Gene: ENSG00000131187 (Homo sapiens)

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Gene Identifier
ENSG00000131187
Transcript Identifier
ENST00000253496
Gene Type
Coding gene
Location
5 : 177402292-177409527 : negative

Family Information

Homologous gene family
HOM02SEM000009
(875 genes in 18 species)
specific family
Orthologous gene family
ORTHO02SEM000010
(778 genes in 18 species)
specific family

Descriptions

gene_descr
coagulation factor XII (Hageman factor)

Identifiers

Type Value
pidENSP00000253496
HGNC3530
UniprotP00748
RefSeq_mRNANM_000505.3
EMBLCHEMBL2821
EMBLAC145098
EMBLAF538691
EMBLM11723
EMBLM13147
EMBLM17464
EMBLM17465
EMBLM17466
EMBLM31315
EMBLU71274

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0051919
IDA
Genome Projectpositive regulation of fibrinolysis
GO:0051919
IDA
Gene Ontologypositive regulation of fibrinolysis1
GO:0051788
IDA
Genome Projectresponse to misfolded protein
GO:0051788
IDA
Gene Ontologyresponse to misfolded protein2
GO:0045087
TAS
Genome Projectinnate immune response
GO:0045087
TAS
Gene Ontologyinnate immune response3
GO:0042730
IEA
Genome Projectfibrinolysis
GO:0031638
IDA
Genome Projectzymogen activation
GO:0031638
IDA
Gene Ontologyzymogen activation1 2 4
GO:0030194
IDA
Genome Projectpositive regulation of blood coagulation
GO:0030194
IDA
Gene Ontologypositive regulation of blood coagulation4
GO:0016540
IDA
Genome Projectprotein autoprocessing
GO:0016540
IDA
Gene Ontologyprotein autoprocessing2
GO:0016485
IDA
Genome Projectprotein processing
GO:0016485
IDA
Gene Ontologyprotein processing2
GO:0010756
IDA
Genome Projectpositive regulation of plasminogen activation
GO:0010756
IDA
Gene Ontologypositive regulation of plasminogen activation1
GO:0007597
TAS, IC
Genome Projectblood coagulation, intrinsic pathway
GO:0007597
TAS, IC
Gene Ontologyblood coagulation, intrinsic pathway2
GO:0002542
IDA
Genome ProjectFactor XII activation
GO:0002542
IDA
Gene OntologyFactor XII activation2
GO:0002353
IDA
Genome Projectplasma kallikrein-kinin cascade
GO:0002353
IDA
Gene Ontologyplasma kallikrein-kinin cascade2 4
GO:0030155
IEA
PLAZA Integrative Orthologyregulation of cell adhesion ENSG00000122861
GO:0051234
IEA
PLAZA Integrative Orthologyestablishment of localization ENSG00000122861
GO:0048870
IEA
PLAZA Integrative Orthologycell motility ENSG00000122861
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction FBgn0039568
GO:0002275
IEA
PLAZA Integrative Orthologymyeloid cell activation involved in immune response ENSG00000122861
GO:0061302
IEA
PLAZA Integrative Orthologysmooth muscle cell-matrix adhesion ENSG00000122861
GO:0002274
IEA
PLAZA Integrative Orthologymyeloid leukocyte activation ENSG00000122861
GO:0043299
IEA
PLAZA Integrative Orthologyleukocyte degranulation ENSG00000122861
GO:0007165
IEA
PLAZA Integrative Orthologysignal transduction ENSG00000167755
GO:0007160
IEA
PLAZA Integrative Orthologycell-matrix adhesion ENSG00000122861
GO:0014910
IEA
PLAZA Integrative Orthologyregulation of smooth muscle cell migration ENSG00000122861
GO:0032504
IEA
PLAZA Integrative Orthologymulticellular organism reproduction FBgn0039568
GO:0045745
IEA
PLAZA Integrative Orthologypositive regulation of G protein-coupled receptor signaling pathway ENSG00000167755
GO:0002263
IEA
PLAZA Integrative Orthologycell activation involved in immune response ENSG00000122861
GO:0007155
IEA
PLAZA Integrative Orthologycell adhesion ENSG00000148702
GO:0007154
IEA
PLAZA Integrative Orthologycell communication ENSG00000167755
GO:0042119
IEA
PLAZA Integrative Orthologyneutrophil activation ENSG00000122861
GO:0030335
IEA
PLAZA Integrative Orthologypositive regulation of cell migration ENSG00000122861
GO:0070997
IEA
PLAZA Integrative Orthologyneuron death ENSG00000167755
GO:0030334
IEA
PLAZA Integrative Orthologyregulation of cell migration ENSG00000122861
GO:0010469
IEA
PLAZA Integrative Orthologyregulation of signaling receptor activity ENSG00000122861
GO:0006928
IEA
PLAZA Integrative Orthologymovement of cell or subcellular component ENSG00000122861
GO:0051179
IEA
PLAZA Integrative Orthologylocalization ENSG00000122861
GO:0032879
IEA
