Gene: ENSG00000106144 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000106144
Transcript Identifier
ENST00000310447
Gene Type
Coding gene
Location
7 : 143288456-143305071 : positive

Family Information

Homologous gene family
HOM02SEM003735
(21 genes in 3 species)
specific family
Orthologous gene family
ORTHO02SEM008012
(10 genes in 3 species)
specific family

Descriptions

gene_descr
caspase 2, apoptosis-related cysteine peptidase

Identifiers

Type Value
pidENSP00000312664
HGNC1503
UniprotP42575
RefSeq_mRNANM_032982.3
EMBLCHEMBL4884
EMBLAB209640
EMBLAC073342
EMBLAF314174
EMBLAF314175
EMBLAK291274
EMBLAY219042
EMBLBC002427
EMBLBT007240
EMBLCH471198
EMBLCR541748
EMBLU13021
EMBLU13022

Toolbox

Explore

Create

View

Browse

 

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2001235
IEA
Genome Projectpositive regulation of apoptotic signaling pathway
GO:0097194
TAS
Genome Projectexecution phase of apoptosis
GO:0097194
TAS
Gene Ontologyexecution phase of apoptosis1
GO:0097192
IEA
Genome Projectextrinsic apoptotic signaling pathway in absence of ligand
GO:0097190
TAS
Genome Projectapoptotic signaling pathway
GO:0097190
TAS
Gene Ontologyapoptotic signaling pathway1
GO:0071260
IEP
Genome Projectcellular response to mechanical stimulus
GO:0071260
IEP
Gene Ontologycellular response to mechanical stimulus2
GO:0043525
IEA
Genome Projectpositive regulation of neuron apoptotic process
GO:0043066
NAS
Genome Projectnegative regulation of apoptotic process
GO:0043066
NAS
Gene Ontologynegative regulation of apoptotic process3
GO:0043065
IDA
Genome Projectpositive regulation of apoptotic process
GO:0043065
IDA
Gene Ontologypositive regulation of apoptotic process4
GO:0042981
TAS
Genome Projectregulation of apoptotic process
GO:0042981
TAS
Gene Ontologyregulation of apoptotic process
GO:0035234
IEA
Genome Projectectopic germ cell programmed cell death
GO:0016485
IDA
Genome Projectprotein processing
GO:0016485
IDA
Gene Ontologyprotein processing5
GO:0008630
TAS
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage
GO:0008630
TAS
Gene Ontologyintrinsic apoptotic signaling pathway in response to DNA damage1
GO:0007568
IEA
Genome Projectaging
GO:0007420
IEA
Genome Projectbrain development
GO:0006977
IMP
Genome ProjectDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006977
IMP
Gene OntologyDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest6
GO:0006919
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915
NAS
Genome Projectapoptotic process
GO:0006915
NAS
Gene Ontologyapoptotic process3
GO:0003407
IEA
Genome Projectneural retina development
GO:0001554
IEA
Genome Projectluteolysis
GO:0030036
IEA
PLAZA Integrative Orthologyactin cytoskeleton organization WBGene00000417
GO:0051239
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal process WBGene00000417
GO:0030155
IEA
PLAZA Integrative Orthologyregulation of cell adhesion WBGene00000417
GO:0016540
IEA
PLAZA Integrative Orthologyprotein autoprocessing WBGene00000417
GO:0097435
IEA
PLAZA Integrative Orthologysupramolecular fiber organization WBGene00000417
GO:0019098
IEA
PLAZA Integrative Orthologyreproductive behavior WBGene00000417
GO:0031647
IEA
PLAZA Integrative Orthologyregulation of protein stability WBGene00000417
GO:0009617
IEA
PLAZA Integrative Orthologyresponse to bacterium WBGene00000417
GO:1905808
IEA
PLAZA Integrative Orthologypositive regulation of synapse pruning WBGene00000417
GO:0098883
IEA
PLAZA Integrative Orthologysynapse pruning WBGene00000417
GO:0022411
IEA
PLAZA Integrative Orthologycellular component disassembly WBGene00000417
GO:0006996
IEA
PLAZA Integrative Orthologyorganelle organization WBGene00000417
GO:1901575
IEA
PLAZA Integrative Orthologyorganic substance catabolic process WBGene00000417
GO:0030042
IEA
PLAZA Integrative Orthologyactin filament depolymerization WBGene00000417
GO:0030163
IEA
PLAZA Integrative Orthologyprotein catabolic process WBGene00000417
GO:0050829
IEA
PLAZA Integrative Orthologydefense response to Gram-negative bacterium WBGene00000417
GO:0032984
IEA
PLAZA Integrative Orthologyprotein-containing complex disassembly WBGene00000417
GO:0010035
IEA
PLAZA Integrative Orthologyresponse to inorganic substance WBGene00000417
GO:0048580
IEA
PLAZA Integrative Orthologyregulation of post-embryonic development WBGene00000417
GO:0071478
IEA
PLAZA Integrative Orthologycellular response to radiation WBGene00000417
GO:0070268
IEA
PLAZA Integrative Orthologycornification ENSG00000105141
