Gene: ENSG00000108424 (Homo sapiens)

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Gene Identifier
ENSG00000108424
Transcript Identifier
ENST00000290158
Gene Type
Coding gene
Location
17 : 47650245-47682404 : positive

Family Information

Homologous gene family
HOM02SEM001523
(38 genes in 25 species)
specific family
Orthologous gene family
ORTHO02SEM001546
(38 genes in 25 species)
specific family

Descriptions

gene_descr
karyopherin (importin) beta 1

Identifiers

Type Value
pidENSP00000290158
HGNC6400
UniprotQ14974
RefSeq_mRNANM_002265.5

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0090307
IMP
Genome Projectmitotic spindle assembly
GO:0090307
IMP
Gene Ontologymitotic spindle assembly1
GO:0075733
TAS
Genome Projectintracellular transport of virus
GO:0075733
TAS
Gene Ontologyintracellular transport of virus
GO:0045540
TAS
Genome Projectregulation of cholesterol biosynthetic process
GO:0045540
TAS
Gene Ontologyregulation of cholesterol biosynthetic process
GO:0045184
IMP
Genome Projectestablishment of protein localization
GO:0045184
IMP
Gene Ontologyestablishment of protein localization1
GO:0043312
TAS
Genome Projectneutrophil degranulation
GO:0043312
TAS
Gene Ontologyneutrophil degranulation
GO:0040001
IMP
Genome Projectestablishment of mitotic spindle localization
GO:0040001
IMP
Gene Ontologyestablishment of mitotic spindle localization1
GO:0031291
IMP
Genome ProjectRan protein signal transduction
GO:0031291
IMP
Gene OntologyRan protein signal transduction1
GO:0030953
IMP
Genome Projectastral microtubule organization
GO:0030953
IMP
Gene Ontologyastral microtubule organization1
GO:0019054
TAS
Genome Projectmodulation by virus of host process
GO:0019054
TAS
Gene Ontologymodulation by virus of host process
GO:0007080
IMP
Genome Projectmitotic metaphase plate congression
GO:0007080
IMP
Gene Ontologymitotic metaphase plate congression1
GO:0007079
IMP
Genome Projectmitotic chromosome movement towards spindle pole
GO:0007079
IMP
Gene Ontologymitotic chromosome movement towards spindle pole1
GO:0006610
IDA
Genome Projectribosomal protein import into nucleus
GO:0006610
IDA
Gene Ontologyribosomal protein import into nucleus2
GO:0006607
TAS
Genome ProjectNLS-bearing protein import into nucleus
GO:0006606
IDA
Genome Projectprotein import into nucleus
GO:0006606
IDA
Gene Ontologyprotein import into nucleus3
GO:0006309
TAS
Genome Projectapoptotic DNA fragmentation
GO:0006309
TAS
Gene Ontologyapoptotic DNA fragmentation
GO:0000060
TAS
Genome Projectprotein import into nucleus, translocation
GO:0000060
TAS
Gene Ontologyprotein import into nucleus, translocation4
GO:0030036
IEA
PLAZA Integrative Orthologyactin cytoskeleton organization FBgn0262743
GO:0030154
IEA
PLAZA Integrative Orthologycell differentiation FBgn0262743
GO:0048477
IEA
PLAZA Integrative Orthologyoogenesis FBgn0262743
GO:0048869
IEA
PLAZA Integrative Orthologycellular developmental process FBgn0262743
GO:0022412
IEA
PLAZA Integrative Orthologycellular process involved in reproduction in multicellular organism FBgn0262743
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction WBGene00002075
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process FBgn0262743
GO:0048468
IEA
PLAZA Integrative Orthologycell development FBgn0262743
GO:0044703
IEA
PLAZA Integrative Orthologymulti-organism reproductive process FBgn0262743
GO:0007281
IEA
PLAZA Integrative Orthologygerm cell development FBgn0262743
GO:0032501
IEA
PLAZA Integrative Orthologymulticellular organismal process WBGene00002075
GO:0032502
IEA
PLAZA Integrative Orthologydevelopmental process WBGene00002075
GO:0032504
IEA
PLAZA Integrative Orthologymulticellular organism reproduction FBgn0262743
GO:0032989
IEA
PLAZA Integrative Orthologycellular component morphogenesis FBgn0262743
GO:0060429
IEA
PLAZA Integrative Orthologyepithelium development FBgn0262743
GO:0002066
IEA
PLAZA Integrative Orthologycolumnar/cuboidal epithelial cell development FBgn0262743
GO:0002065
IEA
PLAZA Integrative Orthologycolumnar/cuboidal epithelial cell differentiation FBgn0262743
GO:0007276
IEA
PLAZA Integrative Orthologygamete generation FBgn0262743
GO:0009653
IEA
PLAZA Integrative Orthologyanatomical structure morphogenesis FBgn0262743
GO:0002064
IEA
PLAZA Integrative Orthologyepithelial cell development FBgn0262743
GO:0048856
IEA
PLAZA Integrative Orthologyanatomical structure development WBGene00002075
GO:0008360
IEA
PLAZA Integrative Orthologyregulation of cell shape FBgn0262743
GO:0007275
IEA
PLAZA Integrative Orthologymulticellular organism development WBGene00002075
GO:0019953
IEA
PLAZA Integrative Orthologysexual reproduction FBgn0262743
GO:0030855
IEA
PLAZA Integrative Orthologyepithelial cell differentiation FBgn0262743
GO:0009888
IEA
PLAZA Integrative Orthologytissue development FBgn0262743
GO:0048646
IEA
PLAZA Integrative Orthologyanatomical structure formation involved in morphogenesis FBgn0262743
GO:0007304
IEA
PLAZA Integrative Orthologychorion-containing eggshell formation FBgn0262743
GO:0000902
IEA
PLAZA Integrative Orthologycell morphogenesis FBgn0262743
GO:0048609
IEA
PLAZA Integrative Orthologymulticellular organismal reproductive process FBgn0262743
GO:0051128
IEA
PLAZA Integrative Orthologyregulation of cellular component organization FBgn0262743
GO:0065008
IEA
PLAZA Integrative Orthologyregulation of biological quality FBgn0262743
GO:0030703
IEA
PLAZA Integrative Orthologyeggshell formation FBgn0262743
GO:0030707
IEA
PLAZA Integrative Orthologyovarian follicle cell development FBgn0262743
GO:0050793
IEA
PLAZA Integrative Orthologyregulation of developmental process FBgn0262743
GO:0030029
IEA
PLAZA Integrative Orthologyactin filament-based process FBgn0262743
GO:0003006
IEA
PLAZA Integrative Orthologydevelopmental process involved in reproduction FBgn0262743
GO:0022603
IEA
PLAZA Integrative Orthologyregulation of anatomical structure morphogenesis FBgn0262743
GO:0007015
IEA
PLAZA Integrative Orthologyactin filament organization FBgn0262743
GO:0009792
IEA
PLAZA Integrative Orthologyembryo development ending in birth or egg hatching WBGene00002075
GO:0022604
IEA
PLAZA Integrative Orthologyregulation of cell morphogenesis FBgn0262743
GO:0009790
IEA
PLAZA Integrative Orthologyembryo development WBGene00002075
GO:0007292
IEA
PLAZA Integrative Orthologyfemale gamete generation FBgn0262743

