Gene: ENSG00000125885 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000125885
Transcript Identifier
ENST00000378886
Gene Type
Coding gene
Location
20 : 5952016-5994391 : positive

Family Information

Homologous gene family
HOM02SEM000093
(240 genes in 26 species)
specific family
Orthologous gene family
ORTHO02SEM000083
(223 genes in 26 species)
specific family

Descriptions

gene_descr
minichromosome maintenance complex component 8

Identifiers

Type Value
pidENSP00000368164
HGNC16147
UniprotQ9UJA3
RefSeq_mRNANM_001281521.1

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0048232
ISS
Genome Projectmale gamete generation
GO:0048232
ISS
Gene Ontologymale gamete generation
GO:0007292
ISS
Genome Projectfemale gamete generation
GO:0007292
ISS
Gene Ontologyfemale gamete generation
GO:0006974
IDA
Genome Projectcellular response to DNA damage stimulus
GO:0006974
IDA
Gene Ontologycellular response to DNA damage stimulus1
GO:0006270
IEA
Genome ProjectDNA replication initiation
GO:0006260
TAS
Genome ProjectDNA replication
GO:0006260
IGI
TAS
Gene OntologyDNA replication2
GO:0000724
IEA
Genome Projectdouble-strand break repair via homologous recombination
GO:0000724
IMP
Gene Ontologydouble-strand break repair via homologous recombination2
GO:0000082
TAS
Genome ProjectG1/S transition of mitotic cell cycle
GO:0000082
TAS
Gene OntologyG1/S transition of mitotic cell cycle
GO:0071168
IMP
Gene Ontologyprotein localization to chromatin2
GO:0050821
IMP
Gene Ontologyprotein stabilization2 3
GO:0036298
IMP
Gene Ontologyrecombinational interstrand cross-link repair2
GO:2000104
IEA
PLAZA Integrative Orthologynegative regulation of DNA-dependent DNA replication SPCC16A11.17
GO:0050789
IEA
PLAZA Integrative Orthologyregulation of biological process SPCC16A11.17
GO:0071103
IEA
PLAZA Integrative OrthologyDNA conformation change SPCC16A11.17
GO:0010605
IEA
PLAZA Integrative Orthologynegative regulation of macromolecule metabolic process SPCC16A11.17
GO:0043462
IEA
PLAZA Integrative Orthologyregulation of ATPase activity SPCC16A11.17
GO:0048478
IEA
PLAZA Integrative Orthologyreplication fork protection SPCC16A11.17
GO:0022412
IEA
PLAZA Integrative Orthologycellular process involved in reproduction in multicellular organism AT3G09660
GO:0006996
IEA
PLAZA Integrative Orthologyorganelle organization SPCC16A11.17
GO:0044786
IEA
PLAZA Integrative Orthologycell cycle DNA replication SPCC16A11.17
GO:0048229
IEA
PLAZA Integrative Orthologygametophyte development AT3G09660
GO:1905774
IEA
PLAZA Integrative Orthologyregulation of DNA helicase activity SPCC16A11.17
GO:1905775
IEA
PLAZA Integrative Orthologynegative regulation of DNA helicase activity SPCC16A11.17
GO:0036388
IEA
PLAZA Integrative Orthologypre-replicative complex assembly YPR019W
GO:0032502
IEA
PLAZA Integrative Orthologydevelopmental process AT3G09660
GO:0010558
IEA
PLAZA Integrative Orthologynegative regulation of macromolecule biosynthetic process SPCC16A11.17
GO:0010556
IEA
PLAZA Integrative Orthologyregulation of macromolecule biosynthetic process SPCC16A11.17
GO:0032508
IEA
PLAZA Integrative OrthologyDNA duplex unwinding SPCC16A11.17
GO:0051346
IEA
PLAZA Integrative Orthologynegative regulation of hydrolase activity SPCC16A11.17
GO:0048856
IEA
PLAZA Integrative Orthologyanatomical structure development AT3G09660
GO:0033043
IEA
PLAZA Integrative Orthologyregulation of organelle organization SPCC16A11.17
GO:0007275
IEA
PLAZA Integrative Orthologymulticellular organism development AT3G09660
GO:0033044
IEA
PLAZA Integrative Orthologyregulation of chromosome organization SPCC16A11.17