GO:0010954
IEA
PLAZA Integrative Orthologypositive regulation of protein processing WBGene00000417
GO:0010038
IEA
PLAZA Integrative Orthologyresponse to metal ion WBGene00000417
GO:0071479
IEA
PLAZA Integrative Orthologycellular response to ionizing radiation WBGene00000417
GO:0048585
IEA
PLAZA Integrative Orthologynegative regulation of response to stimulus WBGene00000417
GO:0045595
IEA
PLAZA Integrative Orthologyregulation of cell differentiation WBGene00000417
GO:0009607
IEA
PLAZA Integrative Orthologyresponse to biotic stimulus WBGene00000417
GO:1905803
IEA
PLAZA Integrative Orthologynegative regulation of cellular response to manganese ion WBGene00000417
GO:1905806
IEA
PLAZA Integrative Orthologyregulation of synapse pruning WBGene00000417
GO:0007155
IEA
PLAZA Integrative Orthologycell adhesion WBGene00000417
GO:1901565
IEA
PLAZA Integrative Orthologyorganonitrogen compound catabolic process WBGene00000417
GO:1905802
IEA
PLAZA Integrative Orthologyregulation of cellular response to manganese ion WBGene00000417
GO:1901046
IEA
PLAZA Integrative Orthologypositive regulation of oviposition WBGene00000417
GO:0009056
IEA
PLAZA Integrative Orthologycatabolic process WBGene00000417
GO:0009057
IEA
PLAZA Integrative Orthologymacromolecule catabolic process WBGene00000417
GO:0046716
IEA
PLAZA Integrative Orthologymuscle cell cellular homeostasis WBGene00000417
GO:0043207
IEA
PLAZA Integrative Orthologyresponse to external biotic stimulus WBGene00000417
GO:0010042
IEA
PLAZA Integrative Orthologyresponse to manganese ion WBGene00000417
GO:0031424
IEA
PLAZA Integrative Orthologykeratinization ENSG00000105141
GO:0071840
IEA
PLAZA Integrative Orthologycellular component organization or biogenesis WBGene00000417
GO:0050803
IEA
PLAZA Integrative Orthologyregulation of synapse structure or activity WBGene00000417
GO:0016043
IEA
PLAZA Integrative Orthologycellular component organization WBGene00000417
GO:0010468
IEA
PLAZA Integrative Orthologyregulation of gene expression WBGene00000417
GO:0071287
IEA
PLAZA Integrative Orthologycellular response to manganese ion WBGene00000417
GO:0010628
IEA
PLAZA Integrative Orthologypositive regulation of gene expression WBGene00000417
GO:0042592
IEA
PLAZA Integrative Orthologyhomeostatic process WBGene00000417
GO:0009913
IEA
PLAZA Integrative Orthologyepidermal cell differentiation ENSG00000105141
GO:0030216
IEA
PLAZA Integrative Orthologykeratinocyte differentiation ENSG00000105141
GO:0098542
IEA
PLAZA Integrative Orthologydefense response to other organism WBGene00000417
GO:0030855
IEA
PLAZA Integrative Orthologyepithelial cell differentiation ENSG00000105141
GO:0009888
IEA
PLAZA Integrative Orthologytissue development ENSG00000105141
GO:0042742
IEA
PLAZA Integrative Orthologydefense response to bacterium WBGene00000417
GO:0048569
IEA
PLAZA Integrative Orthologypost-embryonic animal organ development WBGene00000417
GO:0042221
IEA
PLAZA Integrative Orthologyresponse to chemical WBGene00000417
GO:0050808
IEA
PLAZA Integrative Orthologysynapse organization WBGene00000417
GO:0008154
IEA
PLAZA Integrative Orthologyactin polymerization or depolymerization WBGene00000417
GO:0050807
IEA
PLAZA Integrative Orthologyregulation of synapse organization WBGene00000417
GO:0010212
IEA
PLAZA Integrative Orthologyresponse to ionizing radiation WBGene00000417
GO:0070887
IEA
PLAZA Integrative Orthologycellular response to chemical stimulus WBGene00000417
GO:0010332
IEA
PLAZA Integrative Orthologyresponse to gamma radiation WBGene00000417
GO:0010453
IEA
PLAZA Integrative Orthologyregulation of cell fate commitment WBGene00000417
GO:0018991
IEA
PLAZA Integrative Orthologyoviposition WBGene00000417
GO:0097202
IEA
PLAZA Integrative Orthologyactivation of cysteine-type endopeptidase activity WBGene00000417
GO:0046662
IEA
PLAZA Integrative Orthologyregulation of oviposition WBGene00000417
GO:0007610
IEA
PLAZA Integrative Orthologybehavior WBGene00000417
GO:0002164
IEA
PLAZA Integrative Orthologylarval development WBGene00000417
GO:0008544
IEA
PLAZA Integrative Orthologyepidermis development ENSG00000105141
GO:0040034
IEA
PLAZA Integrative Orthologyregulation of development, heterochronic WBGene00000417
GO:2000026
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal development WBGene00000417
GO:0070613
IEA
PLAZA Integrative Orthologyregulation of protein processing WBGene00000417
GO:0045165
IEA
PLAZA Integrative Orthologycell fate commitment WBGene00000417
GO:0040028
IEA
