Gene: ENSG00000122861 (Homo sapiens)

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Gene Identifier
ENSG00000122861
Transcript Identifier
ENST00000372764
Gene Type
Coding gene
Location
10 : 73911556-73916565 : positive

Family Information

Homologous gene family
HOM02SEM000009
(875 genes in 18 species)
specific family
Orthologous gene family
ORTHO02SEM000010
(778 genes in 18 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
plasminogen activator, urokinase

Identifiers

Type Value
pidENSP00000361850
HGNC9052
UniprotP00749
RefSeq_mRNANM_002658.3

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2000097
IDA
Genome Projectregulation of smooth muscle cell-matrix adhesion
GO:2000097
IDA
Gene Ontologyregulation of smooth muscle cell-matrix adhesion1
GO:0061041
IC
Genome Projectregulation of wound healing
GO:0061041
IC
Gene Ontologyregulation of wound healing1
GO:0043312
TAS
Genome Projectneutrophil degranulation
GO:0043312
TAS
Gene Ontologyneutrophil degranulation
GO:0042730
TAS
Genome Projectfibrinolysis
GO:0042730
TAS
Gene Ontologyfibrinolysis
GO:0042127
IEA
Genome Projectregulation of cell proliferation
GO:0033628
IDA
Genome Projectregulation of cell adhesion mediated by integrin
GO:0033628
IDA
Gene Ontologyregulation of cell adhesion mediated by integrin1
GO:0031639
IDA
Genome Projectplasminogen activation
GO:0031639
IDA
Gene Ontologyplasminogen activation2
GO:0030335
IDA
Genome Projectpositive regulation of cell migration
GO:0030335
IDA
Gene Ontologypositive regulation of cell migration3
GO:0014910
IDA
Genome Projectregulation of smooth muscle cell migration
GO:0014910
IDA
Gene Ontologyregulation of smooth muscle cell migration1
GO:0014909
IEA
Genome Projectsmooth muscle cell migration
GO:0010469
IDA
Genome Projectregulation of signaling receptor activity
GO:0010469
IDA
Gene Ontologyregulation of signaling receptor activity1
GO:0007596
IEA
Genome Projectblood coagulation
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007165
TAS
Gene Ontologysignal transduction4
GO:0006935
TAS
Genome Projectchemotaxis
GO:0006935
TAS
Gene Ontologychemotaxis4
GO:0006508
IBA
Genome Projectproteolysis
GO:0001666
IEA
Genome Projectresponse to hypoxia
GO:0030194
IEA
PLAZA Integrative Orthologypositive regulation of blood coagulation ENSG00000131187
GO:0051173
IEA
PLAZA Integrative Orthologypositive regulation of nitrogen compound metabolic process ENSG00000131187
GO:0051171
IEA
PLAZA Integrative Orthologyregulation of nitrogen compound metabolic process ENSG00000131187
GO:0044237
IEA
PLAZA Integrative Orthologycellular metabolic process ENSG00000131187
GO:0051246
IEA
PLAZA Integrative Orthologyregulation of protein metabolic process ENSG00000131187
GO:0002675
IEA
PLAZA Integrative Orthologypositive regulation of acute inflammatory response ENSG00000131187
GO:0051247
IEA
PLAZA Integrative Orthologypositive regulation of protein metabolic process ENSG00000131187
GO:0006954
IEA
PLAZA Integrative Orthologyinflammatory response ENSG00000131187
GO:0008219
IEA
PLAZA Integrative Orthologycell death ENSG00000167755
GO:0051240
IEA
PLAZA Integrative Orthologypositive regulation of multicellular organismal process ENSG00000131187
GO:0010033
IEA
PLAZA Integrative Orthologyresponse to organic substance ENSG00000131187
GO:0090303
IEA
PLAZA Integrative Orthologypositive regulation of wound healing ENSG00000131187
GO:0007186
IEA
PLAZA Integrative OrthologyG protein-coupled receptor signaling pathway ENSG00000167755
GO:0050729
IEA
PLAZA Integrative Orthologypositive regulation of inflammatory response ENSG00000131187
GO:0008277
IEA
PLAZA Integrative Orthologyregulation of G protein-coupled receptor signaling pathway ENSG00000167755
GO:0009967
IEA
PLAZA Integrative Orthologypositive regulation of signal transduction ENSG00000167755
GO:0002254
IEA
PLAZA Integrative Orthologykinin cascade ENSG00000131187
GO:0031349
IEA
PLAZA Integrative Orthologypositive regulation of defense response ENSG00000131187
GO:0023056
IEA
PLAZA Integrative Orthologypositive regulation of signaling ENSG00000167755
GO:0072378
IEA
PLAZA Integrative Orthologyblood coagulation, fibrin clot formation ENSG00000131187
GO:0002526
IEA
PLAZA Integrative Orthologyacute inflammatory response ENSG00000131187
GO:0072376
IEA
PLAZA Integrative Orthologyprotein activation cascade ENSG00000131187
