Gene: ENSG00000132646 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000132646
Transcript Identifier
ENST00000379160
Gene Type
Coding gene
Location
20 : 5115283-5119798 : negative

Family Information

Homologous gene family
HOM02SEM001586
(37 genes in 26 species)
specific family
Orthologous gene family
ORTHO02SEM001764
(35 genes in 26 species)
specific family

Descriptions

gene_descr
proliferating cell nuclear antigen

Identifiers

Type Value
pidENSP00000368458
HGNC8729
UniprotP12004
RefSeq_mRNANM_002592.2

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1902990
ISS
Genome Projectmitotic telomere maintenance via semi-conservative replication
GO:1902990
ISS
Gene Ontologymitotic telomere maintenance via semi-conservative replication1
GO:1902065
IEA
Genome Projectresponse to L-glutamate
GO:0097421
IEA
Genome Projectliver regeneration
GO:0071548
IEA
Genome Projectresponse to dexamethasone
GO:0070987
TAS
Genome Projecterror-free translesion synthesis
GO:0070987
TAS
Gene Ontologyerror-free translesion synthesis
GO:0070301
IEA
Genome Projectcellular response to hydrogen peroxide
GO:0046686
IEA
Genome Projectresponse to cadmium ion
GO:0045740
IMP
Genome Projectpositive regulation of DNA replication
GO:0045740
IMP
Gene Ontologypositive regulation of DNA replication2
GO:0045739
IMP
Genome Projectpositive regulation of DNA repair
GO:0045739
IMP
Gene Ontologypositive regulation of DNA repair2
GO:0044849
IEA
Genome Projectestrous cycle
GO:0042769
TAS
Genome ProjectDNA damage response, detection of DNA damage
GO:0042769
TAS
Gene OntologyDNA damage response, detection of DNA damage
GO:0042276
TAS
Genome Projecterror-prone translesion synthesis
GO:0042276
TAS
Gene Ontologyerror-prone translesion synthesis
GO:0034644
IDA
Genome Projectcellular response to UV
GO:0034644
IDA
Gene Ontologycellular response to UV2
GO:0033683
TAS
Genome Projectnucleotide-excision repair, DNA incision
GO:0033683
TAS
Gene Ontologynucleotide-excision repair, DNA incision
GO:0032355
IEA
Genome Projectresponse to estradiol
GO:0032077
IDA
Genome Projectpositive regulation of deoxyribonuclease activity
GO:0032077
IDA
Gene Ontologypositive regulation of deoxyribonuclease activity3
GO:0031297
ISS
Genome Projectreplication fork processing
GO:0031297
ISS
Gene Ontologyreplication fork processing1
GO:0030855
IEP
Genome Projectepithelial cell differentiation
GO:0030855
IEP
Gene Ontologyepithelial cell differentiation4
GO:0019985
IDA
TAS
Genome Projecttranslesion synthesis
GO:0019985
IDA
TAS
Gene Ontologytranslesion synthesis5
GO:0016925
TAS
Genome Projectprotein sumoylation
GO:0016567
TAS
Genome Projectprotein ubiquitination
GO:0016567
TAS
Gene Ontologyprotein ubiquitination
GO:0008283
TAS
Genome Projectcell proliferation
GO:0008283
TAS
Gene Ontologycell proliferation6
GO:0007507
IEA
Genome Projectheart development
GO:0006977
TAS
Genome ProjectDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006977
TAS
Gene OntologyDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006298
IDA
TAS
Genome Projectmismatch repair
GO:0006298
IDA
TAS
Gene Ontologymismatch repair7
GO:0006297
TAS
Genome Projectnucleotide-excision repair, DNA gap filling
GO:0006297
TAS
Gene Ontologynucleotide-excision repair, DNA gap filling
GO:0006296
TAS
Genome Projectnucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006296
TAS
Gene Ontologynucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006283
TAS
Genome Projecttranscription-coupled nucleotide-excision repair
GO:0006283
TAS
Gene Ontologytranscription-coupled nucleotide-excision repair
GO:0006266
TAS
Genome ProjectDNA ligation
GO:0000723
TAS
Genome Projecttelomere maintenance
GO:0000723
TAS
Gene Ontologytelomere maintenance
GO:0000722
TAS
Genome Projecttelomere maintenance via recombination
GO:0000083
TAS
Genome Projectregulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000083
TAS
Gene Ontologyregulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0032201
TAS
Gene Ontologytelomere maintenance via semi-conservative replication
GO:0010605
IEA
PLAZA Integrative Orthologynegative regulation of macromolecule metabolic process YBR088C
GO:0048477
IEA
PLAZA Integrative Orthologyoogenesis FBgn0005655
GO:0022412
IEA
PLAZA Integrative Orthologycellular process involved in reproduction in multicellular organism FBgn0005655
GO:0048468
IEA
PLAZA Integrative Orthologycell development FBgn0005655
GO:1905777
IEA
PLAZA Integrative Orthologyregulation of exonuclease activity YBR088C
GO:1905779
IEA
PLAZA Integrative Orthologypositive regulation of exonuclease activity YBR088C
GO:1901575
IEA
PLAZA Integrative Orthologyorganic substance catabolic process SPBC16D10.09
GO:0034087
IEA
PLAZA Integrative Orthologyestablishment of mitotic sister chromatid cohesion YBR088C
GO:0030163
IEA
PLAZA Integrative Orthologyprotein catabolic process SPBC16D10.09
GO:0044703
IEA
PLAZA Integrative Orthologymulti-organism reproductive process FBgn0005655
GO:0034085
IEA
PLAZA Integrative Orthologyestablishment of sister chromatid cohesion YBR088C
GO:0007281
IEA
PLAZA Integrative Orthologygerm cell development FBgn0005655
GO:0051347
IEA
PLAZA Integrative Orthologypositive regulation of transferase activity SPBC16D10.09
GO:2000573
IEA
PLAZA Integrative Orthologypositive regulation of DNA biosynthetic process SPBC16D10.09
