Gene: ENSG00000117748 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000117748
Transcript Identifier
ENST00000313433
Gene Type
Coding gene
Location
1 : 27892163-27914443 : negative

Family Information

Homologous gene family
HOM02SEM002708
(27 genes in 21 species)
specific family
Orthologous gene family
ORTHO02SEM002940
(26 genes in 21 species)
specific family

Descriptions

gene_descr
replication protein A2, 32kDa

Identifiers

Type Value
pidENSP00000363015
HGNC10290
UniprotP15927

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2000001
IMP
Genome Projectregulation of DNA damage checkpoint
GO:2000001
IMP
Gene Ontologyregulation of DNA damage checkpoint1
GO:1901796
TAS
Genome Projectregulation of signal transduction by p53 class mediator
GO:1900034
TAS
Genome Projectregulation of cellular response to heat
GO:1900034
TAS
Gene Ontologyregulation of cellular response to heat
GO:0070987
TAS
Genome Projecterror-free translesion synthesis
GO:0070987
TAS
Gene Ontologyerror-free translesion synthesis
GO:0042769
TAS
Genome ProjectDNA damage response, detection of DNA damage
GO:0042769
TAS
Gene OntologyDNA damage response, detection of DNA damage
GO:0042276
TAS
Genome Projecterror-prone translesion synthesis
GO:0042276
TAS
Gene Ontologyerror-prone translesion synthesis
GO:0036297
TAS
Genome Projectinterstrand cross-link repair
GO:0036297
TAS
Gene Ontologyinterstrand cross-link repair
GO:0034502
IDA
Genome Projectprotein localization to chromosome
GO:0034502
IDA
Gene Ontologyprotein localization to chromosome2 3
GO:0033683
TAS
Genome Projectnucleotide-excision repair, DNA incision
GO:0033683
TAS
Gene Ontologynucleotide-excision repair, DNA incision
GO:0031571
IMP
Genome Projectmitotic G1 DNA damage checkpoint
GO:0031571
IMP
Gene Ontologymitotic G1 DNA damage checkpoint4
GO:0019985
TAS
Genome Projecttranslesion synthesis
GO:0019985
TAS
Gene Ontologytranslesion synthesis
GO:0010569
IMP
Genome Projectregulation of double-strand break repair via homologous recombination
GO:0010569
IMP
Gene Ontologyregulation of double-strand break repair via homologous recombination5
GO:0006298
IMP
TAS
Genome Projectmismatch repair
GO:0006298
IMP
Gene Ontologymismatch repair6
GO:0006297
TAS
Genome Projectnucleotide-excision repair, DNA gap filling
GO:0006297
TAS
Gene Ontologynucleotide-excision repair, DNA gap filling
GO:0006296
TAS
Genome Projectnucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006296
TAS
Gene Ontologynucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006295
TAS
Genome Projectnucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006294
TAS
Genome Projectnucleotide-excision repair, preincision complex assembly
GO:0006294
TAS
Gene Ontologynucleotide-excision repair, preincision complex assembly
GO:0006293
TAS
Genome Projectnucleotide-excision repair, preincision complex stabilization
GO:0006293
TAS
Gene Ontologynucleotide-excision repair, preincision complex stabilization
GO:0006289
IMP
Genome Projectnucleotide-excision repair
GO:0006289
IMP
Gene Ontologynucleotide-excision repair6
GO:0006284
IDA
Genome Projectbase-excision repair
GO:0006284
IDA
Gene Ontologybase-excision repair7
GO:0006283
TAS
Genome Projecttranscription-coupled nucleotide-excision repair
GO:0006283
TAS
Gene Ontologytranscription-coupled nucleotide-excision repair
GO:0006260
IDA, IMP
TAS
Genome ProjectDNA replication
GO:0006260
IDA, IMP
TAS
Gene OntologyDNA replication6 8
GO:0000724
IMP
Genome Projectdouble-strand break repair via homologous recombination
GO:0000724
IMP
Gene Ontologydouble-strand break repair via homologous recombination9
GO:0000723
IMP
IC
Genome Projecttelomere maintenance
GO:0000723
IMP
IC
Gene Ontologytelomere maintenance10 11
GO:0000722
TAS
Genome Projecttelomere maintenance via recombination
GO:0000082
TAS
Genome ProjectG1/S transition of mitotic cell cycle
GO:0000082
TAS
Gene OntologyG1/S transition of mitotic cell cycle
