Gene: ENSG00000127946 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000127946
Transcript Identifier
ENST00000336926
Gene Type
Coding gene
Location
7 : 75538172-75738920 : negative

Family Information

Homologous gene family
HOM02SEM010519
(8 genes in 5 species)
specific family
Orthologous gene family
ORTHO02SEM009279
(8 genes in 5 species)
specific family

Descriptions

gene_descr
huntingtin interacting protein 1

Identifiers

Type Value
pidENSP00000336747
HGNC4913
UniprotO00291
RefSeq_mRNANM_005338.6

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2000588
IMP
Genome Projectpositive regulation of platelet-derived growth factor receptor-beta signaling pathway
GO:2000588
IMP
Gene Ontologypositive regulation of platelet-derived growth factor receptor-beta signaling pathway1
GO:0099637
TAS
Genome Projectneurotransmitter receptor transport
GO:0099637
TAS
Gene Ontologyneurotransmitter receptor transport2
GO:0097190
IDA
Genome Projectapoptotic signaling pathway
GO:0097190
IDA
Gene Ontologyapoptotic signaling pathway3
GO:0072583
IEA
Genome Projectclathrin-dependent endocytosis
GO:0061024
TAS
Genome Projectmembrane organization
GO:0061024
TAS
Gene Ontologymembrane organization
GO:0051897
IC
Genome Projectpositive regulation of protein kinase B signaling
GO:0051897
IC
Gene Ontologypositive regulation of protein kinase B signaling1
GO:0050821
IDA
Genome Projectprotein stabilization
GO:0050821
IDA
Gene Ontologyprotein stabilization1
GO:0048268
IDA
Genome Projectclathrin coat assembly
GO:0048268
IDA
Gene Ontologyclathrin coat assembly4 5
GO:0048260
IMP
Genome Projectpositive regulation of receptor-mediated endocytosis
GO:0048260
IMP
Gene Ontologypositive regulation of receptor-mediated endocytosis4 6
GO:0045742
IMP
Genome Projectpositive regulation of epidermal growth factor receptor signaling pathway
GO:0045742
IMP
Gene Ontologypositive regulation of epidermal growth factor receptor signaling pathway1
GO:0042981
IDA
Genome Projectregulation of apoptotic process
GO:0042981
IDA
Gene Ontologyregulation of apoptotic process7
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030100
NAS
Genome Projectregulation of endocytosis
GO:0030100
NAS
Gene Ontologyregulation of endocytosis2
GO:0007010
IEA
Genome Projectcytoskeleton organization
GO:0006919
IDA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
IDA
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process7
GO:0006915
IDA
Genome Projectapoptotic process
GO:0006915
IDA
Gene Ontologyapoptotic process7
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0030952
IEA
PLAZA Integrative Orthologyestablishment or maintenance of cytoskeleton polarity SPAC688.11
GO:0030036
IEA
PLAZA Integrative Orthologyactin cytoskeleton organization SPAC688.11
GO:0030950
IEA
PLAZA Integrative Orthologyestablishment or maintenance of actin cytoskeleton polarity SPAC688.11
GO:0032970
IEA
PLAZA Integrative Orthologyregulation of actin filament-based process ENSG00000130787
GO:0044396
IEA
PLAZA Integrative Orthologyactin cortical patch organization YNL243W
GO:0097435
IEA
PLAZA Integrative Orthologysupramolecular fiber organization YNL243W
GO:0048511
IEA
PLAZA Integrative Orthologyrhythmic process WBGene00022717
GO:0030837
IEA
PLAZA Integrative Orthologynegative regulation of actin filament polymerization ENSG00000130787
GO:0030832
IEA
PLAZA Integrative Orthologyregulation of actin filament length ENSG00000130787
GO:0030833
IEA
PLAZA Integrative Orthologyregulation of actin filament polymerization ENSG00000130787
GO:0007049
IEA
PLAZA Integrative Orthologycell cycle YNL243W
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction YNL243W
GO:0030041
IEA
PLAZA Integrative Orthologyactin filament polymerization ENSG00000130787
GO:0007163
IEA
PLAZA Integrative Orthologyestablishment or maintenance of cell polarity SPAC688.11
GO:0098916
IEA