GO:0051336
IEA
PLAZA Integrative Orthologyregulation of hydrolase activity SPCC16A11.17
GO:0044092
IEA
PLAZA Integrative Orthologynegative regulation of molecular function SPCC16A11.17
GO:0071840
IEA
PLAZA Integrative Orthologycellular component organization or biogenesis SPCC16A11.17
GO:0016043
IEA
PLAZA Integrative Orthologycellular component organization SPCC16A11.17
GO:0051053
IEA
PLAZA Integrative Orthologynegative regulation of DNA metabolic process SPCC16A11.17
GO:0009889
IEA
PLAZA Integrative Orthologyregulation of biosynthetic process SPCC16A11.17
GO:0008156
IEA
PLAZA Integrative Orthologynegative regulation of DNA replication SPCC16A11.17
GO:0044085
IEA
PLAZA Integrative Orthologycellular component biogenesis YPR019W
GO:0048285
IEA
PLAZA Integrative Orthologyorganelle fission AT3G09660
GO:0051321
IEA
PLAZA Integrative Orthologymeiotic cell cycle SPCC16A11.17
GO:0051171
IEA
PLAZA Integrative Orthologyregulation of nitrogen compound metabolic process SPCC16A11.17
GO:0051052
IEA
PLAZA Integrative Orthologyregulation of DNA metabolic process SPCC16A11.17
GO:0051172
IEA
PLAZA Integrative Orthologynegative regulation of nitrogen compound metabolic process SPCC16A11.17
GO:0022607
IEA
PLAZA Integrative Orthologycellular component assembly YPR019W
GO:1903046
IEA
PLAZA Integrative Orthologymeiotic cell cycle process SPCC16A11.17
GO:1905462
IEA
PLAZA Integrative Orthologyregulation of DNA duplex unwinding SPCC16A11.17
GO:2001251
IEA
PLAZA Integrative Orthologynegative regulation of chromosome organization SPCC16A11.17
GO:1905463
IEA
PLAZA Integrative Orthologynegative regulation of DNA duplex unwinding SPCC16A11.17
GO:0090329
IEA
PLAZA Integrative Orthologyregulation of DNA-dependent DNA replication SPCC16A11.17
GO:0031324
IEA
PLAZA Integrative Orthologynegative regulation of cellular metabolic process SPCC16A11.17
GO:0031323
IEA
PLAZA Integrative Orthologyregulation of cellular metabolic process SPCC16A11.17
GO:0080090
IEA
PLAZA Integrative Orthologyregulation of primary metabolic process SPCC16A11.17
GO:0031326
IEA
PLAZA Integrative Orthologyregulation of cellular biosynthetic process SPCC16A11.17
GO:0071824
IEA
PLAZA Integrative Orthologyprotein-DNA complex subunit organization YPR019W
GO:0051276
IEA
PLAZA Integrative Orthologychromosome organization SPCC16A11.17
GO:0031327
IEA
PLAZA Integrative Orthologynegative regulation of cellular biosynthetic process SPCC16A11.17
GO:0007127
IEA
PLAZA Integrative Orthologymeiosis I FBgn0003227
GO:0006279
IEA
PLAZA Integrative Orthologypremeiotic DNA replication SPCC16A11.17
GO:0006275
IEA
PLAZA Integrative Orthologyregulation of DNA replication SPCC16A11.17
GO:0006271
IEA
PLAZA Integrative OrthologyDNA strand elongation involved in DNA replication YPR019W
GO:0022616
IEA
PLAZA Integrative OrthologyDNA strand elongation YPR019W
GO:0000727
IEA
PLAZA Integrative Orthologydouble-strand break repair via break-induced replication YPR019W
GO:0032780
IEA
PLAZA Integrative Orthologynegative regulation of ATPase activity SPCC16A11.17
GO:0061982
IEA
PLAZA Integrative Orthologymeiosis I cell cycle process FBgn0003227
GO:0060255
IEA
PLAZA Integrative Orthologyregulation of macromolecule metabolic process SPCC16A11.17
GO:0043933
IEA
PLAZA Integrative Orthologyprotein-containing complex subunit organization YPR019W
GO:0140013
IEA
PLAZA Integrative Orthologymeiotic nuclear division AT3G09660
GO:1902292
IEA
PLAZA Integrative Orthologycell cycle DNA replication initiation SPCC16A11.17
GO:0019222
IEA
PLAZA Integrative Orthologyregulation of metabolic process SPCC16A11.17
