Gene: ENSG00000101384 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000101384
Transcript Identifier
ENST00000254958
Gene Type
Coding gene
Location
20 : 10639498-10673530 : negative

Family Information

Homologous gene family
HOM02SEM010027
(9 genes in 3 species)
specific family
Orthologous gene family
ORTHO02SEM016703
(3 genes in 2 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
jagged 1

Identifiers

Type Value
pidENSP00000254958
HGNC6188
UniprotP78504
RefSeq_mRNANM_000214.2
EMBLCHEMBL3217396
EMBLAF003837
EMBLAF028593
EMBLAK302554
EMBLAL035456
EMBLBC126205
EMBLBC126207
EMBLU61276
EMBLU73936
EMBLU77720

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2000737
IMP
Genome Projectnegative regulation of stem cell differentiation
GO:2000737
IMP
Gene Ontologynegative regulation of stem cell differentiation1
GO:0097150
IEP
Genome Projectneuronal stem cell population maintenance
GO:0097150
IEP
Gene Ontologyneuronal stem cell population maintenance1
GO:0072070
IEA
Genome Projectloop of Henle development
GO:0072017
IEA
Genome Projectdistal tubule development
GO:0072015
ISS
Genome Projectglomerular visceral epithelial cell development
GO:0072015
ISS
Gene Ontologyglomerular visceral epithelial cell development
GO:0072006
ISS
Genome Projectnephron development
GO:0072006
ISS
Gene Ontologynephron development
GO:0061444
ISS
Genome Projectendocardial cushion cell development
GO:0061444
ISS
Gene Ontologyendocardial cushion cell development
GO:0061314
IMP
IC
Genome ProjectNotch signaling involved in heart development
GO:0061314
IMP
IC
Gene OntologyNotch signaling involved in heart development2 3
GO:0061309
ISS
Genome Projectcardiac neural crest cell development involved in outflow tract morphogenesis
GO:0061309
ISS
Gene Ontologycardiac neural crest cell development involved in outflow tract morphogenesis
GO:0061156
IMP
Genome Projectpulmonary artery morphogenesis
GO:0061156
IMP
Gene Ontologypulmonary artery morphogenesis2
GO:0061073
IEA
Genome Projectciliary body morphogenesis
GO:0060411
ISS
Genome Projectcardiac septum morphogenesis
GO:0060411
ISS
Gene Ontologycardiac septum morphogenesis
GO:0045944
IMP
Genome Projectpositive regulation of transcription by RNA polymerase II
GO:0045944
IMP
Gene Ontologypositive regulation of transcription by RNA polymerase II3
GO:0045747
ISS
Genome Projectpositive regulation of Notch signaling pathway
GO:0045747
ISS
Gene Ontologypositive regulation of Notch signaling pathway
GO:0045669
IEA
Genome Projectpositive regulation of osteoblast differentiation
GO:0045665
IEA
Genome Projectnegative regulation of neuron differentiation
GO:0045639
IEA
Genome Projectpositive regulation of myeloid cell differentiation
GO:0045602
IEA
Genome Projectnegative regulation of endothelial cell differentiation
GO:0045599
IEA
Genome Projectnegative regulation of fat cell differentiation
GO:0045446
NAS
Genome Projectendothelial cell differentiation
GO:0045446
NAS
Gene Ontologyendothelial cell differentiation4
GO:0045445
NAS
Genome Projectmyoblast differentiation
GO:0045445
NAS
Gene Ontologymyoblast differentiation4
GO:0042491
IEA
Genome Projectinner ear auditory receptor cell differentiation
GO:0042127
NAS
Genome Projectregulation of cell proliferation
GO:0042127
NAS
Gene Ontologyregulation of cell proliferation4
GO:0035909
ISS
Genome Projectaorta morphogenesis
GO:0035909
ISS
Gene Ontologyaorta morphogenesis
GO:0032495
IEA
