Gene: ENSG00000106100 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000106100
Transcript Identifier
ENST00000222823
Gene Type
Coding gene
Location
7 : 30425638-30456921 : negative

Family Information

Homologous gene family
HOM02SEM000951
(50 genes in 5 species)
specific family

Descriptions

gene_descr
nucleotide-binding oligomerization domain containing 1

Identifiers

Type Value
pidENSP00000222823
HGNC16390
UniprotQ9Y239
UniprotA0A024RA73
RefSeq_mRNANM_006092.2
EMBLCHEMBL1293222
EMBLAACC02000087
EMBLAC005154
EMBLAC006027
EMBLAF113925
EMBLAF126484
EMBLAF149774
EMBLAK300367
EMBLBC040339
EMBLCH471073

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1904417
IEA
Genome Projectpositive regulation of xenophagy
GO:1901224
IMP
Genome Projectpositive regulation of NIK/NF-kappaB signaling
GO:1901224
IMP
Gene Ontologypositive regulation of NIK/NF-kappaB signaling1
GO:0071225
IMP
Genome Projectcellular response to muramyl dipeptide
GO:0071225
IMP
Gene Ontologycellular response to muramyl dipeptide1
GO:0070423
TAS
Genome Projectnucleotide-binding oligomerization domain containing signaling pathway
GO:0070423
TAS
Gene Ontologynucleotide-binding oligomerization domain containing signaling pathway
GO:0070374
IEA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0051259
TAS
Genome Projectprotein complex oligomerization
GO:0051259
TAS
Gene Ontologyprotein complex oligomerization2
GO:0051092
IDA
TAS
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051092
IDA
TAS
Gene Ontologypositive regulation of NF-kappaB transcription factor activity3 4
GO:0051000
IEA
Genome Projectpositive regulation of nitric-oxide synthase activity
GO:0050830
IEA
Genome Projectdefense response to Gram-positive bacterium
GO:0046330
IEA
Genome Projectpositive regulation of JNK cascade
GO:0045087
IEA
Genome Projectinnate immune response
GO:0043280
IDA
Genome Projectpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043280
IDA
Gene Ontologypositive regulation of cysteine-type endopeptidase activity involved in apoptotic process5
GO:0043123
IDA
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123
IDA
Gene Ontologypositive regulation of I-kappaB kinase/NF-kappaB signaling5
GO:0042742
IDA
Genome Projectdefense response to bacterium
GO:0042742
IDA
Gene Ontologydefense response to bacterium6
GO:0042228
IDA
Genome Projectinterleukin-8 biosynthetic process
GO:0042228
IDA
Gene Ontologyinterleukin-8 biosynthetic process6
GO:0035556
IDA
Genome Projectintracellular signal transduction
GO:0035556
IDA
Gene Ontologyintracellular signal transduction6
GO:0032760
IEA
Genome Projectpositive regulation of tumor necrosis factor production
GO:0032755
IEA
Genome Projectpositive regulation of interleukin-6 production
GO:0032731
IEA
Genome Projectpositive regulation of interleukin-1 beta production
GO:0016579
TAS
Genome Projectprotein deubiquitination
GO:0016045
IDA
Genome Projectdetection of bacterium
GO:0016045
IDA
Gene Ontologydetection of bacterium6
GO:0009595
TAS
Genome Projectdetection of biotic stimulus
GO:0009595
TAS
Gene Ontologydetection of biotic stimulus2
GO:0007254
TAS
Genome ProjectJNK cascade
GO:0007254
TAS
Gene OntologyJNK cascade
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007165
TAS
Gene Ontologysignal transduction2
GO:0006954
TAS
Genome Projectinflammatory response
GO:0006954
TAS
Gene Ontologyinflammatory response2
GO:0006952
TAS
Genome Projectdefense response
GO:0006952
TAS
Gene Ontologydefense response2
GO:0006919
IDA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
IDA
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process5
GO:0006915
IEA
Genome Projectapoptotic process
GO:0002606
ISS
Genome Projectpositive regulation of dendritic cell antigen processing and presentation
GO:0002606
ISS
Gene Ontologypositive regulation of dendritic cell antigen processing and presentation
GO:0000187
TAS
Genome Projectactivation of MAPK activity
GO:0000187
TAS
Gene Ontologyactivation of MAPK activity
GO:0070498
TAS
Gene Ontologyinterleukin-1-mediated signaling pathway
GO:0050701
IEA
PLAZA Integrative Orthologyinterleukin-1 secretion ENSG00000167207
GO:0050702
IEA
PLAZA Integrative Orthologyinterleukin-1 beta secretion ENSG00000167207
GO:0030277
IEA
PLAZA Integrative Orthologymaintenance of gastrointestinal epithelium ENSG00000167207
GO:0002828
IEA
PLAZA Integrative Orthologyregulation of type 2 immune response ENSG00000167207
GO:0070534
IEA
PLAZA Integrative Orthologyprotein K63-linked ubiquitination ENSG00000167207
GO:0050704
IEA
PLAZA Integrative Orthologyregulation of interleukin-1 secretion ENSG00000167207
GO:0048871
IEA
PLAZA Integrative Orthologymulticellular organismal homeostasis ENSG00000167207
GO:0071222
IEA
PLAZA Integrative Orthologycellular response to lipopolysaccharide ENSG00000167207
GO:0051234
IEA
PLAZA Integrative Orthologyestablishment of localization ENSG00000167207
GO:1903508
IEA
PLAZA Integrative Orthologypositive regulation of nucleic acid-templated transcription ENSG00000167207
GO:0042092
IEA
PLAZA Integrative Orthologytype 2 immune response ENSG00000167207
GO:0050663
IEA
PLAZA Integrative Orthologycytokine secretion ENSG00000167207
