Gene: ENSG00000103496 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000103496
Transcript Identifier
ENST00000313843
Gene Type
Coding gene
Location
16 : 31033806-31039803 : positive

Family Information

Homologous gene family
HOM02SEM001270
(42 genes in 22 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
syntaxin 4

Identifiers

Type Value
pidENSP00000317714
HGNC11439
UniprotQ12846
RefSeq_mRNANM_001272095.1
RefSeq_mRNANM_004604.4
EMBLAC135050
EMBLAF026007
EMBLAF318489
EMBLAJ000541
EMBLAK091833
EMBLAK315716
EMBLBC002436
EMBLBT007326
EMBLCH471192
EMBLCR541806
EMBLU07158
EMBLX85784

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2000010
IMP
Genome Projectpositive regulation of protein localization to cell surface
GO:2000010
IMP
Gene Ontologypositive regulation of protein localization to cell surface1
GO:1990668
TAS
Genome Projectvesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
GO:1990668
TAS
Gene Ontologyvesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
GO:1903078
IMP
Genome Projectpositive regulation of protein localization to plasma membrane
GO:1903078
IMP
Gene Ontologypositive regulation of protein localization to plasma membrane1 2 3
GO:1902041
IMP
Genome Projectregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902041
IMP
Gene Ontologyregulation of extrinsic apoptotic signaling pathway via death domain receptors3
GO:0060291
IDA
Genome Projectlong-term synaptic potentiation
GO:0060291
IDA
Gene Ontologylong-term synaptic potentiation4
GO:0051024
IMP
Genome Projectpositive regulation of immunoglobulin secretion
GO:0051024
IMP
Gene Ontologypositive regulation of immunoglobulin secretion5
GO:0050921
IMP
Genome Projectpositive regulation of chemotaxis
GO:0050921
IMP
Gene Ontologypositive regulation of chemotaxis1
GO:0048284
IDA
Genome Projectorganelle fusion
GO:0048284
IDA
Gene Ontologyorganelle fusion4
GO:0048278
IBA
Genome Projectvesicle docking
GO:0045785
IMP
Genome Projectpositive regulation of cell adhesion
GO:0045785
IMP
Gene Ontologypositive regulation of cell adhesion1
GO:0043311
IMP
Genome Projectpositive regulation of eosinophil degranulation
GO:0043311
IMP
Gene Ontologypositive regulation of eosinophil degranulation6
GO:0043085
IMP
Genome Projectpositive regulation of catalytic activity
GO:0043085
IMP
Gene Ontologypositive regulation of catalytic activity3
GO:0035774
IDA, IMP
Genome Projectpositive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0035774
IDA, IMP
Gene Ontologypositive regulation of insulin secretion involved in cellular response to glucose stimulus7 8
GO:0035493
IEA
Genome ProjectSNARE complex assembly
GO:0033194
IDA
Genome Projectresponse to hydroperoxide
GO:0033194
IDA
Gene Ontologyresponse to hydroperoxide9
GO:0031629
IBA
Genome Projectsynaptic vesicle fusion to presynaptic active zone membrane
GO:0030335
IMP
Genome Projectpositive regulation of cell migration
GO:0030335
IMP
Gene Ontologypositive regulation of cell migration2
GO:0017157
IMP
Genome Projectregulation of exocytosis
GO:0017157
IMP
Gene Ontologyregulation of exocytosis4
GO:0008284
IMP
Genome Projectpositive regulation of cell proliferation
GO:0008284
IMP
Gene Ontologypositive regulation of cell proliferation1
GO:0006892
TAS
Genome Projectpost-Golgi vesicle-mediated transport
GO:0006886
IBA