PLAZA Integrative Orthologyanterograde trans-synaptic signaling WBGene00022717
GO:0032501
IEA
PLAZA Integrative Orthologymulticellular organismal process WBGene00022717
GO:0008637
IEA
PLAZA Integrative Orthologyapoptotic mitochondrial changes ENSG00000130787
GO:0032505
IEA
PLAZA Integrative Orthologyreproduction of a single-celled organism YNL243W
GO:0045229
IEA
PLAZA Integrative Orthologyexternal encapsulating structure organization YNL243W
GO:0000910
IEA
PLAZA Integrative Orthologycytokinesis YNL243W
GO:0033043
IEA
PLAZA Integrative Orthologyregulation of organelle organization ENSG00000130787
GO:0019954
IEA
PLAZA Integrative Orthologyasexual reproduction YNL243W
GO:0007588
IEA
PLAZA Integrative Orthologyexcretion WBGene00022717
GO:0007624
IEA
PLAZA Integrative Orthologyultradian rhythm WBGene00022717
GO:0000147
IEA
PLAZA Integrative Orthologyactin cortical patch assembly YNL243W
GO:0008154
IEA
PLAZA Integrative Orthologyactin polymerization or depolymerization ENSG00000130787
GO:1901030
IEA
PLAZA Integrative Orthologypositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ENSG00000130787
GO:0061640
IEA
PLAZA Integrative Orthologycytoskeleton-dependent cytokinesis YNL243W
GO:0071852
IEA
PLAZA Integrative Orthologyfungal-type cell wall organization or biogenesis YNL243W
GO:0001505
IEA
PLAZA Integrative Orthologyregulation of neurotransmitter levels WBGene00022717
GO:0043393
IEA
PLAZA Integrative Orthologyregulation of protein binding ENSG00000130787
GO:0044087
IEA
PLAZA Integrative Orthologyregulation of cellular component biogenesis ENSG00000130787
GO:0003008
IEA
PLAZA Integrative Orthologysystem process WBGene00022717
GO:1902904
IEA
PLAZA Integrative Orthologynegative regulation of supramolecular fiber organization ENSG00000130787
GO:1902903
IEA
PLAZA Integrative Orthologyregulation of supramolecular fiber organization ENSG00000130787
GO:0030865
IEA
PLAZA Integrative Orthologycortical cytoskeleton organization SPAC688.11
GO:0030866
IEA
PLAZA Integrative Orthologycortical actin cytoskeleton organization SPAC688.11
GO:0006887
IEA
PLAZA Integrative Orthologyexocytosis YNL243W
GO:1901028
IEA
PLAZA Integrative Orthologyregulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ENSG00000130787
GO:1902110
IEA
PLAZA Integrative Orthologypositive regulation of mitochondrial membrane permeability involved in apoptotic process ENSG00000130787
GO:1903047
IEA
PLAZA Integrative Orthologymitotic cell cycle process YNL243W
GO:0032092
IEA
PLAZA Integrative Orthologypositive regulation of protein binding ENSG00000130787
GO:2001235
IEA
PLAZA Integrative Orthologypositive regulation of apoptotic signaling pathway ENSG00000130787
GO:2001233
IEA
PLAZA Integrative Orthologyregulation of apoptotic signaling pathway ENSG00000130787
GO:0032535
IEA
PLAZA Integrative Orthologyregulation of cellular component size ENSG00000130787
GO:0099537
IEA
PLAZA Integrative Orthologytrans-synaptic signaling WBGene00022717
GO:0099536
IEA
PLAZA Integrative Orthologysynaptic signaling WBGene00022717
GO:1902108
IEA
PLAZA Integrative Orthologyregulation of mitochondrial membrane permeability involved in apoptotic process ENSG00000130787
GO:0007006
IEA
PLAZA Integrative Orthologymitochondrial membrane organization ENSG00000130787
GO:0007005
IEA
PLAZA Integrative Orthologymitochondrion organization ENSG00000130787
GO:0043254
IEA
PLAZA Integrative Orthologyregulation of protein complex assembly ENSG00000130787
GO:0007121
IEA
PLAZA Integrative Orthologybipolar cellular bud site selection YNL243W
GO:0090559
IEA
PLAZA Integrative Orthologyregulation of membrane permeability ENSG00000130787
GO:0032940
IEA
PLAZA Integrative Orthologysecretion by cell YNL243W
GO:0071555
IEA
PLAZA Integrative Orthologycell wall organization YNL243W
GO:0071554
IEA
PLAZA Integrative Orthologycell wall organization or biogenesis YNL243W
GO:0031333
IEA