GO:0006357
IEA
PLAZA Integrative Orthologyregulation of transcription by RNA polymerase II ENSG00000167207
GO:0042886
IEA
PLAZA Integrative Orthologyamide transport ENSG00000167207
GO:0002793
IEA
PLAZA Integrative Orthologypositive regulation of peptide secretion ENSG00000167207
GO:0002791
IEA
PLAZA Integrative Orthologyregulation of peptide secretion ENSG00000167207
GO:0002790
IEA
PLAZA Integrative Orthologypeptide secretion ENSG00000167207
GO:0090087
IEA
PLAZA Integrative Orthologyregulation of peptide transport ENSG00000167207
GO:0050707
IEA
PLAZA Integrative Orthologyregulation of cytokine secretion ENSG00000167207
GO:0050706
IEA
PLAZA Integrative Orthologyregulation of interleukin-1 beta secretion ENSG00000167207
GO:0050708
IEA
PLAZA Integrative Orthologyregulation of protein secretion ENSG00000167207
GO:0010557
IEA
PLAZA Integrative Orthologypositive regulation of macromolecule biosynthetic process ENSG00000167207
GO:0033036
IEA
PLAZA Integrative Orthologymacromolecule localization ENSG00000167207
GO:0032620
IEA
PLAZA Integrative Orthologyinterleukin-17 production ENSG00000167207
GO:0032740
IEA
PLAZA Integrative Orthologypositive regulation of interleukin-17 production ENSG00000167207
GO:0051223
IEA
PLAZA Integrative Orthologyregulation of protein transport ENSG00000167207
GO:0002534
IEA
PLAZA Integrative Orthologycytokine production involved in inflammatory response ENSG00000167207
GO:0051222
IEA
PLAZA Integrative Orthologypositive regulation of protein transport ENSG00000167207
GO:0002532
IEA
PLAZA Integrative Orthologyproduction of molecular mediator involved in inflammatory response ENSG00000167207
GO:0042113
IEA
PLAZA Integrative OrthologyB cell activation ENSG00000167207
GO:1904951
IEA
PLAZA Integrative Orthologypositive regulation of establishment of protein localization ENSG00000167207
GO:0016567
IEA
PLAZA Integrative Orthologyprotein ubiquitination ENSG00000167207
GO:0070997
IEA
PLAZA Integrative Orthologyneuron death ENSG00000179709
GO:0042592
IEA
PLAZA Integrative Orthologyhomeostatic process ENSG00000167207
GO:0010628
IEA
PLAZA Integrative Orthologypositive regulation of gene expression ENSG00000167207
GO:0051179
IEA
PLAZA Integrative Orthologylocalization ENSG00000167207
GO:0032879
IEA
PLAZA Integrative Orthologyregulation of localization ENSG00000167207
GO:1902914
IEA
PLAZA Integrative Orthologyregulation of protein polyubiquitination ENSG00000167207
GO:0032757
IEA
PLAZA Integrative Orthologypositive regulation of interleukin-8 production ENSG00000167207
GO:1902916
IEA
PLAZA Integrative Orthologypositive regulation of protein polyubiquitination ENSG00000167207
GO:0045184
IEA
PLAZA Integrative Orthologyestablishment of protein localization ENSG00000167207
GO:0002696
IEA
PLAZA Integrative Orthologypositive regulation of leukocyte activation ENSG00000167207
GO:0002694
IEA
PLAZA Integrative Orthologyregulation of leukocyte activation ENSG00000167207
GO:0006810
IEA
PLAZA Integrative Orthologytransport ENSG00000167207
GO:0007586
IEA
PLAZA Integrative Orthologydigestion ENSG00000167207
GO:1902523
IEA
PLAZA Integrative Orthologypositive regulation of protein K63-linked ubiquitination ENSG00000167207
GO:0032880
IEA
PLAZA Integrative Orthologyregulation of protein localization ENSG00000167207
GO:0071219
IEA
PLAZA Integrative Orthologycellular response to molecule of bacterial origin ENSG00000167207
GO:0031396
IEA
PLAZA Integrative Orthologyregulation of protein ubiquitination ENSG00000167207
GO:0071216
IEA
PLAZA Integrative Orthologycellular response to biotic stimulus ENSG00000167207
GO:0031398
IEA
PLAZA Integrative Orthologypositive regulation of protein ubiquitination ENSG00000167207
GO:0051047
IEA
PLAZA Integrative Orthologypositive regulation of secretion ENSG00000167207
GO:0003008
IEA
PLAZA Integrative Orthologysystem process ENSG00000167207
GO:0050871
IEA
PLAZA Integrative Orthologypositive regulation of B cell activation ENSG00000167207
GO:0051046
IEA
PLAZA Integrative Orthologyregulation of secretion ENSG00000167207
GO:0002830
IEA
PLAZA Integrative Orthologypositive regulation of type 2 immune response ENSG00000167207
GO:0051049
IEA
PLAZA Integrative Orthologyregulation of transport ENSG00000167207
GO:0002440
IEA
PLAZA Integrative Orthologyproduction of molecular mediator of immune response ENSG00000167207
GO:0051050
IEA
PLAZA Integrative Orthologypositive regulation of transport ENSG00000167207
GO:0006366
IEA
PLAZA Integrative Orthologytranscription by RNA polymerase II ENSG00000167207
GO:0022600
IEA
PLAZA Integrative Orthologydigestive system process ENSG00000167207
GO:0009593
IEA
PLAZA Integrative Orthologydetection of chemical stimulus ENSG00000167207
GO:1903320
IEA
PLAZA Integrative Orthologyregulation of protein modification by small protein conjugation or removal ENSG00000167207
GO:0032494
IEA
PLAZA Integrative Orthologyresponse to peptidoglycan ENSG00000167207
GO:1903322
IEA
PLAZA Integrative Orthologypositive regulation of protein modification by small protein conjugation or removal ENSG00000167207
GO:0032490
IEA
PLAZA Integrative Orthologydetection of molecule of bacterial origin ENSG00000167207