Genome Projectintracellular protein transport
GO:0030435
IEA
PLAZA Integrative Orthologysporulation resulting in formation of a cellular spore SPCC825.03c
GO:0010564
IEA
PLAZA Integrative Orthologyregulation of cell cycle process WBGene00006374
GO:0051239
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal process FBgn0024980
GO:0030154
IEA
PLAZA Integrative Orthologycell differentiation SPCC825.03c
GO:0030437
IEA
PLAZA Integrative Orthologyascospore formation SPCC825.03c
GO:0048869
IEA
PLAZA Integrative Orthologycellular developmental process SPCC825.03c
GO:0007049
IEA
PLAZA Integrative Orthologycell cycle SPCC825.03c
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction SPCC825.03c
GO:0048589
IEA
PLAZA Integrative Orthologydevelopmental growth FBgn0024980
GO:0048468
IEA
PLAZA Integrative Orthologycell development SPCC825.03c
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process SPCC825.03c
GO:0044703
IEA
PLAZA Integrative Orthologymulti-organism reproductive process SPCC825.03c
GO:0022413
IEA
PLAZA Integrative Orthologyreproductive process in single-celled organism SPCC825.03c
GO:0032501
IEA
PLAZA Integrative Orthologymulticellular organismal process WBGene00006372
GO:0032467
IEA
PLAZA Integrative Orthologypositive regulation of cytokinesis WBGene00006374
GO:0032502
IEA
PLAZA Integrative Orthologydevelopmental process SPCC825.03c
GO:0098917
IEA
PLAZA Integrative Orthologyretrograde trans-synaptic signaling FBgn0024980
GO:0032465
IEA
PLAZA Integrative Orthologyregulation of cytokinesis WBGene00006374
GO:0050890
IEA
PLAZA Integrative Orthologycognition WBGene00006372
GO:0032989
IEA
PLAZA Integrative Orthologycellular component morphogenesis SPCC825.03c
GO:0098876
IEA
PLAZA Integrative Orthologyvesicle-mediated transport to the plasma membrane YMR183C
GO:0032505
IEA
PLAZA Integrative Orthologyreproduction of a single-celled organism SPCC825.03c
GO:0060468
IEA
PLAZA Integrative Orthologyprevention of polyspermy WBGene00006374
GO:0060467
IEA
PLAZA Integrative Orthologynegative regulation of fertilization WBGene00006374
GO:0000910
IEA
PLAZA Integrative Orthologycytokinesis WBGene00006374
GO:0007399
IEA
PLAZA Integrative Orthologynervous system development FBgn0024980
GO:0048856
IEA
PLAZA Integrative Orthologyanatomical structure development SPCC825.03c
GO:0007275
IEA
PLAZA Integrative Orthologymulticellular organism development FBgn0024980
GO:0080154
IEA
PLAZA Integrative Orthologyregulation of fertilization WBGene00006374
GO:1904396
IEA
PLAZA Integrative Orthologyregulation of neuromuscular junction development FBgn0024980
GO:0044091
IEA
PLAZA Integrative Orthologymembrane biogenesis SPCC825.03c
GO:0019953
IEA
PLAZA Integrative Orthologysexual reproduction SPCC825.03c
GO:0050803
IEA
PLAZA Integrative Orthologyregulation of synapse structure or activity FBgn0024980
GO:0007614
IEA
PLAZA Integrative Orthologyshort-term memory WBGene00006372
GO:0048731
IEA
PLAZA Integrative Orthologysystem development FBgn0024980
GO:0007343
IEA
PLAZA Integrative Orthologyegg activation WBGene00006374
GO:0050808
IEA
PLAZA Integrative Orthologysynapse organization FBgn0024980
GO:0006893
IEA
PLAZA Integrative OrthologyGolgi to plasma membrane transport YMR183C
GO:0050807
IEA
PLAZA Integrative Orthologyregulation of synapse organization FBgn0024980
