Gene: ENSG00000129521 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000129521
Transcript Identifier
ENST00000250457
Gene Type
Coding gene
Location
14 : 33925891-33950752 : negative

Family Information

Homologous gene family
HOM02SEM005178
(16 genes in 6 species)
specific family

Descriptions

gene_descr
egl-9 family hypoxia-inducible factor 3

Identifiers

Type Value
pidENSP00000250457
HGNC14661
UniprotQ9H6Z9
RefSeq_mRNANM_022073.3
EMBLCHEMBL5705
EMBLAJ310545
EMBLAK025273
EMBLBC010992
EMBLBC064924
EMBLBC105939
EMBLBC111057

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0061418
TAS
Genome Projectregulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061418
TAS
Gene Ontologyregulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0055114
IEA
Genome Projectoxidation-reduction process
GO:0043523
ISS
Genome Projectregulation of neuron apoptotic process
GO:0043523
ISS
Gene Ontologyregulation of neuron apoptotic process
GO:0042127
IEP
Genome Projectregulation of cell proliferation
GO:0042127
IEP
Gene Ontologyregulation of cell proliferation1
GO:0018401
IDA
Genome Projectpeptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0018401
IDA
Gene Ontologypeptidyl-proline hydroxylation to 4-hydroxy-L-proline2
GO:0018126
IDA
Genome Projectprotein hydroxylation
GO:0018126
IDA
Gene Ontologyprotein hydroxylation3
GO:0006974
IEA
Genome Projectcellular response to DNA damage stimulus
GO:0006919
IEP
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
IEP
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process1
GO:0006915
IEP
Genome Projectapoptotic process
GO:0006915
IEP
Gene Ontologyapoptotic process1
GO:0001666
IEP
Genome Projectresponse to hypoxia
GO:0001666
IEP
Gene Ontologyresponse to hypoxia1
GO:0042493
IEA
PLAZA Integrative Orthologyresponse to drug ENSG00000135766
GO:0051234
IEA
PLAZA Integrative Orthologyestablishment of localization FBgn0264785
GO:0042886
IEA
PLAZA Integrative Orthologyamide transport FBgn0264785
GO:1901698
IEA
PLAZA Integrative Orthologyresponse to nitrogen compound ENSG00000135766
GO:1901575
IEA
PLAZA Integrative Orthologyorganic substance catabolic process ENSG00000269858
GO:0035295
IEA
PLAZA Integrative Orthologytube development FBgn0264785
GO:0030163
IEA
PLAZA Integrative Orthologyprotein catabolic process ENSG00000269858
GO:0032501
IEA
PLAZA Integrative Orthologymulticellular organismal process FBgn0264785
GO:0032502
IEA
PLAZA Integrative Orthologydevelopmental process FBgn0264785
GO:0010035
IEA
PLAZA Integrative Orthologyresponse to inorganic substance ENSG00000135766
GO:0033036
IEA
PLAZA Integrative Orthologymacromolecule localization WBGene00001178
GO:0006979
IEA
PLAZA Integrative Orthologyresponse to oxidative stress ENSG00000135766
GO:0007430
IEA
PLAZA Integrative Orthologyterminal branching, open tracheal system FBgn0264785
GO:0048856
IEA
PLAZA Integrative Orthologyanatomical structure development FBgn0264785
GO:1901565
IEA
PLAZA Integrative Orthologyorganonitrogen compound catabolic process ENSG00000269858
GO:0007275
IEA
PLAZA Integrative Orthologymulticellular organism development FBgn0264785
GO:0009056
IEA
PLAZA Integrative Orthologycatabolic process ENSG00000269858
GO:0009057
IEA
PLAZA Integrative Orthologymacromolecule catabolic process ENSG00000269858
GO:0016049
IEA
PLAZA Integrative Orthologycell growth FBgn0264785
GO:0044092
IEA
PLAZA Integrative Orthologynegative regulation of molecular function ENSG00000135766
GO:0071840
IEA
PLAZA Integrative Orthologycellular component organization or biogenesis FBgn0264785
GO:0016043
IEA
PLAZA Integrative Orthologycellular component organization FBgn0264785
GO:0042592
IEA
PLAZA Integrative Orthologyhomeostatic process ENSG00000269858
GO:0048731
IEA
PLAZA Integrative Orthologysystem development FBgn0264785
GO:0051179
IEA
PLAZA Integrative Orthologylocalization WBGene00001178
GO:0032879
IEA
PLAZA Integrative Orthologyregulation of localization WBGene00001178
GO:0045184
IEA
PLAZA Integrative Orthologyestablishment of protein localization FBgn0264785
GO:0009887
IEA
PLAZA Integrative Orthologyanimal organ morphogenesis FBgn0264785
GO:0009888
IEA
PLAZA Integrative Orthologytissue development FBgn0264785
GO:0006810
IEA
PLAZA Integrative Orthologytransport FBgn0264785
GO:0000302
IEA
PLAZA Integrative Orthologyresponse to reactive oxygen species ENSG00000135766
GO:0060439
IEA
PLAZA Integrative Orthologytrachea morphogenesis FBgn0264785
GO:0043433
IEA
