Gene: ENSG00000103490 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000103490
Transcript Identifier
ENST00000247470
Gene Type
Coding gene
Location
16 : 31201585-31202690 : negative

Family Information

Homologous gene family
HOM02SEM032823
(2 genes in 1 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
PYD and CARD domain containing

Identifiers

Type Value
pidENSP00000247470
HGNC16608
UniprotQ9ULZ3
RefSeq_mRNANM_013258.4
EMBLAB023416
EMBLAF184072
EMBLAF184073
EMBLAF255794
EMBLAF310103
EMBLAF384665
EMBLAK000211
EMBLBC004470
EMBLBC013569

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2001242
IDA
Genome Projectregulation of intrinsic apoptotic signaling pathway
GO:2001242
IDA
Gene Ontologyregulation of intrinsic apoptotic signaling pathway1
GO:2001238
IDA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway
GO:2001238
IDA
Gene Ontologypositive regulation of extrinsic apoptotic signaling pathway2
GO:2001181
IMP
Genome Projectpositive regulation of interleukin-10 secretion
GO:2001181
IMP
Gene Ontologypositive regulation of interleukin-10 secretion3
GO:2001056
IDA
Genome Projectpositive regulation of cysteine-type endopeptidase activity
GO:2001056
IDA
Gene Ontologypositive regulation of cysteine-type endopeptidase activity4
GO:2000778
IMP
Genome Projectpositive regulation of interleukin-6 secretion
GO:2000778
IMP
Gene Ontologypositive regulation of interleukin-6 secretion3
GO:2000484
IMP
Genome Projectpositive regulation of interleukin-8 secretion
GO:2000484
IMP
Gene Ontologypositive regulation of interleukin-8 secretion3
GO:2000406
ISS
Genome Projectpositive regulation of T cell migration
GO:2000406
ISS
Gene Ontologypositive regulation of T cell migration
GO:0090200
IDA
Genome Projectpositive regulation of release of cytochrome c from mitochondria
GO:0090200
IDA
Gene Ontologypositive regulation of release of cytochrome c from mitochondria1
GO:0090197
IMP
Genome Projectpositive regulation of chemokine secretion
GO:0090197
IMP
Gene Ontologypositive regulation of chemokine secretion5
GO:0072332
IMP
Genome Projectintrinsic apoptotic signaling pathway by p53 class mediator
GO:0072332
IMP
Gene Ontologyintrinsic apoptotic signaling pathway by p53 class mediator1
GO:0071901
IDA
Genome Projectnegative regulation of protein serine/threonine kinase activity
GO:0071901
IDA
Gene Ontologynegative regulation of protein serine/threonine kinase activity6
GO:0071356
IDA
Genome Projectcellular response to tumor necrosis factor
GO:0071356
IDA
Gene Ontologycellular response to tumor necrosis factor6
GO:0071347
IDA
Genome Projectcellular response to interleukin-1
GO:0071347
IDA
Gene Ontologycellular response to interleukin-16
GO:0071222
IDA
Genome Projectcellular response to lipopolysaccharide
GO:0071222
IDA
Gene Ontologycellular response to lipopolysaccharide6
GO:0070374
IMP
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0070374
IMP
Gene Ontologypositive regulation of ERK1 and ERK2 cascade5
GO:0051607
IDA
Genome Projectdefense response to virus
GO:0051607
IDA
Gene Ontologydefense response to virus7
GO:0051092
IDA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051092
IDA, IPI
Gene Ontologypositive regulation of NF-kappaB transcription factor activity8 9 10
GO:0051091
IDA
Genome Projectpositive regulation of DNA-binding transcription factor activity
GO:0051091
IDA
Gene Ontologypositive regulation of DNA-binding transcription factor activity11
GO:0050870
IMP
Genome Projectpositive regulation of T cell activation
GO:0050870
IMP
Gene Ontologypositive regulation of T cell activation12
GO:0050829
IMP
Genome Projectdefense response to Gram-negative bacterium
GO:0050829
IMP
Gene Ontologydefense response to Gram-negative bacterium3 5
GO:0050766
ISS
Genome Projectpositive regulation of phagocytosis
GO:0050766
ISS
Gene Ontologypositive regulation of phagocytosis
GO:0050718
IDA
Genome Projectpositive regulation of interleukin-1 beta secretion
GO:0050718
IDA
Gene Ontologypositive regulation of interleukin-1 beta secretion13
GO:0046330
IMP
Genome Projectpositive regulation of JNK cascade
GO:0046330
IMP
Gene Ontologypositive regulation of JNK cascade5
GO:0045087
IEA
Genome Projectinnate immune response
GO:0044351
ISS
Genome Projectmacropinocytosis
GO:0044351
ISS
Gene Ontologymacropinocytosis
GO:0043312
TAS
Genome Projectneutrophil degranulation
GO:0043312
TAS
Gene Ontologyneutrophil degranulation
GO:0043280
IDA
Genome Projectpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043280
IDA
Gene Ontologypositive regulation of cysteine-type endopeptidase activity involved in apoptotic process13
GO:0043124
IDA
Genome Projectnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124
IDA
Gene Ontologynegative regulation of I-kappaB kinase/NF-kappaB signaling6
GO:0043065
IDA
Genome Projectpositive regulation of apoptotic process
GO:0043065
IDA
Gene Ontologypositive regulation of apoptotic process8
GO:0042771
IMP
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042771
IMP
Gene Ontologyintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator1
GO:0042104
ISS
Genome Projectpositive regulation of activated T cell proliferation
GO:0042104
ISS
Gene Ontologypositive regulation of activated T cell proliferation
GO:0033209
IDA
Genome Projecttumor necrosis factor-mediated signaling pathway
GO:0033209
IDA
Gene Ontologytumor necrosis factor-mediated signaling pathway9
GO:0032760
IMP
Genome Projectpositive regulation of tumor necrosis factor production
GO:0032760
IMP
Gene Ontologypositive regulation of tumor necrosis factor production3 5
GO:0032755
ISS
Genome Projectpositive regulation of interleukin-6 production
GO:0032755
ISS
Gene Ontologypositive regulation of interleukin-6 production
GO:0032729
ISS
Genome Projectpositive regulation of interferon-gamma production
GO:0032729
ISS
Gene Ontologypositive regulation of interferon-gamma production
GO:0032688
IMP
Genome Projectnegative regulation of interferon-beta production
GO:0032688
IMP
Gene Ontologynegative regulation of interferon-beta production14
GO:0032088
IMP
Genome Projectnegative regulation of NF-kappaB transcription factor activity
GO:0032088
IMP
Gene Ontologynegative regulation of NF-kappaB transcription factor activity15
GO:0031647
ISS
Genome Projectregulation of protein stability
GO:0031647
ISS
Gene Ontologyregulation of protein stability
GO:0030838
ISS
Genome Projectpositive regulation of actin filament polymerization
GO:0030838
ISS
Gene Ontologypositive regulation of actin filament polymerization
GO:0010803
IMP
Genome Projectregulation of tumor necrosis factor-mediated signaling pathway
GO:0010803
IMP
Gene Ontologyregulation of tumor necrosis factor-mediated signaling pathway1
GO:0007165
NAS
Genome Projectsignal transduction
GO:0007165
NAS
Gene Ontologysignal transduction16
GO:0006954
IEA
Genome Projectinflammatory response
GO:0006919
NAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
NAS
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process16
GO:0006915
TAS
Genome Projectapoptotic process
GO:0002821
IMP
Genome Projectpositive regulation of adaptive immune response
GO:0002821
IMP
Gene Ontologypositive regulation of adaptive immune response12
GO:0002588
ISS
Genome Projectpositive regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0002588
ISS
Gene Ontologypositive regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0002277
ISS
Genome Projectmyeloid dendritic cell activation involved in immune response
GO:0002277
ISS
Gene Ontologymyeloid dendritic cell activation involved in immune response
GO:0002218
IDA
Genome Projectactivation of innate immune response
GO:0002218
IDA
Gene Ontologyactivation of innate immune response7
GO:0001773
IMP
Genome Projectmyeloid dendritic cell activation
GO:0001773
IMP
Gene Ontologymyeloid dendritic cell activation12
GO:1900016
IMP
Gene Ontologynegative regulation of cytokine production involved in inflammatory response17
GO:0051260
IDA
Gene Ontologyprotein homooligomerization17
GO:0070997
IEA
PLAZA Integrative Orthologyneuron death ENSG00000091592
GO:0051402
IEA
PLAZA Integrative Orthologyneuron apoptotic process ENSG00000091592
GO:1904784
IEA
PLAZA Integrative OrthologyNLRP1 inflammasome complex assembly ENSG00000091592