PLAZA Integrative Orthologynegative regulation of protein complex assembly ENSG00000130787
GO:0010638
IEA
PLAZA Integrative Orthologypositive regulation of organelle organization ENSG00000130787
GO:0010639
IEA
PLAZA Integrative Orthologynegative regulation of organelle organization ENSG00000130787
GO:0000281
IEA
PLAZA Integrative Orthologymitotic cytokinesis YNL243W
GO:0097345
IEA
PLAZA Integrative Orthologymitochondrial outer membrane permeabilization ENSG00000130787
GO:0000282
IEA
PLAZA Integrative Orthologycellular bud site selection YNL243W
GO:0099643
IEA
PLAZA Integrative Orthologysignal release from synapse WBGene00022717
GO:0051301
IEA
PLAZA Integrative Orthologycell division YNL243W
GO:0110053
IEA
PLAZA Integrative Orthologyregulation of actin filament organization ENSG00000130787
GO:0000278
IEA
PLAZA Integrative Orthologymitotic cell cycle YNL243W
GO:0007114
IEA
PLAZA Integrative Orthologycell budding YNL243W
GO:0032272
IEA
PLAZA Integrative Orthologynegative regulation of protein polymerization ENSG00000130787
GO:0032271
IEA
PLAZA Integrative Orthologyregulation of protein polymerization ENSG00000130787
GO:0010821
IEA
PLAZA Integrative Orthologyregulation of mitochondrion organization ENSG00000130787
GO:0010822
IEA
PLAZA Integrative Orthologypositive regulation of mitochondrion organization ENSG00000130787
GO:0030010
IEA
PLAZA Integrative Orthologyestablishment of cell polarity YNL243W
GO:0051494
IEA
PLAZA Integrative Orthologynegative regulation of cytoskeleton organization ENSG00000130787
GO:0051098
IEA
PLAZA Integrative Orthologyregulation of binding ENSG00000130787
GO:0051493
IEA
PLAZA Integrative Orthologyregulation of cytoskeleton organization ENSG00000130787
GO:0051099
IEA
PLAZA Integrative Orthologypositive regulation of binding ENSG00000130787
GO:0032956
IEA
PLAZA Integrative Orthologyregulation of actin cytoskeleton organization ENSG00000130787
GO:0051258
IEA
PLAZA Integrative Orthologyprotein polymerization ENSG00000130787
GO:0031505
IEA
PLAZA Integrative Orthologyfungal-type cell wall organization YNL243W
GO:0007269
IEA
PLAZA Integrative Orthologyneurotransmitter secretion WBGene00022717
GO:0046902
IEA
PLAZA Integrative Orthologyregulation of mitochondrial membrane permeability ENSG00000130787
GO:0048523
IEA
PLAZA Integrative Orthologynegative regulation of cellular process ENSG00000130787
GO:1902686
IEA
PLAZA Integrative Orthologymitochondrial outer membrane permeabilization involved in programmed cell death ENSG00000130787
GO:0007268
IEA
PLAZA Integrative Orthologychemical synaptic transmission WBGene00022717
GO:0090066
IEA
PLAZA Integrative Orthologyregulation of anatomical structure size ENSG00000130787
GO:0007267
IEA
PLAZA Integrative Orthologycell-cell signaling WBGene00022717
GO:1905710
IEA
PLAZA Integrative Orthologypositive regulation of membrane permeability ENSG00000130787
GO:0035794
IEA
PLAZA Integrative Orthologypositive regulation of mitochondrial membrane permeability ENSG00000130787
GO:0046903
IEA
PLAZA Integrative Orthologysecretion YNL243W
GO:0030421
IEA
PLAZA Integrative Orthologydefecation WBGene00022717
GO:0051129
IEA
PLAZA Integrative Orthologynegative regulation of cellular component organization ENSG00000130787
GO:0023061
IEA
PLAZA Integrative Orthologysignal release WBGene00022717
GO:0006839
IEA
PLAZA Integrative Orthologymitochondrial transport ENSG00000130787
GO:0006836
IEA
PLAZA Integrative Orthologyneurotransmitter transport WBGene00022717
GO:0030029
IEA
PLAZA Integrative Orthologyactin filament-based process SPAC688.11
GO:0048519
IEA
PLAZA Integrative Orthologynegative regulation of biological process ENSG00000130787
GO:0007015
IEA
PLAZA Integrative Orthologyactin filament organization YNL243W
GO:0022402
IEA
PLAZA Integrative Orthologycell cycle process YNL243W
GO:0008064
IEA
PLAZA Integrative Orthologyregulation of actin polymerization or depolymerization ENSG00000130787