GO:0010628
IEA
PLAZA Integrative Orthologypositive regulation of gene expression ENSG00000131187
GO:0010468
IEA
PLAZA Integrative Orthologyregulation of gene expression ENSG00000131187
GO:0050727
IEA
PLAZA Integrative Orthologyregulation of inflammatory response ENSG00000131187
GO:0031347
IEA
PLAZA Integrative Orthologyregulation of defense response ENSG00000131187
GO:0070997
IEA
PLAZA Integrative Orthologyneuron death ENSG00000167755
GO:0032270
IEA
PLAZA Integrative Orthologypositive regulation of cellular protein metabolic process ENSG00000131187
GO:0009893
IEA
PLAZA Integrative Orthologypositive regulation of metabolic process ENSG00000131187
GO:0007597
IEA
PLAZA Integrative Orthologyblood coagulation, intrinsic pathway ENSG00000131187
GO:0045862
IEA
PLAZA Integrative Orthologypositive regulation of proteolysis ENSG00000131187
GO:0002541
IEA
PLAZA Integrative Orthologyactivation of plasma proteins involved in acute inflammatory response ENSG00000131187
GO:0002542
IEA
PLAZA Integrative OrthologyFactor XII activation ENSG00000131187
GO:0045745
IEA
PLAZA Integrative Orthologypositive regulation of G protein-coupled receptor signaling pathway ENSG00000167755
GO:0048584
IEA
PLAZA Integrative Orthologypositive regulation of response to stimulus ENSG00000131187
GO:0032504
IEA
PLAZA Integrative Orthologymulticellular organism reproduction FBgn0039568
GO:0044260
IEA
PLAZA Integrative Orthologycellular macromolecule metabolic process ENSG00000131187
GO:0019222
IEA
PLAZA Integrative Orthologyregulation of metabolic process ENSG00000131187
GO:0032268
IEA
PLAZA Integrative Orthologyregulation of cellular protein metabolic process ENSG00000131187
GO:0032103
IEA
PLAZA Integrative Orthologypositive regulation of response to external stimulus ENSG00000131187
GO:0010756
IEA
PLAZA Integrative Orthologypositive regulation of plasminogen activation ENSG00000131187
GO:0010954
IEA
PLAZA Integrative Orthologypositive regulation of protein processing ENSG00000131187
GO:0010755
IEA
PLAZA Integrative Orthologyregulation of plasminogen activation ENSG00000131187
GO:0051788
IEA
PLAZA Integrative Orthologyresponse to misfolded protein ENSG00000131187
GO:0060255
IEA
PLAZA Integrative Orthologyregulation of macromolecule metabolic process ENSG00000131187
GO:1903036
IEA
PLAZA Integrative Orthologypositive regulation of response to wounding ENSG00000131187
GO:0051919
IEA
PLAZA Integrative Orthologypositive regulation of fibrinolysis ENSG00000131187
GO:0051917
IEA
PLAZA Integrative Orthologyregulation of fibrinolysis ENSG00000131187
GO:0030162
IEA
PLAZA Integrative Orthologyregulation of proteolysis ENSG00000131187
GO:0044267
IEA
PLAZA Integrative Orthologycellular protein metabolic process ENSG00000131187
GO:1900048
IEA
PLAZA Integrative Orthologypositive regulation of hemostasis ENSG00000131187
GO:0006952
IEA
PLAZA Integrative Orthologydefense response ENSG00000131187
GO:1903319
IEA
PLAZA Integrative Orthologypositive regulation of protein maturation ENSG00000131187
GO:0002353
IEA
PLAZA Integrative Orthologyplasma kallikrein-kinin cascade ENSG00000131187
GO:1903317
IEA
PLAZA Integrative Orthologyregulation of protein maturation ENSG00000131187
GO:0002673
IEA
PLAZA Integrative Orthologyregulation of acute inflammatory response ENSG00000131187
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction FBgn0039568
GO:0010604
IEA
PLAZA Integrative Orthologypositive regulation of macromolecule metabolic process ENSG00000131187
GO:0010647
IEA
PLAZA Integrative Orthologypositive regulation of cell communication ENSG00000167755
GO:0045087
IEA
PLAZA Integrative Orthologyinnate immune response ENSG00000131187
GO:0035966
IEA
PLAZA Integrative Orthologyresponse to topologically incorrect protein ENSG00000131187
GO:0016540
IEA
PLAZA Integrative Orthologyprotein autoprocessing ENSG00000131187
GO:0031325
IEA
PLAZA Integrative Orthologypositive regulation of cellular metabolic process ENSG00000131187
GO:0080090
IEA
PLAZA Integrative Orthologyregulation of primary metabolic process ENSG00000131187
GO:0031323
IEA
PLAZA Integrative Orthologyregulation of cellular metabolic process ENSG00000131187
GO:0070613
IEA
PLAZA Integrative Orthologyregulation of protein processing ENSG00000131187
GO:0050820
IEA
PLAZA Integrative Orthologypositive regulation of coagulation ENSG00000131187