GO:0032120
IEA
PLAZA Integrative Orthologyascospore-type prospore membrane assembly SPCC825.03c
GO:0050877
IEA
PLAZA Integrative Orthologynervous system process WBGene00006372
GO:0051963
IEA
PLAZA Integrative Orthologyregulation of synapse assembly FBgn0024980
GO:0051726
IEA
PLAZA Integrative Orthologyregulation of cell cycle WBGene00006374
GO:0044087
IEA
PLAZA Integrative Orthologyregulation of cellular component biogenesis FBgn0024980
GO:0003008
IEA
PLAZA Integrative Orthologysystem process WBGene00006372
GO:0051960
IEA
PLAZA Integrative Orthologyregulation of nervous system development FBgn0024980
GO:0051321
IEA
PLAZA Integrative Orthologymeiotic cell cycle SPCC825.03c
GO:0007611
IEA
PLAZA Integrative Orthologylearning or memory WBGene00006372
GO:0003006
IEA
PLAZA Integrative Orthologydevelopmental process involved in reproduction SPCC825.03c
GO:0007610
IEA
PLAZA Integrative Orthologybehavior WBGene00006372
GO:0007613
IEA
PLAZA Integrative Orthologymemory WBGene00006372
GO:1903046
IEA
PLAZA Integrative Orthologymeiotic cell cycle process SPCC825.03c
GO:0007338
IEA
PLAZA Integrative Orthologysingle fertilization WBGene00006374
GO:2000026
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal development FBgn0024980
GO:0031321
IEA
PLAZA Integrative Orthologyascospore-type prospore assembly SPCC825.03c
GO:0010927
IEA
PLAZA Integrative Orthologycellular component assembly involved in morphogenesis SPCC825.03c
GO:0071709
IEA
PLAZA Integrative Orthologymembrane assembly SPCC825.03c
GO:0043935
IEA
PLAZA Integrative Orthologysexual sporulation resulting in formation of a cellular spore SPCC825.03c
GO:0043934
IEA
PLAZA Integrative Orthologysporulation SPCC825.03c
GO:0051705
IEA
PLAZA Integrative Orthologymulti-organism behavior FBgn0024980
GO:0051704
IEA
PLAZA Integrative Orthologymulti-organism process SPCC825.03c
GO:0051781
IEA
PLAZA Integrative Orthologypositive regulation of cell division WBGene00006374
GO:0051302
IEA
PLAZA Integrative Orthologyregulation of cell division WBGene00006374
GO:0051301
IEA
PLAZA Integrative Orthologycell division WBGene00006374
GO:0099097
IEA
PLAZA Integrative Orthologyprospore membrane biogenesis SPCC825.03c
GO:0009653
IEA
PLAZA Integrative Orthologyanatomical structure morphogenesis SPCC825.03c
GO:0045787
IEA
PLAZA Integrative Orthologypositive regulation of cell cycle WBGene00006374
GO:0034293
IEA
PLAZA Integrative Orthologysexual sporulation SPCC825.03c
GO:2000242
IEA
PLAZA Integrative Orthologynegative regulation of reproductive process WBGene00006374
GO:0007416
IEA
PLAZA Integrative Orthologysynapse assembly FBgn0024980
GO:0040007
IEA
PLAZA Integrative Orthologygrowth FBgn0024980
GO:0040008
IEA
PLAZA Integrative Orthologyregulation of growth FBgn0024980
GO:0009566
IEA
PLAZA Integrative Orthologyfertilization WBGene00006374
GO:0048646
IEA
PLAZA Integrative Orthologyanatomical structure formation involved in morphogenesis SPCC825.03c
GO:0090068
IEA
PLAZA Integrative Orthologypositive regulation of cell cycle process WBGene00006374
GO:0060471
IEA
PLAZA Integrative Orthologycortical granule exocytosis WBGene00006374
GO:0051128
IEA
PLAZA Integrative Orthologyregulation of cellular component organization FBgn0024980
GO:0002118
IEA
PLAZA Integrative Orthologyaggressive behavior FBgn0024980
GO:0051124