GO:0097549
IEA
PLAZA Integrative Orthologychromatin organization involved in negative regulation of transcription YBR088C
GO:0010558
IEA
PLAZA Integrative Orthologynegative regulation of macromolecule biosynthetic process YBR088C
GO:0034401
IEA
PLAZA Integrative Orthologychromatin organization involved in regulation of transcription YBR088C
GO:0044265
IEA
PLAZA Integrative Orthologycellular macromolecule catabolic process SPBC16D10.09
GO:0043570
IEA
PLAZA Integrative Orthologymaintenance of DNA repeat elements YBR088C
GO:0032989
IEA
PLAZA Integrative Orthologycellular component morphogenesis FBgn0005655
GO:0007307
IEA
PLAZA Integrative Orthologyeggshell chorion gene amplification FBgn0005655
GO:0007306
IEA
PLAZA Integrative Orthologyeggshell chorion assembly FBgn0005655
GO:0009607
IEA
PLAZA Integrative Orthologyresponse to biotic stimulus FBgn0005655
GO:1903507
IEA
PLAZA Integrative Orthologynegative regulation of nucleic acid-templated transcription YBR088C
GO:0006348
IEA
PLAZA Integrative Orthologychromatin silencing at telomere YBR088C
GO:0006342
IEA
PLAZA Integrative Orthologychromatin silencing YBR088C
GO:0044257
IEA
PLAZA Integrative Orthologycellular protein catabolic process SPBC16D10.09
GO:0007276
IEA
PLAZA Integrative Orthologygamete generation FBgn0005655
GO:0007399
IEA
PLAZA Integrative Orthologynervous system development FBgn0005655
GO:1901565
IEA
PLAZA Integrative Orthologyorganonitrogen compound catabolic process SPBC16D10.09
GO:0009056
IEA
PLAZA Integrative Orthologycatabolic process SPBC16D10.09
GO:0009057
IEA
PLAZA Integrative Orthologymacromolecule catabolic process SPBC16D10.09
GO:0043207
IEA
PLAZA Integrative Orthologyresponse to external biotic stimulus FBgn0005655
GO:0019953
IEA
PLAZA Integrative Orthologysexual reproduction FBgn0005655
GO:0051338
IEA
PLAZA Integrative Orthologyregulation of transferase activity SPBC16D10.09
GO:0010629
IEA
PLAZA Integrative Orthologynegative regulation of gene expression YBR088C
GO:0044248
IEA
PLAZA Integrative Orthologycellular catabolic process SPBC16D10.09
GO:1903459
IEA
PLAZA Integrative Orthologymitotic DNA replication lagging strand elongation SPBC16D10.09
GO:0045732
IEA
PLAZA Integrative Orthologypositive regulation of protein catabolic process SPBC16D10.09
GO:0007064
IEA
PLAZA Integrative Orthologymitotic sister chromatid cohesion YBR088C
GO:0070914
IEA
PLAZA Integrative OrthologyUV-damage excision repair SPBC16D10.09
GO:0007062
IEA
PLAZA Integrative Orthologysister chromatid cohesion YBR088C
GO:0035753
IEA
PLAZA Integrative Orthologymaintenance of DNA trinucleotide repeats YBR088C
GO:0030466
IEA
PLAZA Integrative Orthologychromatin silencing at silent mating-type cassette YBR088C
GO:0098813
IEA
PLAZA Integrative Orthologynuclear chromosome segregation YBR088C
GO:2000278
IEA
PLAZA Integrative Orthologyregulation of DNA biosynthetic process SPBC16D10.09
GO:0044085
IEA
PLAZA Integrative Orthologycellular component biogenesis FBgn0032813
GO:0048285
IEA
PLAZA Integrative Orthologyorganelle fission YBR088C
GO:0051321
IEA
PLAZA Integrative Orthologymeiotic cell cycle YBR088C
GO:0003006
IEA
PLAZA Integrative Orthologydevelopmental process involved in reproduction FBgn0005655
GO:0007059
IEA
PLAZA Integrative Orthologychromosome segregation YBR088C
GO:0051172
IEA
PLAZA Integrative Orthologynegative regulation of nitrogen compound metabolic process YBR088C
GO:0042176
IEA
PLAZA Integrative Orthologyregulation of protein catabolic process SPBC16D10.09
GO:0022607
IEA
PLAZA Integrative Orthologycellular component assembly FBgn0032813
GO:1903046
IEA
PLAZA Integrative Orthologymeiotic cell cycle process YBR088C
GO:0007052
IEA
PLAZA Integrative Orthologymitotic spindle organization FBgn0005655
GO:0007051
IEA
PLAZA Integrative Orthologyspindle organization FBgn0005655
GO:0000819
IEA
PLAZA Integrative Orthologysister chromatid segregation YBR088C
GO:0007292
IEA
PLAZA Integrative Orthologyfemale gamete generation FBgn0005655
GO:0031324
IEA
PLAZA Integrative Orthologynegative regulation of cellular metabolic process YBR088C
GO:0090329
IEA
PLAZA Integrative Orthologyregulation of DNA-dependent DNA replication SPBC16D10.09
GO:0019730
IEA
PLAZA Integrative Orthologyantimicrobial humoral response FBgn0005655
GO:0031327
IEA
PLAZA Integrative Orthologynegative regulation of cellular biosynthetic process YBR088C
GO:0010927
IEA
PLAZA Integrative Orthologycellular component assembly involved in morphogenesis FBgn0005655
GO:0031329
IEA
PLAZA Integrative Orthologyregulation of cellular catabolic process SPBC16D10.09
GO:0040029
IEA
PLAZA Integrative Orthologyregulation of gene expression, epigenetic YBR088C
GO:1902983
IEA
PLAZA Integrative OrthologyDNA strand elongation involved in mitotic DNA replication SPBC16D10.09
GO:0006277
IEA
PLAZA Integrative OrthologyDNA amplification FBgn0005655
GO:0006272
IEA
PLAZA Integrative Orthologyleading strand elongation YBR088C
GO:0006271
IEA
PLAZA Integrative OrthologyDNA strand elongation involved in DNA replication SPBC16D10.09
GO:0022616
IEA
PLAZA Integrative OrthologyDNA strand elongation SPBC16D10.09
GO:0006273
IEA
PLAZA Integrative Orthologylagging strand elongation SPBC16D10.09
GO:0061982
IEA
PLAZA Integrative Orthologymeiosis I cell cycle process YBR088C