PLAZA Integrative Orthologyregulation of localization ENSG00000122861
GO:0002446
IEA
PLAZA Integrative Orthologyneutrophil mediated immunity ENSG00000122861
GO:0002444
IEA
PLAZA Integrative Orthologymyeloid leukocyte mediated immunity ENSG00000122861
GO:0006810
IEA
PLAZA Integrative Orthologytransport ENSG00000122861
GO:0008277
IEA
PLAZA Integrative Orthologyregulation of G protein-coupled receptor signaling pathway ENSG00000167755
GO:0043312
IEA
PLAZA Integrative Orthologyneutrophil degranulation ENSG00000122861
GO:0007186
IEA
PLAZA Integrative OrthologyG protein-coupled receptor signaling pathway ENSG00000167755
GO:0014812
IEA
PLAZA Integrative Orthologymuscle cell migration ENSG00000122861
GO:0045055
IEA
PLAZA Integrative Orthologyregulated exocytosis ENSG00000122861
GO:0002443
IEA
PLAZA Integrative Orthologyleukocyte mediated immunity ENSG00000122861
GO:0006887
IEA
PLAZA Integrative Orthologyexocytosis ENSG00000122861
GO:0002283
IEA
PLAZA Integrative Orthologyneutrophil activation involved in immune response ENSG00000122861
GO:0042330
IEA
PLAZA Integrative Orthologytaxis ENSG00000122861
GO:2000147
IEA
PLAZA Integrative Orthologypositive regulation of cell motility ENSG00000122861
GO:0010646
IEA
PLAZA Integrative Orthologyregulation of cell communication ENSG00000167755
GO:2000145
IEA
PLAZA Integrative Orthologyregulation of cell motility ENSG00000122861
GO:0051716
IEA
PLAZA Integrative Orthologycellular response to stimulus ENSG00000167755
GO:0045321
IEA
PLAZA Integrative Orthologyleukocyte activation ENSG00000122861
GO:0010647
IEA
PLAZA Integrative Orthologypositive regulation of cell communication ENSG00000167755
GO:0051674
IEA
PLAZA Integrative Orthologylocalization of cell ENSG00000122861
GO:0033627
IEA
PLAZA Integrative Orthologycell adhesion mediated by integrin ENSG00000122861
GO:0001775
IEA
PLAZA Integrative Orthologycell activation ENSG00000122861
GO:0033628
IEA
PLAZA Integrative Orthologyregulation of cell adhesion mediated by integrin ENSG00000122861
GO:0022610
IEA
PLAZA Integrative Orthologybiological adhesion ENSG00000148702
GO:0032940
IEA
PLAZA Integrative Orthologysecretion by cell ENSG00000122861
GO:0016477
IEA
PLAZA Integrative Orthologycell migration ENSG00000122861
GO:0016192
IEA
PLAZA Integrative Orthologyvesicle-mediated transport ENSG00000122861
GO:0006935
IEA
PLAZA Integrative Orthologychemotaxis ENSG00000122861
GO:0040017
IEA
PLAZA Integrative Orthologypositive regulation of locomotion ENSG00000122861
GO:0051270
IEA
PLAZA Integrative Orthologyregulation of cellular component movement ENSG00000122861
GO:0051272
IEA
PLAZA Integrative Orthologypositive regulation of cellular component movement ENSG00000122861
GO:0036230
IEA
PLAZA Integrative Orthologygranulocyte activation ENSG00000122861
GO:0040011
IEA
PLAZA Integrative Orthologylocomotion ENSG00000122861
GO:0040012
IEA
PLAZA Integrative Orthologyregulation of locomotion ENSG00000122861
GO:0031589
IEA
PLAZA Integrative Orthologycell-substrate adhesion ENSG00000122861
GO:0023052
IEA
PLAZA Integrative Orthologysignaling ENSG00000167755
GO:0023051
IEA
PLAZA Integrative Orthologyregulation of signaling ENSG00000167755
GO:0001952
IEA
PLAZA Integrative Orthologyregulation of cell-matrix adhesion ENSG00000122861
GO:0023056
IEA
PLAZA Integrative Orthologypositive regulation of signaling ENSG00000167755
GO:0065009
IEA
PLAZA Integrative Orthologyregulation of molecular function ENSG00000122861
GO:0009966
IEA
PLAZA Integrative Orthologyregulation of signal transduction ENSG00000167755
GO:0009967
IEA
PLAZA Integrative Orthologypositive regulation of signal transduction ENSG00000167755
GO:0002252
IEA
PLAZA Integrative Orthologyimmune effector process ENSG00000122861
GO:2000097
IEA
PLAZA Integrative Orthologyregulation of smooth muscle cell-matrix adhesion ENSG00000122861
GO:0046903
IEA
PLAZA Integrative Orthologysecretion ENSG00000122861
GO:0010810
IEA
PLAZA Integrative Orthologyregulation of cell-substrate adhesion ENSG00000122861
GO:0008219
IEA
PLAZA Integrative Orthologycell death ENSG00000167755
GO:0002366
IEA
PLAZA Integrative Orthologyleukocyte activation involved in immune response ENSG00000122861