PLAZA Integrative Orthologynegative regulation of DNA-binding transcription factor activity ENSG00000135766
GO:0045454
IEA
PLAZA Integrative Orthologycell redox homeostasis ENSG00000269858
GO:0060438
IEA
PLAZA Integrative Orthologytrachea development FBgn0264785
GO:0045732
IEA
PLAZA Integrative Orthologypositive regulation of protein catabolic process ENSG00000269858
GO:0032880
IEA
PLAZA Integrative Orthologyregulation of protein localization WBGene00001178
GO:0048729
IEA
PLAZA Integrative Orthologytissue morphogenesis FBgn0264785
GO:0071731
IEA
PLAZA Integrative Orthologyresponse to nitric oxide ENSG00000135766
GO:0032364
IEA
PLAZA Integrative Orthologyoxygen homeostasis ENSG00000135766
GO:0035239
IEA
PLAZA Integrative Orthologytube morphogenesis FBgn0264785
GO:0051168
IEA
PLAZA Integrative Orthologynuclear export FBgn0264785
GO:0006913
IEA
PLAZA Integrative Orthologynucleocytoplasmic transport FBgn0264785
GO:0051169
IEA
PLAZA Integrative Orthologynuclear transport FBgn0264785
GO:0060446
IEA
PLAZA Integrative Orthologybranching involved in open tracheal system development FBgn0264785
GO:0061138
IEA
PLAZA Integrative Orthologymorphogenesis of a branching epithelium FBgn0264785
GO:1901700
IEA
PLAZA Integrative Orthologyresponse to oxygen-containing compound ENSG00000135766
GO:0006886
IEA
PLAZA Integrative Orthologyintracellular protein transport FBgn0264785
GO:0042176
IEA
PLAZA Integrative Orthologyregulation of protein catabolic process ENSG00000269858
GO:0060562
IEA
PLAZA Integrative Orthologyepithelial tube morphogenesis FBgn0264785
GO:0071702
IEA
PLAZA Integrative Orthologyorganic substance transport FBgn0264785
GO:0071705
IEA
PLAZA Integrative Orthologynitrogen compound transport FBgn0264785
GO:0019725
IEA
PLAZA Integrative Orthologycellular homeostasis ENSG00000269858
GO:0001763
IEA
PLAZA Integrative Orthologymorphogenesis of a branching structure FBgn0264785
GO:0060429
IEA
PLAZA Integrative Orthologyepithelium development FBgn0264785
GO:0009894
IEA
PLAZA Integrative Orthologyregulation of catabolic process ENSG00000269858
GO:0009653
IEA
PLAZA Integrative Orthologyanatomical structure morphogenesis FBgn0264785
GO:0009896
IEA
PLAZA Integrative Orthologypositive regulation of catabolic process ENSG00000269858
GO:0033483
IEA
PLAZA Integrative Orthologygas homeostasis ENSG00000135766
GO:0060541
IEA
PLAZA Integrative Orthologyrespiratory system development FBgn0264785
GO:0034613
IEA
PLAZA Integrative Orthologycellular protein localization FBgn0264785
GO:0015833
IEA
PLAZA Integrative Orthologypeptide transport FBgn0264785
GO:0001558
IEA
PLAZA Integrative Orthologyregulation of cell growth FBgn0264785
GO:0002009
IEA
PLAZA Integrative Orthologymorphogenesis of an epithelium FBgn0264785
GO:0007424
IEA
PLAZA Integrative Orthologyopen tracheal system development FBgn0264785
GO:0040007
IEA
PLAZA Integrative Orthologygrowth FBgn0264785
GO:0040008
IEA
PLAZA Integrative Orthologyregulation of growth FBgn0264785
GO:0006611
IEA
PLAZA Integrative Orthologyprotein export from nucleus FBgn0264785
GO:0046907
IEA
PLAZA Integrative Orthologyintracellular transport FBgn0264785
GO:0065008
IEA
PLAZA Integrative Orthologyregulation of biological quality ENSG00000269858
GO:0051128
IEA
PLAZA Integrative Orthologyregulation of cellular component organization FBgn0264785
GO:0051649
IEA
PLAZA Integrative Orthologyestablishment of localization in cell FBgn0264785
GO:0051641
IEA
PLAZA Integrative Orthologycellular localization FBgn0264785
GO:0030307
IEA
PLAZA Integrative Orthologypositive regulation of cell growth FBgn0264785
GO:0097366
IEA
PLAZA Integrative Orthologyresponse to bronchodilator ENSG00000135766
GO:0051090
IEA
PLAZA Integrative Orthologyregulation of DNA-binding transcription factor activity ENSG00000135766
GO:0048519
IEA
PLAZA Integrative Orthologynegative regulation of biological process ENSG00000135766
GO:0048754
IEA
PLAZA Integrative Orthologybranching morphogenesis of an epithelial tube FBgn0264785
GO:0048513
IEA
PLAZA Integrative Orthologyanimal organ development FBgn0264785
GO:0008104
IEA
PLAZA Integrative Orthologyprotein localization WBGene00001178
GO:0048878
IEA
PLAZA Integrative Orthologychemical homeostasis ENSG00000135766
GO:0015031
IEA
PLAZA Integrative Orthologyprotein transport FBgn0264785
GO:0070727
IEA
PLAZA Integrative Orthologycellular macromolecule localization FBgn0264785
GO:0045927
IEA
PLAZA Integrative Orthologypositive regulation of growth FBgn0264785