GO:0050864
IEA
PLAZA Integrative Orthologyregulation of B cell activation ENSG00000167207
GO:0071702
IEA
PLAZA Integrative Orthologyorganic substance transport ENSG00000167207
GO:0050865
IEA
PLAZA Integrative Orthologyregulation of cell activation ENSG00000167207
GO:0032496
IEA
PLAZA Integrative Orthologyresponse to lipopolysaccharide ENSG00000167207
GO:0050867
IEA
PLAZA Integrative Orthologypositive regulation of cell activation ENSG00000167207
GO:0032499
IEA
PLAZA Integrative Orthologydetection of peptidoglycan ENSG00000167207
GO:0032498
IEA
PLAZA Integrative Orthologydetection of muramyl dipeptide ENSG00000167207
GO:0045321
IEA
PLAZA Integrative Orthologyleukocyte activation ENSG00000167207
GO:0031328
IEA
PLAZA Integrative Orthologypositive regulation of cellular biosynthetic process ENSG00000167207
GO:0001775
IEA
PLAZA Integrative Orthologycell activation ENSG00000167207
GO:0001894
IEA
PLAZA Integrative Orthologytissue homeostasis ENSG00000167207
GO:0046649
IEA
PLAZA Integrative Orthologylymphocyte activation ENSG00000167207
GO:0009306
IEA
PLAZA Integrative Orthologyprotein secretion ENSG00000167207
GO:1900044
IEA
PLAZA Integrative Orthologyregulation of protein K63-linked ubiquitination ENSG00000167207
GO:0000209
IEA
PLAZA Integrative Orthologyprotein polyubiquitination ENSG00000167207
GO:0032660
IEA
PLAZA Integrative Orthologyregulation of interleukin-17 production ENSG00000167207
GO:0071705
IEA
PLAZA Integrative Orthologynitrogen compound transport ENSG00000167207
GO:0032940
IEA
PLAZA Integrative Orthologysecretion by cell ENSG00000167207
GO:0033993
IEA
PLAZA Integrative Orthologyresponse to lipid ENSG00000167207
GO:0071396
IEA
PLAZA Integrative Orthologycellular response to lipid ENSG00000167207
GO:0045944
IEA
PLAZA Integrative Orthologypositive regulation of transcription by RNA polymerase II ENSG00000167207
GO:0009891
IEA
PLAZA Integrative Orthologypositive regulation of biosynthetic process ENSG00000167207
GO:0032677
IEA
PLAZA Integrative Orthologyregulation of interleukin-8 production ENSG00000167207
GO:0015833
IEA
PLAZA Integrative Orthologypeptide transport ENSG00000167207
GO:0050727
IEA
PLAZA Integrative Orthologyregulation of inflammatory response ENSG00000167207
GO:0051251
IEA
PLAZA Integrative Orthologypositive regulation of lymphocyte activation ENSG00000167207
GO:0070431
IEA
PLAZA Integrative Orthologynucleotide-binding oligomerization domain containing 2 signaling pathway ENSG00000167207
GO:0010669
IEA
PLAZA Integrative Orthologyepithelial structure maintenance ENSG00000167207
GO:0051254
IEA
PLAZA Integrative Orthologypositive regulation of RNA metabolic process ENSG00000167207
GO:0002367
IEA
PLAZA Integrative Orthologycytokine production involved in immune response ENSG00000167207
GO:0002374
IEA
PLAZA Integrative Orthologycytokine secretion involved in immune response ENSG00000167207
GO:0050729
IEA
PLAZA Integrative Orthologypositive regulation of inflammatory response ENSG00000167207
GO:1903530
IEA
PLAZA Integrative Orthologyregulation of secretion by cell ENSG00000167207
GO:1903532
IEA
PLAZA Integrative Orthologypositive regulation of secretion by cell ENSG00000167207
GO:0045935
IEA
PLAZA Integrative Orthologypositive regulation of nucleobase-containing compound metabolic process ENSG00000167207
GO:0046903
IEA
PLAZA Integrative Orthologysecretion ENSG00000167207
GO:0065008
IEA
PLAZA Integrative Orthologyregulation of biological quality ENSG00000167207
GO:1902680
IEA
PLAZA Integrative Orthologypositive regulation of RNA biosynthetic process ENSG00000167207
GO:0032446
IEA
PLAZA Integrative Orthologyprotein modification by small protein conjugation ENSG00000167207
GO:0051249
IEA
PLAZA Integrative Orthologyregulation of lymphocyte activation ENSG00000167207
GO:0050714
IEA
PLAZA Integrative Orthologypositive regulation of protein secretion ENSG00000167207
GO:0070201
IEA
PLAZA Integrative Orthologyregulation of establishment of protein localization ENSG00000167207
GO:0050716
IEA
PLAZA Integrative Orthologypositive regulation of interleukin-1 secretion ENSG00000167207
GO:0050715
IEA
PLAZA Integrative Orthologypositive regulation of cytokine secretion ENSG00000167207
GO:0045893
IEA
PLAZA Integrative Orthologypositive regulation of transcription, DNA-templated ENSG00000167207
GO:0002237
IEA
PLAZA Integrative Orthologyresponse to molecule of bacterial origin ENSG00000167207
GO:0060249
IEA
PLAZA Integrative Orthologyanatomical structure homeostasis ENSG00000167207
GO:1900017
IEA
PLAZA Integrative Orthologypositive regulation of cytokine production involved in inflammatory response ENSG00000167207
GO:0048519
IEA
PLAZA Homology (enrichment)negative regulation of biological process HOM02SEM000951
GO:1900015
IEA
PLAZA Integrative Orthologyregulation of cytokine production involved in inflammatory response ENSG00000167207
GO:0008104
IEA
PLAZA Integrative Orthologyprotein localization ENSG00000167207
GO:0050718
IEA
PLAZA Integrative Orthologypositive regulation of interleukin-1 beta secretion ENSG00000167207
GO:0015031
IEA
PLAZA Integrative Orthologyprotein transport ENSG00000167207