GO:0030154
IEA
PLAZA Integrative Orthologycell differentiation FBgn0032906
GO:0071103
IEA
PLAZA Integrative OrthologyDNA conformation change YNL312W
GO:0010605
IEA
PLAZA Integrative Orthologynegative regulation of macromolecule metabolic process AT2G24490
GO:0051234
IEA
PLAZA Integrative Orthologyestablishment of localization YNL312W
GO:0048869
IEA
PLAZA Integrative Orthologycellular developmental process FBgn0032906
GO:0007127
IEA
PLAZA Integrative Orthologymeiosis I YNL312W
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction YNL312W
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process YNL312W
GO:0043412
IEA
PLAZA Integrative Orthologymacromolecule modification YNL312W
GO:0006278
IEA
PLAZA Integrative OrthologyRNA-dependent DNA biosynthetic process YNL312W
GO:0044267
IEA
PLAZA Integrative Orthologycellular protein metabolic process YNL312W
GO:0007004
IEA
PLAZA Integrative Orthologytelomere maintenance via telomerase YNL312W
GO:0061982
IEA
PLAZA Integrative Orthologymeiosis I cell cycle process YNL312W
GO:0006270
IEA
PLAZA Integrative OrthologyDNA replication initiation ENSG00000204086
GO:0016458
IEA
PLAZA Integrative Orthologygene silencing AT2G24490
GO:0032501
IEA
PLAZA Integrative Orthologymulticellular organismal process FBgn0032906
GO:0140013
IEA
PLAZA Integrative Orthologymeiotic nuclear division YNL312W
GO:0032502
IEA
PLAZA Integrative Orthologydevelopmental process FBgn0032906
GO:0000280
IEA
PLAZA Integrative Orthologynuclear division YNL312W
GO:0010833
IEA
PLAZA Integrative Orthologytelomere maintenance via telomere lengthening YNL312W
GO:0032508
IEA
PLAZA Integrative OrthologyDNA duplex unwinding YNL312W
GO:0006268
IEA
PLAZA Integrative OrthologyDNA unwinding involved in DNA replication YNL312W
GO:0006265
IEA
PLAZA Integrative OrthologyDNA topological change YNL312W
GO:1901564
IEA
PLAZA Integrative Orthologyorganonitrogen compound metabolic process YNL312W
GO:0048856
IEA
PLAZA Integrative Orthologyanatomical structure development FBgn0032906
GO:0006464
IEA
PLAZA Integrative Orthologycellular protein modification process YNL312W
GO:0007399
IEA
PLAZA Integrative Orthologynervous system development FBgn0032906
GO:0009892
IEA
PLAZA Integrative Orthologynegative regulation of metabolic process AT2G24490
GO:0007275
IEA
PLAZA Integrative Orthologymulticellular organism development FBgn0032906
GO:0030491
IEA
PLAZA Integrative Orthologyheteroduplex formation YNL312W
GO:0032392
IEA
PLAZA Integrative OrthologyDNA geometric change YNL312W
GO:0019538
IEA
PLAZA Integrative Orthologyprotein metabolic process YNL312W
GO:0016567
IEA
PLAZA Integrative Orthologyprotein ubiquitination YNL312W
GO:0035825
IEA
PLAZA Integrative Orthologyhomologous recombination YNL312W
GO:0010467
IEA
PLAZA Integrative Orthologygene expression AT2G24490
GO:0010468
IEA
PLAZA Integrative Orthologyregulation of gene expression AT2G24490
GO:0048731
IEA
PLAZA Integrative Orthologysystem development FBgn0032906
GO:0045184
IEA
PLAZA Integrative Orthologyestablishment of protein localization YNL312W
GO:0010629
IEA
PLAZA Integrative Orthologynegative regulation of gene expression AT2G24490
GO:0032446
IEA
PLAZA Integrative Orthologyprotein modification by small protein conjugation YNL312W
GO:0070647
IEA
PLAZA Integrative Orthologyprotein modification by small protein conjugation or removal YNL312W
GO:0048285
IEA
PLAZA Integrative Orthologyorganelle fission YNL312W
GO:0051321
IEA
PLAZA Integrative Orthologymeiotic cell cycle YNL312W
GO:0022008
IEA
PLAZA Integrative Orthologyneurogenesis FBgn0032906
GO:0007131
IEA
PLAZA Integrative Orthologyreciprocal meiotic recombination YNL312W
GO:1903046
IEA
PLAZA Integrative Orthologymeiotic cell cycle process YNL312W
GO:0036211
IEA
PLAZA Integrative Orthologyprotein modification process YNL312W
GO:0032201
TAS
Gene Ontologytelomere maintenance via semi-conservative replication