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0031545
EXP, IDA
Genome Projectpeptidyl-proline 4-dioxygenase activity
GO:0031545
EXP, IDA
Gene Ontologypeptidyl-proline 4-dioxygenase activity2 4 5 6
GO:0031418
IEA
Genome ProjectL-ascorbic acid binding
GO:0016706
IDA
Genome Projectoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0016706
IDA
Gene Ontologyoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors7
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding3 6 8 9 10 11 12 13 14 15 16
GO:0005506
IEA
Genome Projectiron ion binding
GO:0019826
IEA
PLAZA Integrative Orthologyoxygen sensor activity ENSG00000269858
GO:0019825
IEA
PLAZA Integrative Orthologyoxygen binding ENSG00000269858
GO:0008144
IEA
PLAZA Integrative Orthologydrug binding ENSG00000269858
GO:0008198
IEA
PLAZA Integrative Orthologyferrous iron binding ENSG00000269858

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005829
IDA
TAS
Gene Ontologycytosol
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm4
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005654
TAS
Gene Ontologynucleoplasm
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus4
GO:0042995
IEA
PLAZA Integrative Orthologycell projection WBGene00001178
GO:0097458
IEA
PLAZA Integrative Orthologyneuron part WBGene00001178
GO:0120025
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection WBGene00001178
GO:0097447
IEA
PLAZA Integrative Orthologydendritic tree WBGene00001178
GO:0120038
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection part WBGene00001178
GO:0044463
IEA
PLAZA Integrative Orthologycell projection part WBGene00001178
GO:0043005
IEA
PLAZA Integrative Orthologyneuron projection WBGene00001178
GO:0036477
IEA
PLAZA Integrative Orthologysomatodendritic compartment WBGene00001178
GO:0030425
IEA
PLAZA Integrative Orthologydendrite WBGene00001178

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR005123Oxoglutarate/iron-dependent dioxygenase
IPR006620Prolyl 4-hydroxylase, alpha subunit

No MapMan annotations defined for this gene.
KeggID Description
K09592EGLN, HPH; hypoxia-inducible factor prolyl hydroxylase [EC:1.14.11.29]
No chloroplast target sequence found.