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0050700
IDA
Genome ProjectCARD domain binding
GO:0050700
IDA
Gene OntologyCARD domain binding5
GO:0042834
TAS
Genome Projectpeptidoglycan binding
GO:0042834
TAS
Gene Ontologypeptidoglycan binding2
GO:0042803
IPI
Genome Projectprotein homodimerization activity
GO:0042803
IPI
Gene Ontologyprotein homodimerization activity7
GO:0042802
IDA, IPI
Genome Projectidentical protein binding
GO:0042802
IDA, IPI
Gene Ontologyidentical protein binding5 7
GO:0008656
TAS
Genome Projectcysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008656
TAS
Gene Ontologycysteine-type endopeptidase activator activity involved in apoptotic process5
GO:0005524
IEA
Genome ProjectATP binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding4 8 9 10 11 12 13 14
GO:0044877
IPI
Gene Ontologyprotein-containing complex binding10
GO:0019899
IEA
PLAZA Integrative Orthologyenzyme binding ENSG00000167207
GO:0008092
IEA
PLAZA Integrative Orthologycytoskeletal protein binding ENSG00000167207
GO:0051879
IEA
PLAZA Integrative OrthologyHsp90 protein binding ENSG00000167207
GO:0032500
IEA
PLAZA Integrative Orthologymuramyl dipeptide binding ENSG00000167207
GO:0003779
IEA
PLAZA Integrative Orthologyactin binding ENSG00000167207
GO:0033218
IEA
PLAZA Integrative Orthologyamide binding ENSG00000167207
GO:0019900
IEA
PLAZA Integrative Orthologykinase binding ENSG00000167207
GO:0042277
IEA
PLAZA Integrative Orthologypeptide binding ENSG00000167207
GO:0031072
IEA
PLAZA Integrative Orthologyheat shock protein binding ENSG00000167207
GO:0019901
IEA
PLAZA Integrative Orthologyprotein kinase binding ENSG00000167207
GO:0030544
IEA
PLAZA Integrative OrthologyHsp70 protein binding ENSG00000167207

