Gene: ENSG00000102606 (Homo sapiens)

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Gene Identifier
ENSG00000102606
Transcript Identifier
ENST00000375741
Gene Type
Coding gene
Location
13 : 111115527-111292332 : positive

Family Information

Homologous gene family
HOM02SEM014481
(6 genes in 4 species)
specific family
Orthologous gene family
ORTHO02SEM013360
(4 genes in 3 species)
specific family

Descriptions

gene_descr
Rho guanine nucleotide exchange factor (GEF) 7

Identifiers

Type Value
pidENSP00000364893
HGNC15607
UniprotQ14155
RefSeq_mRNANM_001113511.1
EMBLAB075521
EMBLAB177849
EMBLAL139086
EMBLAL390754
EMBLAL834228
EMBLBC033905
EMBLBC050521
EMBLBC060776
EMBLCH471085
EMBLD63476

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2000394
IMP
Genome Projectpositive regulation of lamellipodium morphogenesis
GO:2000394
Gene Ontologypositive regulation of lamellipodium morphogenesis1
GO:1904424
IMP
Genome Projectregulation of GTP binding
GO:1904424
IMP
Gene Ontologyregulation of GTP binding2
GO:1900026
IMP
Genome Projectpositive regulation of substrate adhesion-dependent cell spreading
GO:1900026
Gene Ontologypositive regulation of substrate adhesion-dependent cell spreading1
GO:0060124
IEA
Genome Projectpositive regulation of growth hormone secretion
GO:0051056
TAS
Genome Projectregulation of small GTPase mediated signal transduction
GO:0051056
TAS
Gene Ontologyregulation of small GTPase mediated signal transduction
GO:0048041
IDA
Genome Projectfocal adhesion assembly
GO:0048041
Gene Ontologyfocal adhesion assembly1
GO:0048013
TAS
Genome Projectephrin receptor signaling pathway
GO:0048013
TAS
Gene Ontologyephrin receptor signaling pathway
GO:0043547
IDA, IMP
Genome Projectpositive regulation of GTPase activity
GO:0043547
IDA
Gene Ontologypositive regulation of GTPase activity1 3
GO:0043065
IMP
TAS
Genome Projectpositive regulation of apoptotic process
GO:0043065
IMP
TAS
Gene Ontologypositive regulation of apoptotic process4
GO:0042059
TAS
Genome Projectnegative regulation of epidermal growth factor receptor signaling pathway
GO:0042059
TAS
Gene Ontologynegative regulation of epidermal growth factor receptor signaling pathway
GO:0035556
IEA
Genome Projectintracellular signal transduction
GO:0035023
IEA
Genome Projectregulation of Rho protein signal transduction
GO:0032092
IEA
Genome Projectpositive regulation of protein binding
GO:0030032
ISS
Genome Projectlamellipodium assembly
GO:0030032
ISS
Gene Ontologylamellipodium assembly
GO:0010763
IDA
Genome Projectpositive regulation of fibroblast migration
GO:0010763
Gene Ontologypositive regulation of fibroblast migration1
GO:0007399
IEA
Genome Projectnervous system development
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007165
TAS
Gene Ontologysignal transduction5
GO:0007030
IMP
Genome ProjectGolgi organization
GO:0007030
IMP
Gene OntologyGolgi organization2
GO:0002244
IEA
Genome Projecthematopoietic progenitor cell differentiation
GO:0051239
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal process FBgn0015803
GO:0035329
IEA
PLAZA Integrative Orthologyhippo signaling FBgn0015803
GO:0050803
IEA
PLAZA Integrative Orthologyregulation of synapse structure or activity FBgn0015803
GO:0008406
IEA
PLAZA Integrative Orthologygonad development WBGene00010776
GO:0040007
IEA
PLAZA Integrative Orthologygrowth FBgn0015803
GO:0009887
IEA
PLAZA Integrative Orthologyanimal organ morphogenesis WBGene00010776
GO:0040008
IEA
PLAZA Integrative Orthologyregulation of growth FBgn0015803
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction WBGene00010776
GO:0009967
IEA
PLAZA Integrative Orthologypositive regulation of signal transduction FBgn0015803
GO:0048589
IEA
PLAZA Integrative Orthologydevelopmental growth FBgn0015803
GO:0046620
IEA
PLAZA Integrative Orthologyregulation of organ growth FBgn0015803
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process WBGene00010776
GO:0045137
IEA
PLAZA Integrative Orthologydevelopment of primary sexual characteristics WBGene00010776
GO:0050808
IEA
PLAZA Integrative Orthologysynapse organization FBgn0015803
GO:0050807
IEA
PLAZA Integrative Orthologyregulation of synapse organization FBgn0015803
GO:0048608
IEA
PLAZA Integrative Orthologyreproductive structure development WBGene00010776
GO:0035332
IEA
PLAZA Integrative Orthologypositive regulation of hippo signaling FBgn0015803
GO:0035330
IEA
PLAZA Integrative Orthologyregulation of hippo signaling FBgn0015803
GO:0007548
IEA
PLAZA Integrative Orthologysex differentiation WBGene00010776
GO:0001764
IEA
PLAZA Integrative Orthologyneuron migration WBGene00010776
GO:0003006
IEA
PLAZA Integrative Orthologydevelopmental process involved in reproduction WBGene00010776
GO:0048584
IEA
PLAZA Integrative Orthologypositive regulation of response to stimulus FBgn0015803
GO:0040039
IEA
PLAZA Integrative Orthologyinductive cell migration WBGene00010776
GO:0048638
IEA
PLAZA Integrative Orthologyregulation of developmental growth FBgn0015803
GO:0061458
IEA
PLAZA Integrative Orthologyreproductive system development WBGene00010776
GO:1902533
IEA
PLAZA Integrative Orthologypositive regulation of intracellular signal transduction FBgn0015803
GO:0048699
IEA
PLAZA Integrative Orthologygeneration of neurons WBGene00010776
GO:0022008
IEA
PLAZA Integrative Orthologyneurogenesis WBGene00010776
GO:0035262
IEA
PLAZA Integrative Orthologygonad morphogenesis WBGene00010776
GO:0035265
IEA
PLAZA Integrative Orthologyorgan growth FBgn0015803
GO:0007186
TAS
Gene OntologyG protein-coupled receptor signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0019901
IPI
Genome Projectprotein kinase binding
GO:0019901
IPI
Gene Ontologyprotein kinase binding3
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding2 3 4 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25
GO:0005089
TAS
Genome ProjectRho guanyl-nucleotide exchange factor activity
GO:0005089
TAS
Gene OntologyRho guanyl-nucleotide exchange factor activity
GO:0005085
EXP, IDA
TAS
Genome Projectguanyl-nucleotide exchange factor activity
GO:0005085
EXP, IDA
TAS
Gene Ontologyguanyl-nucleotide exchange factor activity3 26 27
GO:0032947
IEA
PLAZA Integrative Orthologyprotein-containing complex scaffold activity FBgn0015803
GO:0005198
IEA
PLAZA Integrative Orthologystructural molecule activity FBgn0015803