IEA
PLAZA Integrative Orthologysynaptic growth at neuromuscular junction FBgn0024980
GO:0050793
IEA
PLAZA Integrative Orthologyregulation of developmental process FBgn0024980
GO:0007528
IEA
PLAZA Integrative Orthologyneuromuscular junction development FBgn0024980
GO:0048638
IEA
PLAZA Integrative Orthologyregulation of developmental growth FBgn0024980
GO:0002121
IEA
PLAZA Integrative Orthologyinter-male aggressive behavior FBgn0024980
GO:0048519
IEA
PLAZA Integrative Orthologynegative regulation of biological process WBGene00006374
GO:0022402
IEA
PLAZA Integrative Orthologycell cycle process SPCC825.03c
GO:0008582
IEA
PLAZA Integrative Orthologyregulation of synaptic growth at neuromuscular junction FBgn0024980
GO:2000241
IEA
PLAZA Integrative Orthologyregulation of reproductive process WBGene00006374
GO:0043900
IEA
PLAZA Integrative Orthologyregulation of multi-organism process WBGene00006374
GO:0043901
IEA
PLAZA Integrative Orthologynegative regulation of multi-organism process WBGene00006374
GO:0019221
TAS
Gene Ontologycytokine-mediated signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0016230
IMP
Genome Projectsphingomyelin phosphodiesterase activator activity
GO:0016230
IMP
Gene Ontologysphingomyelin phosphodiesterase activator activity3
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding6 7 10 11 12 13 14 15 16
GO:0005484
IBA
Genome ProjectSNAP receptor activity
GO:0000149
IBA
Genome ProjectSNARE binding
GO:1902936
IEA
PLAZA Integrative Orthologyphosphatidylinositol bisphosphate binding YPL232W
GO:0005543
IEA
PLAZA Integrative Orthologyphospholipid binding YMR183C
GO:0070300
IEA
PLAZA Integrative Orthologyphosphatidic acid binding YMR183C
GO:0043325
IEA
PLAZA Integrative Orthologyphosphatidylinositol-3,4-bisphosphate binding YPL232W
GO:0043168
IEA
PLAZA Integrative Orthologyanion binding YMR183C
GO:0043167
IEA
PLAZA Integrative Orthologyion binding YMR183C
GO:0005546
IEA
PLAZA Integrative Orthologyphosphatidylinositol-4,5-bisphosphate binding YPL232W
GO:0035091
IEA
PLAZA Integrative Orthologyphosphatidylinositol binding YPL232W
GO:0008289
IEA
PLAZA Integrative Orthologylipid binding YMR183C
GO:0080025
IEA
PLAZA Integrative Orthologyphosphatidylinositol-3,5-bisphosphate binding YPL232W
GO:1901981
IEA
PLAZA Integrative Orthologyphosphatidylinositol phosphate binding YPL232W

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0070062
Gene Ontologyextracellular exosome17
GO:0048471
IEA
Genome Projectperinuclear region of cytoplasm
GO:0045202
IDA
Genome Projectsynapse
GO:0045202
IDA
Gene Ontologysynapse4
GO:0043219
IEA
Genome Projectlateral loop
GO:0043197
IDA
Genome Projectdendritic spine
GO:0043197
IDA
Gene Ontologydendritic spine4
GO:0042581
IDA
Genome Projectspecific granule
GO:0042581
IDA
Gene Ontologyspecific granule18
GO:0036477
IDA
Genome Projectsomatodendritic compartment
GO:0036477
IDA
Gene Ontologysomatodendritic compartment4
GO:0035749
IEA
Genome Projectmyelin sheath adaxonal region
GO:0031201
IDA
Genome ProjectSNARE complex
GO:0031201
IDA
Gene OntologySNARE complex10 19
GO:0030670
TAS
Genome Projectphagocytic vesicle membrane
GO:0030670
TAS
Gene Ontologyphagocytic vesicle membrane
GO:0030027
IDA
Genome Projectlamellipodium
GO:0030027
IDA
Gene Ontologylamellipodium1
GO:0016323
IDA
