Gene: ENSG00000102871 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000102871
Transcript Identifier
ENST00000345057
Gene Type
Coding gene
Location
16 : 67154649-67156660 : negative

Family Information

Homologous gene family
HOM02SEM094774
(orphan gene)
specific family

Descriptions

gene_descr
TNFRSF1A-associated via death domain

Identifiers

Type Value
pidENSP00000341268
HGNC12030
UniprotQ15628
RefSeq_mRNANM_003789.3
EMBLAC074143
EMBLAJ311614
EMBLAJ311615
EMBLAJ311616
EMBLAK090673
EMBLAK315654
EMBLAY575851
EMBLAY995114
EMBLBC004491
EMBLBT006934
EMBLCH471092
EMBLL41690

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1902042
TAS
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042
TAS
Gene Ontologynegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902041
TAS
Genome Projectregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902041
TAS
Gene Ontologyregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0097296
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097191
IMP
TAS
Genome Projectextrinsic apoptotic signaling pathway
GO:0097191
IMP
TAS
Gene Ontologyextrinsic apoptotic signaling pathway1 2
GO:0071550
TAS
Genome Projectdeath-inducing signaling complex assembly
GO:0071550
TAS
Gene Ontologydeath-inducing signaling complex assembly
GO:0060544
TAS
Genome Projectregulation of necroptotic process
GO:0051798
IEA
Genome Projectpositive regulation of hair follicle development
GO:0051291
IEA
Genome Projectprotein heterooligomerization
GO:0051092
TAS
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051092
TAS
Gene Ontologypositive regulation of NF-kappaB transcription factor activity2
GO:0043123
IEP
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123
IEP
Gene Ontologypositive regulation of I-kappaB kinase/NF-kappaB signaling3
GO:0043065
TAS
Genome Projectpositive regulation of apoptotic process
GO:0043065
TAS
Gene Ontologypositive regulation of apoptotic process2
GO:0033209
TAS
Genome Projecttumor necrosis factor-mediated signaling pathway
GO:0033209
TAS
Gene Ontologytumor necrosis factor-mediated signaling pathway4
GO:0010803
TAS
Genome Projectregulation of tumor necrosis factor-mediated signaling pathway
GO:0010803
TAS
Gene Ontologyregulation of tumor necrosis factor-mediated signaling pathway
GO:0008625
TAS
Genome Projectextrinsic apoptotic signaling pathway via death domain receptors
GO:0008625
TAS
Gene Ontologyextrinsic apoptotic signaling pathway via death domain receptors4
GO:0007249
TAS
Genome ProjectI-kappaB kinase/NF-kappaB signaling
GO:0007249
TAS
Gene OntologyI-kappaB kinase/NF-kappaB signaling
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007165
TAS
Gene Ontologysignal transduction5
GO:0006919
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
TAS
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915
TAS
Genome Projectapoptotic process
GO:0006915
TAS
Gene Ontologyapoptotic process5

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070513
IPI
Genome Projectdeath domain binding
GO:0070513
IPI
Gene Ontologydeath domain binding4
GO:0060090
IPI
Genome Projectmolecular adaptor activity
GO:0060090
IPI
Gene Ontologymolecular adaptor activity4
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042802
IPI
Gene Ontologyidentical protein binding5 6
GO:0019900
IPI
Genome Projectkinase binding
GO:0019900
IPI
Gene Ontologykinase binding4
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding1 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25
GO:0005164
IEA
Genome Projecttumor necrosis factor receptor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0045121
IEA
Genome Projectmembrane raft
GO:0043235
IDA
Genome Projectreceptor complex
GO:0043235
IDA
Gene Ontologyreceptor complex4
GO:0031264
TAS
Genome Projectdeath-inducing signaling complex
GO:0031264
TAS
Gene Ontologydeath-inducing signaling complex2
GO:0005886
IDA
Genome Projectplasma membrane
GO:0005886
IDA
Gene Ontologyplasma membrane21
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0005829
TAS
Genome Projectcytosol
GO:0005829
TAS
Gene Ontologycytosol
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm6 21
GO:0005634
IEA
Genome Projectnucleus

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000488Death domain
IPR009095TRADD, N-terminal
IPR011029Death-like domain superfamily

No MapMan annotations defined for this gene.
KeggID Description
K03171TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
No chloroplast target sequence found.