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0097153
IBA
Genome Projectcysteine-type endopeptidase activity involved in apoptotic process
GO:0070700
IPI
Genome ProjectBMP receptor binding
GO:0070700
IPI
Gene OntologyBMP receptor binding18
GO:0042803
IDA
Genome Projectprotein homodimerization activity
GO:0042803
IDA
Gene Ontologyprotein homodimerization activity13
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042802
IPI
Gene Ontologyidentical protein binding19 20 21
GO:0032090
IPI
Genome ProjectPyrin domain binding
GO:0032090
IPI
Gene OntologyPyrin domain binding13
GO:0019899
IPI
Genome Projectenzyme binding
GO:0019899
IPI
Gene Ontologyenzyme binding18
GO:0017024
IPI
Genome Projectmyosin I binding
GO:0017024
IPI
Gene Ontologymyosin I binding18
GO:0008656
NAS
Genome Projectcysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008656
NAS
Gene Ontologycysteine-type endopeptidase activator activity involved in apoptotic process16
GO:0005523
IPI
Genome Projecttropomyosin binding
GO:0005523
IPI
Gene Ontologytropomyosin binding18
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding1 4 9 13 14 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33
GO:0005138
IPI
Genome Projectinterleukin-6 receptor binding
GO:0005138
IPI
Gene Ontologyinterleukin-6 receptor binding18
GO:0002020
IPI
Genome Projectprotease binding
GO:0002020
IPI
Gene Ontologyprotease binding18
GO:0046983
IDA
Gene Ontologyprotein dimerization activity17
GO:0032555
IEA
PLAZA Integrative Orthologypurine ribonucleotide binding ENSG00000091592
GO:0030554
IEA
PLAZA Integrative Orthologyadenyl nucleotide binding ENSG00000091592
GO:0032553
IEA
PLAZA Integrative Orthologyribonucleotide binding ENSG00000091592
GO:0017076
IEA
PLAZA Integrative Orthologypurine nucleotide binding ENSG00000091592
GO:0097367
IEA
PLAZA Integrative Orthologycarbohydrate derivative binding ENSG00000091592
GO:0097159
IEA
PLAZA Integrative Orthologyorganic cyclic compound binding ENSG00000091592
GO:0035639
IEA
PLAZA Integrative Orthologypurine ribonucleoside triphosphate binding ENSG00000091592
GO:0032559
IEA
PLAZA Integrative Orthologyadenyl ribonucleotide binding ENSG00000091592
GO:0005524
IEA
PLAZA Integrative OrthologyATP binding ENSG00000091592
GO:0000166
IEA
PLAZA Integrative Orthologynucleotide binding ENSG00000091592
GO:0043168
IEA
PLAZA Integrative Orthologyanion binding ENSG00000091592
GO:0036094
IEA
PLAZA Integrative Orthologysmall molecule binding ENSG00000091592
GO:0043167
IEA
PLAZA Integrative Orthologyion binding ENSG00000091592
GO:1901265
IEA
PLAZA Integrative Orthologynucleoside phosphate binding ENSG00000091592
GO:0008144
IEA
PLAZA Integrative Orthologydrug binding ENSG00000091592
GO:1901363
IEA
PLAZA Integrative Orthologyheterocyclic compound binding ENSG00000091592