GO:0043933
IEA
PLAZA Integrative Orthologyprotein-containing complex subunit organization FBgn0032813
GO:0016458
IEA
PLAZA Integrative Orthologygene silencing YBR088C
GO:0051704
IEA
PLAZA Integrative Orthologymulti-organism process FBgn0005655
GO:0031331
IEA
PLAZA Integrative Orthologypositive regulation of cellular catabolic process SPBC16D10.09
GO:0032268
IEA
PLAZA Integrative Orthologyregulation of cellular protein metabolic process SPBC16D10.09
GO:0140014
IEA
PLAZA Integrative Orthologymitotic nuclear division YBR088C
GO:0000280
IEA
PLAZA Integrative Orthologynuclear division YBR088C
GO:1902969
IEA
PLAZA Integrative Orthologymitotic DNA replication SPBC16D10.09
GO:0002066
IEA
PLAZA Integrative Orthologycolumnar/cuboidal epithelial cell development FBgn0005655
GO:0002065
IEA
PLAZA Integrative Orthologycolumnar/cuboidal epithelial cell differentiation FBgn0005655
GO:0000710
IEA
PLAZA Integrative Orthologymeiotic mismatch repair YBR088C
GO:0009894
IEA
PLAZA Integrative Orthologyregulation of catabolic process SPBC16D10.09
GO:0009653
IEA
PLAZA Integrative Orthologyanatomical structure morphogenesis FBgn0005655
GO:0002064
IEA
PLAZA Integrative Orthologyepithelial cell development FBgn0005655
GO:0009896
IEA
PLAZA Integrative Orthologypositive regulation of catabolic process SPBC16D10.09
GO:0009890
IEA
PLAZA Integrative Orthologynegative regulation of biosynthetic process YBR088C
GO:0051707
IEA
PLAZA Integrative Orthologyresponse to other organism FBgn0005655
GO:1902850
IEA
PLAZA Integrative Orthologymicrotubule cytoskeleton organization involved in mitosis FBgn0005655
GO:0009892
IEA
PLAZA Integrative Orthologynegative regulation of metabolic process YBR088C
GO:1903022
IEA
PLAZA Integrative Orthologypositive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands YBR088C
GO:1902296
IEA
PLAZA Integrative OrthologyDNA strand elongation involved in cell cycle DNA replication SPBC16D10.09
GO:1903021
IEA
PLAZA Integrative Orthologyregulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands YBR088C
GO:0032270
IEA
PLAZA Integrative Orthologypositive regulation of cellular protein metabolic process SPBC16D10.09
GO:0051259
IEA
PLAZA Integrative Orthologyprotein complex oligomerization FBgn0032813
GO:0000070
IEA
PLAZA Integrative Orthologymitotic sister chromatid segregation YBR088C
GO:0051253
IEA
PLAZA Integrative Orthologynegative regulation of RNA metabolic process YBR088C
GO:0002376
IEA
PLAZA Integrative Orthologyimmune system process FBgn0005655
GO:0045934
IEA
PLAZA Integrative Orthologynegative regulation of nucleobase-containing compound metabolic process YBR088C
GO:0007304
IEA
PLAZA Integrative Orthologychorion-containing eggshell formation FBgn0005655
GO:0000226
IEA
PLAZA Integrative Orthologymicrotubule cytoskeleton organization FBgn0005655
GO:0048646
IEA
PLAZA Integrative Orthologyanatomical structure formation involved in morphogenesis FBgn0005655
GO:0051260
IEA
PLAZA Integrative Orthologyprotein homooligomerization FBgn0032813
GO:1900264
IEA
PLAZA Integrative Orthologypositive regulation of DNA-directed DNA polymerase activity SPBC16D10.09
GO:1900262
IEA
PLAZA Integrative Orthologyregulation of DNA-directed DNA polymerase activity SPBC16D10.09
GO:0065003
IEA
PLAZA Integrative Orthologyprotein-containing complex assembly FBgn0032813
GO:0045814
IEA
PLAZA Integrative Orthologynegative regulation of gene expression, epigenetic YBR088C
GO:0070206
IEA
PLAZA Integrative Orthologyprotein trimerization FBgn0032813
GO:0070207
IEA
PLAZA Integrative Orthologyprotein homotrimerization FBgn0032813
GO:2000113
IEA
PLAZA Integrative Orthologynegative regulation of cellular macromolecule biosynthetic process YBR088C
GO:0006959
IEA
PLAZA Integrative Orthologyhumoral immune response FBgn0005655
GO:0030707
IEA
PLAZA Integrative Orthologyovarian follicle cell development FBgn0005655
GO:0045892
IEA
PLAZA Integrative Orthologynegative regulation of transcription, DNA-templated YBR088C
GO:0006955
IEA
PLAZA Integrative Orthologyimmune response FBgn0005655
GO:0030703
IEA
PLAZA Integrative Orthologyeggshell formation FBgn0005655
GO:0051247
IEA
PLAZA Integrative Orthologypositive regulation of protein metabolic process SPBC16D10.09
GO:0051246
IEA
PLAZA Integrative Orthologyregulation of protein metabolic process SPBC16D10.09
GO:0007017
IEA
PLAZA Integrative Orthologymicrotubule-based process FBgn0005655
GO:1902679
IEA
PLAZA Integrative Orthologynegative regulation of RNA biosynthetic process YBR088C
GO:1902319
IEA
PLAZA Integrative OrthologyDNA strand elongation involved in nuclear cell cycle DNA replication SPBC16D10.09
GO:0006325
IEA
PLAZA Integrative Orthologychromatin organization YBR088C
GO:0022008
IEA
PLAZA Integrative Orthologyneurogenesis FBgn0005655
GO:1903364
IEA
PLAZA Integrative Orthologypositive regulation of cellular protein catabolic process SPBC16D10.09
GO:0007010
IEA
PLAZA Integrative Orthologycytoskeleton organization FBgn0005655
GO:1902392
IEA
PLAZA Integrative Orthologyregulation of exodeoxyribonuclease activity YBR088C
GO:1902394
IEA
PLAZA Integrative Orthologypositive regulation of exodeoxyribonuclease activity YBR088C
GO:1903362
IEA
PLAZA Integrative Orthologyregulation of cellular protein catabolic process SPBC16D10.09