PLAZA Integrative Orthologyregulation of vulval development WBGene00000417
GO:0022610
IEA
PLAZA Integrative Orthologybiological adhesion WBGene00000417
GO:1903317
IEA
PLAZA Integrative Orthologyregulation of protein maturation WBGene00000417
GO:0006952
IEA
PLAZA Integrative Orthologydefense response WBGene00000417
GO:1903319
IEA
PLAZA Integrative Orthologypositive regulation of protein maturation WBGene00000417
GO:1902742
IEA
PLAZA Integrative Orthologyapoptotic process involved in development WBGene00000417
GO:0040025
IEA
PLAZA Integrative Orthologyvulval development WBGene00000417
GO:0019725
IEA
PLAZA Integrative Orthologycellular homeostasis WBGene00000417
GO:0043933
IEA
PLAZA Integrative Orthologyprotein-containing complex subunit organization WBGene00000417
GO:0051704
IEA
PLAZA Integrative Orthologymulti-organism process WBGene00000417
GO:2001228
IEA
PLAZA Integrative Orthologyregulation of response to gamma radiation WBGene00000417
GO:1905843
IEA
PLAZA Integrative Orthologyregulation of cellular response to gamma radiation WBGene00000417
GO:0060429
IEA
PLAZA Integrative Orthologyepithelium development ENSG00000105141
GO:1905845
IEA
PLAZA Integrative Orthologypositive regulation of cellular response to gamma radiation WBGene00000417
GO:0051707
IEA
PLAZA Integrative Orthologyresponse to other organism WBGene00000417
GO:0040011
IEA
PLAZA Integrative Orthologylocomotion WBGene00000417
GO:0040012
IEA
PLAZA Integrative Orthologyregulation of locomotion WBGene00000417
GO:2001230
IEA
PLAZA Integrative Orthologypositive regulation of response to gamma radiation WBGene00000417
GO:2000243
IEA
PLAZA Integrative Orthologypositive regulation of reproductive process WBGene00000417
GO:0071248
IEA
PLAZA Integrative Orthologycellular response to metal ion WBGene00000417
GO:0051130
IEA
PLAZA Integrative Orthologypositive regulation of cellular component organization WBGene00000417
GO:0071480
IEA
PLAZA Integrative Orthologycellular response to gamma radiation WBGene00000417
GO:0071241
IEA
PLAZA Integrative Orthologycellular response to inorganic substance WBGene00000417
GO:1904747
IEA
PLAZA Integrative Orthologypositive regulation of apoptotic process involved in development WBGene00000417
GO:1904748
IEA
PLAZA Integrative Orthologyregulation of apoptotic process involved in development WBGene00000417
GO:0051261
IEA
PLAZA Integrative Orthologyprotein depolymerization WBGene00000417
GO:0065008
IEA
PLAZA Integrative Orthologyregulation of biological quality WBGene00000417
GO:0051128
IEA
PLAZA Integrative Orthologyregulation of cellular component organization WBGene00000417
GO:0001708
IEA
PLAZA Integrative Orthologycell fate specification WBGene00000417
GO:0061062
IEA
PLAZA Integrative Orthologyregulation of nematode larval development WBGene00000417
GO:0051240
IEA
PLAZA Integrative Orthologypositive regulation of multicellular organismal process WBGene00000417
GO:0048520
IEA
PLAZA Integrative Orthologypositive regulation of behavior WBGene00000417
GO:0002119
IEA
PLAZA Integrative Orthologynematode larval development WBGene00000417
GO:0050793
IEA
PLAZA Integrative Orthologyregulation of developmental process WBGene00000417
GO:0031638
IEA
PLAZA Integrative Orthologyzymogen activation WBGene00000417
GO:0030029
IEA
PLAZA Integrative Orthologyactin filament-based process WBGene00000417
GO:0050795
IEA
PLAZA Integrative Orthologyregulation of behavior WBGene00000417
GO:0060249
IEA
PLAZA Integrative Orthologyanatomical structure homeostasis WBGene00000417
GO:0043624
IEA
PLAZA Integrative Orthologycellular protein complex disassembly WBGene00000417
GO:0043588
IEA
PLAZA Integrative Orthologyskin development ENSG00000105141
GO:0051094
IEA
PLAZA Integrative Orthologypositive regulation of developmental process WBGene00000417
GO:0007015
IEA
PLAZA Integrative Orthologyactin filament organization WBGene00000417
GO:0009314
IEA
PLAZA Integrative Orthologyresponse to radiation WBGene00000417
GO:0009791
IEA
PLAZA Integrative Orthologypost-embryonic development WBGene00000417
GO:0009792
IEA
PLAZA Integrative Orthologyembryo development ending in birth or egg hatching WBGene00000417
GO:0007010
IEA
PLAZA Integrative Orthologycytoskeleton organization WBGene00000417
GO:2000241
IEA
PLAZA Integrative Orthologyregulation of reproductive process WBGene00000417
GO:0042659
IEA
PLAZA Integrative Orthologyregulation of cell fate specification WBGene00000417
GO:0009790
IEA
PLAZA Integrative Orthologyembryo development WBGene00000417

