Gene: ENSG00000111602 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000111602
Transcript Identifier
ENST00000553532
Gene Type
Coding gene
Location
12 : 56417716-56434170 : negative

Family Information

Homologous gene family
HOM02SEM022654
(4 genes in 3 species)
specific family
Orthologous gene family
ORTHO02SEM013543
(4 genes in 3 species)
specific family

Descriptions

gene_descr
timeless circadian clock

Identifiers

Type Value
pidENSP00000450607
HGNC11813
UniprotQ9UNS1
RefSeq_mRNANM_003920.3

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0042127
IMP
Genome Projectregulation of cell proliferation
GO:0042127
IMP
Gene Ontologyregulation of cell proliferation1
GO:2000781
IMP
Genome Projectpositive regulation of double-strand break repair
GO:2000781
IMP
Gene Ontologypositive regulation of double-strand break repair2
GO:1904976
IMP
Genome Projectcellular response to bleomycin
GO:1904976
IMP
Gene Ontologycellular response to bleomycin2
GO:0072719
IMP
Genome Projectcellular response to cisplatin
GO:0072719
IMP
Gene Ontologycellular response to cisplatin2
GO:0072711
IMP
Genome Projectcellular response to hydroxyurea
GO:0072711
IMP
Gene Ontologycellular response to hydroxyurea2
GO:0051301
IEA
Genome Projectcell division
GO:0048754
IEA
Genome Projectbranching morphogenesis of an epithelial tube
GO:0045892
IDA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045892
IDA
Gene Ontologynegative regulation of transcription, DNA-templated3
GO:0044770
IMP
Genome Projectcell cycle phase transition
GO:0044770
IMP
Gene Ontologycell cycle phase transition1
GO:0042752
IMP
Genome Projectregulation of circadian rhythm
GO:0042752
IMP
Gene Ontologyregulation of circadian rhythm4
GO:0030324
IEA
Genome Projectlung development
GO:0009628
TAS
Genome Projectresponse to abiotic stimulus
GO:0009582
TAS
Genome Projectdetection of abiotic stimulus
GO:0009582
TAS
Gene Ontologydetection of abiotic stimulus5
GO:0007623
ISS
Genome Projectcircadian rhythm
GO:0007623
ISS
Gene Ontologycircadian rhythm
GO:0006974
IMP
ISS
Genome Projectcellular response to DNA damage stimulus
GO:0006974
IMP
ISS
Gene Ontologycellular response to DNA damage stimulus2
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006260
TAS
Genome ProjectDNA replication
GO:0002009
ISS
Genome Projectmorphogenesis of an epithelium
GO:0002009
ISS
Gene Ontologymorphogenesis of an epithelium
GO:0000122
IEA
Genome Projectnegative regulation of transcription by RNA polymerase II
GO:0010564
IEA
PLAZA Integrative Orthologyregulation of cell cycle process WBGene00006571
GO:0051239
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal process FBgn0014396
GO:0006909
IEA
PLAZA Integrative Orthologyphagocytosis FBgn0014396
GO:0048871
IEA
PLAZA Integrative Orthologymulticellular organismal homeostasis FBgn0014396
GO:0019098
IEA
PLAZA Integrative Orthologyreproductive behavior FBgn0014396
GO:0051234
IEA
PLAZA Integrative Orthologyestablishment of localization FBgn0014396
GO:0002027
IEA
PLAZA Integrative Orthologyregulation of heart rate FBgn0014396
GO:0042886
IEA
PLAZA Integrative Orthologyamide transport FBgn0014396
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction WBGene00006571
GO:0022410
IEA
PLAZA Integrative Orthologycircadian sleep/wake cycle process FBgn0014396
GO:0006996
IEA
PLAZA Integrative Orthologyorganelle organization WBGene00006571
GO:0007562
IEA
PLAZA Integrative Orthologyeclosion FBgn0014396
GO:0008015
IEA
PLAZA Integrative Orthologyblood circulation FBgn0014396
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process WBGene00006571
GO:0090087
IEA
PLAZA Integrative Orthologyregulation of peptide transport FBgn0014396
GO:0008016
IEA
PLAZA Integrative Orthologyregulation of heart contraction FBgn0014396
GO:0044703
IEA
