Gene: ENSG00000101695 (Homo sapiens)

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Gene Identifier
ENSG00000101695
Transcript Identifier
ENST00000217740
Gene Type
Coding gene
Location
18 : 32018864-32068384 : positive

Family Information

Homologous gene family
HOM02SEM017130
(5 genes in 1 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
ring finger protein 125, E3 ubiquitin protein ligase

Identifiers

Type Value
pidENSP00000217740
HGNC21150
UniprotQ96EQ8
RefSeq_mRNANM_017831.3
EMBLAK000463
EMBLBC012021

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0039536
IDA
Genome Projectnegative regulation of RIG-I signaling pathway
GO:0039536
IDA
Gene Ontologynegative regulation of RIG-I signaling pathway1 2
GO:0032480
IDA
Genome Projectnegative regulation of type I interferon production
GO:0032480
IDA
Gene Ontologynegative regulation of type I interferon production1 2
GO:0032436
IBA
Genome Projectpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0006511
IDA
Genome Projectubiquitin-dependent protein catabolic process
GO:0006511
IDA
Gene Ontologyubiquitin-dependent protein catabolic process1 2
GO:0002250
IEA
Genome Projectadaptive immune response
GO:0000209
IDA
IBA
Genome Projectprotein polyubiquitination
GO:0000209
IDA
Gene Ontologyprotein polyubiquitination3
GO:0006281
IEA
PLAZA Integrative OrthologyDNA repair ENSG00000134758
GO:1901360
IEA
PLAZA Integrative Orthologyorganic cyclic compound metabolic process ENSG00000134758
GO:0006302
IEA
PLAZA Integrative Orthologydouble-strand break repair ENSG00000134758
GO:0046483
IEA
PLAZA Integrative Orthologyheterocycle metabolic process ENSG00000134758
GO:0033554
IEA
PLAZA Integrative Orthologycellular response to stress ENSG00000134758
GO:0034641
IEA
PLAZA Integrative Orthologycellular nitrogen compound metabolic process ENSG00000134758
GO:0090304
IEA
PLAZA Integrative Orthologynucleic acid metabolic process ENSG00000134758
GO:0010792
IEA
PLAZA Integrative OrthologyDNA double-strand break processing involved in repair via single-strand annealing ENSG00000134758
GO:0000729
IEA
PLAZA Integrative OrthologyDNA double-strand break processing ENSG00000134758
GO:0000726
IEA
PLAZA Integrative Orthologynon-recombinational repair ENSG00000134758
GO:0000725
IEA
PLAZA Integrative Orthologyrecombinational repair ENSG00000134758
GO:0000724
IEA
PLAZA Integrative Orthologydouble-strand break repair via homologous recombination ENSG00000134758
GO:0006310
IEA
PLAZA Integrative OrthologyDNA recombination ENSG00000134758
GO:0006974
IEA
PLAZA Integrative Orthologycellular response to DNA damage stimulus ENSG00000134758
GO:0006259
IEA
PLAZA Integrative OrthologyDNA metabolic process ENSG00000134758
GO:0006139
IEA
PLAZA Integrative Orthologynucleobase-containing compound metabolic process ENSG00000134758
GO:0006725
IEA
PLAZA Integrative Orthologycellular aromatic compound metabolic process ENSG00000134758
GO:0045002
IEA
PLAZA Integrative Orthologydouble-strand break repair via single-strand annealing ENSG00000134758

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0061630
IDA
IBA
Genome Projectubiquitin protein ligase activity
GO:0061630
IDA
Gene Ontologyubiquitin protein ligase activity1 3 4
GO:0031624
IPI
IBA
Genome Projectubiquitin conjugating enzyme binding
GO:0031624
IPI
Gene Ontologyubiquitin conjugating enzyme binding3
GO:0008270
IDA
Genome Projectzinc ion binding
GO:0008270
IDA
Gene Ontologyzinc ion binding3
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding1 2 5
GO:0002039
IPI
Genome Projectp53 binding
GO:0002039
IPI
Gene Ontologyp53 binding4
GO:1901363
IEA
PLAZA Integrative Orthologyheterocyclic compound binding ENSG00000134758
GO:0003697
IEA
PLAZA Integrative Orthologysingle-stranded DNA binding ENSG00000134758
GO:0019900
IEA
PLAZA Integrative Orthologykinase binding ENSG00000134758
GO:0019901
IEA
PLAZA Integrative Orthologyprotein kinase binding ENSG00000134758
GO:0003676
IEA
PLAZA Integrative Orthologynucleic acid binding ENSG00000134758
GO:0003677
IEA
PLAZA Integrative OrthologyDNA binding ENSG00000134758
GO:0097159
IEA
PLAZA Integrative Orthologyorganic cyclic compound binding ENSG00000134758

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0043231
IDA
Genome Projectintracellular membrane-bounded organelle
GO:0043231
IDA
Gene Ontologyintracellular membrane-bounded organelle6
GO:0034098
IDA
Genome ProjectVCP-NPL4-UFD1 AAA ATPase complex
GO:0034098
IDA
Gene OntologyVCP-NPL4-UFD1 AAA ATPase complex2
GO:0000139
IDA
Genome ProjectGolgi membrane
GO:0000139
IDA
Gene OntologyGolgi membrane6
GO:0090734
IEA
PLAZA Integrative Orthologysite of DNA damage ENSG00000134758
GO:0035861
IEA
PLAZA Integrative Orthologysite of double-strand break ENSG00000134758
GO:0005694
IEA
PLAZA Integrative Orthologychromosome ENSG00000134758
GO:0043228
IEA
PLAZA Integrative Orthologynon-membrane-bounded organelle ENSG00000134758
GO:0005829
IEA
PLAZA Integrative Orthologycytosol ENSG00000124226
GO:0043232
IEA
PLAZA Integrative Orthologyintracellular non-membrane-bounded organelle ENSG00000134758
GO:0005886
IEA
PLAZA Integrative Orthologyplasma membrane ENSG00000124226
GO:0044427
IEA
PLAZA Integrative Orthologychromosomal part ENSG00000134758
GO:0005634
IEA
PLAZA Integrative Orthologynucleus ENSG00000134758
GO:0071944
IEA
PLAZA Integrative Orthologycell periphery ENSG00000124226

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001841Zinc finger, RING-type
IPR008598Drought induced 19 protein type, zinc-binding domain
IPR013083Zinc finger, RING/FYVE/PHD-type
IPR017907Zinc finger, RING-type, conserved site
IPR034734Zinc finger C2HC RNF-type

No MapMan annotations defined for this gene.
KeggID Description
K12170RNF125; E3 ubiquitin-protein ligase RNF125
No chloroplast target sequence found.