrative Orthologychloroplast AT1G09620

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001412Aminoacyl-tRNA synthetase, class I, conserved site
IPR002300Aminoacyl-tRNA synthetase, class Ia
IPR004493Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic
IPR009008Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
IPR009080Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
IPR013155Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
IPR014729Rossmann-like alpha/beta/alpha sandwich fold

No MapMan annotations defined for this gene.
KeggID Description
K01869LARS, leuS; leucyl-tRNA synthetase [EC:6.1.1.4]
No chloroplast target sequence found.