PLAZA Integrative Orthologymulti-organism reproductive process FBgn0014396
GO:0071478
IEA
PLAZA Integrative Orthologycellular response to radiation FBgn0014396
GO:0033157
IEA
PLAZA Integrative Orthologyregulation of intracellular protein transport FBgn0014396
GO:0033036
IEA
PLAZA Integrative Orthologymacromolecule localization FBgn0014396
GO:0051100
IEA
PLAZA Integrative Orthologynegative regulation of binding FBgn0014396
GO:0045475
IEA
PLAZA Integrative Orthologylocomotor rhythm FBgn0014396
GO:0051223
IEA
PLAZA Integrative Orthologyregulation of protein transport FBgn0014396
GO:0009605
IEA
PLAZA Integrative Orthologyresponse to external stimulus FBgn0014396
GO:0032504
IEA
PLAZA Integrative Orthologymulticellular organism reproduction FBgn0014396
GO:0051101
IEA
PLAZA Integrative Orthologyregulation of DNA binding FBgn0014396
GO:0051983
IEA
PLAZA Integrative Orthologyregulation of chromosome segregation WBGene00006571
GO:0046957
IEA
PLAZA Integrative Orthologynegative phototaxis FBgn0014396
GO:0060627
IEA
PLAZA Integrative Orthologyregulation of vesicle-mediated transport FBgn0014396
GO:0033043
IEA
PLAZA Integrative Orthologyregulation of organelle organization WBGene00006571
GO:0033044
IEA
PLAZA Integrative Orthologyregulation of chromosome organization WBGene00006571
GO:0009453
IEA
PLAZA Integrative Orthologyenergy taxis FBgn0014396
GO:0033045
IEA
PLAZA Integrative Orthologyregulation of sister chromatid segregation WBGene00006571
GO:0060341
IEA
PLAZA Integrative Orthologyregulation of cellular localization FBgn0014396
GO:1900180
IEA
PLAZA Integrative Orthologyregulation of protein localization to nucleus FBgn0014396
GO:0050764
IEA
PLAZA Integrative Orthologyregulation of phagocytosis FBgn0014396
GO:0044092
IEA
PLAZA Integrative Orthologynegative regulation of molecular function FBgn0014396
GO:0050766
IEA
PLAZA Integrative Orthologypositive regulation of phagocytosis FBgn0014396
GO:0019953
IEA
PLAZA Integrative Orthologysexual reproduction FBgn0014396
GO:0050802
IEA
PLAZA Integrative Orthologycircadian sleep/wake cycle, sleep FBgn0014396
GO:0104004
IEA
PLAZA Integrative Orthologycellular response to environmental stimulus FBgn0014396
GO:0071840
IEA
PLAZA Integrative Orthologycellular component organization or biogenesis WBGene00006571
GO:0016043
IEA
PLAZA Integrative Orthologycellular component organization WBGene00006571
GO:0045187
IEA
PLAZA Integrative Orthologyregulation of circadian sleep/wake cycle, sleep FBgn0014396
GO:0007618
IEA
PLAZA Integrative Orthologymating FBgn0014396
GO:0042592
IEA
PLAZA Integrative Orthologyhomeostatic process FBgn0014396
GO:0051177
IEA
PLAZA Integrative Orthologymeiotic sister chromatid cohesion WBGene00006571
GO:0071684
IEA
PLAZA Integrative Orthologyorganism emergence from protective structure FBgn0014396
GO:0032879
IEA
PLAZA Integrative Orthologyregulation of localization FBgn0014396
GO:0051179
IEA
PLAZA Integrative Orthologylocalization FBgn0014396
GO:0007617
IEA
PLAZA Integrative Orthologymating behavior FBgn0014396
GO:0045184
IEA
PLAZA Integrative Orthologyestablishment of protein localization FBgn0014396
GO:0007622
IEA
PLAZA Integrative Orthologyrhythmic behavior FBgn0014396
GO:0046822
IEA
PLAZA Integrative Orthologyregulation of nucleocytoplasmic transport FBgn0014396
GO:0006810
IEA
PLAZA Integrative Orthologytransport FBgn0014396
GO:0009648
IEA
PLAZA Integrative Orthologyphotoperiodism FBgn0014396
GO:0006897
IEA
PLAZA Integrative Orthologyendocytosis FBgn0014396
GO:0007620
IEA
PLAZA Integrative Orthologycopulation FBgn0014396
GO:0007064
IEA
PLAZA Integrative Orthologymitotic sister chromatid cohesion WBGene00006571
GO:0007063
IEA
PLAZA Integrative Orthologyregulation of sister chromatid cohesion WBGene00006571
GO:0032880
IEA
PLAZA Integrative Orthologyregulation of protein localization FBgn0014396
