Gene: ENSG00000103266 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000103266
Transcript Identifier
ENST00000219548
Gene Type
Coding gene
Location
16 : 680526-682489 : positive

Family Information

Homologous gene family
HOM02SEM011441
(7 genes in 5 species)
specific family

Descriptions

gene_descr
STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase

Identifiers

Type Value
pidENSP00000219548
HGNC11427
UniprotQ9UNE7
RefSeq_mRNANM_005861.3

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0090035
IDA
Genome Projectpositive regulation of chaperone-mediated protein complex assembly
GO:0090035
IDA
Gene Ontologypositive regulation of chaperone-mediated protein complex assembly1
GO:0071218
IDA
Genome Projectcellular response to misfolded protein
GO:0071218
IDA
Gene Ontologycellular response to misfolded protein1
GO:0070534
IDA
Genome Projectprotein K63-linked ubiquitination
GO:0070534
IDA
Gene Ontologyprotein K63-linked ubiquitination2
GO:0051865
IDA
Genome Projectprotein autoubiquitination
GO:0051865
IDA
Gene Ontologyprotein autoubiquitination2 3
GO:0051604
TAS
Genome Projectprotein maturation
GO:0051604
TAS
Gene Ontologyprotein maturation2
GO:0051443
IEA
Genome Projectpositive regulation of ubiquitin-protein transferase activity
GO:0043161
IDA
Genome Projectproteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043161
IDA, IMP
TAS
Gene Ontologyproteasome-mediated ubiquitin-dependent protein catabolic process4 5 6 7
GO:0038128
TAS
Genome ProjectERBB2 signaling pathway
GO:0038128
TAS
Gene OntologyERBB2 signaling pathway
GO:0032436
IDA
Genome Projectpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032436
IDA
Gene Ontologypositive regulation of proteasomal ubiquitin-dependent protein catabolic process8
GO:0032091
IEA
Genome Projectnegative regulation of protein binding
GO:0031943
IDA
Genome Projectregulation of glucocorticoid metabolic process
GO:0031943
IDA
Gene Ontologyregulation of glucocorticoid metabolic process8
GO:0031647
IDA
Genome Projectregulation of protein stability
GO:0031647
IDA
Gene Ontologyregulation of protein stability9
GO:0031398
IDA
Genome Projectpositive regulation of protein ubiquitination
GO:0031398
IDA
Gene Ontologypositive regulation of protein ubiquitination1 8
GO:0030968
IEA
Genome Projectendoplasmic reticulum unfolded protein response
GO:0030579
IDA
Genome Projectubiquitin-dependent SMAD protein catabolic process
GO:0030579
IDA
Gene Ontologyubiquitin-dependent SMAD protein catabolic process4
GO:0030512
IMP
TAS
Genome Projectnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0030512
IMP
TAS
Gene Ontologynegative regulation of transforming growth factor beta receptor signaling pathway6
GO:0030433
IEA
Genome Projectubiquitin-dependent ERAD pathway
GO:0030433
IMP
Gene Ontologyubiquitin-dependent ERAD pathway10
GO:0016567
IDA, IMP
Genome Projectprotein ubiquitination
GO:0016567
IDA, IMP
Gene Ontologyprotein ubiquitination7 9 11
GO:0006515
IDA
Genome Projectprotein quality control for misfolded or incompletely synthesized proteins
GO:0006515
IDA
Gene Ontologyprotein quality control for misfolded or incompletely synthesized proteins1
GO:0006511
IMP
Genome Projectubiquitin-dependent protein catabolic process
GO:0006511
IMP, IGI
ISS
Gene Ontologyubiquitin-dependent protein catabolic process10 12 13
GO:0006281
IEA
Genome ProjectDNA repair
GO:0000209
IDA, IMP
Genome Projectprotein polyubiquitination
GO:0000209
IDA, IMP
Gene Ontologyprotein polyubiquitination4 13 14
GO:0071456
ISS
Gene Ontologycellular response to hypoxia
GO:0034605
ISS
Gene Ontologycellular response to heat
GO:0002931
ISS
Gene Ontologyresponse to ischemia
GO:0030154
IEA
PLAZA Integrative Orthologycell differentiation WBGene00000500
GO:0030036
IEA
PLAZA Integrative Orthologyactin cytoskeleton organization WBGene00000500
GO:0097435
IEA
PLAZA Integrative Orthologysupramolecular fiber organization WBGene00000500
GO:0042692
IEA
PLAZA Integrative Orthologymuscle cell differentiation WBGene00000500
GO:0019098
IEA
PLAZA Integrative Orthologyreproductive behavior WBGene00000500
GO:0009737
IEA
PLAZA Integrative Orthologyresponse to abscisic acid AT3G07370
GO:0030239
IEA
PLAZA Integrative Orthologymyofibril assembly WBGene00000500
GO:0010927
IEA
PLAZA Integrative Orthologycellular component assembly involved in morphogenesis WBGene00000500
GO:0001101
IEA