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0016324
IEA
Genome Projectapical plasma membrane
GO:0016323
IDA
Genome Projectbasolateral plasma membrane
GO:0016323
IDA
Gene Ontologybasolateral plasma membrane4
GO:0005829
TAS
Genome Projectcytosol
GO:0005829
TAS
Gene Ontologycytosol
GO:0005737
IDA
TAS
Genome Projectcytoplasm
GO:0005737
IDA
TAS
Gene Ontologycytoplasm2 5
GO:0012505
IEA
PLAZA Integrative Orthologyendomembrane system ENSG00000167207
GO:0009986
IEA
PLAZA Integrative Orthologycell surface ENSG00000167207
GO:0044422
IEA
PLAZA Integrative Orthologyorganelle part ENSG00000167207
GO:0044428
IEA
PLAZA Integrative Orthologynuclear part ENSG00000167207
GO:0032991
IEA
PLAZA Integrative Orthologyprotein-containing complex ENSG00000167207
GO:0005794
IEA
PLAZA Integrative OrthologyGolgi apparatus ENSG00000167207
GO:0005856
IEA
PLAZA Integrative Orthologycytoskeleton ENSG00000167207
GO:0031982
IEA
PLAZA Integrative Orthologyvesicle ENSG00000167207
GO:0005634
IEA
PLAZA Integrative Orthologynucleus ENSG00000167207
GO:0044446
IEA
PLAZA Integrative Orthologyintracellular organelle part ENSG00000167207
GO:0043232
IEA
PLAZA Integrative Orthologyintracellular non-membrane-bounded organelle ENSG00000167207
GO:0008180
IEA
PLAZA Integrative OrthologyCOP9 signalosome ENSG00000167207
GO:0043231
IEA
PLAZA Integrative Orthologyintracellular membrane-bounded organelle ENSG00000167207
GO:0043227
IEA
PLAZA Integrative Orthologymembrane-bounded organelle ENSG00000167207
GO:0043228
IEA
PLAZA Integrative Orthologynon-membrane-bounded organelle ENSG00000167207
GO:0043226
IEA
PLAZA Integrative Orthologyorganelle ENSG00000167207
GO:0043229
IEA
PLAZA Integrative Orthologyintracellular organelle ENSG00000167207

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001315CARD domain
IPR001611Leucine-rich repeat
IPR007111NACHT nucleoside triphosphatase
IPR011029Death-like domain superfamily

No MapMan annotations defined for this gene.
KeggID Description
K08727NOD1, CARD4; nucleotide-binding oligomerization domain-containing protein 1
No chloroplast target sequence found.