Gene: ENSG00000125686 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000125686
Transcript Identifier
ENST00000300651
Gene Type
Coding gene
Location
17 : 39407475-39451062 : negative

Family Information

Homologous gene family
HOM02SEM048993
(2 genes in 2 species)
specific family
Orthologous gene family
ORTHO02SEM019917
(2 genes in 2 species)
specific family

Descriptions

gene_descr
mediator complex subunit 1

Identifiers

Type Value
pidENSP00000300651
HGNC9234
UniprotQ15648
RefSeq_mRNANM_004774.3

Toolbox

Explore

Create

View

Browse

 

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2001141
IMP
Genome Projectregulation of RNA biosynthetic process
GO:2001141
IMP
Gene Ontologyregulation of RNA biosynthetic process1
GO:2000347
IEA
Genome Projectpositive regulation of hepatocyte proliferation
GO:2000273
IMP
Genome Projectpositive regulation of signaling receptor activity
GO:2000273
IMP
Gene Ontologypositive regulation of signaling receptor activity2
GO:0097067
IDA
Genome Projectcellular response to thyroid hormone stimulus
GO:0097067
IDA
Gene Ontologycellular response to thyroid hormone stimulus2
GO:0071383
IDA
Genome Projectcellular response to steroid hormone stimulus
GO:0071383
IDA
Gene Ontologycellular response to steroid hormone stimulus2
GO:0071364
IDA
Genome Projectcellular response to epidermal growth factor stimulus
GO:0071364
IDA
Gene Ontologycellular response to epidermal growth factor stimulus3
GO:0070562
IEA
Genome Projectregulation of vitamin D receptor signaling pathway
GO:0070371
IDA
Genome ProjectERK1 and ERK2 cascade
GO:0070371
IDA
Gene OntologyERK1 and ERK2 cascade2
GO:0070318
IEA
Genome Projectpositive regulation of G0 to G1 transition
GO:0060750
IEA
Genome Projectepithelial cell proliferation involved in mammary gland duct elongation
GO:0060745
IEA
Genome Projectmammary gland branching involved in pregnancy
GO:0060744
IEA
Genome Projectmammary gland branching involved in thelarche
GO:0060335
IEA
Genome Projectpositive regulation of interferon-gamma-mediated signaling pathway
GO:0051726
NAS
Genome Projectregulation of cell cycle
GO:0051726
NAS
Gene Ontologyregulation of cell cycle3
GO:0048822
IEA
Genome Projectenucleate erythrocyte development
GO:0048821
ISS
Genome Projecterythrocyte development
GO:0048821
ISS
Gene Ontologyerythrocyte development
GO:0045944
IDA, IMP
Genome Projectpositive regulation of transcription by RNA polymerase II
GO:0045944
IDA, IMP
Gene Ontologypositive regulation of transcription by RNA polymerase II4 5 6 7 8 9
GO:0045893
IDA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045893
IDA
Gene Ontologypositive regulation of transcription, DNA-templated3 10
GO:0045665
ISS
Genome Projectnegative regulation of neuron differentiation
GO:0045665
ISS
Gene Ontologynegative regulation of neuron differentiation
GO:0045648
IMP
Genome Projectpositive regulation of erythrocyte differentiation
GO:0045648
IMP
Gene Ontologypositive regulation of erythrocyte differentiation11
GO:0045618
IMP
Genome Projectpositive regulation of keratinocyte differentiation
GO:0045618
IMP
Gene Ontologypositive regulation of keratinocyte differentiation6
GO:0045444
IDA
Genome Projectfat cell differentiation
GO:0045444
IDA
Gene Ontologyfat cell differentiation5
GO:0043066
ISS
Genome Projectnegative regulation of apoptotic process
GO:0043066
ISS
Gene Ontologynegative regulation of apoptotic process