GO:0000280
IEA
PLAZA Integrative Orthologynuclear division AT3G09660
GO:0010639
IEA
PLAZA Integrative Orthologynegative regulation of organelle organization SPCC16A11.17
GO:1902969
IEA
PLAZA Integrative Orthologymitotic DNA replication SPCC16A11.17
GO:0006268
IEA
PLAZA Integrative OrthologyDNA unwinding involved in DNA replication AT2G16440
GO:0006267
IEA
PLAZA Integrative Orthologypre-replicative complex assembly involved in nuclear cell cycle DNA replication YPR019W
GO:1902975
IEA
PLAZA Integrative Orthologymitotic DNA replication initiation SPCC16A11.17
GO:0009890
IEA
PLAZA Integrative Orthologynegative regulation of biosynthetic process SPCC16A11.17
GO:0009892
IEA
PLAZA Integrative Orthologynegative regulation of metabolic process SPCC16A11.17
GO:1902299
IEA
PLAZA Integrative Orthologypre-replicative complex assembly involved in cell cycle DNA replication YPR019W
GO:0019219
IEA
PLAZA Integrative Orthologyregulation of nucleobase-containing compound metabolic process SPCC16A11.17
GO:0032392
IEA
PLAZA Integrative OrthologyDNA geometric change SPCC16A11.17
GO:1902450
IEA
PLAZA Integrative Orthologynegative regulation of ATP-dependent DNA helicase activity SPCC16A11.17
GO:0035825
IEA
PLAZA Integrative Orthologyhomologous recombination FBgn0003227
GO:0051097
IEA
PLAZA Integrative Orthologynegative regulation of helicase activity SPCC16A11.17
GO:0043086
IEA
PLAZA Integrative Orthologynegative regulation of catalytic activity SPCC16A11.17
GO:1902449
IEA
PLAZA Integrative Orthologyregulation of ATP-dependent DNA helicase activity SPCC16A11.17
GO:0065009
IEA
PLAZA Integrative Orthologyregulation of molecular function SPCC16A11.17
GO:0045934
IEA
PLAZA Integrative Orthologynegative regulation of nucleobase-containing compound metabolic process SPCC16A11.17
GO:0048523
IEA
PLAZA Integrative Orthologynegative regulation of cellular process SPCC16A11.17
GO:0007140
IEA
PLAZA Integrative Orthologymale meiotic nuclear division AT3G09660
GO:0065004
IEA
PLAZA Integrative Orthologyprotein-DNA complex assembly YPR019W
GO:0007143
IEA
PLAZA Integrative Orthologyfemale meiotic nuclear division AT3G09660
GO:0065003
IEA
PLAZA Integrative Orthologyprotein-containing complex assembly YPR019W
GO:0051128
IEA
PLAZA Integrative Orthologyregulation of cellular component organization SPCC16A11.17
GO:0051129
IEA
PLAZA Integrative Orthologynegative regulation of cellular component organization SPCC16A11.17
GO:2000112
IEA
PLAZA Integrative Orthologyregulation of cellular macromolecule biosynthetic process SPCC16A11.17
GO:0034622
IEA
PLAZA Integrative Orthologycellular protein-containing complex assembly YPR019W
GO:2000113
IEA
PLAZA Integrative Orthologynegative regulation of cellular macromolecule biosynthetic process SPCC16A11.17
GO:0050790
IEA
PLAZA Integrative Orthologyregulation of catalytic activity SPCC16A11.17
GO:0050794
IEA
PLAZA Integrative Orthologyregulation of cellular process SPCC16A11.17
GO:0048519
IEA
PLAZA Integrative Orthologynegative regulation of biological process SPCC16A11.17
GO:0009555
IEA
PLAZA Integrative Orthologypollen development AT3G09660
GO:1902315
IEA
PLAZA Integrative Orthologynuclear cell cycle DNA replication initiation SPCC16A11.17
GO:0045005
IEA
PLAZA Integrative OrthologyDNA-dependent DNA replication maintenance of fidelity SPCC16A11.17
GO:0051095
IEA
PLAZA Integrative Orthologyregulation of helicase activity SPCC16A11.17
GO:0007131
IEA
PLAZA Integrative Orthologyreciprocal meiotic recombination FBgn0003227
GO:0033260
IEA
PLAZA Integrative Orthologynuclear DNA replication SPCC16A11.17