Genome Projectresponse to muramyl dipeptide
GO:0030334
NAS
Genome Projectregulation of cell migration
GO:0030216
NAS
Genome Projectkeratinocyte differentiation
GO:0030216
NAS
Gene Ontologykeratinocyte differentiation5
GO:0030097
NAS
Genome Projecthemopoiesis
GO:0030097
NAS
Gene Ontologyhemopoiesis4
GO:0007399
NAS
Genome Projectnervous system development
GO:0007399
NAS
Gene Ontologynervous system development6
GO:0007220
TAS
Genome ProjectNotch receptor processing
GO:0007219
IMP
TAS, NAS
Genome ProjectNotch signaling pathway
GO:0007219
IMP
NAS
Gene OntologyNotch signaling pathway1 7
GO:0003215
ISS
Genome Projectcardiac right ventricle morphogenesis
GO:0003215
ISS
Gene Ontologycardiac right ventricle morphogenesis
GO:0003184
IMP
Genome Projectpulmonary valve morphogenesis
GO:0003184
IMP
Gene Ontologypulmonary valve morphogenesis2 3
GO:0002456
IMP
Genome ProjectT cell mediated immunity
GO:0002456
IMP
Gene OntologyT cell mediated immunity8
GO:0002011
IEA
Genome Projectmorphogenesis of an epithelial sheet
GO:0001974
IEA
Genome Projectblood vessel remodeling
GO:0001709
NAS
Genome Projectcell fate determination
GO:0001709
NAS
Gene Ontologycell fate determination9
GO:0001525
NAS
Genome Projectangiogenesis
GO:0001525
NAS
Gene Ontologyangiogenesis10
GO:0062043
ISS
Gene Ontologypositive regulation of cardiac epithelial to mesenchymal transition
GO:0030336
IDA
Gene Ontologynegative regulation of cell migration11
GO:0022408
IDA
Gene Ontologynegative regulation of cell-cell adhesion11
GO:0003180
NAS
Gene Ontologyaortic valve morphogenesis12
GO:0001953
IDA
Gene Ontologynegative regulation of cell-matrix adhesion11
GO:0009790
IEA
PLAZA Homology (enrichment)embryo development HOM02SEM010027
GO:0035166
IEA
PLAZA Integrative Orthologypost-embryonic hemopoiesis FBgn0004197
GO:0035167
IEA
PLAZA Integrative Orthologylarval lymph gland hemopoiesis FBgn0004197
GO:0035168
IEA
PLAZA Integrative Orthologylarval lymph gland hemocyte differentiation FBgn0004197
GO:0035161
IEA
PLAZA Integrative Orthologyimaginal disc lineage restriction FBgn0004197
GO:0035282
IEA
PLAZA Integrative Orthologysegmentation FBgn0004197
GO:0009791
IEA
PLAZA Integrative Orthologypost-embryonic development FBgn0004197
GO:0036011
IEA
PLAZA Integrative Orthologyimaginal disc-derived leg segmentation FBgn0004197
GO:0035285
IEA
PLAZA Integrative Orthologyappendage segmentation FBgn0004197
GO:0009953
IEA
PLAZA Integrative Orthologydorsal/ventral pattern formation FBgn0004197
GO:0035272
IEA
PLAZA Integrative Orthologyexocrine system development FBgn0004197
GO:0007267
IEA
PLAZA Integrative Orthologycell-cell signaling FBgn0004197
GO:0007389
IEA
PLAZA Integrative Orthologypattern specification process FBgn0004197
GO:0042386
IEA
PLAZA Integrative Orthologyhemocyte differentiation FBgn0004197
GO:0042387
IEA
PLAZA Integrative Orthologyplasmatocyte differentiation FBgn0004197
GO:0002521
IEA
PLAZA Integrative Orthologyleukocyte differentiation ENSG00000184916
GO:0023057
IEA
PLAZA Integrative Orthologynegative regulation of signaling FBgn0004197
GO:0030098
IEA
PLAZA Integrative Orthologylymphocyte differentiation ENSG00000184916
GO:0007472
IEA
PLAZA Integrative Orthologywing disc morphogenesis FBgn0004197
GO:0007476
IEA
PLAZA Integrative Orthologyimaginal disc-derived wing morphogenesis FBgn0004197
GO:0007478
IEA
PLAZA Integrative Orthologyleg disc morphogenesis FBgn0004197
GO:0000278
IEA