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070182
IPI
Genome ProjectDNA polymerase binding
GO:0070182
IPI
Gene OntologyDNA polymerase binding2 8
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042802
IPI
Gene Ontologyidentical protein binding9 10
GO:0035035
IPI
Genome Projecthistone acetyltransferase binding
GO:0035035
IPI
Gene Ontologyhistone acetyltransferase binding2
GO:0032405
IDA
Genome ProjectMutLalpha complex binding
GO:0032405
IDA
Gene OntologyMutLalpha complex binding7
GO:0032139
IDA
Genome Projectdinucleotide insertion or deletion binding
GO:0032139
IDA
Gene Ontologydinucleotide insertion or deletion binding7
GO:0030971
IPI
Genome Projectreceptor tyrosine kinase binding
GO:0030971
IPI
Gene Ontologyreceptor tyrosine kinase binding11
GO:0030337
IEA
Genome ProjectDNA polymerase processivity factor activity
GO:0030331
IEA
Genome Projectestrogen receptor binding
GO:0019899
IPI
Genome Projectenzyme binding
GO:0019899
IPI
Gene Ontologyenzyme binding1
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding7 9 10 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63
GO:0003684
IDA
Genome Projectdamaged DNA binding
GO:0003684
IDA
Gene Ontologydamaged DNA binding2
GO:0003682
IDA
Genome Projectchromatin binding
GO:0003682
IDA
Gene Ontologychromatin binding2 64
GO:0000701
IDA
Genome Projectpurine-specific mismatch base pair DNA N-glycosylase activity
GO:0000701
IDA
Gene Ontologypurine-specific mismatch base pair DNA N-glycosylase activity7