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005546
IDA
Genome Projectphosphatidylinositol-4,5-bisphosphate binding
GO:0005546
IDA
Gene Ontologyphosphatidylinositol-4,5-bisphosphate binding1
GO:0080025
IDA
Genome Projectphosphatidylinositol-3,5-bisphosphate binding
GO:0080025
IDA
Gene Ontologyphosphatidylinositol-3,5-bisphosphate binding1
GO:0051015
IDA
Genome Projectactin filament binding
GO:0051015
IDA
Gene Ontologyactin filament binding8
GO:0046982
IPI
Genome Projectprotein heterodimerization activity
GO:0046982
IPI
Gene Ontologyprotein heterodimerization activity9
GO:0043325
IDA
Genome Projectphosphatidylinositol-3,4-bisphosphate binding
GO:0043325
IDA
Gene Ontologyphosphatidylinositol-3,4-bisphosphate binding1
GO:0042803
IDA
Genome Projectprotein homodimerization activity
GO:0042803
IDA
Gene Ontologyprotein homodimerization activity8 9
GO:0035615
IC
Genome Projectclathrin adaptor activity
GO:0035615
IC
Gene Ontologyclathrin adaptor activity8
GO:0035612
IPI
Genome ProjectAP-2 adaptor complex binding
GO:0035612
IPI
Gene OntologyAP-2 adaptor complex binding9
GO:0035254
TAS
Genome Projectglutamate receptor binding
GO:0035254
TAS
Gene Ontologyglutamate receptor binding2
GO:0035091
IDA
Genome Projectphosphatidylinositol binding
GO:0035091
IDA
Gene Ontologyphosphatidylinositol binding1
GO:0032266
IDA
Genome Projectphosphatidylinositol-3-phosphate binding
GO:0032266
IDA
Gene Ontologyphosphatidylinositol-3-phosphate binding1
GO:0032051
IPI
Genome Projectclathrin light chain binding
GO:0032051
IPI
Gene Ontologyclathrin light chain binding8 9
GO:0030276
IDA
Genome Projectclathrin binding
GO:0030276
IDA
Gene Ontologyclathrin binding1 4
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding5 7 10 11 12 13 14 15 16 17 18 19
GO:0005200
TAS
Genome Projectstructural constituent of cytoskeleton
GO:0005200
TAS
Gene Ontologystructural constituent of cytoskeleton10
GO:0005154
TAS
Genome Projectepidermal growth factor receptor binding
GO:0005154
TAS
Gene Ontologyepidermal growth factor receptor binding2
GO:0005547
IEA
PLAZA Integrative Orthologyphosphatidylinositol-3,4,5-trisphosphate binding ENSG00000130787