GO:0042789
ISS
Genome ProjectmRNA transcription by RNA polymerase II
GO:0042789
ISS
Gene OntologymRNA transcription by RNA polymerase II
GO:0035855
ISS
Genome Projectmegakaryocyte development
GO:0035855
ISS
Gene Ontologymegakaryocyte development
GO:0035729
IEA
Genome Projectcellular response to hepatocyte growth factor stimulus
GO:0035357
IEA
Genome Projectperoxisome proliferator activated receptor signaling pathway
GO:0035162
IEA
Genome Projectembryonic hemopoiesis
GO:0035116
IEA
Genome Projectembryonic hindlimb morphogenesis
GO:0035050
IEA
Genome Projectembryonic heart tube development
GO:0033601
IEA
Genome Projectpositive regulation of mammary gland epithelial cell proliferation
GO:0033160
IEA
Genome Projectpositive regulation of protein import into nucleus, translocation
GO:0033148
IEA
Genome Projectpositive regulation of intracellular estrogen receptor signaling pathway
GO:0031100
IEA
Genome Projectanimal organ regeneration
GO:0030521
IDA
Genome Projectandrogen receptor signaling pathway
GO:0030521
IDA
Gene Ontologyandrogen receptor signaling pathway12
GO:0030518
IDA
Genome Projectintracellular steroid hormone receptor signaling pathway
GO:0030518
IDA
Gene Ontologyintracellular steroid hormone receptor signaling pathway13
GO:0030224
IEA
Genome Projectmonocyte differentiation
GO:0030216
IMP
Genome Projectkeratinocyte differentiation
GO:0030216
IMP
Gene Ontologykeratinocyte differentiation1
GO:0019216
TAS
Genome Projectregulation of lipid metabolic process
GO:0019216
TAS
Gene Ontologyregulation of lipid metabolic process
GO:0016567
IEA
Genome Projectprotein ubiquitination
GO:0010839
IMP
Genome Projectnegative regulation of keratinocyte proliferation
GO:0010839
IMP
Gene Ontologynegative regulation of keratinocyte proliferation1
GO:0010628
IDA, IMP
Genome Projectpositive regulation of gene expression
GO:0010628
IDA, IMP
Gene Ontologypositive regulation of gene expression1 8
GO:0007595
IEA
Genome Projectlactation
GO:0007420
IEA
Genome Projectbrain development
GO:0006702
IMP
Genome Projectandrogen biosynthetic process
GO:0006702
IMP
Gene Ontologyandrogen biosynthetic process9
GO:0006590
IEA
Genome Projectthyroid hormone generation
GO:0006367
IDA
TAS
Genome Projecttranscription initiation from RNA polymerase II promoter
GO:0006367
IDA
TAS
Gene Ontologytranscription initiation from RNA polymerase II promoter12
GO:0006356
IDA
Genome Projectregulation of transcription by RNA polymerase I
GO:0006356
IDA
Gene Ontologyregulation of transcription by RNA polymerase I3
GO:0003406
IEA
Genome Projectretinal pigment epithelium development
GO:0003222
IEA
Genome Projectventricular trabecula myocardium morphogenesis
GO:0002154
IMP
Genome Projectthyroid hormone mediated signaling pathway
GO:0002154
IMP
Gene Ontologythyroid hormone mediated signaling pathway3
GO:0002088
ISS
Genome Projectlens development in camera-type eye
GO:0002088
ISS
Gene Ontologylens development in camera-type eye
GO:0001892
IEA
Genome Projectembryonic placenta development
GO:0001889
IEA
Genome Projectliver development
GO:0001525
ISS
Genome Projectangiogenesis
GO:0001525
ISS
Gene Ontologyangiogenesis
GO:0000902
IMP
Genome Projectcell morphogenesis
GO:0000902
IMP
Gene Ontologycell morphogenesis1
GO:0000122
ISS
Genome Projectnegative regulation of transcription by RNA polymerase II
GO:0000122
ISS
Gene Ontologynegative regulation of transcription by RNA polymerase II