PLAZA Integrative Orthologyresponse to acid chemical AT3G07370
GO:0048869
IEA
PLAZA Integrative Orthologycellular developmental process WBGene00000500
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction WBGene00000500
GO:0006996
IEA
PLAZA Integrative Orthologyorganelle organization WBGene00000500
GO:0007568
IEA
PLAZA Integrative Orthologyaging WBGene00000500
GO:0048468
IEA
PLAZA Integrative Orthologycell development WBGene00000500
GO:1901699
IEA
PLAZA Integrative Orthologycellular response to nitrogen compound FBgn0027052
GO:1901652
IEA
PLAZA Integrative Orthologyresponse to peptide FBgn0027052
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process WBGene00000500
GO:0055001
IEA
PLAZA Integrative Orthologymuscle cell development WBGene00000500
GO:1901653
IEA
PLAZA Integrative Orthologycellular response to peptide FBgn0027052
GO:0032502
IEA
PLAZA Integrative Orthologydevelopmental process WBGene00000500
GO:0032501
IEA
PLAZA Integrative Orthologymulticellular organismal process WBGene00000500
GO:0097305
IEA
PLAZA Integrative Orthologyresponse to alcohol AT3G07370
GO:0033993
IEA
PLAZA Integrative Orthologyresponse to lipid AT3G07370
GO:0032868
IEA
PLAZA Integrative Orthologyresponse to insulin FBgn0027052
GO:0032989
IEA
PLAZA Integrative Orthologycellular component morphogenesis WBGene00000500
GO:0051146
IEA
PLAZA Integrative Orthologystriated muscle cell differentiation WBGene00000500
GO:0032504
IEA
PLAZA Integrative Orthologymulticellular organism reproduction WBGene00000500
GO:0032869
IEA
PLAZA Integrative Orthologycellular response to insulin stimulus FBgn0027052
GO:0009653
IEA
PLAZA Integrative Orthologyanatomical structure morphogenesis WBGene00000500
GO:0048856
IEA
PLAZA Integrative Orthologyanatomical structure development WBGene00000500
GO:1900077
IEA
PLAZA Integrative Orthologynegative regulation of cellular response to insulin stimulus FBgn0027052
GO:0008286
IEA
PLAZA Integrative Orthologyinsulin receptor signaling pathway FBgn0027052
GO:0007275
IEA
PLAZA Integrative Orthologymulticellular organism development WBGene00000500
GO:0040011
IEA
PLAZA Integrative Orthologylocomotion WBGene00000500
GO:1900076
IEA
PLAZA Integrative Orthologyregulation of cellular response to insulin stimulus FBgn0027052
GO:0009651
IEA
PLAZA Integrative Orthologyresponse to salt stress AT3G07370
GO:0032870
IEA
PLAZA Integrative Orthologycellular response to hormone stimulus FBgn0027052
GO:0043434
IEA
PLAZA Integrative Orthologyresponse to peptide hormone FBgn0027052
GO:0046627
IEA
PLAZA Integrative Orthologynegative regulation of insulin receptor signaling pathway FBgn0027052
GO:0046626
IEA
PLAZA Integrative Orthologyregulation of insulin receptor signaling pathway FBgn0027052
GO:0009725
IEA
PLAZA Integrative Orthologyresponse to hormone AT3G07370
GO:0048646
IEA
PLAZA Integrative Orthologyanatomical structure formation involved in morphogenesis WBGene00000500
GO:0045214
IEA
PLAZA Integrative Orthologysarcomere organization WBGene00000500
GO:0006970
IEA
PLAZA Integrative Orthologyresponse to osmotic stress AT3G07370
GO:0031032
IEA
PLAZA Integrative Orthologyactomyosin structure organization WBGene00000500
GO:0048609
IEA
PLAZA Integrative Orthologymulticellular organismal reproductive process WBGene00000500
GO:0071417
IEA
PLAZA Integrative Orthologycellular response to organonitrogen compound FBgn0027052
GO:0061061
IEA
PLAZA Integrative Orthologymuscle structure development WBGene00000500
GO:0018991
IEA
PLAZA Integrative Orthologyoviposition WBGene00000500
GO:0055002
IEA
PLAZA Integrative Orthologystriated muscle cell development WBGene00000500
GO:0010259
IEA
PLAZA Integrative Orthologymulticellular organism aging WBGene00000500
GO:0071375
IEA
PLAZA Integrative Orthologycellular response to peptide hormone stimulus FBgn0027052
GO:0030029
IEA
PLAZA Integrative Orthologyactin filament-based process WBGene00000500
GO:0007610
IEA
PLAZA Integrative Orthologybehavior WBGene00000500
GO:1901700
IEA
PLAZA Integrative Orthologyresponse to oxygen-containing compound AT3G07370
GO:1901701
IEA
PLAZA Integrative Orthologycellular response to oxygen-containing compound FBgn0027052
GO:0008340
IEA
PLAZA Integrative Orthologydetermination of adult lifespan WBGene00000500
GO:0007010
IEA
PLAZA Integrative Orthologycytoskeleton organization WBGene00000500
GO:0070925
IEA
PLAZA Integrative Orthologyorganelle assembly WBGene00000500