GO:0042749
IEA
PLAZA Integrative Orthologyregulation of circadian sleep/wake cycle FBgn0014396
GO:0048609
IEA
PLAZA Integrative Orthologymulticellular organismal reproductive process FBgn0014396
GO:0007062
IEA
PLAZA Integrative Orthologysister chromatid cohesion WBGene00006571
GO:0042745
IEA
PLAZA Integrative Orthologycircadian sleep/wake cycle FBgn0014396
GO:0030100
IEA
PLAZA Integrative Orthologyregulation of endocytosis FBgn0014396
GO:2000678
IEA
PLAZA Integrative Orthologynegative regulation of transcription regulatory region DNA binding FBgn0014396
GO:0071214
IEA
PLAZA Integrative Orthologycellular response to abiotic stimulus FBgn0014396
GO:0051726
IEA
PLAZA Integrative Orthologyregulation of cell cycle WBGene00006571
GO:0098813
IEA
PLAZA Integrative Orthologynuclear chromosome segregation WBGene00006571
GO:2000677
IEA
PLAZA Integrative Orthologyregulation of transcription regulatory region DNA binding FBgn0014396
GO:0098657
IEA
PLAZA Integrative Orthologyimport into cell FBgn0014396
GO:0003008
IEA
PLAZA Integrative Orthologysystem process FBgn0014396
GO:0043392
IEA
PLAZA Integrative Orthologynegative regulation of DNA binding FBgn0014396
GO:0048285
IEA
PLAZA Integrative Orthologyorganelle fission WBGene00006571
GO:0051321
IEA
PLAZA Integrative Orthologymeiotic cell cycle WBGene00006571
GO:0006913
IEA
PLAZA Integrative Orthologynucleocytoplasmic transport FBgn0014396
GO:0051049
IEA
PLAZA Integrative Orthologyregulation of transport FBgn0014396
GO:0051169
IEA
PLAZA Integrative Orthologynuclear transport FBgn0014396
GO:0003015
IEA
PLAZA Integrative Orthologyheart process FBgn0014396
GO:0007610
IEA
PLAZA Integrative Orthologybehavior FBgn0014396
GO:0003013
IEA
PLAZA Integrative Orthologycirculatory system process FBgn0014396
GO:0006886
IEA
PLAZA Integrative Orthologyintracellular protein transport FBgn0014396
GO:0051050
IEA
PLAZA Integrative Orthologypositive regulation of transport FBgn0014396
GO:0051170
IEA
PLAZA Integrative Orthologyimport into nucleus FBgn0014396
GO:0042331
IEA
PLAZA Integrative Orthologyphototaxis FBgn0014396
GO:0007059
IEA
PLAZA Integrative Orthologychromosome segregation WBGene00006571
GO:0042330
IEA
PLAZA Integrative Orthologytaxis FBgn0014396
GO:1903046
IEA
PLAZA Integrative Orthologymeiotic cell cycle process WBGene00006571
GO:1903047
IEA
PLAZA Integrative Orthologymitotic cell cycle process WBGene00006571
GO:0060047
IEA
PLAZA Integrative Orthologyheart contraction FBgn0014396
GO:0000819
IEA
PLAZA Integrative Orthologysister chromatid segregation WBGene00006571
GO:0052129
IEA
PLAZA Integrative Orthologynegative energy taxis FBgn0014396
GO:0071702
IEA
PLAZA Integrative Orthologyorganic substance transport FBgn0014396
GO:0017038
IEA
PLAZA Integrative Orthologyprotein import FBgn0014396
GO:0001659
IEA
PLAZA Integrative Orthologytemperature homeostasis FBgn0014396
GO:0051276
IEA
PLAZA Integrative Orthologychromosome organization WBGene00006571
GO:1903827
IEA
PLAZA Integrative Orthologyregulation of cellular protein localization FBgn0014396
GO:0072594
IEA
PLAZA Integrative Orthologyestablishment of protein localization to organelle FBgn0014396
GO:0031570
IEA
PLAZA Integrative OrthologyDNA integrity checkpoint FBgn0038118
GO:0061983
IEA
PLAZA Integrative Orthologymeiosis II cell cycle process WBGene00006571
GO:0071705
IEA
PLAZA Integrative Orthologynitrogen compound transport FBgn0014396
GO:0140013
IEA
PLAZA Integrative Orthologymeiotic nuclear division WBGene00006571
GO:0051704
IEA
PLAZA Integrative Orthologymulti-organism process FBgn0014396
GO:0032386
IEA
PLAZA Integrative Orthologyregulation of intracellular transport FBgn0014396
GO:0140014
IEA
PLAZA Integrative Orthologymitotic nuclear division WBGene00006571
GO:0000280
IEA