PLAZA Integrative Orthologymitotic cell cycle FBgn0004197
GO:0048542
IEA
PLAZA Integrative Orthologylymph gland development FBgn0004197
GO:0048663
IEA
PLAZA Homology (enrichment)neuron fate commitment HOM02SEM010027
GO:0051704
IEA
PLAZA Integrative Orthologymulti-organism process ENSG00000184916
GO:0035017
IEA
PLAZA Integrative Orthologycuticle pattern formation FBgn0004197
GO:0007480
IEA
PLAZA Integrative Orthologyimaginal disc-derived leg morphogenesis FBgn0004197
GO:0048707
IEA
PLAZA Integrative Orthologyinstar larval or pupal morphogenesis FBgn0004197
GO:0033077
IEA
PLAZA Integrative OrthologyT cell differentiation in thymus ENSG00000184916
GO:0022612
IEA
PLAZA Integrative Orthologygland morphogenesis FBgn0004197
GO:0046649
IEA
PLAZA Integrative Orthologylymphocyte activation ENSG00000184916
GO:0042688
IEA
PLAZA Integrative Orthologycrystal cell differentiation FBgn0004197
GO:0042689
IEA
PLAZA Integrative Orthologyregulation of crystal cell differentiation FBgn0004197
GO:0001775
IEA
PLAZA Integrative Orthologycell activation ENSG00000184916
GO:1903707
IEA
PLAZA Integrative Orthologynegative regulation of hemopoiesis FBgn0004197
GO:0010648
IEA
PLAZA Integrative Orthologynegative regulation of cell communication FBgn0004197
GO:0045321
IEA
PLAZA Integrative Orthologyleukocyte activation ENSG00000184916
GO:0060562
IEA
PLAZA Integrative Orthologyepithelial tube morphogenesis FBgn0004197
GO:0007450
IEA
PLAZA Integrative Orthologydorsal/ventral pattern formation, imaginal disc FBgn0004197
GO:0007451
IEA
PLAZA Integrative Orthologydorsal/ventral lineage restriction, imaginal disc FBgn0004197
GO:0035120
IEA
PLAZA Integrative Orthologypost-embryonic appendage morphogenesis FBgn0004197
GO:0045168
IEA
PLAZA Integrative Orthologycell-cell signaling involved in cell fate commitment FBgn0004197
GO:0002164
IEA
PLAZA Integrative Orthologylarval development FBgn0004197
GO:0002165
IEA
PLAZA Integrative Orthologyinstar larval or pupal development FBgn0004197
GO:0042335
IEA
PLAZA Integrative Orthologycuticle development FBgn0004197
GO:0002683
IEA
PLAZA Integrative Orthologynegative regulation of immune system process FBgn0004197
GO:0002168
IEA
PLAZA Integrative Orthologyinstar larval development FBgn0004197
GO:0001745
IEA
PLAZA Integrative Orthologycompound eye morphogenesis FBgn0004197
GO:0042063
IEA
PLAZA Integrative Orthologygliogenesis FBgn0004197
GO:0048563
IEA
PLAZA Integrative Orthologypost-embryonic animal organ morphogenesis FBgn0004197
GO:0016330
IEA
PLAZA Integrative Orthologysecond mitotic wave involved in compound eye morphogenesis FBgn0004197
GO:0035114
IEA
PLAZA Integrative Orthologyimaginal disc-derived appendage morphogenesis FBgn0004197
GO:0048609
IEA
PLAZA Integrative Orthologymulticellular organismal reproductive process ENSG00000184916
GO:0009886
IEA
PLAZA Integrative Orthologypost-embryonic animal morphogenesis FBgn0004197
GO:0045610
IEA
PLAZA Integrative Orthologyregulation of hemocyte differentiation FBgn0004197
GO:0048569
IEA
PLAZA Integrative Orthologypost-embryonic animal organ development FBgn0004197
GO:0045611
IEA
PLAZA Integrative Orthologynegative regulation of hemocyte differentiation FBgn0004197
GO:0045058
IEA
PLAZA Integrative OrthologyT cell selection ENSG00000184916
GO:0045614
IEA
PLAZA Integrative Orthologynegative regulation of plasmatocyte differentiation FBgn0004197
GO:0045613
IEA
PLAZA Integrative Orthologyregulation of plasmatocyte differentiation FBgn0004197