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0008385
IDA
TAS
Genome ProjectIkappaB kinase complex
GO:0008385
IDA
TAS
Gene OntologyIkappaB kinase complex6 9
GO:0097169
IDA
Genome ProjectAIM2 inflammasome complex
GO:0097169
IDA
Gene OntologyAIM2 inflammasome complex4
GO:0072559
IDA
Genome ProjectNLRP3 inflammasome complex
GO:0072559
IDA
Gene OntologyNLRP3 inflammasome complex13
GO:0072558
IDA
Genome ProjectNLRP1 inflammasome complex
GO:0072558
IDA
Gene OntologyNLRP1 inflammasome complex34
GO:0035578
TAS
Genome Projectazurophil granule lumen
GO:0035578
TAS
Gene Ontologyazurophil granule lumen
GO:0034774
TAS
Genome Projectsecretory granule lumen
GO:0034774
TAS
Gene Ontologysecretory granule lumen
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005829
IDA
TAS
Gene Ontologycytosol
GO:0005783
IEA
Genome Projectendoplasmic reticulum
GO:0005739
IDA
Genome Projectmitochondrion
GO:0005739
IDA
Gene Ontologymitochondrion1
GO:0005737
IDA
NAS
Genome Projectcytoplasm
GO:0005737
IDA
NAS
Gene Ontologycytoplasm1 13 16 35
GO:0005730
IDA
Genome Projectnucleolus
GO:0005730
IDA
Gene Ontologynucleolus
GO:0005634
IDA
ISS
Genome Projectnucleus
GO:0005634
IDA
ISS
Gene Ontologynucleus
GO:0005576
TAS
Genome Projectextracellular region
GO:0005576
TAS
Gene Ontologyextracellular region
GO:0005654
IEA
PLAZA Integrative Orthologynucleoplasm ENSG00000091592

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001315CARD domain
IPR004020DAPIN domain
IPR011029Death-like domain superfamily
IPR033516CARD8/ASC/NALP1, CARD domain

No MapMan annotations defined for this gene.
KeggID Description
K12799PYCARD, ASC; apoptosis-associated speck-like protein containing a CARD
No chloroplast target sequence found.