Genome Projectbasolateral plasma membrane
GO:0016323
IDA
Gene Ontologybasolateral plasma membrane20
GO:0016021
IBA
Genome Projectintegral component of membrane
GO:0016020
IDA
Genome Projectmembrane
GO:0016020
IDA
Gene Ontologymembrane21
GO:0009986
IDA
Genome Projectcell surface
GO:0009986
IDA
Gene Ontologycell surface4 11
GO:0008021
IBA
Genome Projectsynaptic vesicle
GO:0005886
IDA
TAS
Genome Projectplasma membrane
GO:0005886
IDA
TAS
Gene Ontologyplasma membrane1 3
GO:0005829
TAS
Genome Projectcytosol
GO:0005829
TAS
Gene Ontologycytosol
GO:0005802
IEA
Genome Projecttrans-Golgi network
GO:0005773
TAS
Genome Projectvacuole
GO:0005773
TAS
Gene Ontologyvacuole20
GO:0005768
IDA
Genome Projectendosome
GO:0005768
IDA
Gene Ontologyendosome3
GO:0005622
IDA
Genome Projectintracellular
GO:0005622
IDA
Gene Ontologyintracellular5
GO:0005615
IDA
Genome Projectextracellular space
GO:0005615
IDA
Gene Ontologyextracellular space9
GO:0000322
IEA
Genome Projectstorage vacuole
GO:0045121
IEA
PLAZA Integrative Orthologymembrane raft SPCC825.03c
GO:0042764
IEA
PLAZA Integrative Orthologyascospore-type prospore SPCC825.03c
GO:0042763
IEA
PLAZA Integrative Orthologyintracellular immature spore SPCC825.03c
GO:0005783
IEA
PLAZA Integrative Orthologyendoplasmic reticulum YMR183C
GO:0005887
IEA
PLAZA Integrative Orthologyintegral component of plasma membrane WBGene00006374
GO:0005774
IEA
PLAZA Integrative Orthologyvacuolar membrane YPL232W
GO:0097060
IEA
PLAZA Integrative Orthologysynaptic membrane FBgn0024980
GO:0045211
IEA
PLAZA Integrative Orthologypostsynaptic membrane FBgn0024980
GO:0051286
IEA
PLAZA Integrative Orthologycell tip SPCC825.03c
GO:0070056
IEA
PLAZA Integrative Orthologyprospore membrane leading edge SPCC825.03c
GO:0070057
IEA
PLAZA Integrative Orthologyprospore membrane spindle pole body attachment site SPCC825.03c
GO:0000324
IEA
PLAZA Integrative Orthologyfungal-type vacuole YPL232W
GO:0000323
IEA
PLAZA Integrative Orthologylytic vacuole YPL232W
GO:0000329
IEA
PLAZA Integrative Orthologyfungal-type vacuole membrane YPL232W
GO:0044853
IEA
PLAZA Integrative Orthologyplasma membrane raft SPCC825.03c
GO:0032154
IEA
PLAZA Integrative Orthologycleavage furrow WBGene00006374
GO:0032153
IEA
PLAZA Integrative Orthologycell division site SPCC825.03c
GO:0031226
IEA
PLAZA Integrative Orthologyintrinsic component of plasma membrane WBGene00006374
GO:0032155
IEA
PLAZA Integrative Orthologycell division site part WBGene00006374
GO:0098589
IEA
PLAZA Integrative Orthologymembrane region SPCC825.03c
GO:0060473
IEA
PLAZA Integrative Orthologycortical granule WBGene00006374
GO:0098857
IEA
PLAZA Integrative Orthologymembrane microdomain SPCC825.03c
GO:0098852
IEA
PLAZA Integrative Orthologylytic vacuole membrane YPL232W
GO:0005628
IEA
PLAZA Integrative Orthologyprospore membrane SPCC825.03c
GO:0044437
IEA
PLAZA Integrative Orthologyvacuolar part YPL232W
GO:0098978
EXP, IDA
Gene Ontologyglutamatergic synapse22
GO:0098794
EXP, IDA
Gene Ontologypostsynapse22

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000727Target SNARE coiled-coil homology domain
IPR006011Syntaxin, N-terminal domain
IPR006012Syntaxin/epimorphin, conserved site
IPR010989SNARE

No MapMan annotations defined for this gene.
KeggID Description
K13502STX4; syntaxin 4
No chloroplast target sequence found.