Gene: ENSG00000113520 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000113520
Transcript Identifier
ENST00000231449
Gene Type
Coding gene
Location
5 : 132674051-132682587 : positive

Family Information

Homologous gene family
HOM02SEM088667
(orphan gene)
specific family

Descriptions

gene_descr
interleukin 4

Identifiers

Type Value
pidENSP00000231449
HGNC6014
UniprotP05112
UniprotD4HNR6
RefSeq_mRNANM_000589.3
EMBLCH471062
EMBLFJ807883

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2001237
IEA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway
GO:2000424
IEA
Genome Projectpositive regulation of eosinophil chemotaxis
GO:2000352
IMP
Genome Projectnegative regulation of endothelial cell apoptotic process
GO:2000352
IMP
Gene Ontologynegative regulation of endothelial cell apoptotic process1
GO:2000320
IEA
Genome Projectnegative regulation of T-helper 17 cell differentiation
GO:1903660
IMP
Genome Projectnegative regulation of complement-dependent cytotoxicity
GO:1903660
IMP
Gene Ontologynegative regulation of complement-dependent cytotoxicity1
GO:1903428
IEA
Genome Projectpositive regulation of reactive oxygen species biosynthetic process
GO:1901741
IEA
Genome Projectpositive regulation of myoblast fusion
GO:0097192
IEA
Genome Projectextrinsic apoptotic signaling pathway in absence of ligand
GO:0097028
IDA
Genome Projectdendritic cell differentiation
GO:0097028
IDA
Gene Ontologydendritic cell differentiation2
GO:0071677
IEA
Genome Projectpositive regulation of mononuclear cell migration
GO:0071288
IEA
Genome Projectcellular response to mercury ion
GO:0070351
IEA
Genome Projectnegative regulation of white fat cell proliferation
GO:0060041
IEA
Genome Projectretina development in camera-type eye
GO:0051091
IEA
Genome Projectpositive regulation of DNA-binding transcription factor activity
GO:0050776
ISS
Genome Projectregulation of immune response
GO:0050776
ISS
Gene Ontologyregulation of immune response
GO:0048304
ISS
Genome Projectpositive regulation of isotype switching to IgG isotypes
GO:0048304
ISS
Gene Ontologypositive regulation of isotype switching to IgG isotypes
GO:0048295
ISS
Genome Projectpositive regulation of isotype switching to IgE isotypes
GO:0048295
ISS
Gene Ontologypositive regulation of isotype switching to IgE isotypes
GO:0045944
ISS
Genome Projectpositive regulation of transcription by RNA polymerase II
GO:0045944
ISS
Gene Ontologypositive regulation of transcription by RNA polymerase II
GO:0045893
IDA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045893
IDA
Gene Ontologypositive regulation of transcription, DNA-templated3 4 5
GO:0045892
IDA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045892
IDA
Gene Ontologynegative regulation of transcription, DNA-templated3 6
GO:0045671
ISS
Genome Projectnegative regulation of osteoclast differentiation
GO:0045671
ISS
Gene Ontologynegative regulation of osteoclast differentiation
GO:0045582
IDA
Genome Projectpositive regulation of T cell differentiation
GO:0045582
IDA
Gene Ontologypositive regulation of T cell differentiation5
GO:0045471
IEA
Genome Projectresponse to ethanol
GO:0045348
ISS
Genome Projectpositive regulation of MHC class II biosynthetic process
GO:0045348
ISS
Gene Ontologypositive regulation of MHC class II biosynthetic process
GO:0045191
TAS
Genome Projectregulation of isotype switching
GO:0045191
TAS
Gene Ontologyregulation of isotype switching7
GO:0045189
TAS
Genome Projectconnective tissue growth factor biosynthetic process
GO:0045189
TAS
Gene Ontologyconnective tissue growth factor biosynthetic process8
GO:0045080
IEA
Genome Projectpositive regulation of chemokine biosynthetic process
GO:0045064
IEA
Genome ProjectT-helper 2 cell differentiation
GO:0045019
IEA
Genome Projectnegative regulation of nitric oxide biosynthetic process
GO:0043306
IEA
Genome Projectpositive regulation of mast cell degranulation
GO:0043066
ISS
Genome Projectnegative regulation of apoptotic process
GO:0043066
ISS
Gene Ontologynegative regulation of apoptotic process
GO:0043031
IEA
Genome Projectnegative regulation of macrophage activation
GO:0043011
IDA