PLAZA Integrative Orthologynuclear division WBGene00006571
GO:0007626
IEA
PLAZA Integrative Orthologylocomotory behavior FBgn0014396
GO:0016192
IEA
PLAZA Integrative Orthologyvesicle-mediated transport FBgn0014396
GO:0009649
IEA
PLAZA Integrative Orthologyentrainment of circadian clock FBgn0014396
GO:0000278
IEA
PLAZA Integrative Orthologymitotic cell cycle WBGene00006571
GO:0009416
IEA
PLAZA Integrative Orthologyresponse to light stimulus FBgn0014396
GO:0070192
IEA
PLAZA Integrative Orthologychromosome organization involved in meiotic cell cycle WBGene00006571
GO:0044057
IEA
PLAZA Integrative Orthologyregulation of system process FBgn0014396
GO:0045786
IEA
PLAZA Integrative Orthologynegative regulation of cell cycle FBgn0038118
GO:0040011
IEA
PLAZA Integrative Orthologylocomotion FBgn0014396
GO:0034613
IEA
PLAZA Integrative Orthologycellular protein localization FBgn0014396
GO:0015833
IEA
PLAZA Integrative Orthologypeptide transport FBgn0014396
GO:0033365
IEA
PLAZA Integrative Orthologyprotein localization to organelle FBgn0014396
GO:0000070
IEA
PLAZA Integrative Orthologymitotic sister chromatid segregation WBGene00006571
GO:0051098
IEA
PLAZA Integrative Orthologyregulation of binding FBgn0014396
GO:0051130
IEA
PLAZA Integrative Orthologypositive regulation of cellular component organization FBgn0014396
GO:0045144
IEA
PLAZA Integrative Orthologymeiotic sister chromatid segregation WBGene00006571
GO:0000075
IEA
PLAZA Integrative Orthologycell cycle checkpoint FBgn0038118
GO:0000077
IEA
PLAZA Integrative OrthologyDNA damage checkpoint FBgn0038118
GO:0071482
IEA
PLAZA Integrative Orthologycellular response to light stimulus FBgn0014396
GO:0065009
IEA
PLAZA Integrative Orthologyregulation of molecular function FBgn0014396
GO:1904589
IEA
PLAZA Integrative Orthologyregulation of protein import FBgn0014396
GO:0046907
IEA
PLAZA Integrative Orthologyintracellular transport FBgn0014396
GO:0042306
IEA
PLAZA Integrative Orthologyregulation of protein import into nucleus FBgn0014396
GO:0065008
IEA
PLAZA Integrative Orthologyregulation of biological quality FBgn0014396
GO:0051128
IEA
PLAZA Integrative Orthologyregulation of cellular component organization WBGene00006571
GO:0034504
IEA
PLAZA Integrative Orthologyprotein localization to nucleus FBgn0014396
GO:0051649
IEA
PLAZA Integrative Orthologyestablishment of localization in cell FBgn0014396
GO:0070201
IEA
PLAZA Integrative Orthologyregulation of establishment of protein localization FBgn0014396
GO:0045132
IEA
PLAZA Integrative Orthologymeiotic chromosome segregation WBGene00006571
GO:0051641
IEA
PLAZA Integrative Orthologycellular localization FBgn0014396
GO:0050795
IEA
PLAZA Integrative Orthologyregulation of behavior FBgn0014396
GO:0048512
IEA
PLAZA Integrative Orthologycircadian behavior FBgn0014396
GO:1903522
IEA
PLAZA Integrative Orthologyregulation of blood circulation FBgn0014396
GO:0003053
IEA
PLAZA Integrative Orthologycircadian regulation of heart rate FBgn0014396
GO:0008104
IEA
PLAZA Integrative Orthologyprotein localization FBgn0014396
GO:0009314
IEA
PLAZA Integrative Orthologyresponse to radiation FBgn0014396
GO:0007135
IEA
PLAZA Integrative Orthologymeiosis II WBGene00006571
GO:0015031
IEA
PLAZA Integrative Orthologyprotein transport FBgn0014396
GO:0045807
IEA
PLAZA Integrative Orthologypositive regulation of endocytosis FBgn0014396
GO:0060086
IEA
PLAZA Integrative Orthologycircadian temperature homeostasis FBgn0014396
GO:0009792
IEA
PLAZA Integrative Orthologyembryo development ending in birth or egg hatching WBGene00006571
GO:0070727
IEA
PLAZA Integrative Orthologycellular macromolecule localization FBgn0014396
GO:0008062
IEA
PLAZA Integrative Orthologyeclosion rhythm FBgn0014396
GO:0009790
IEA
PLAZA Integrative Orthologyembryo development WBGene00006571

