Gene: ENSG00000120885 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000120885
Transcript Identifier
ENST00000523500
Gene Type
Coding gene
Location
8 : 27598241-27610571 : negative

Family Information

Homologous gene family
HOM02SEM040991
(2 genes in 1 species)
specific family

Descriptions

gene_descr
clusterin

Identifiers

Type Value
pidENSP00000429620
HGNC2095
UniprotP10909
EMBLAF311103
EMBLAK093399
EMBLAK313870
EMBLAY341244
EMBLAY513288
EMBLBC010514
EMBLBC019588
EMBLBU150467
EMBLBX648414
EMBLCR599675
EMBLJ02908
EMBLL00974
EMBLM25915
EMBLM63376
EMBLM63377
EMBLM63378
EMBLM63379
EMBLM64722
EMBLM74816
EMBLX14723

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2000060
IMP
Genome Projectpositive regulation of ubiquitin-dependent protein catabolic process
GO:2000060
IMP
Gene Ontologypositive regulation of ubiquitin-dependent protein catabolic process1
GO:1905907
IDA
TAS
Genome Projectnegative regulation of amyloid fibril formation
GO:1905907
IDA
TAS
Gene Ontologynegative regulation of amyloid fibril formation2 3 4
GO:1905895
IMP
Genome Projectnegative regulation of cellular response to tunicamycin
GO:1905895
IMP
Gene Ontologynegative regulation of cellular response to tunicamycin5
GO:1905892
IMP
Genome Projectnegative regulation of cellular response to thapsigargin
GO:1905892
IMP
Gene Ontologynegative regulation of cellular response to thapsigargin5
GO:1903573
IMP
Genome Projectnegative regulation of response to endoplasmic reticulum stress
GO:1903573
IMP
Gene Ontologynegative regulation of response to endoplasmic reticulum stress5
GO:1902998
IMP
Genome Projectpositive regulation of neurofibrillary tangle assembly
GO:1902998
IMP
Gene Ontologypositive regulation of neurofibrillary tangle assembly6
GO:1902949
IMP
Genome Projectpositive regulation of tau-protein kinase activity
GO:1902949
IMP
Gene Ontologypositive regulation of tau-protein kinase activity6
GO:1902847
IMP
Genome Projectregulation of neuronal signal transduction
GO:1902847
IMP
Gene Ontologyregulation of neuronal signal transduction7
GO:1902430
IDA
Genome Projectnegative regulation of amyloid-beta formation
GO:1902430
IDA
Gene Ontologynegative regulation of amyloid-beta formation8 9
GO:1902230
IMP
Genome Projectnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902230
IMP
Gene Ontologynegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage10
GO:1902004
ISS
Genome Projectpositive regulation of amyloid-beta formation
GO:1902004
ISS
Gene Ontologypositive regulation of amyloid-beta formation
GO:1901216
IDA, IMP
ISS
Genome Projectpositive regulation of neuron death
GO:1901216
IDA, IMP
ISS
Gene Ontologypositive regulation of neuron death6 11
GO:1901214
IDA, IMP
Genome Projectregulation of neuron death
GO:1901214
IDA, IMP
Gene Ontologyregulation of neuron death9 12
GO:1900221
IDA
Genome Projectregulation of amyloid-beta clearance
GO:1900221
IDA
Gene Ontologyregulation of amyloid-beta clearance13
GO:0090201
TAS
Genome Projectnegative regulation of release of cytochrome c from mitochondria
GO:0090201
TAS
Gene Ontologynegative regulation of release of cytochrome c from mitochondria5
GO:0061741
IC
Genome Projectchaperone-mediated protein transport involved in chaperone-mediated autophagy
GO:0061741
IC
Gene Ontologychaperone-mediated protein transport involved in chaperone-mediated autophagy2
GO:0061740
IC
Genome Projectprotein targeting to lysosome involved in chaperone-mediated autophagy
GO:0061740
IC
Gene Ontologyprotein targeting to lysosome involved in chaperone-mediated autophagy2
GO:0061518
IDA
Genome Projectmicroglial cell proliferation
