Gene: ENSG00000105483 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000105483
Transcript Identifier
ENST00000519940
Gene Type
Coding gene
Location
19 : 48211710-48241020 : negative

Family Information

Homologous gene family
HOM02SEM000951
(50 genes in 5 species)
specific family

Descriptions

gene_descr
caspase recruitment domain family, member 8

Identifiers

Type Value
pidENSP00000428883
HGNC17057
UniprotQ9Y2G2

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0050718
IDA
Genome Projectpositive regulation of interleukin-1 beta secretion
GO:0050718
IDA
Gene Ontologypositive regulation of interleukin-1 beta secretion1
GO:0043280
IDA
Genome Projectpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043280
IDA
Gene Ontologypositive regulation of cysteine-type endopeptidase activity involved in apoptotic process1 2
GO:0043124
IDA
Genome Projectnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124
IDA
Gene Ontologynegative regulation of I-kappaB kinase/NF-kappaB signaling3
GO:0006919
IEA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915
IEA
Genome Projectapoptotic process
GO:0097340
IDA
Gene Ontologyinhibition of cysteine-type endopeptidase activity2
GO:0050713
IDA
Gene Ontologynegative regulation of interleukin-1 beta secretion2
GO:0032088
IMP
Gene Ontologynegative regulation of NF-kappaB transcription factor activity2
GO:0031665
IDA
Gene Ontologynegative regulation of lipopolysaccharide-mediated signaling pathway2
GO:0010804
IMP
Gene Ontologynegative regulation of tumor necrosis factor-mediated signaling pathway2
GO:0070997
IEA
PLAZA Integrative Orthologyneuron death ENSG00000091592
GO:0031347
IEA
PLAZA Integrative Orthologyregulation of defense response ENSG00000091592
GO:0071840
IEA
PLAZA Integrative Orthologycellular component organization or biogenesis ENSG00000091592
GO:0050727
IEA
PLAZA Integrative Orthologyregulation of inflammatory response ENSG00000091592
GO:0016043
IEA
PLAZA Integrative Orthologycellular component organization ENSG00000091592
GO:0006950
IEA
PLAZA Integrative Orthologyresponse to stress ENSG00000091592
GO:0006952
IEA
PLAZA Integrative Orthologydefense response ENSG00000091592
GO:1904784
IEA
PLAZA Integrative OrthologyNLRP1 inflammasome complex assembly ENSG00000091592
GO:0065003
IEA
PLAZA Integrative Orthologyprotein-containing complex assembly ENSG00000091592
GO:0043933
IEA
PLAZA Integrative Orthologyprotein-containing complex subunit organization ENSG00000091592
GO:0051402
IEA
PLAZA Integrative Orthologyneuron apoptotic process ENSG00000091592
GO:0044085
IEA
PLAZA Integrative Orthologycellular component biogenesis ENSG00000091592
GO:0006954
IEA
PLAZA Integrative Orthologyinflammatory response ENSG00000091592
GO:0080134
IEA
PLAZA Integrative Orthologyregulation of response to stress ENSG00000091592
GO:0022607
IEA
PLAZA Integrative Orthologycellular component assembly ENSG00000091592

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0042803
IDA
Genome Projectprotein homodimerization activity
GO:0042803
IDA
Gene Ontologyprotein homodimerization activity1
GO:0032089
IPI
Genome ProjectNACHT domain binding
GO:0032089
IPI
Gene OntologyNACHT domain binding1
GO:0008656
IDA
Genome Projectcysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008656
IDA
Gene Ontologycysteine-type endopeptidase activator activity involved in apoptotic process1
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding1 3
GO:0050700
IPI
Gene OntologyCARD domain binding2
GO:0019899
IEA
PLAZA Integrative Orthologyenzyme binding ENSG00000091592
GO:0032555
IEA
PLAZA Integrative Orthologypurine ribonucleotide binding ENSG00000091592
GO:0030554
IEA
PLAZA Integrative Orthologyadenyl nucleotide binding ENSG00000091592
GO:0032553
IEA
PLAZA Integrative Orthologyribonucleotide binding ENSG00000091592
GO:0017076
IEA
PLAZA Integrative Orthologypurine nucleotide binding ENSG00000091592
GO:0097159
IEA
PLAZA Integrative Orthologyorganic cyclic compound binding ENSG00000091592
GO:0032559
IEA
PLAZA Integrative Orthologyadenyl ribonucleotide binding ENSG00000091592
GO:0097367
IEA
PLAZA Integrative Orthologycarbohydrate derivative binding ENSG00000091592
GO:0035639
IEA
PLAZA Integrative Orthologypurine ribonucleoside triphosphate binding ENSG00000091592
GO:0005524
IEA
PLAZA Integrative OrthologyATP binding ENSG00000091592
GO:0000166
IEA
PLAZA Integrative Orthologynucleotide binding ENSG00000091592
GO:0043168
IEA
PLAZA Integrative Orthologyanion binding ENSG00000091592
GO:0036094
IEA
PLAZA Integrative Orthologysmall molecule binding ENSG00000091592
GO:0043167
IEA
PLAZA Integrative Orthologyion binding ENSG00000091592
GO:1901265
IEA
PLAZA Integrative Orthologynucleoside phosphate binding ENSG00000091592
GO:0008144
IEA
PLAZA Integrative Orthologydrug binding ENSG00000091592
GO:1901363
IEA
PLAZA Integrative Orthologyheterocyclic compound binding ENSG00000091592

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0072559
IDA
Genome ProjectNLRP3 inflammasome complex
GO:0072559
IDA
Gene OntologyNLRP3 inflammasome complex1
GO:0005829
IDA
Genome Projectcytosol
GO:0005829
IDA
Gene Ontologycytosol
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm1
GO:0005654
IDA
Genome Projectnucleoplasm
GO:0005654
IDA
Gene Ontologynucleoplasm
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus3
GO:0032991
IDA
Gene Ontologyprotein-containing complex2
GO:0072558
IEA
PLAZA Integrative OrthologyNLRP1 inflammasome complex ENSG00000091592

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001315CARD domain
IPR011029Death-like domain superfamily
IPR025307FIIND domain

No MapMan annotations defined for this gene.
KeggID Description
K12801CARD8, CARDINAL; caspase recruitment domain-containing protein 8
No chloroplast target sequence found.