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding5 6 7 8 9
GO:0004252
IBA
TAS
Genome Projectserine-type endopeptidase activity
GO:0004252
TAS
Gene Ontologyserine-type endopeptidase activity
GO:0097367
IEA
PLAZA Integrative Orthologycarbohydrate derivative binding ENSG00000148702
GO:0051787
IEA
PLAZA Integrative Orthologymisfolded protein binding ENSG00000131187
GO:0005539
IEA
PLAZA Integrative Orthologyglycosaminoglycan binding ENSG00000148702

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070821
TAS
Genome Projecttertiary granule membrane
GO:0070821
TAS
Gene Ontologytertiary granule membrane
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0070062
Gene Ontologyextracellular exosome10
GO:0035579
TAS
Genome Projectspecific granule membrane
GO:0035579
TAS
Gene Ontologyspecific granule membrane
GO:0009986
IDA
Genome Projectcell surface
GO:0009986
IDA
Gene Ontologycell surface11
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0005925
Gene Ontologyfocal adhesion12
GO:0005886
TAS
Genome Projectplasma membrane
GO:0005886
TAS
Gene Ontologyplasma membrane
GO:0005615
IDA
Genome Projectextracellular space
GO:0005615
IDA
Gene Ontologyextracellular space11
GO:0005576
TAS
Genome Projectextracellular region
GO:0005576
TAS
Gene Ontologyextracellular region

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000001Kringle
IPR000742EGF-like domain
IPR001254Serine proteases, trypsin domain
IPR001314Peptidase S1A, chymotrypsin family
IPR009003Peptidase S1, PA clan
IPR013032EGF-like, conserved site
IPR013806Kringle-like fold
IPR018056Kringle, conserved site
IPR018114Serine proteases, trypsin family, histidine active site
IPR033116Serine proteases, trypsin family, serine active site
IPR034814Urokinase-type plasminogen activator

No MapMan annotations defined for this gene.
KeggID Description
K01348PLAU; urokinase plasminogen activator
No chloroplast target sequence found.