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005524
IEA
Genome ProjectATP binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding2 4 5 6 7
GO:0004386
IEA
Genome Projecthelicase activity
GO:0003677
IEA
Genome ProjectDNA binding
GO:0032408
IDA
Gene OntologyMutSbeta complex binding7
GO:0032407
IDA
Gene OntologyMutSalpha complex binding7
GO:0032406
IDA
Gene OntologyMutLbeta complex binding7
GO:0019899
IPI
Gene Ontologyenzyme binding2 3 7
GO:0003682
IDA
Gene Ontologychromatin binding2
GO:0017116
IEA
PLAZA Integrative Orthologysingle-stranded DNA-dependent ATP-dependent DNA helicase activity SPCC16A11.17
GO:1990518
IEA
PLAZA Integrative Orthologysingle-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity SPCC16A11.17
GO:0008094
IEA
PLAZA Integrative OrthologyDNA-dependent ATPase activity SPCC16A11.17
GO:0033677
IEA
PLAZA Integrative OrthologyDNA/RNA helicase activity SPCC16A11.17
GO:0033679
IEA
PLAZA Integrative Orthology3'-5' DNA/RNA helicase activity SPCC16A11.17
GO:0043565
IEA
PLAZA Integrative Orthologysequence-specific DNA binding YPR019W
GO:0042623
IEA
PLAZA Integrative OrthologyATPase activity, coupled SPCC16A11.17
GO:0008026
IEA
PLAZA Integrative OrthologyATP-dependent helicase activity SPCC16A11.17
GO:1990837
IEA
PLAZA Integrative Orthologysequence-specific double-stranded DNA binding YPR019W
GO:0043142
IEA
PLAZA Integrative Orthologysingle-stranded DNA-dependent ATPase activity SPCC16A11.17
GO:0043140
IEA
PLAZA Integrative OrthologyATP-dependent 3'-5' DNA helicase activity SPCC16A11.17
GO:0003678
IEA
PLAZA Integrative OrthologyDNA helicase activity SPCC16A11.17
GO:1990163
IEA
PLAZA Integrative OrthologyATP-dependent four-way junction helicase activity YPR019W
GO:0043138
IEA
PLAZA Integrative Orthology3'-5' DNA helicase activity SPCC16A11.17
GO:0140097
IEA
PLAZA Integrative Orthologycatalytic activity, acting on DNA SPCC16A11.17
GO:0140098
IEA
PLAZA Integrative Orthologycatalytic activity, acting on RNA SPCC16A11.17
GO:0004003
IEA
PLAZA Integrative OrthologyATP-dependent DNA helicase activity SPCC16A11.17
GO:0009378
IEA
PLAZA Integrative Orthologyfour-way junction helicase activity YPR019W
GO:0070035
IEA
PLAZA Integrative Orthologypurine NTP-dependent helicase activity SPCC16A11.17
GO:0003727
IEA
PLAZA Integrative Orthologysingle-stranded RNA binding SPCC16A11.17
GO:0003724
IEA
PLAZA Integrative OrthologyRNA helicase activity SPCC16A11.17
GO:0003723
IEA
PLAZA Integrative OrthologyRNA binding SPCC16A11.17
GO:0003688
IEA
PLAZA Integrative OrthologyDNA replication origin binding YPR019W
GO:0003697
IEA
PLAZA Integrative Orthologysingle-stranded DNA binding SPCC16A11.17
GO:0003690
IEA
PLAZA Integrative Orthologydouble-stranded DNA binding YPR019W
GO:0016887
IEA
PLAZA Integrative OrthologyATPase activity SPCC16A11.17