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0061630
IEA
Genome Projectubiquitin protein ligase activity
GO:0050693
IPI
Genome ProjectLBD domain binding
GO:0050693
IPI
Gene OntologyLBD domain binding8
GO:0046966
IDA, IPI
Genome Projectthyroid hormone receptor binding
GO:0046966
IDA, IPI
Gene Ontologythyroid hormone receptor binding4 10
GO:0042975
IPI
Genome Projectperoxisome proliferator activated receptor binding
GO:0042975
IPI
Gene Ontologyperoxisome proliferator activated receptor binding4
GO:0042974
IPI
Genome Projectretinoic acid receptor binding
GO:0042974
IPI
Gene Ontologyretinoic acid receptor binding4
GO:0042809
IPI
TAS, NAS
Genome Projectvitamin D receptor binding
GO:0042809
IPI
TAS, NAS
Gene Ontologyvitamin D receptor binding1 4 14
GO:0036033
IDA
Genome Projectmediator complex binding
GO:0036033
IDA
Gene Ontologymediator complex binding2
GO:0035257
IPI
Genome Projectnuclear hormone receptor binding
GO:0035257
IPI
Gene Ontologynuclear hormone receptor binding15
GO:0031490
IEA
Genome Projectchromatin DNA binding
GO:0030375
IMP
Genome Projectthyroid hormone receptor coactivator activity
GO:0030375
IMP
Gene Ontologythyroid hormone receptor coactivator activity2
GO:0030374
IMP
NAS
Genome Projectnuclear receptor transcription coactivator activity
GO:0030374
IMP
NAS
Gene Ontologynuclear receptor transcription coactivator activity7 14
GO:0030331
IPI
Genome Projectestrogen receptor binding
GO:0030331
IPI
Gene Ontologyestrogen receptor binding4
GO:0016922
IDA, IPI
Genome Projectnuclear receptor binding
GO:0016922
IDA, IPI
Gene Ontologynuclear receptor binding2 4
GO:0008134
IPI
Genome Projecttranscription factor binding
GO:0008134
IPI
Gene Ontologytranscription factor binding7 9
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding2 4 7 11 16 17 18 19 20 21
GO:0003713
IDA, IMP
Genome Projecttranscription coactivator activity
GO:0003713
IDA, IMP
Gene Ontologytranscription coactivator activity1 3 4 5 9 11
GO:0003712
IDA
Genome Projecttranscription coregulator activity
GO:0003712
IDA
Gene Ontologytranscription coregulator activity10 12
GO:0003682
IMP
Genome Projectchromatin binding
GO:0003682
IMP
Gene Ontologychromatin binding7
GO:0001047
IDA
Genome Projectcore promoter binding
GO:0001047
IDA
Gene Ontologycore promoter binding11
GO:0000981
ISS
Genome ProjectDNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000981
ISS
Gene OntologyDNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000978
IEA
Genome ProjectRNA polymerase II proximal promoter sequence-specific DNA binding
GO:0038023
IDA
Gene Ontologysignaling receptor activity12
GO:0000979
IDA
Gene OntologyRNA polymerase II core promoter sequence-specific DNA binding7

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0032993
IEA
Genome Projectprotein-DNA complex
GO:0016592
IDA, IMP
Genome Projectmediator complex
GO:0016592
IDA, IMP
Gene Ontologymediator complex5 7 10 22
GO:0016020
IDA
Genome Projectmembrane
GO:0016020
Gene Ontologymembrane23
GO:0005730
IDA
Genome Projectnucleolus
GO:0005730
IDA
Gene Ontologynucleolus3
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005654
IDA
TAS
Gene Ontologynucleoplasm
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus1 3 8 9 24
GO:0000785
IEA
Genome Projectchromatin
GO:0000151
IEA
Genome Projectubiquitin ligase complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR019680Mediator complex, subunit Med1

No MapMan annotations defined for this gene.
KeggID Description
K15144MED1; mediator of RNA polymerase II transcription subunit 1
No chloroplast target sequence found.