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0030122
IDA
Genome ProjectAP-2 adaptor complex
GO:0030122
IDA
Gene OntologyAP-2 adaptor complex1
GO:0098890
IEA
Genome Projectextrinsic component of postsynaptic membrane
GO:0098888
IEA
Genome Projectextrinsic component of presynaptic membrane
GO:0098794
TAS
Genome Projectpostsynapse
GO:0098794
TAS
Gene Ontologypostsynapse2
GO:0098793
IDA
Genome Projectpresynapse
GO:0098793
IDA
Gene Ontologypresynapse2
GO:0043231
IDA
Genome Projectintracellular membrane-bounded organelle
GO:0043231
IDA
Gene Ontologyintracellular membrane-bounded organelle
GO:0031234
IEA
Genome Projectextrinsic component of cytoplasmic side of plasma membrane
GO:0030136
IDA
Genome Projectclathrin-coated vesicle
GO:0030136
IDA
Gene Ontologyclathrin-coated vesicle20
GO:0016020
TAS
Genome Projectmembrane
GO:0016020
TAS
Gene Ontologymembrane21
GO:0005856
TAS
Genome Projectcytoskeleton
GO:0005856
TAS
Gene Ontologycytoskeleton21
GO:0005829
TAS
Genome Projectcytosol
GO:0005829
TAS
Gene Ontologycytosol
GO:0005794
IDA
Genome ProjectGolgi apparatus
GO:0005794
IDA
Gene OntologyGolgi apparatus7
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm22
GO:0005634
TAS
Genome Projectnucleus
GO:0005634
TAS
Gene Ontologynucleus2
GO:0035841
IEA
PLAZA Integrative Orthologynew growing cell tip SPAC688.11
GO:0035840
IEA
PLAZA Integrative Orthologyold growing cell tip SPAC688.11
GO:0099738
IEA
PLAZA Integrative Orthologycell cortex region SPAC688.11
GO:0005937
IEA
PLAZA Integrative Orthologymating projection YNL243W
GO:0044430
IEA
PLAZA Integrative Orthologycytoskeletal part SPAC688.11
GO:0005938
IEA
PLAZA Integrative Orthologycell cortex SPAC688.11
GO:0005935
IEA
PLAZA Integrative Orthologycellular bud neck YNL243W
GO:0005933
IEA
PLAZA Integrative Orthologycellular bud YNL243W
GO:0000131
IEA
PLAZA Integrative Orthologyincipient cellular bud site YNL243W
GO:0043332
IEA
PLAZA Integrative Orthologymating projection tip YNL243W
GO:0031252
IEA
PLAZA Integrative Orthologycell leading edge ENSG00000130787
GO:0031097
IEA
PLAZA Integrative Orthologymedial cortex SPAC688.11
GO:0031253
IEA
PLAZA Integrative Orthologycell projection membrane ENSG00000130787
GO:0031256
IEA
PLAZA Integrative Orthologyleading edge membrane ENSG00000130787
GO:0032587
IEA
PLAZA Integrative Orthologyruffle membrane ENSG00000130787
GO:0001726
IEA
PLAZA Integrative Orthologyruffle ENSG00000130787
GO:0099568
IEA
PLAZA Integrative Orthologycytoplasmic region SPAC688.11
GO:0042995
IEA
PLAZA Integrative Orthologycell projection YNL243W
GO:0061645
IEA
PLAZA Integrative Orthologyendocytic patch SPAC688.11
GO:0120025
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection YNL243W
GO:0030863
IEA
PLAZA Integrative Orthologycortical cytoskeleton SPAC688.11
GO:0030864
IEA
PLAZA Integrative Orthologycortical actin cytoskeleton SPAC688.11
GO:0015629
IEA
PLAZA Integrative Orthologyactin cytoskeleton SPAC688.11
GO:0051286
IEA
PLAZA Integrative Orthologycell tip SPAC688.11
GO:0120038
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection part YNL243W
GO:0030479
IEA
PLAZA Integrative Orthologyactin cortical patch SPAC688.11
GO:0044463
IEA
PLAZA Integrative Orthologycell projection part YNL243W
GO:0032153
IEA
PLAZA Integrative Orthologycell division site SPAC688.11
GO:0032155
IEA
PLAZA Integrative Orthologycell division site part SPAC688.11
GO:0044448
IEA
PLAZA Integrative Orthologycell cortex part SPAC688.11
GO:0035838
IEA
PLAZA Integrative Orthologygrowing cell tip SPAC688.11
GO:0030427
IEA
PLAZA Integrative Orthologysite of polarized growth SPAC688.11

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR002558I/LWEQ domain
IPR008942ENTH/VHS
IPR011417AP180 N-terminal homology (ANTH) domain
IPR013809ENTH domain
IPR030224Sla2 family
IPR030554Huntingtin-interacting protein 1
IPR032422Huntingtin-interacting protein 1, clathrin-binding domain

No MapMan annotations defined for this gene.
KeggID Description
K04559HIP1; huntingtin interacting protein 1
No chloroplast target sequence found.