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0097200
IBA
Genome Projectcysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042802
IPI
Gene Ontologyidentical protein binding7 8 9
GO:0019904
IPI
Genome Projectprotein domain specific binding
GO:0019904
IPI
Gene Ontologyprotein domain specific binding5
GO:0019899
ISS
Genome Projectenzyme binding
GO:0019899
ISS
Gene Ontologyenzyme binding10
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding3 8 10 11 12 13 14 15
GO:0004197
IDA
NAS
Genome Projectcysteine-type endopeptidase activity
GO:0004197
IDA
NAS
Gene Ontologycysteine-type endopeptidase activity3 4 5 6
GO:0008656
IEA
PLAZA Integrative Orthologycysteine-type endopeptidase activator activity involved in apoptotic process WBGene00000417
GO:0098772
IEA
PLAZA Integrative Orthologymolecular function regulator WBGene00000417
GO:0043028
IEA
PLAZA Integrative Orthologycysteine-type endopeptidase regulator activity involved in apoptotic process WBGene00000417
GO:0061134
IEA
PLAZA Integrative Orthologypeptidase regulator activity WBGene00000417
GO:0030234
IEA
PLAZA Integrative Orthologyenzyme regulator activity WBGene00000417
GO:0008047
IEA
PLAZA Integrative Orthologyenzyme activator activity WBGene00000417
GO:0016505
IEA
PLAZA Integrative Orthologypeptidase activator activity involved in apoptotic process WBGene00000417
GO:0016504
IEA
PLAZA Integrative Orthologypeptidase activator activity WBGene00000417