GO:0030217
IEA
PLAZA Integrative OrthologyT cell differentiation ENSG00000184916
GO:0045061
IEA
PLAZA Integrative Orthologythymic T cell selection ENSG00000184916
GO:0035107
IEA
PLAZA Integrative Orthologyappendage morphogenesis FBgn0004197
GO:0019953
IEA
PLAZA Integrative Orthologysexual reproduction ENSG00000184916
GO:0035220
IEA
PLAZA Integrative Orthologywing disc development FBgn0004197
GO:0042110
IEA
PLAZA Integrative OrthologyT cell activation ENSG00000184916
GO:0007276
IEA
PLAZA Integrative Orthologygamete generation ENSG00000184916
GO:0048732
IEA
PLAZA Integrative Orthologygland development FBgn0004197
GO:0007552
IEA
PLAZA Integrative Orthologymetamorphosis FBgn0004197
GO:0007431
IEA
PLAZA Integrative Orthologysalivary gland development FBgn0004197
GO:0045746
IEA
PLAZA Integrative Orthologynegative regulation of Notch signaling pathway FBgn0004197
GO:0007436
IEA
PLAZA Integrative Orthologylarval salivary gland morphogenesis FBgn0004197
GO:0048737
IEA
PLAZA Integrative Orthologyimaginal disc-derived appendage development FBgn0004197
GO:0048736
IEA
PLAZA Integrative Orthologyappendage development FBgn0004197
GO:0007435
IEA
PLAZA Integrative Orthologysalivary gland morphogenesis FBgn0004197
GO:0032504
IEA
PLAZA Integrative Orthologymulticellular organism reproduction ENSG00000184916
GO:0009968
IEA
PLAZA Integrative Orthologynegative regulation of signal transduction FBgn0004197
GO:0048581
IEA
PLAZA Integrative Orthologynegative regulation of post-embryonic development FBgn0004197
GO:0048585
IEA
PLAZA Integrative Orthologynegative regulation of response to stimulus FBgn0004197
GO:0035218
IEA
PLAZA Integrative Orthologyleg disc development FBgn0004197
GO:0048580
IEA
PLAZA Integrative Orthologyregulation of post-embryonic development FBgn0004197
GO:0035214
IEA
PLAZA Integrative Orthologyeye-antennal disc development FBgn0004197
GO:0044703
IEA
PLAZA Integrative Orthologymulti-organism reproductive process ENSG00000184916
GO:0007560
IEA
PLAZA Integrative Orthologyimaginal disc morphogenesis FBgn0004197
GO:0007283
IEA
PLAZA Integrative Orthologyspermatogenesis ENSG00000184916
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process ENSG00000184916
GO:0007444
IEA
PLAZA Integrative Orthologyimaginal disc development FBgn0004197
GO:0035170
IEA
PLAZA Integrative Orthologylymph gland crystal cell differentiation FBgn0004197
GO:0035171
IEA
PLAZA Integrative Orthologylamellocyte differentiation FBgn0004197
GO:0007447
IEA
PLAZA Integrative Orthologyimaginal disc pattern formation FBgn0004197
GO:0003002
IEA
PLAZA Integrative Orthologyregionalization FBgn0004197
GO:0048749
IEA
PLAZA Integrative Orthologycompound eye development FBgn0004197
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction ENSG00000184916
GO:0007049
IEA
PLAZA Integrative Orthologycell cycle FBgn0004197
GO:0048232
IEA
PLAZA Integrative Orthologymale gamete generation ENSG00000184916
GO:0030718
IEA
PLAZA Integrative Orthologygerm-line stem cell population maintenance FBgn0004197
GO:0046331
IEA
PLAZA Integrative Orthologylateral inhibition FBgn0004197
GO:0014009
IEA
PLAZA Integrative Orthologyglial cell proliferation FBgn0004197
GO:0035203
IEA
PLAZA Integrative Orthologyregulation of lamellocyte differentiation FBgn0004197
GO:0035204
IEA
PLAZA Integrative Orthologynegative regulation of lamellocyte differentiation FBgn0004197