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0051787
IC
Genome Projectmisfolded protein binding
GO:0051787
IC
Gene Ontologymisfolded protein binding2
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding5 6
GO:0005509
IEA
Genome Projectcalcium ion binding
GO:0004252
IDA
TAS
Genome Projectserine-type endopeptidase activity
GO:0004252
IDA
TAS
Gene Ontologyserine-type endopeptidase activity2 4
GO:0005539
IEA
PLAZA Integrative Orthologyglycosaminoglycan binding ENSG00000148702
GO:0097367
IEA
PLAZA Integrative Orthologycarbohydrate derivative binding ENSG00000148702

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0070062
Gene Ontologyextracellular exosome7
GO:0005886
TAS
Genome Projectplasma membrane
GO:0005886
TAS
Gene Ontologyplasma membrane
GO:0005615
IDA
Genome Projectextracellular space
GO:0005615
IDA
Gene Ontologyextracellular space4
GO:0005576
TAS
Genome Projectextracellular region
GO:0005576
TAS
Gene Ontologyextracellular region
GO:0098805
IEA
PLAZA Integrative Orthologywhole membrane ENSG00000122861
GO:0012505
IEA
PLAZA Integrative Orthologyendomembrane system ENSG00000122861
GO:0012506
IEA
PLAZA Integrative Orthologyvesicle membrane ENSG00000122861
GO:0009986
IEA
PLAZA Integrative Orthologycell surface ENSG00000122861
GO:0031090
IEA
PLAZA Integrative Orthologyorganelle membrane ENSG00000122861
GO:0044424
IEA
PLAZA Integrative Orthologyintracellular part ENSG00000167755
GO:0044422
IEA
PLAZA Integrative Orthologyorganelle part ENSG00000122861
GO:0035579
IEA
PLAZA Integrative Orthologyspecific granule membrane ENSG00000122861
GO:0097708
IEA
PLAZA Integrative Orthologyintracellular vesicle ENSG00000122861
GO:0070821
IEA
PLAZA Integrative Orthologytertiary granule membrane ENSG00000122861
GO:0070820
IEA
PLAZA Integrative Orthologytertiary granule ENSG00000122861
GO:0031410
IEA
PLAZA Integrative Orthologycytoplasmic vesicle ENSG00000122861
GO:0005924
IEA
PLAZA Integrative Orthologycell-substrate adherens junction ENSG00000122861
GO:0005925
IEA
PLAZA Integrative Orthologyfocal adhesion ENSG00000122861
GO:0030054
IEA
PLAZA Integrative Orthologycell junction ENSG00000122861
GO:0030055
IEA
PLAZA Integrative Orthologycell-substrate junction ENSG00000122861
GO:0042581
IEA
PLAZA Integrative Orthologyspecific granule ENSG00000122861
GO:0099503
IEA
PLAZA Integrative Orthologysecretory vesicle ENSG00000122861
GO:0005737
IEA
PLAZA Integrative Orthologycytoplasm ENSG00000167755
GO:0005622
IEA
PLAZA Integrative Orthologyintracellular ENSG00000167755
GO:0098588
IEA
PLAZA Integrative Orthologybounding membrane of organelle ENSG00000122861
GO:0030659
IEA
PLAZA Integrative Orthologycytoplasmic vesicle membrane ENSG00000122861
GO:0005912
IEA
PLAZA Integrative Orthologyadherens junction ENSG00000122861
GO:0044446
IEA
PLAZA Integrative Orthologyintracellular organelle part ENSG00000122861
GO:0044444
IEA
PLAZA Integrative Orthologycytoplasmic part ENSG00000122861
GO:0030141
IEA
PLAZA Integrative Orthologysecretory granule ENSG00000122861
GO:0070161
IEA
PLAZA Integrative Orthologyanchoring junction ENSG00000122861
GO:0030667
IEA
PLAZA Integrative Orthologysecretory granule membrane ENSG00000122861
GO:0044433
IEA
PLAZA Integrative Orthologycytoplasmic vesicle part ENSG00000122861
GO:0043229
IEA
PLAZA Integrative Orthologyintracellular organelle ENSG00000122861

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000001Kringle
IPR000083Fibronectin, type I
IPR000562Fibronectin type II domain
IPR000742EGF-like domain
IPR001254Serine proteases, trypsin domain
IPR001314Peptidase S1A, chymotrypsin family
IPR001881EGF-like calcium-binding domain
IPR009003Peptidase S1, PA clan
IPR013032EGF-like, conserved site
IPR013806Kringle-like fold
IPR014394Coagulation factor XII/hepatocyte growth factor activator
IPR018056Kringle, conserved site
IPR018114Serine proteases, trypsin family, histidine active site
IPR033116Serine proteases, trypsin family, serine active site

No MapMan annotations defined for this gene.
KeggID Description
K01328F12; coagulation factor XII (Hageman factor)
No chloroplast target sequence found.