GO:0061518
IDA
Gene Ontologymicroglial cell proliferation11
GO:0061077
IDA
Genome Projectchaperone-mediated protein folding
GO:0061077
IDA
Gene Ontologychaperone-mediated protein folding14
GO:0060548
IMP
TAS
Genome Projectnegative regulation of cell death
GO:0060548
IMP
TAS
Gene Ontologynegative regulation of cell death5 15
GO:0051788
IDA
Genome Projectresponse to misfolded protein
GO:0051788
IDA
Gene Ontologyresponse to misfolded protein16
GO:0051131
IDA
Genome Projectchaperone-mediated protein complex assembly
GO:0051131
IDA
Gene Ontologychaperone-mediated protein complex assembly9
GO:0051092
IMP
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051092
IMP
Gene Ontologypositive regulation of NF-kappaB transcription factor activity1
GO:0050821
IDA
Genome Projectprotein stabilization
GO:0050821
IDA
Gene Ontologyprotein stabilization14
GO:0048260
IGI
Genome Projectpositive regulation of receptor-mediated endocytosis
GO:0048260
IGI
Gene Ontologypositive regulation of receptor-mediated endocytosis2
GO:0045429
IDA
Genome Projectpositive regulation of nitric oxide biosynthetic process
GO:0045429
IDA
Gene Ontologypositive regulation of nitric oxide biosynthetic process11
GO:0045087
IEA
Genome Projectinnate immune response
GO:0043691
TAS
Genome Projectreverse cholesterol transport
GO:0043691
TAS
Gene Ontologyreverse cholesterol transport17
GO:0032760
IDA
Genome Projectpositive regulation of tumor necrosis factor production
GO:0032760
IDA
Gene Ontologypositive regulation of tumor necrosis factor production11
GO:0032464
IDA
Genome Projectpositive regulation of protein homooligomerization
GO:0032464
IDA
Gene Ontologypositive regulation of protein homooligomerization3
GO:0032463
IDA, IMP
Genome Projectnegative regulation of protein homooligomerization
GO:0032463
IDA, IMP
Gene Ontologynegative regulation of protein homooligomerization3 4 10
GO:0032436
IMP
Genome Projectpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032436
IMP
Gene Ontologypositive regulation of proteasomal ubiquitin-dependent protein catabolic process1
GO:0032286
IMP
Genome Projectcentral nervous system myelin maintenance
GO:0032286
IMP
Gene Ontologycentral nervous system myelin maintenance18
GO:0030449
TAS
Genome Projectregulation of complement activation
GO:0030449
TAS
Gene Ontologyregulation of complement activation
GO:0019730
TAS
Genome Projectantimicrobial humoral response
GO:0019730
TAS
Gene Ontologyantimicrobial humoral response
GO:0017038
IDA
Genome Projectprotein import
GO:0017038
IDA
Gene Ontologyprotein import13
GO:0010628
ISS
Genome Projectpositive regulation of gene expression
GO:0010628
ISS
Gene Ontologypositive regulation of gene expression
GO:0009615
IEP
Genome Projectresponse to virus
GO:0009615
IEP
Gene Ontologyresponse to virus19
GO:0006958
IEA
Genome Projectcomplement activation, classical pathway
GO:0006956
TAS
Genome Projectcomplement activation
GO:0006956
TAS
Gene Ontologycomplement activation20
GO:0006629
NAS
Genome Projectlipid metabolic process
GO:0006629
NAS
Gene Ontologylipid metabolic process21
GO:0002576
TAS
Genome Projectplatelet degranulation
GO:0002576
TAS
Gene Ontologyplatelet degranulation
GO:0001836
IC
Genome Projectrelease of cytochrome c from mitochondria
GO:0001836
IC
Gene Ontologyrelease of cytochrome c from mitochondria10
GO:0001774
IDA
Genome Projectmicroglial cell activation
GO:0001774
IDA
Gene Ontologymicroglial cell activation11
GO:0000902
IDA
Genome Projectcell morphogenesis
GO:0000902
IDA
Gene Ontologycell morphogenesis11
GO:1905908
TAS
Gene Ontologypositive regulation of amyloid fibril formation22