Genome Projectmyeloid dendritic cell differentiation
GO:0043011
IDA
Gene Ontologymyeloid dendritic cell differentiation9
GO:0042832
IEA
Genome Projectdefense response to protozoan
GO:0042531
IEA
Genome Projectpositive regulation of tyrosine phosphorylation of STAT protein
GO:0042531
IGI
Gene Ontologypositive regulation of tyrosine phosphorylation of STAT protein10
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042325
ISS
Genome Projectregulation of phosphorylation
GO:0042325
ISS
Gene Ontologyregulation of phosphorylation
GO:0042104
IEA
Genome Projectpositive regulation of activated T cell proliferation
GO:0042102
ISS
Genome Projectpositive regulation of T cell proliferation
GO:0042102
ISS
Gene Ontologypositive regulation of T cell proliferation
GO:0042092
TAS
Genome Projecttype 2 immune response
GO:0042092
TAS
Gene Ontologytype 2 immune response11
GO:0035745
IDA
Genome ProjectT-helper 2 cell cytokine production
GO:0035745
IDA
Gene OntologyT-helper 2 cell cytokine production5
GO:0034097
IEA
Genome Projectresponse to cytokine
GO:0032736
IDA
Genome Projectpositive regulation of interleukin-13 production
GO:0032736
IDA
Gene Ontologypositive regulation of interleukin-13 production4
GO:0032733
IEA
Genome Projectpositive regulation of interleukin-10 production
GO:0031296
IEA
Genome ProjectB cell costimulation
GO:0030890
ISS
Genome Projectpositive regulation of B cell proliferation
GO:0030890
ISS
Gene Ontologypositive regulation of B cell proliferation
GO:0030183
TAS
Genome ProjectB cell differentiation
GO:0030183
TAS
Gene OntologyB cell differentiation7
GO:0014070
IEA
Genome Projectresponse to organic cyclic compound
GO:0010633
IDA
Genome Projectnegative regulation of epithelial cell migration
GO:0010633
IDA
Gene Ontologynegative regulation of epithelial cell migration12
GO:0010155
IEA
Genome Projectregulation of proton transport
GO:0008203
ISS
Genome Projectcholesterol metabolic process
GO:0008203
ISS
Gene Ontologycholesterol metabolic process13
GO:0007584
IEA
Genome Projectresponse to nutrient
GO:0007565
IEA
Genome Projectfemale pregnancy
GO:0006968
TAS
Genome Projectcellular defense response
GO:0006955
TAS
Genome Projectimmune response
GO:0006955
TAS
Gene Ontologyimmune response14
GO:0006935
TAS
Genome Projectchemotaxis
GO:0002677
IEA
Genome Projectnegative regulation of chronic inflammatory response
GO:0002674
IEA
Genome Projectnegative regulation of acute inflammatory response
GO:0002296
IEA
Genome ProjectT-helper 1 cell lineage commitment
GO:0002230
IEA
Genome Projectpositive regulation of defense response to virus by host
GO:0002227
IEA
Genome Projectinnate immune response in mucosa
GO:0001774
IEA
Genome Projectmicroglial cell activation
GO:0120162
ISS
Gene Ontologypositive regulation of cold-induced thermogenesis15
GO:0042976
IGI
Gene Ontologyactivation of Janus kinase activity10
GO:0042110
IGI
Gene OntologyT cell activation16
GO:0019221
TAS
Gene Ontologycytokine-mediated signaling pathway
GO:0016239
ISS
Gene Ontologypositive regulation of macroautophagy
GO:0010628
IGI
Gene Ontologypositive regulation of gene expression10

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0008083
NAS
Genome Projectgrowth factor activity
GO:0008083
NAS
Gene Ontologygrowth factor activity7
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding17 18 19 20
GO:0005136
TAS
Genome Projectinterleukin-4 receptor binding
GO:0005136
TAS
Gene Ontologyinterleukin-4 receptor binding7
GO:0005125
IEA
Genome Projectcytokine activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0009897
IEA
Genome Projectexternal side of plasma membrane
GO:0005615
TAS
Genome Projectextracellular space
GO:0005615
TAS
Gene Ontologyextracellular space7
GO:0005576
TAS
Genome Projectextracellular region
GO:0005576
TAS
Gene Ontologyextracellular region

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001325Interleukin-4/interleukin-13
IPR002354Interleukin-4
IPR009079Four-helical cytokine-like, core
IPR018096Interleukin-4/interleukin-13, conserved site

No MapMan annotations defined for this gene.
KeggID Description
K05430IL4; interleukin 4
No chloroplast target sequence found.