Gene: ENSG00000111445 (Homo sapiens)

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Gene Identifier
ENSG00000111445
Transcript Identifier
ENST00000454402
Gene Type
Coding gene
Location
12 : 118016828-118031278 : positive

Family Information

Homologous gene family
HOM02SEM000388
(90 genes in 26 species)
specific family
Orthologous gene family
ORTHO02SEM000793
(57 genes in 26 species)
specific family

Descriptions

gene_descr
replication factor C (activator 1) 5, 36.5kDa

Identifiers

Type Value
pidENSP00000408295
HGNC9973
UniprotP40937
RefSeq_mRNANM_001206801.1
RefSeq_mRNANM_007370.5

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1901796
TAS
Genome Projectregulation of signal transduction by p53 class mediator
GO:1900264
IDA
Genome Projectpositive regulation of DNA-directed DNA polymerase activity
GO:1900264
IDA
Gene Ontologypositive regulation of DNA-directed DNA polymerase activity1
GO:0070987
TAS
Genome Projecterror-free translesion synthesis
GO:0070987
TAS
Gene Ontologyerror-free translesion synthesis
GO:0042769
TAS
Genome ProjectDNA damage response, detection of DNA damage
GO:0042769
TAS
Gene OntologyDNA damage response, detection of DNA damage
GO:0042276
TAS
Genome Projecterror-prone translesion synthesis
GO:0042276
TAS
Gene Ontologyerror-prone translesion synthesis
GO:0033683
TAS
Genome Projectnucleotide-excision repair, DNA incision
GO:0033683
TAS
Gene Ontologynucleotide-excision repair, DNA incision
GO:0019985
TAS
Genome Projecttranslesion synthesis
GO:0019985
TAS
Gene Ontologytranslesion synthesis
GO:0006297
TAS
Genome Projectnucleotide-excision repair, DNA gap filling
GO:0006297
TAS
Gene Ontologynucleotide-excision repair, DNA gap filling
GO:0006296
TAS
Genome Projectnucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006296
TAS
Gene Ontologynucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006283
TAS
Genome Projecttranscription-coupled nucleotide-excision repair
GO:0006283
TAS
Gene Ontologytranscription-coupled nucleotide-excision repair
GO:0006281
NAS
Genome ProjectDNA repair
GO:0006281
NAS
Gene OntologyDNA repair2
GO:0006260
TAS, NAS
Genome ProjectDNA replication
GO:0006260
TAS, NAS
Gene OntologyDNA replication2
GO:0000722
TAS
Genome Projecttelomere maintenance via recombination
GO:0032201
TAS
Gene Ontologytelomere maintenance via semi-conservative replication
GO:0030154
IEA
PLAZA Integrative Orthologycell differentiation FBgn0032244
GO:0046331
IEA
PLAZA Integrative Orthologylateral inhibition FBgn0032244
GO:0045165
IEA
PLAZA Integrative Orthologycell fate commitment FBgn0032244
GO:0048869
IEA
PLAZA Integrative Orthologycellular developmental process FBgn0032244
GO:0006952
IEA
PLAZA Integrative Orthologydefense response AT1G77470
GO:0006272
IEA
PLAZA Integrative Orthologyleading strand elongation YNL290W
GO:0006271
IEA
PLAZA Integrative OrthologyDNA strand elongation involved in DNA replication SPAC27E2.10c
GO:0022616
IEA
PLAZA Integrative OrthologyDNA strand elongation SPAC27E2.10c
GO:0032501
IEA
PLAZA Integrative Orthologymulticellular organismal process FBgn0032244
GO:0032502
IEA
PLAZA Integrative Orthologydevelopmental process FBgn0032244
GO:0071478
IEA
PLAZA Integrative Orthologycellular response to radiation SPAC27E2.10c
GO:0034644
IEA
PLAZA Integrative Orthologycellular response to UV SPAC27E2.10c
GO:0048585
IEA
PLAZA Integrative Orthologynegative regulation of response to stimulus AT1G77470
GO:0016070
IEA
PLAZA Integrative OrthologyRNA metabolic process YNL290W
GO:0009416
IEA
PLAZA Integrative Orthologyresponse to light stimulus SPAC27E2.10c
GO:0009411
IEA
PLAZA Integrative Orthologyresponse to UV SPAC27E2.10c
GO:0048856
IEA
PLAZA Integrative Orthologyanatomical structure development FBgn0032244
GO:0007399
IEA
PLAZA Integrative Orthologynervous system development FBgn0032244
GO:0007275
IEA
PLAZA Integrative Orthologymulticellular organism development FBgn0032244
GO:0031348
IEA
PLAZA Integrative Orthologynegative regulation of defense response AT1G77470
GO:0031347
IEA
PLAZA Integrative Orthologyregulation of defense response AT1G77470
GO:0104004
IEA
PLAZA Integrative Orthologycellular response to environmental stimulus SPAC27E2.10c
GO:0048731
IEA
PLAZA Integrative Orthologysystem development FBgn0032244
GO:0071482
IEA
PLAZA Integrative Orthologycellular response to light stimulus SPAC27E2.10c
GO:0006298
IEA
PLAZA Integrative Orthologymismatch repair YNL290W
GO:0007267
IEA
PLAZA Integrative Orthologycell-cell signaling FBgn0032244
GO:0070914
IEA
PLAZA Integrative OrthologyUV-damage excision repair SPAC27E2.10c
GO:0007062
IEA
PLAZA Integrative Orthologysister chromatid cohesion YNL290W
GO:0098813
IEA
PLAZA Integrative Orthologynuclear chromosome segregation YNL290W
GO:0071214
IEA
PLAZA Integrative Orthologycellular response to abiotic stimulus SPAC27E2.10c
GO:0009628
IEA
PLAZA Integrative Orthologyresponse to abiotic stimulus SPAC27E2.10c
GO:0048519
IEA
PLAZA Integrative Orthologynegative regulation of biological process AT1G77470
GO:0045168
IEA
PLAZA Integrative Orthologycell-cell signaling involved in cell fate commitment FBgn0032244
GO:0022008
IEA
PLAZA Integrative Orthologyneurogenesis FBgn0032244
GO:0007059
IEA
PLAZA Integrative Orthologychromosome segregation YNL290W
GO:0080134
IEA
PLAZA Integrative Orthologyregulation of response to stress AT1G77470
GO:0009314
IEA
PLAZA Integrative Orthologyresponse to radiation SPAC27E2.10c
GO:0000819
IEA
PLAZA Integrative Orthologysister chromatid segregation YNL290W