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0016887
IDA
Genome ProjectATPase activity
GO:0016887
IDA
Gene OntologyATPase activity14
GO:0051787
IDA, IPI
Genome Projectmisfolded protein binding
GO:0051787
IDA, IPI
Gene Ontologymisfolded protein binding14 16
GO:0051087
ISS
Genome Projectchaperone binding
GO:0051087
ISS
Gene Ontologychaperone binding
GO:0050750
IPI
Genome Projectlow-density lipoprotein particle receptor binding
GO:0050750
IPI
Gene Ontologylow-density lipoprotein particle receptor binding2
GO:0031625
IDA
Genome Projectubiquitin protein ligase binding
GO:0031625
IDA
Gene Ontologyubiquitin protein ligase binding1
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding10 23 24 25 26 27 28 29
GO:0001540
IPI
Genome Projectamyloid-beta binding
GO:0001540
IDA, IPI
Gene Ontologyamyloid-beta binding2 3 4
GO:0048156
IPI
Gene Ontologytau protein binding27
GO:0044877
IPI
Gene Ontologyprotein-containing complex binding3 4

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0071944
IDA
Genome Projectcell periphery
GO:0071944
IDA
Gene Ontologycell periphery5
GO:0031012
IDA
Genome Projectextracellular matrix
GO:0031012
Gene Ontologyextracellular matrix30
GO:0097440
IDA
Genome Projectapical dendrite
GO:0097440
IDA
Gene Ontologyapical dendrite12
GO:0097418
IDA
Genome Projectneurofibrillary tangle
GO:0097418
IDA
Gene Ontologyneurofibrillary tangle6 12
GO:0072562
IDA
Genome Projectblood microparticle
GO:0072562
Gene Ontologyblood microparticle31
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0070062
Gene Ontologyextracellular exosome32 33 34
GO:0048471
IDA
Genome Projectperinuclear region of cytoplasm
GO:0048471
IDA
Gene Ontologyperinuclear region of cytoplasm1
GO:0042583
IEA
Genome Projectchromaffin granule
GO:0034366
IDA
Genome Projectspherical high-density lipoprotein particle
GO:0034366
IDA
Gene Ontologyspherical high-density lipoprotein particle17
GO:0031966
IEA
Genome Projectmitochondrial membrane
GO:0031093
TAS
Genome Projectplatelet alpha granule lumen
GO:0031093
TAS
Gene Ontologyplatelet alpha granule lumen
GO:0009986
IDA
Genome Projectcell surface
GO:0009986
IDA
Gene Ontologycell surface25
GO:0005829
IEA
Genome Projectcytosol
GO:0005794
ISS
Genome ProjectGolgi apparatus
GO:0005794
ISS
Gene OntologyGolgi apparatus
GO:0005783
IEA
Genome Projectendoplasmic reticulum
GO:0005739
IDA
Genome Projectmitochondrion
GO:0005739
IDA
Gene Ontologymitochondrion10
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm12 27
GO:0005634
IEA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus27
GO:0005622
TAS
Genome Projectintracellular
GO:0005622
TAS
Gene Ontologyintracellular15
GO:0005615
IDA
Genome Projectextracellular space
GO:0005615
IDA
Gene Ontologyextracellular space10 14 16 25 35 36
GO:0005576
TAS
Genome Projectextracellular region
GO:0005576
TAS
Gene Ontologyextracellular region15 37
GO:0016020
IDA
Gene Ontologymembrane27
GO:0062023
Gene Ontologycollagen-containing extracellular matrix36 38
GO:0005856
IDA
Gene Ontologycytoskeleton27
GO:0032991
IDA
Gene Ontologyprotein-containing complex2 25

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000753Clusterin-like
IPR016014Clusterin, N-terminal
IPR016015Clusterin, C-terminal
IPR016016Clusterin
IPR033986Clusterin, conserved site

No MapMan annotations defined for this gene.
KeggID Description
K17252CLU; clusterin
No chloroplast target sequence found.