Gene: ENSG00000104689 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000104689
Transcript Identifier
ENST00000221132
Gene Type
Coding gene
Location
8 : 23191694-23225061 : negative

Family Information

Homologous gene family
HOM02SEM017726
(4 genes in 1 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
tumor necrosis factor receptor superfamily, member 10a

Identifiers

Type Value
pidENSP00000221132
HGNC11904
UniprotO00220
RefSeq_mRNANM_003844.3
EMBLCHEMBL3551
EMBLAC100861
EMBLAK291299
EMBLBC012866
EMBLBT006906
EMBLEF064713
EMBLU90875

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1902042
TAS
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042
TAS
Gene Ontologynegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902041
TAS
Genome Projectregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902041
TAS
Gene Ontologyregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0097296
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097191
IDA
Genome Projectextrinsic apoptotic signaling pathway
GO:0097191
IDA
Gene Ontologyextrinsic apoptotic signaling pathway1
GO:0071260
IEP
Genome Projectcellular response to mechanical stimulus
GO:0071260
IEP
Gene Ontologycellular response to mechanical stimulus2
GO:0050900
TAS
Genome Projectleukocyte migration
GO:0050900
TAS
Gene Ontologyleukocyte migration
GO:0042981
IBA
TAS
Genome Projectregulation of apoptotic process
GO:0042981
TAS
Gene Ontologyregulation of apoptotic process
GO:0042127
IBA
Genome Projectregulation of cell proliferation
GO:0036462
IDA
Genome ProjectTRAIL-activated apoptotic signaling pathway
GO:0036462
IDA
Gene OntologyTRAIL-activated apoptotic signaling pathway1
GO:0033209
IEA
Genome Projecttumor necrosis factor-mediated signaling pathway
GO:0032496
IBA
Genome Projectresponse to lipopolysaccharide
GO:0008625
NAS
Genome Projectextrinsic apoptotic signaling pathway via death domain receptors
GO:0008625
NAS
Gene Ontologyextrinsic apoptotic signaling pathway via death domain receptors3
GO:0007275
IBA
Genome Projectmulticellular organism development
GO:0007250
NAS
Genome Projectactivation of NF-kappaB-inducing kinase activity
GO:0007250
NAS
Gene Ontologyactivation of NF-kappaB-inducing kinase activity4 5
GO:0007166
TAS
Genome Projectcell surface receptor signaling pathway
GO:0007166
TAS
Gene Ontologycell surface receptor signaling pathway
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007165
TAS
Gene Ontologysignal transduction6
GO:0006955
IBA
Genome Projectimmune response
GO:0006954
IBA
Genome Projectinflammatory response
GO:0006919
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
TAS
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915
NAS
Genome Projectapoptotic process
GO:0006915
NAS
Gene Ontologyapoptotic process3
GO:0034976
IEA
PLAZA Integrative Orthologyresponse to endoplasmic reticulum stress ENSG00000120889
GO:0007249
IEA
PLAZA Integrative OrthologyI-kappaB kinase/NF-kappaB signaling ENSG00000120889
GO:0070059
IEA
PLAZA Integrative Orthologyintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ENSG00000120889
GO:0097193
IEA
PLAZA Integrative Orthologyintrinsic apoptotic signaling pathway ENSG00000120889
GO:0033554
IEA
PLAZA Integrative Orthologycellular response to stress ENSG00000120889
GO:0043122
IEA
PLAZA Integrative Orthologyregulation of I-kappaB kinase/NF-kappaB signaling ENSG00000120889
GO:0043123
IEA
PLAZA Integrative Orthologypositive regulation of I-kappaB kinase/NF-kappaB signaling ENSG00000120889

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0045569
NAS
Genome ProjectTRAIL binding
GO:0045569
NAS
Gene OntologyTRAIL binding7
GO:0008134
IPI
Genome Projecttranscription factor binding
GO:0008134
IPI
Gene Ontologytranscription factor binding8
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding1 8 9 10 11
GO:0005035
TAS
Genome Projectdeath receptor activity
GO:0005035
TAS
Gene Ontologydeath receptor activity6
GO:0005031
IBA
Genome Projecttumor necrosis factor-activated receptor activity
GO:0002020
IPI
Genome Projectprotease binding
GO:0002020
IPI
Gene Ontologyprotease binding1
GO:0038023
NAS
Gene Ontologysignaling receptor activity3

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0016021
IC
Genome Projectintegral component of membrane
GO:0009986
IDA
Genome Projectcell surface
GO:0009986
IDA
Gene Ontologycell surface12
GO:0005887
IBA
Genome Projectintegral component of plasma membrane
GO:0005886
TAS
Genome Projectplasma membrane
GO:0005886
TAS
Gene Ontologyplasma membrane
GO:0005622
IEA
Genome Projectintracellular

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000488Death domain
IPR001368TNFR/NGFR cysteine-rich region
IPR011029Death-like domain superfamily
IPR020465Tumour necrosis factor receptor 10
IPR034024Tumor necrosis factor receptor 10, N-terminal
IPR034029Tumour necrosis factor receptor 10A/B, death domain

No MapMan annotations defined for this gene.
KeggID Description
K04722CD262, TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b
No chloroplast target sequence found.