Gene: ENSG00000117560 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000117560
Transcript Identifier
ENST00000367721
Gene Type
Coding gene
Location
1 : 172659202-172666016 : positive

Family Information

Homologous gene family
HOM02SEM011265
(8 genes in 1 species)
specific family

Descriptions

gene_descr
Fas ligand (TNF superfamily, member 6)

Identifiers

Type Value
pidENSP00000356694
HGNC11936
UniprotP48023
UniprotQ53ZZ1
RefSeq_mRNANM_000639.2
EMBLAK314874
EMBLAY225406
EMBLCH471067
EMBLEF064739

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2000353
IDA
Genome Projectpositive regulation of endothelial cell apoptotic process
GO:2000353
IDA
Gene Ontologypositive regulation of endothelial cell apoptotic process1
GO:1903514
IDA
Genome Projectrelease of sequestered calcium ion into cytosol by endoplasmic reticulum
GO:1903514
IDA
Gene Ontologyrelease of sequestered calcium ion into cytosol by endoplasmic reticulum2
GO:1902042
TAS
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042
TAS
Gene Ontologynegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902041
TAS
Genome Projectregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902041
TAS
Gene Ontologyregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0097527
IDA
Genome Projectnecroptotic signaling pathway
GO:0097527
IDA
Gene Ontologynecroptotic signaling pathway3
GO:0097296
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097191
IDA
Genome Projectextrinsic apoptotic signaling pathway
GO:0097191
IDA
Gene Ontologyextrinsic apoptotic signaling pathway4
GO:0097190
IDA
TAS
Genome Projectapoptotic signaling pathway
GO:0097190
IDA
TAS
Gene Ontologyapoptotic signaling pathway3
GO:0070848
IEA
Genome Projectresponse to growth factor
GO:0070266
IDA
Genome Projectnecroptotic process
GO:0070266
IDA
Gene Ontologynecroptotic process3
GO:0070231
IDA
Genome ProjectT cell apoptotic process
GO:0070231
IDA
Gene OntologyT cell apoptotic process5
GO:0048388
IEA
Genome Projectendosomal lumen acidification
GO:0046666
IEA
Genome Projectretinal cell programmed cell death
GO:0045742
IEA
Genome Projectpositive regulation of epidermal growth factor receptor signaling pathway
GO:0043525
IEA
Genome Projectpositive regulation of neuron apoptotic process
GO:0043123
IEP
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123
IEP
Gene Ontologypositive regulation of I-kappaB kinase/NF-kappaB signaling6
GO:0043065
IDA
Genome Projectpositive regulation of apoptotic process
GO:0043065
IDA
Gene Ontologypositive regulation of apoptotic process7 8
GO:0032496
IEA
Genome Projectresponse to lipopolysaccharide
GO:0030644
IEA
Genome Projectcellular chloride ion homeostasis
GO:0016525
IDA
Genome Projectnegative regulation of angiogenesis
GO:0016525
IDA
Gene Ontologynegative regulation of angiogenesis1
GO:0008625
IDA
Genome Projectextrinsic apoptotic signaling pathway via death domain receptors
GO:0008625
IDA
Gene Ontologyextrinsic apoptotic signaling pathway via death domain receptors1 2
GO:0008284
IEA
Genome Projectpositive regulation of cell proliferation
GO:0007267
TAS
Genome Projectcell-cell signaling
GO:0007267
TAS
Gene Ontologycell-cell signaling9
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007165
TAS
Gene Ontologysignal transduction9
GO:0006955
IEA
Genome Projectimmune response
GO:0006925
IEA
Genome Projectinflammatory cell apoptotic process
GO:0006919
IMP, IGI
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
IMP, IGI
TAS
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process10 11
GO:0006915
TAS
Genome Projectapoptotic process
GO:0006915
TAS
Gene Ontologyapoptotic process12
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0000122
IDA
Genome Projectnegative regulation of transcription by RNA polymerase II
GO:0000122
IDA
Gene Ontologynegative regulation of transcription by RNA polymerase II13
GO:0019221
TAS
Gene Ontologycytokine-mediated signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding14 15 16 17 18 19 20 21 22 23 24 25
GO:0005164
IEA
Genome Projecttumor necrosis factor receptor binding
GO:0005125
IEA
Genome Projectcytokine activity
GO:0005123
IEA
Genome Projectdeath receptor binding
GO:0005102
TAS
Genome Projectsignaling receptor binding
GO:0005102
TAS
Gene Ontologysignaling receptor binding9

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0070062
IDA
Gene Ontologyextracellular exosome5
GO:0060205
IEA
Genome Projectcytoplasmic vesicle lumen
GO:0048471
IEA
Genome Projectperinuclear region of cytoplasm
GO:0043202
IEA
Genome Projectlysosomal lumen
GO:0009897
IEA
Genome Projectexternal side of plasma membrane
GO:0005901
IEA
Genome Projectcaveola
GO:0005887
TAS
Genome Projectintegral component of plasma membrane
GO:0005887
TAS
Gene Ontologyintegral component of plasma membrane9
GO:0005886
IDA
Genome Projectplasma membrane
GO:0005886
IDA
Gene Ontologyplasma membrane26
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus13
GO:0005615
IDA
Genome Projectextracellular space
GO:0005615
IDA
Gene Ontologyextracellular space1
GO:0005576
TAS
Genome Projectextracellular region
GO:0005576
TAS
Gene Ontologyextracellular region

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR006052Tumour necrosis factor domain
IPR006053Tumour necrosis factor
IPR008983Tumour necrosis factor-like domain superfamily
IPR021184Tumour necrosis factor, conserved site
IPR028326Tumor necrosis factor ligand superfamily member 6

No MapMan annotations defined for this gene.
KeggID Description
K04389CD178, FASLG; tumor necrosis factor (ligand) superfamily, member 6
No chloroplast target sequence found.