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0051879
IEA
Genome ProjectHsp90 protein binding
GO:0019904
IPI
Genome Projectprotein domain specific binding
GO:0019904
IPI
Gene Ontologyprotein domain specific binding5
GO:0019899
IPI
Genome Projectenzyme binding
GO:0019899
IPI
Gene Ontologyenzyme binding6
GO:0008565
IBA
Genome Projectprotein transporter activity
GO:0008536
IEA
Genome ProjectRan GTPase binding
GO:0008270
TAS
Genome Projectzinc ion binding
GO:0008270
TAS
Gene Ontologyzinc ion binding4
GO:0008139
TAS
Genome Projectnuclear localization sequence binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25
GO:0003723
IDA
Genome ProjectRNA binding
GO:0003723
Gene OntologyRNA binding26

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1904813
TAS
Genome Projectficolin-1-rich granule lumen
GO:1904813
TAS
Gene Ontologyficolin-1-rich granule lumen
GO:0071782
IDA
Genome Projectendoplasmic reticulum tubular network
GO:0071782
IDA
Gene Ontologyendoplasmic reticulum tubular network6
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0070062
Gene Ontologyextracellular exosome27 28 29
GO:0035580
TAS
Genome Projectspecific granule lumen
GO:0035580
TAS
Gene Ontologyspecific granule lumen
GO:0034399
IBA
Genome Projectnuclear periphery
GO:0031965
IDA
IBA
Genome Projectnuclear membrane
GO:0031965
IDA
Gene Ontologynuclear membrane
GO:0016020
IDA
Genome Projectmembrane
GO:0016020
Gene Ontologymembrane30
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005829
IDA
TAS
Gene Ontologycytosol
GO:0005737
TAS
Genome Projectcytoplasm
GO:0005737
TAS
Gene Ontologycytoplasm4
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005654
IDA
TAS
Gene Ontologynucleoplasm
GO:0005643
TAS
Genome Projectnuclear pore
GO:0005643
TAS
Gene Ontologynuclear pore31
GO:0005635
IDA
Genome Projectnuclear envelope
GO:0005635
IDA
Gene Ontologynuclear envelope6
GO:0005576
TAS
Genome Projectextracellular region
GO:0005576
TAS
Gene Ontologyextracellular region
GO:0010494
ISS
Gene Ontologycytoplasmic stress granule
GO:0005819
IEA
PLAZA Integrative Orthologyspindle SPAC1B1.03c
GO:0044430
IEA
PLAZA Integrative Orthologycytoskeletal part SPAC1B1.03c
GO:0043186
IEA
PLAZA Integrative OrthologyP granule FBgn0262743
GO:0005856
IEA
PLAZA Integrative Orthologycytoskeleton SPAC1B1.03c
GO:0051233
IEA
PLAZA Integrative Orthologyspindle midzone SPAC1B1.03c
GO:0005811
IEA
PLAZA Integrative Orthologylipid droplet FBgn0262743
GO:0060293
IEA
PLAZA Integrative Orthologygerm plasm FBgn0262743
GO:0072686
IEA
PLAZA Integrative Orthologymitotic spindle SPAC1B1.03c
GO:1990023
IEA
PLAZA Integrative Orthologymitotic spindle midzone SPAC1B1.03c
GO:0009536
IEA
PLAZA Integrative Orthologyplastid AT5G53480
GO:0045495
IEA
PLAZA Integrative Orthologypole plasm FBgn0262743
GO:0009507
IEA
PLAZA Integrative Orthologychloroplast AT5G53480
GO:0005875
IEA
PLAZA Integrative Orthologymicrotubule associated complex FBgn0262743
GO:0015630
IEA
PLAZA Integrative Orthologymicrotubule cytoskeleton SPAC1B1.03c

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000225Armadillo
IPR001494Importin-beta, N-terminal domain
IPR011989Armadillo-like helical
IPR016024Armadillo-type fold
IPR021133HEAT, type 2

No MapMan annotations defined for this gene.
KeggID Description
K14293KPNB1, IPO1; importin subunit beta-1
No chloroplast target sequence found.