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0097362
IDA
Genome ProjectMCM8-MCM9 complex
GO:0097362
IDA
Gene OntologyMCM8-MCM9 complex1 2 3 7
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005654
IDA
TAS
Gene Ontologynucleoplasm
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus2 7
GO:0005656
IEA
PLAZA Integrative Orthologynuclear pre-replicative complex SPCC16A11.17
GO:0005657
IEA
PLAZA Integrative Orthologyreplication fork SPCC16A11.17
GO:0044427
IEA
PLAZA Integrative Orthologychromosomal part SPCC16A11.17
GO:0036387
IEA
PLAZA Integrative Orthologypre-replicative complex SPCC16A11.17
GO:0031261
IEA
PLAZA Integrative OrthologyDNA replication preinitiation complex SPCC16A11.17
GO:0032993
IEA
PLAZA Integrative Orthologyprotein-DNA complex SPCC16A11.17
GO:0071162
IEA
PLAZA Integrative OrthologyCMG complex YPR019W
GO:0000790
IEA
PLAZA Integrative Orthologynuclear chromatin SPCC16A11.17
GO:0000785
IEA
PLAZA Integrative Orthologychromatin SPCC16A11.17
GO:0005829
IEA
PLAZA Integrative Orthologycytosol AT2G16440
GO:0030874
IEA
PLAZA Integrative Orthologynucleolar chromatin SPCC16A11.17
GO:0030875
IEA
PLAZA Integrative OrthologyrDNA protrusion SPCC16A11.17
GO:0005737
IEA
PLAZA Integrative Orthologycytoplasm AT2G16440
GO:0031298
IEA
PLAZA Integrative Orthologyreplication fork protection complex YPR019W
GO:0005730
IEA
PLAZA Integrative Orthologynucleolus SPCC16A11.17
GO:0005694
IEA
PLAZA Integrative Orthologychromosome SPCC16A11.17
GO:0044454
IEA
PLAZA Integrative Orthologynuclear chromosome part SPCC16A11.17
GO:0044451
IEA
PLAZA Integrative Orthologynucleoplasm part SPCC16A11.17
GO:0044452
IEA
PLAZA Integrative Orthologynucleolar part SPCC16A11.17
GO:0000347
IEA
PLAZA Integrative OrthologyTHO complex AT2G16440
GO:0044444
IEA
PLAZA Integrative Orthologycytoplasmic part AT2G16440
GO:0043232
IEA
PLAZA Integrative Orthologyintracellular non-membrane-bounded organelle SPCC16A11.17
GO:0000228
IEA
PLAZA Integrative Orthologynuclear chromosome SPCC16A11.17
GO:0043596
IEA
PLAZA Integrative Orthologynuclear replication fork SPCC16A11.17
GO:0097373
IEA
PLAZA Integrative OrthologyMCM core complex SPCC16A11.17
GO:0043228
IEA
PLAZA Integrative Orthologynon-membrane-bounded organelle SPCC16A11.17

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001208MCM domain
IPR003593AAA+ ATPase domain
IPR012340Nucleic acid-binding, OB-fold
IPR027417P-loop containing nucleoside triphosphate hydrolase
IPR031327Mini-chromosome maintenance protein
IPR033762MCM OB domain

No MapMan annotations defined for this gene.
KeggID Description
K10737MCM8; DNA helicase MCM8 [EC:3.6.4.12]
No chloroplast target sequence found.