Gene: ENSG00000120868 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000120868
Transcript Identifier
ENST00000551964
Gene Type
Coding gene
Location
12 : 98648360-98732566 : positive

Family Information

Homologous gene family
HOM02SEM002905
(26 genes in 4 species)
specific family

Descriptions

gene_descr
apoptotic peptidase activating factor 1

Identifiers

Type Value
pidENSP00000448165
HGNC576
UniprotO14727
RefSeq_mRNANM_181861.1

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2001235
IEA
Genome Projectpositive regulation of apoptotic signaling pathway
GO:1902510
IEA
Genome Projectregulation of apoptotic DNA fragmentation
GO:0097193
TAS
Genome Projectintrinsic apoptotic signaling pathway
GO:0097193
TAS
Gene Ontologyintrinsic apoptotic signaling pathway1
GO:0072432
TAS
Genome Projectresponse to G1 DNA damage checkpoint signaling
GO:0072432
TAS
Gene Ontologyresponse to G1 DNA damage checkpoint signaling1
GO:0071560
IEA
Genome Projectcellular response to transforming growth factor beta stimulus
GO:0070059
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0051402
IEA
Genome Projectneuron apoptotic process
GO:0051260
IEA
Genome Projectprotein homooligomerization
GO:0043312
TAS
Genome Projectneutrophil degranulation
GO:0043312
TAS
Gene Ontologyneutrophil degranulation
GO:0043065
TAS
Genome Projectpositive regulation of apoptotic process
GO:0043065
TAS
Gene Ontologypositive regulation of apoptotic process1
GO:0042981
TAS
Genome Projectregulation of apoptotic process
GO:0042981
TAS
Gene Ontologyregulation of apoptotic process2
GO:0034349
IEA
Genome Projectglial cell apoptotic process
GO:0030900
IEA
Genome Projectforebrain development
GO:0030154
IEA
Genome Projectcell differentiation
GO:0010659
IEA
Genome Projectcardiac muscle cell apoptotic process
GO:0008635
IDA
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0008635
IDA
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c3
GO:0007584
IEA
Genome Projectresponse to nutrient
GO:0007568
IEA
Genome Projectaging
GO:0007399
TAS
Genome Projectnervous system development
GO:0007399
TAS
Gene Ontologynervous system development4
GO:0006919
IDA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
IDA
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process5
GO:0006915
TAS
Genome Projectapoptotic process
GO:0006915
TAS
Gene Ontologyapoptotic process4
GO:0001843
IEA
Genome Projectneural tube closure
GO:0001666
IEA
Genome Projectresponse to hypoxia
GO:0070317
TAS
Gene Ontologynegative regulation of G0 to G1 transition

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0043531
IEA
Genome ProjectADP binding
GO:0042802
IEA
Genome Projectidentical protein binding
GO:0031072
IEA
Genome Projectheat shock protein binding
GO:0008656
IBA
NAS
Genome Projectcysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008656
NAS
Gene Ontologycysteine-type endopeptidase activator activity involved in apoptotic process6
GO:0005524
IEA
Genome ProjectATP binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding3 5 7 8 9 10 11 12 13 14 15 16 17 18
GO:0000166
TAS
Genome Projectnucleotide binding
GO:0000166
TAS
Gene Ontologynucleotide binding19
GO:0016787
IEA
PLAZA Homology (enrichment)hydrolase activity HOM02SEM002905
GO:0016462
IEA
PLAZA Homology (enrichment)pyrophosphatase activity HOM02SEM002905
GO:0017111
IEA
PLAZA Homology (enrichment)nucleoside-triphosphatase activity HOM02SEM002905
GO:0003824
IEA
PLAZA Homology (enrichment)catalytic activity HOM02SEM002905
GO:0003777
IEA
PLAZA Homology (enrichment)microtubule motor activity HOM02SEM002905
GO:0003774
IEA
PLAZA Homology (enrichment)motor activity HOM02SEM002905
GO:0016818
IEA
PLAZA Homology (enrichment)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides HOM02SEM002905
GO:0016817
IEA
PLAZA Homology (enrichment)hydrolase activity, acting on acid anhydrides HOM02SEM002905

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1904813
TAS
Genome Projectficolin-1-rich granule lumen
GO:1904813
TAS
Gene Ontologyficolin-1-rich granule lumen
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0070062
Gene Ontologyextracellular exosome20
GO:0043293
IDA
TAS
Genome Projectapoptosome
GO:0043293
IDA
TAS
Gene Ontologyapoptosome1 5
GO:0034774
TAS
Genome Projectsecretory granule lumen
GO:0034774
TAS
Gene Ontologysecretory granule lumen
GO:0005829
TAS
Genome Projectcytosol
GO:0005829
TAS
Gene Ontologycytosol
GO:0005634
IEA
Genome Projectnucleus
GO:0005576
TAS
Genome Projectextracellular region
GO:0005576
TAS
Gene Ontologyextracellular region
GO:0032991
IDA
Gene Ontologyprotein-containing complex12
GO:0044430
IEA
PLAZA Homology (enrichment)cytoskeletal part HOM02SEM002905
GO:0005856
IEA
PLAZA Homology (enrichment)cytoskeleton HOM02SEM002905
GO:0005875
IEA
PLAZA Homology (enrichment)microtubule associated complex HOM02SEM002905
GO:0043228
IEA
PLAZA Homology (enrichment)non-membrane-bounded organelle HOM02SEM002905
GO:0005871
IEA
PLAZA Homology (enrichment)kinesin complex HOM02SEM002905
GO:0043232
IEA
PLAZA Homology (enrichment)intracellular non-membrane-bounded organelle HOM02SEM002905
GO:0015630
IEA
PLAZA Homology (enrichment)microtubule cytoskeleton HOM02SEM002905

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001315CARD domain
IPR001680WD40 repeat
IPR002182NB-ARC
IPR011029Death-like domain superfamily
IPR011991ArsR-like helix-turn-helix domain
IPR015943WD40/YVTN repeat-like-containing domain superfamily
IPR017251Apoptotic protease-activating factor 1
IPR017986WD40-repeat-containing domain
IPR019775WD40 repeat, conserved site
IPR020472G-protein beta WD-40 repeat
IPR027417P-loop containing nucleoside triphosphate hydrolase

No MapMan annotations defined for this gene.
KeggID Description
K02084APAF1; apoptotic protease-activating factor
No chloroplast target sequence found.