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0061630
IDA, IMP
Genome Projectubiquitin protein ligase activity
GO:0061630
IDA, IMP, IGI
TAS
Gene Ontologyubiquitin protein ligase activity6 9 10 11 14 15 16
GO:0051879
IDA
Genome ProjectHsp90 protein binding
GO:0051879
IDA
Gene OntologyHsp90 protein binding8
GO:0051787
IDA
Genome Projectmisfolded protein binding
GO:0051787
IDA
Gene Ontologymisfolded protein binding1
GO:0046332
IDA, IPI
Genome ProjectSMAD binding
GO:0046332
IDA, IPI
Gene OntologySMAD binding4 6
GO:0042803
IDA
ISS
Genome Projectprotein homodimerization activity
GO:0042803
IDA
ISS
Gene Ontologyprotein homodimerization activity10
GO:0034450
ISS
Genome Projectubiquitin-ubiquitin ligase activity
GO:0034450
ISS
Gene Ontologyubiquitin-ubiquitin ligase activity
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0031625
IPI
Gene Ontologyubiquitin protein ligase binding17
GO:0030911
IDA
Genome ProjectTPR domain binding
GO:0030911
IDA
Gene OntologyTPR domain binding8
GO:0030674
TAS
Genome Projectprotein binding, bridging
GO:0030674
TAS
Gene Ontologyprotein binding, bridging2
GO:0030544
IDA, IPI
Genome ProjectHsp70 protein binding
GO:0030544
IDA, IPI
Gene OntologyHsp70 protein binding6 10 18
GO:0019900
IPI
Genome Projectkinase binding
GO:0019900
IPI
Gene Ontologykinase binding19
GO:0019899
IPI
Genome Projectenzyme binding
GO:0019899
IPI
Gene Ontologyenzyme binding20
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding2 4 6 7 8 9 14 15 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43
GO:0004842
IDA, IMP
TAS
Genome Projectubiquitin-protein transferase activity
GO:0004842
IDA, IMP
TAS
Gene Ontologyubiquitin-protein transferase activity2 13 44
GO:0001664
IPI
Genome ProjectG protein-coupled receptor binding
GO:0001664
IPI
Gene OntologyG protein-coupled receptor binding17
GO:0051087
IPI
Gene Ontologychaperone binding15
GO:0031072
IPI
Gene Ontologyheat shock protein binding15

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0042405
IDA
Genome Projectnuclear inclusion body
GO:0042405
IDA
Gene Ontologynuclear inclusion body1
GO:0031371
TAS
Genome Projectubiquitin conjugating enzyme complex
GO:0031371
TAS
Gene Ontologyubiquitin conjugating enzyme complex2
GO:0030018
IEA
Genome ProjectZ disc
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005829
IDA
TAS
Gene Ontologycytosol
GO:0005783
IDA
Genome Projectendoplasmic reticulum
GO:0005783
IDA
Gene Ontologyendoplasmic reticulum17
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
ISS
Gene Ontologycytoplasm1 18
GO:0005654
IDA
Genome Projectnucleoplasm
GO:0005654
IDA
Gene Ontologynucleoplasm
GO:0000151
IDA
Genome Projectubiquitin ligase complex
GO:0000151
IDA
Gene Ontologyubiquitin ligase complex2 14 17
GO:0101031
IPI
Gene Ontologychaperone complex15
GO:0005634
ISS
Gene Ontologynucleus

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003613U box domain
IPR011990Tetratricopeptide-like helical domain superfamily
IPR013026Tetratricopeptide repeat-containing domain
IPR013083Zinc finger, RING/FYVE/PHD-type
IPR019734Tetratricopeptide repeat

No MapMan annotations defined for this gene.
KeggID Description
K09561STUB1, CHIP; STIP1 homology and U-box containing protein 1
No chloroplast target sequence found.