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0043142
IDA
Genome Projectsingle-stranded DNA-dependent ATPase activity
GO:0043142
IDA
Gene Ontologysingle-stranded DNA-dependent ATPase activity1
GO:0003689
IDA
Genome ProjectDNA clamp loader activity
GO:0003689
IDA
Gene OntologyDNA clamp loader activity1
GO:0019899
NAS
Genome Projectenzyme binding
GO:0019899
NAS
Gene Ontologyenzyme binding2
GO:0005524
IEA
Genome ProjectATP binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding3 4 5
GO:0061860
IEA
PLAZA Integrative OrthologyDNA clamp unloader activity SPAC27E2.10c

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0031390
IDA
Genome ProjectCtf18 RFC-like complex
GO:0031390
IDA
Gene OntologyCtf18 RFC-like complex1
GO:0005663
IDA
Genome ProjectDNA replication factor C complex
GO:0005663
IDA
Gene OntologyDNA replication factor C complex3
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005654
TAS
Gene Ontologynucleoplasm
GO:0044430
IEA
PLAZA Integrative Orthologycytoskeletal part FBgn0032244
GO:0005737
IEA
PLAZA Integrative Orthologycytoplasm SPAC27E2.10c
GO:0005856
IEA
PLAZA Integrative Orthologycytoskeleton FBgn0032244
GO:1904949
IEA
PLAZA Integrative OrthologyATPase complex SPAC27E2.10c
GO:0005730
IEA
PLAZA Integrative Orthologynucleolus AT1G21690
GO:0044454
IEA
PLAZA Integrative Orthologynuclear chromosome part SPAC27E2.10c
GO:1902494
IEA
PLAZA Integrative Orthologycatalytic complex SPAC27E2.10c
GO:0031389
IEA
PLAZA Integrative OrthologyRad17 RFC-like complex YNL290W
GO:0000790
IEA
PLAZA Integrative Orthologynuclear chromatin SPAC27E2.10c
GO:0000785
IEA
PLAZA Integrative Orthologychromatin SPAC27E2.10c
GO:0044444
IEA
PLAZA Integrative Orthologycytoplasmic part SPAC27E2.10c
GO:0000228
IEA
PLAZA Integrative Orthologynuclear chromosome SPAC27E2.10c
GO:0043596
IEA
PLAZA Integrative Orthologynuclear replication fork SPAC27E2.10c
GO:0031391
IEA
PLAZA Integrative OrthologyElg1 RFC-like complex SPAC27E2.10c
GO:0005829
IEA
PLAZA Integrative Orthologycytosol SPAC27E2.10c
GO:0005875
IEA
PLAZA Integrative Orthologymicrotubule associated complex FBgn0032244
GO:0015630
IEA
PLAZA Integrative Orthologymicrotubule cytoskeleton FBgn0032244

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003593AAA+ ATPase domain
IPR003959ATPase, AAA-type, core
IPR008921DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
IPR013748Replication factor C, C-terminal
IPR027417P-loop containing nucleoside triphosphate hydrolase

No MapMan annotations defined for this gene.
KeggID Description
K10756RFC3_5; replication factor C subunit 3/5
No chloroplast target sequence found.