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0046982
IEA
Genome Projectprotein heterodimerization activity
GO:0042803
IEA
Genome Projectprotein homodimerization activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding1 6 7
GO:0008134
IEA
PLAZA Integrative Orthologytranscription factor binding FBgn0014396

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005654
TAS
Gene Ontologynucleoplasm
GO:0005634
IDA
IC
Genome Projectnucleus
GO:0005634
IDA
IC
Gene Ontologynucleus1 3
GO:0000790
IDA
Genome Projectnuclear chromatin
GO:0000790
IDA
Gene Ontologynuclear chromatin1
GO:0032991
IEA
PLAZA Integrative Orthologyprotein-containing complex WBGene00006571
GO:0000793
IEA
PLAZA Integrative Orthologycondensed chromosome WBGene00006571
GO:0008278
IEA
PLAZA Integrative Orthologycohesin complex WBGene00006571
GO:0005829
IEA
PLAZA Integrative Orthologycytosol FBgn0014396
GO:0005737
IEA
PLAZA Integrative Orthologycytoplasm FBgn0014396
GO:0030892
IEA
PLAZA Integrative Orthologymitotic cohesin complex WBGene00006571
GO:0044444
IEA
PLAZA Integrative Orthologycytoplasmic part FBgn0014396

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR006906Timeless protein
IPR007725Timeless C-terminal

No MapMan annotations defined for this gene.
KeggID Description
K03155TIMELESS; timeless
No chloroplast target sequence found.