Gene: ENSG00000121858 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000121858
Transcript Identifier
ENST00000241261
Gene Type
Coding gene
Location
3 : 172506492-172523384 : negative

Family Information

Homologous gene family
HOM02SEM027547
(3 genes in 1 species)
specific family

Descriptions

gene_descr
tumor necrosis factor (ligand) superfamily, member 10

Identifiers

Type Value
pidENSP00000241261
HGNC11925
UniprotP50591
UniprotQ6IBA9
RefSeq_mRNANM_003810.3
EMBLCHEMBL5813
EMBLAC007919
EMBLAC016938
EMBLAK296085
EMBLAK312742
EMBLBC032722
EMBLBT019564
EMBLCH471052
EMBLCR456895
EMBLDQ848564
EMBLEF064708
EMBLEU183231
EMBLU37518
EMBLU57059

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2001238
IDA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway
GO:2001238
IDA
Gene Ontologypositive regulation of extrinsic apoptotic signaling pathway1 2 3
GO:1902042
TAS
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042
TAS
Gene Ontologynegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902041
TAS
Genome Projectregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902041
TAS
Gene Ontologyregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0097296
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0090200
IDA
Genome Projectpositive regulation of release of cytochrome c from mitochondria
GO:0090200
IDA
Gene Ontologypositive regulation of release of cytochrome c from mitochondria3
GO:0043280
IDA
Genome Projectpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043280
IDA
Gene Ontologypositive regulation of cysteine-type endopeptidase activity involved in apoptotic process2 3 4
GO:0043123
IEP
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123
IEP
Gene Ontologypositive regulation of I-kappaB kinase/NF-kappaB signaling5
GO:0043065
IDA
Genome Projectpositive regulation of apoptotic process
GO:0043065
IDA
Gene Ontologypositive regulation of apoptotic process2
GO:0032868
IEA
Genome Projectresponse to insulin
GO:0008584
IEA
Genome Projectmale gonad development
GO:0007267
TAS
Genome Projectcell-cell signaling
GO:0007267
TAS
Gene Ontologycell-cell signaling6
GO:0007166
TAS
Genome Projectcell surface receptor signaling pathway
GO:0007166
TAS
Gene Ontologycell surface receptor signaling pathway
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007165
TAS
Gene Ontologysignal transduction6 7
GO:0006955
IEA
Genome Projectimmune response
GO:0006919
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
TAS
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915
IEA
Genome Projectapoptotic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding1 2 3 4 8 9 10 11 12
GO:0005164
IEA
Genome Projecttumor necrosis factor receptor binding
GO:0005125
IEA
Genome Projectcytokine activity
GO:0005102
TAS
Genome Projectsignaling receptor binding
GO:0005102
TAS
Gene Ontologysignaling receptor binding6 7
GO:0042802
IDA
Gene Ontologyidentical protein binding13
GO:0008270
IDA
Gene Ontologyzinc ion binding13

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0070062
Gene Ontologyextracellular exosome14
GO:0005887
TAS
Genome Projectintegral component of plasma membrane
GO:0005887
TAS
Gene Ontologyintegral component of plasma membrane7
GO:0005615
IEA
Genome Projectextracellular space
GO:0005576
TAS
Genome Projectextracellular region
GO:0005576
TAS
Gene Ontologyextracellular region

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR006052Tumour necrosis factor domain
IPR008983Tumour necrosis factor-like domain superfamily
IPR017355Tumour necrosis factor ligand 10/11
IPR021184Tumour necrosis factor, conserved site

No MapMan annotations defined for this gene.
KeggID Description
K04721CD253, TNFSF10; tumor necrosis factor (ligand) superfamily, member 10
No chloroplast target sequence found.