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0043025
IDA
Genome Projectneuronal cell body
GO:0043025
IDA
Gene Ontologyneuronal cell body3
GO:0043005
IDA
Genome Projectneuron projection
GO:0043005
IDA
Gene Ontologyneuron projection3
GO:0030027
ISS
Genome Projectlamellipodium
GO:0030027
ISS
Gene Ontologylamellipodium
GO:0005938
IEA
Genome Projectcell cortex
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0005925
Gene Ontologyfocal adhesion1
GO:0005886
IEA
Genome Projectplasma membrane
GO:0005829
TAS
Genome Projectcytosol
GO:0005829
TAS
Gene Ontologycytosol
GO:0001726
IEA
Genome Projectruffle
GO:0000322
IEA
Genome Projectstorage vacuole
GO:0030056
IEA
PLAZA Integrative Orthologyhemidesmosome WBGene00010776
GO:0005913
IEA
PLAZA Integrative Orthologycell-cell adherens junction WBGene00010776
GO:0097482
IEA
PLAZA Integrative Orthologymuscle cell postsynaptic specialization FBgn0015803
GO:0005911
IEA
PLAZA Integrative Orthologycell-cell junction WBGene00010776
GO:0031594
IEA
PLAZA Integrative Orthologyneuromuscular junction FBgn0015803
GO:0098975
IEA
PLAZA Integrative Orthologypostsynapse of neuromuscular junction FBgn0015803
GO:0098794
IEA
PLAZA Integrative Orthologypostsynapse FBgn0015803
GO:0099572
IEA
PLAZA Integrative Orthologypostsynaptic specialization FBgn0015803
GO:0045202
IEA
PLAZA Integrative Orthologysynapse FBgn0015803
GO:0044456
IEA
PLAZA Integrative Orthologysynapse part FBgn0015803
GO:0032991
IDA
Gene Ontologyprotein-containing complex6

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000219Dbl homology (DH) domain
IPR001331Guanine-nucleotide dissociation stimulator, CDC24, conserved site
IPR001452SH3 domain
IPR001715Calponin homology domain
IPR001849Pleckstrin homology domain
IPR011993PH-like domain superfamily

No MapMan annotations defined for this gene.
KeggID Description
K13710ARHGEF7, PIXB; Rho guanine nucleotide exchange factor 7
No chloroplast target sequence found.