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0008083
NAS
Genome Projectgrowth factor activity
GO:0008083
NAS
Gene Ontologygrowth factor activity13
GO:0005543
IMP
Genome Projectphospholipid binding
GO:0005543
IMP
Gene Ontologyphospholipid binding14
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding8 15
GO:0005509
IEA
Genome Projectcalcium ion binding
GO:0005198
NAS
Genome Projectstructural molecule activity
GO:0005198
NAS
Gene Ontologystructural molecule activity16
GO:0005112
IPI
NAS
Genome ProjectNotch binding
GO:0005112
IPI
NAS
Gene OntologyNotch binding7 17

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0016020
IMP
TAS
Genome Projectmembrane
GO:0016020
IMP
TAS
Gene Ontologymembrane7 14
GO:0016324
ISS
Genome Projectapical plasma membrane
GO:0016324
ISS
Gene Ontologyapical plasma membrane
GO:0005912
ISS
Genome Projectadherens junction
GO:0005912
ISS
Gene Ontologyadherens junction
GO:0005887
NAS
Genome Projectintegral component of plasma membrane
GO:0005887
NAS
Gene Ontologyintegral component of plasma membrane18
GO:0005886
IDA
TAS
Genome Projectplasma membrane
GO:0005886
IDA
TAS
Gene Ontologyplasma membrane3
GO:0005576
NAS
Genome Projectextracellular region
GO:0005576
NAS
Gene Ontologyextracellular region18
GO:0030424
IEA
PLAZA Integrative Orthologyaxon FBgn0004197
GO:0043005
IEA
PLAZA Integrative Orthologyneuron projection FBgn0004197
GO:0044463
IEA
PLAZA Integrative Orthologycell projection part FBgn0004197
GO:0120038
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection part FBgn0004197
GO:0120025
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection FBgn0004197
GO:0097458
IEA
PLAZA Integrative Orthologyneuron part FBgn0004197
GO:0042995
IEA
PLAZA Integrative Orthologycell projection FBgn0004197
GO:0031256
IEA
PLAZA Integrative Orthologyleading edge membrane FBgn0004197
GO:0031253
IEA
PLAZA Integrative Orthologycell projection membrane FBgn0004197
GO:0032589
IEA
PLAZA Integrative Orthologyneuron projection membrane FBgn0004197
GO:0031252
IEA
PLAZA Integrative Orthologycell leading edge FBgn0004197
GO:0044304
IEA
PLAZA Integrative Orthologymain axon FBgn0004197
GO:0009986
IEA
PLAZA Integrative Orthologycell surface FBgn0004197
GO:0030673
IEA
PLAZA Integrative Orthologyaxolemma FBgn0004197
GO:0033267
IEA
PLAZA Integrative Orthologyaxon part FBgn0004197

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000152EGF-type aspartate/asparagine hydroxylation site
IPR000742EGF-like domain
IPR001007VWFC domain
IPR001774Delta/Serrate/lag-2 (DSL) protein
IPR001881EGF-like calcium-binding domain
IPR009030Growth factor receptor cysteine-rich domain superfamily
IPR011651Notch ligand, N-terminal domain
IPR013032EGF-like, conserved site
IPR018097EGF-like calcium-binding, conserved site
IPR026219Jagged/Serrate protein

No MapMan annotations defined for this gene.
KeggID Description
K06052CD339, JAG1; jagged 1 (Alagille syndrome)
No chloroplast target sequence found.