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070557
IDA
Genome ProjectPCNA-p21 complex
GO:0070557
IDA
Gene OntologyPCNA-p21 complex65
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0070062
Gene Ontologyextracellular exosome66
GO:0043626
IDA
Genome ProjectPCNA complex
GO:0043626
IDA
Gene OntologyPCNA complex2
GO:0043596
IDA
Genome Projectnuclear replication fork
GO:0043596
IDA
Gene Ontologynuclear replication fork18 67
GO:0030894
TAS
Genome Projectreplisome
GO:0030894
TAS
Gene Ontologyreplisome1
GO:0016604
IDA
Genome Projectnuclear body
GO:0016604
IDA
Gene Ontologynuclear body
GO:0005813
IDA
Genome Projectcentrosome
GO:0005813
IDA
Gene Ontologycentrosome68
GO:0005663
TAS
Genome ProjectDNA replication factor C complex
GO:0005663
TAS
Gene OntologyDNA replication factor C complex6
GO:0005657
IDA
Genome Projectreplication fork
GO:0005657
IDA
Gene Ontologyreplication fork69
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005654
IDA
TAS
Gene Ontologynucleoplasm
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus2 70 71
GO:0000784
IDA
Genome Projectnuclear chromosome, telomeric region
GO:0000784
Gene Ontologynuclear chromosome, telomeric region72
GO:0000785
IDA
Gene Ontologychromatin64
GO:0035861
IEA
PLAZA Integrative Orthologysite of double-strand break SPBC16D10.09
GO:0000790
IEA
PLAZA Integrative Orthologynuclear chromatin SPBC16D10.09
GO:0005829
IEA
PLAZA Integrative Orthologycytosol SPBC16D10.09
GO:0005737
IEA
PLAZA Integrative Orthologycytoplasm SPBC16D10.09
GO:0005730
IEA
PLAZA Integrative Orthologynucleolus AT1G07370
GO:0044444
IEA
PLAZA Integrative Orthologycytoplasmic part SPBC16D10.09
GO:0005875
IEA
PLAZA Integrative Orthologymicrotubule associated complex FBgn0005655
GO:0090734
IEA
PLAZA Integrative Orthologysite of DNA damage SPBC16D10.09

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000730Proliferating cell nuclear antigen, PCNA
IPR022648Proliferating cell nuclear antigen, PCNA, N-terminal
IPR022649Proliferating cell nuclear antigen, PCNA, C-terminal
IPR022659Proliferating cell nuclear antigen, PCNA, conserved site

No MapMan annotations defined for this gene.
KeggID Description
K04802PCNA; proliferating cell nuclear antigen
No chloroplast target sequence found.