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0016020
IEA
Genome Projectmembrane
GO:0005829
TAS
Genome Projectcytosol
GO:0005829
TAS
Gene Ontologycytosol
GO:0005739
IEA
Genome Projectmitochondrion
GO:0005737
IBA
Genome Projectcytoplasm
GO:0005634
TAS
Genome Projectnucleus
GO:0005634
TAS
Gene Ontologynucleus1
GO:0048471
IEA
PLAZA Integrative Orthologyperinuclear region of cytoplasm WBGene00000417
GO:0044421
IEA
PLAZA Integrative Orthologyextracellular region part ENSG00000105141
GO:0031012
IEA
PLAZA Integrative Orthologyextracellular matrix ENSG00000105141
GO:1905368
IEA
PLAZA Integrative Orthologypeptidase complex WBGene00000417
GO:1905369
IEA
PLAZA Integrative Orthologyendopeptidase complex WBGene00000417
GO:1902494
IEA
PLAZA Integrative Orthologycatalytic complex WBGene00000417
GO:0032991
IEA
PLAZA Integrative Orthologyprotein-containing complex WBGene00000417
GO:0097458
IEA
PLAZA Integrative Orthologyneuron part WBGene00000417
GO:0008303
IEA
PLAZA Integrative Orthologycaspase complex WBGene00000417
GO:0045202
IEA
PLAZA Integrative Orthologysynapse WBGene00000417
GO:0043025
IEA
PLAZA Integrative Orthologyneuronal cell body WBGene00000417
GO:1903561
IEA
PLAZA Integrative Orthologyextracellular vesicle ENSG00000105141
GO:0005615
IEA
PLAZA Integrative Orthologyextracellular space ENSG00000105141
GO:0070062
IEA
PLAZA Integrative Orthologyextracellular exosome ENSG00000105141
GO:0098793
IEA
PLAZA Integrative Orthologypresynapse WBGene00000417
GO:0005576
IEA
PLAZA Integrative Orthologyextracellular region ENSG00000105141
GO:0044456
IEA
PLAZA Integrative Orthologysynapse part WBGene00000417
GO:0036477
IEA
PLAZA Integrative Orthologysomatodendritic compartment WBGene00000417
GO:0031982
IEA
PLAZA Integrative Orthologyvesicle ENSG00000105141
GO:0044297
IEA
PLAZA Integrative Orthologycell body WBGene00000417
GO:0044445
IEA
PLAZA Integrative Orthologycytosolic part WBGene00000417
GO:0043230
IEA
PLAZA Integrative Orthologyextracellular organelle ENSG00000105141

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001309Peptidase C14, p20 domain
IPR001315CARD domain
IPR002138Peptidase C14, caspase non-catalytic subunit p10
IPR011029Death-like domain superfamily
IPR015917Peptidase C14A, caspase catalytic domain
IPR016129Peptidase family C14A, His active site
IPR029030Caspase-like domain superfamily
IPR033139Peptidase family C14A, cysteine active site

No MapMan annotations defined for this gene.
KeggID Description
K02186CASP2; caspase 2
No chloroplast target sequence found.