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0098505
IDA
Genome ProjectG-rich strand telomeric DNA binding
GO:0098505
IDA
Gene OntologyG-rich strand telomeric DNA binding11
GO:0047485
IEA
Genome Projectprotein N-terminus binding
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0031625
IPI
Gene Ontologyubiquitin protein ligase binding1
GO:0019903
IPI
Genome Projectprotein phosphatase binding
GO:0019903
IPI
Gene Ontologyprotein phosphatase binding5
GO:0019899
IPI
Genome Projectenzyme binding
GO:0019899
IPI
Gene Ontologyenzyme binding12 13
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding2 3 5 9 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36
GO:0003697
IDA
ISS
IC
Genome Projectsingle-stranded DNA binding
GO:0003697
IDA
ISS
IC
Gene Ontologysingle-stranded DNA binding8 37
GO:0003684
IDA
Genome Projectdamaged DNA binding
GO:0003684
IDA
Gene Ontologydamaged DNA binding2 3 15
GO:0003690
IEA
PLAZA Integrative Orthologydouble-stranded DNA binding YNL312W

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0035861
IDA
Genome Projectsite of double-strand break
GO:0035861
IDA
Gene Ontologysite of double-strand break1
GO:0016605
IDA
Genome ProjectPML body
GO:0016605
IDA
Gene OntologyPML body10 38
GO:0000781
IDA
Genome Projectchromosome, telomeric region
GO:0000781
IDA
Gene Ontologychromosome, telomeric region10
GO:0016604
IDA
Genome Projectnuclear body
GO:0016604
IDA
Gene Ontologynuclear body
GO:0005662
IDA, IPI
Genome ProjectDNA replication factor A complex
GO:0005662
IDA, IPI
Gene OntologyDNA replication factor A complex2 3 8 19 39
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005654
IDA
TAS
Gene Ontologynucleoplasm
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus18
GO:0000785
IDA
Genome Projectchromatin
GO:0000785
IDA
Gene Ontologychromatin40
GO:0000784
IDA
Genome Projectnuclear chromosome, telomeric region
GO:0000784
Gene Ontologynuclear chromosome, telomeric region41
GO:0005737
IEA
PLAZA Integrative Orthologycytoplasm SPCC1753.01c
GO:0000794
IEA
PLAZA Integrative Orthologycondensed nuclear chromosome YNL312W
GO:0044444
IEA
PLAZA Integrative Orthologycytoplasmic part SPCC1753.01c
GO:0000793
IEA
PLAZA Integrative Orthologycondensed chromosome YNL312W
GO:0005829
IEA
PLAZA Integrative Orthologycytosol SPCC1753.01c

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR011991ArsR-like helix-turn-helix domain
IPR012340Nucleic acid-binding, OB-fold
IPR014646Replication factor A protein 2
IPR014892Replication protein A, C-terminal

No MapMan annotations defined for this gene.
KeggID Description
K10739RFA2, RPA2; replication factor A2
No chloroplast target sequence found.