Gene: ENSG00000121957 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000121957
Transcript Identifier
ENST00000264126
Gene Type
Coding gene
Location
1 : 108885523-108929940 : positive

Family Information

Homologous gene family
HOM02SEM021516
(4 genes in 3 species)
specific family
Orthologous gene family
ORTHO02SEM013503
(4 genes in 3 species)
specific family

Descriptions

gene_descr
G-protein signaling modulator 2

Identifiers

Type Value
pidENSP00000264126
HGNC29501
UniprotP81274
UniprotA0A024R0F8
RefSeq_mRNANM_013296.4
EMBLCH471122

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1905832
IMP
Genome Projectpositive regulation of spindle assembly
GO:1905832
IMP
Gene Ontologypositive regulation of spindle assembly1
GO:1904778
IMP
Genome Projectpositive regulation of protein localization to cell cortex
GO:1904778
IMP
Gene Ontologypositive regulation of protein localization to cell cortex2 3 4
GO:0060487
IEA
Genome Projectlung epithelial cell differentiation
GO:0060236
IMP
Genome Projectregulation of mitotic spindle organization
GO:0060236
IMP
Gene Ontologyregulation of mitotic spindle organization3
GO:0051661
IMP
Genome Projectmaintenance of centrosome location
GO:0051661
IMP
Gene Ontologymaintenance of centrosome location5
GO:0050790
IEA
Genome Projectregulation of catalytic activity
GO:0031291
IMP
Genome ProjectRan protein signal transduction
GO:0031291
IMP
Gene OntologyRan protein signal transduction2
GO:0007186
TAS
Genome ProjectG protein-coupled receptor signaling pathway
GO:0007186
TAS
Gene OntologyG protein-coupled receptor signaling pathway6
GO:0007052
IMP
Genome Projectmitotic spindle organization
GO:0007052
IMP
Gene Ontologymitotic spindle organization5
GO:0000132
IMP
Genome Projectestablishment of mitotic spindle orientation
GO:0000132
IMP
Gene Ontologyestablishment of mitotic spindle orientation2 4
GO:0008283
IEA
PLAZA Integrative Orthologycell proliferation FBgn0040080
GO:0061351
IEA
PLAZA Integrative Orthologyneural precursor cell proliferation FBgn0040080
GO:0007399
IEA
PLAZA Integrative Orthologynervous system development FBgn0040080
GO:0007631
IEA
PLAZA Integrative Orthologyfeeding behavior WBGene00000092
GO:0022008
IEA
PLAZA Integrative Orthologyneurogenesis FBgn0040080
GO:0048699
IEA
PLAZA Integrative Orthologygeneration of neurons FBgn0040080
GO:0007610
IEA
PLAZA Integrative Orthologybehavior WBGene00000092
GO:0050795
IEA
PLAZA Integrative Orthologyregulation of behavior WBGene00000092
GO:0051301
IEA
PLAZA Integrative Orthologycell division FBgn0040080
GO:0007405
IEA
PLAZA Integrative Orthologyneuroblast proliferation FBgn0040080
GO:0048863
IEA
PLAZA Integrative Orthologystem cell differentiation FBgn0040080
GO:0048103
IEA
PLAZA Integrative Orthologysomatic stem cell division FBgn0040080
GO:0045175
IEA
PLAZA Integrative Orthologybasal protein localization FBgn0040080
GO:0072089
IEA
PLAZA Integrative Orthologystem cell proliferation FBgn0040080
GO:0017145
IEA
PLAZA Integrative Orthologystem cell division FBgn0040080
GO:0036445
IEA
PLAZA Integrative Orthologyneuronal stem cell division FBgn0040080
GO:0001709
IEA
PLAZA Integrative Orthologycell fate determination FBgn0040080
GO:0014017
IEA
PLAZA Integrative Orthologyneuroblast fate commitment FBgn0040080
GO:0014016
IEA
PLAZA Integrative Orthologyneuroblast differentiation FBgn0040080
GO:0048867
IEA
PLAZA Integrative Orthologystem cell fate determination FBgn0040080
GO:0008356
IEA
PLAZA Integrative Orthologyasymmetric cell division FBgn0040080
GO:0007400
IEA
PLAZA Integrative Orthologyneuroblast fate determination FBgn0040080
GO:0048865
IEA
PLAZA Integrative Orthologystem cell fate commitment FBgn0040080
GO:0060259
IEA
PLAZA Integrative Orthologyregulation of feeding behavior WBGene00000092
GO:0098722
IEA
PLAZA Integrative Orthologyasymmetric stem cell division FBgn0040080
GO:0045167
IEA
PLAZA Integrative Orthologyasymmetric protein localization involved in cell fate determination FBgn0040080
GO:0045165
IEA
PLAZA Integrative Orthologycell fate commitment FBgn0040080
GO:0055057
IEA
PLAZA Integrative Orthologyneuroblast division FBgn0040080
GO:0055059
IEA
PLAZA Integrative Orthologyasymmetric neuroblast division FBgn0040080

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070840
IDA
Genome Projectdynein complex binding
GO:0070840
IDA
Gene Ontologydynein complex binding2
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042802
IPI
Gene Ontologyidentical protein binding7
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding1 2 5 7 8 9 10 11 12 13
GO:0005092
ISS
Genome ProjectGDP-dissociation inhibitor activity
GO:0005092
ISS
Gene OntologyGDP-dissociation inhibitor activity
GO:0001965
IEA
Genome ProjectG-protein alpha-subunit binding
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0043621
IMP
Gene Ontologyprotein self-association11
GO:0008022
IPI
Gene Ontologyprotein C-terminus binding11
GO:0019904
IPI
Gene Ontologyprotein domain specific binding11
GO:0005096
IEA
PLAZA Integrative OrthologyGTPase activator activity WBGene00000092
GO:0008047
IEA
PLAZA Integrative Orthologyenzyme activator activity WBGene00000092

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0097431
IDA
Genome Projectmitotic spindle pole
GO:0097431
IDA
Gene Ontologymitotic spindle pole1 5
GO:0099738
IDA
Genome Projectcell cortex region
GO:0099738
IDA
Gene Ontologycell cortex region2 4
GO:0045177
IEA
Genome Projectapical part of cell
GO:0005938
IDA
Genome Projectcell cortex
GO:0005938
IDA, IMP
Gene Ontologycell cortex3 5 11 14
GO:0005829
IDA
Genome Projectcytosol
GO:0005829
IDA
Gene Ontologycytosol
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm1
GO:0097575
IDA
Gene Ontologylateral cell cortex12
GO:0032991
IDA, IMP
Gene Ontologyprotein-containing complex10 11
GO:0005813
IDA
Gene Ontologycentrosome
GO:0045179
IEA
PLAZA Integrative Orthologyapical cortex FBgn0040080
GO:0016020
IEA
PLAZA Integrative Orthologymembrane WBGene00000092

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003109GoLoco motif
IPR011990Tetratricopeptide-like helical domain superfamily
IPR013026Tetratricopeptide repeat-containing domain
IPR019734Tetratricopeptide repeat

No MapMan annotations defined for this gene.
KeggID Description
K15837GPSM2; G-protein signaling modulator 2
No chloroplast target sequence found.