Gene: ENSG00000096968 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000096968
Transcript Identifier
ENST00000381652
Gene Type
Coding gene
Location
9 : 5021988-5126791 : positive

Family Information

Homologous gene family
HOM02SEM000002
(1733 genes in 25 species)
specific family

Descriptions

gene_descr
Janus kinase 2

Identifiers

Type Value
pidENSP00000371067
HGNC6192
UniprotO60674
RefSeq_mRNANM_004972.3
EMBLCHEMBL3301390
EMBLAF001362
EMBLAF005216
EMBLAF058925
EMBLAL161450

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1904707
IEA
Genome Projectpositive regulation of vascular smooth muscle cell proliferation
GO:1904037
IEA
Genome Projectpositive regulation of epithelial cell apoptotic process
GO:1902728
IEA
Genome Projectpositive regulation of growth factor dependent skeletal muscle satellite cell proliferation
GO:0097296
ISS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097296
ISS
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097191
ISS
Genome Projectextrinsic apoptotic signaling pathway
GO:0097191
ISS
Gene Ontologyextrinsic apoptotic signaling pathway
GO:0070671
IDA
Genome Projectresponse to interleukin-12
GO:0070671
IDA
Gene Ontologyresponse to interleukin-121
GO:0061180
ISS
Genome Projectmammary gland epithelium development
GO:0061180
ISS
Gene Ontologymammary gland epithelium development
GO:0060399
ISS
Genome Projectpositive regulation of growth hormone receptor signaling pathway
GO:0060399
ISS
Gene Ontologypositive regulation of growth hormone receptor signaling pathway
GO:0060397
ISS
TAS
Genome ProjectJAK-STAT cascade involved in growth hormone signaling pathway
GO:0060397
ISS
TAS
Gene OntologyJAK-STAT cascade involved in growth hormone signaling pathway
GO:0060396
IDA
Genome Projectgrowth hormone receptor signaling pathway
GO:0060396
IDA
Gene Ontologygrowth hormone receptor signaling pathway2
GO:0060334
TAS
Genome Projectregulation of interferon-gamma-mediated signaling pathway
GO:0060334
TAS
Gene Ontologyregulation of interferon-gamma-mediated signaling pathway
GO:0060333
TAS
Genome Projectinterferon-gamma-mediated signaling pathway
GO:0060333
TAS
Gene Ontologyinterferon-gamma-mediated signaling pathway
GO:0051770
ISS
Genome Projectpositive regulation of nitric-oxide synthase biosynthetic process
GO:0051770
ISS
Gene Ontologypositive regulation of nitric-oxide synthase biosynthetic process
GO:0051091
IEA
Genome Projectpositive regulation of DNA-binding transcription factor activity
GO:0050867
IEA
Genome Projectpositive regulation of cell activation
GO:0050731
ISS
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050731
ISS
Gene Ontologypositive regulation of peptidyl-tyrosine phosphorylation
GO:0050729
IEA
Genome Projectpositive regulation of inflammatory response
GO:0050727
IDA
Genome Projectregulation of inflammatory response
GO:0050727
IDA
Gene Ontologyregulation of inflammatory response2
GO:0048008
IEA
Genome Projectplatelet-derived growth factor receptor signaling pathway
GO:0046777
ISS
Genome Projectprotein autophosphorylation
GO:0046777
ISS
Gene Ontologyprotein autophosphorylation
GO:0046677
IDA
Genome Projectresponse to antibiotic
GO:0046677
IDA
Gene Ontologyresponse to antibiotic3
GO:0045822
IEA
Genome Projectnegative regulation of heart contraction
GO:0045597
IEA
Genome Projectpositive regulation of cell differentiation
GO:0045429
IEA
Genome Projectpositive regulation of nitric oxide biosynthetic process
GO:0045087
IBA
Genome Projectinnate immune response
GO:0043547
IEA
Genome Projectpositive regulation of GTPase activity
GO:0043524
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0043392
ISS
Genome Projectnegative regulation of DNA binding
GO:0043392
ISS
Gene Ontologynegative regulation of DNA binding
GO:0043388
IEA
Genome Projectpositive regulation of DNA binding
GO:0042981
IBA
Genome Projectregulation of apoptotic process
GO:0042976
ISS
Genome Projectactivation of Janus kinase activity
GO:0042976
ISS
Gene Ontologyactivation of Janus kinase activity
GO:0042531
ISS
Genome Projectpositive regulation of tyrosine phosphorylation of STAT protein
GO:0042531
ISS
Gene Ontologypositive regulation of tyrosine phosphorylation of STAT protein
GO:0042127
IBA
Genome Projectregulation of cell proliferation
GO:0038083
IBA
Genome Projectpeptidyl-tyrosine autophosphorylation
GO:0035722
IDA
Genome Projectinterleukin-12-mediated signaling pathway
GO:0035722
IDA
TAS
Gene Ontologyinterleukin-12-mediated signaling pathway1
GO:0035556
ISS
Genome Projectintracellular signal transduction
GO:0035556
ISS
Gene Ontologyintracellular signal transduction
GO:0035409
IDA
Genome Projecthistone H3-Y41 phosphorylation
GO:0035409
IDA
Gene Ontologyhistone H3-Y41 phosphorylation4
GO:0034612
IDA
Genome Projectresponse to tumor necrosis factor
GO:0034612
IDA
Gene Ontologyresponse to tumor necrosis factor5
GO:0033209
IDA
Genome Projecttumor necrosis factor-mediated signaling pathway
GO:0033209
IDA
Gene Ontologytumor necrosis factor-mediated signaling pathway5
GO:0033194
IEA
Genome Projectresponse to hydroperoxide
GO:0033160
IEA
Genome Projectpositive regulation of protein import into nucleus, translocation
GO:0032760
ISS
Genome Projectpositive regulation of tumor necrosis factor production
GO:0032760
ISS
Gene Ontologypositive regulation of tumor necrosis factor production
GO:0032731
IEA
Genome Projectpositive regulation of interleukin-1 beta production
GO:0032516
IEA
Genome Projectpositive regulation of phosphoprotein phosphatase activity
GO:0032496
ISS
Genome Projectresponse to lipopolysaccharide
GO:0032496
ISS
Gene Ontologyresponse to lipopolysaccharide
GO:0032024
IEA
Genome Projectpositive regulation of insulin secretion
GO:0031959
IEA
Genome Projectmineralocorticoid receptor signaling pathway
GO:0031103
IEA
Genome Projectaxon regeneration
GO:0030335
IEA
Genome Projectpositive regulation of cell migration
GO:0030218
ISS, IBA
Genome Projecterythrocyte differentiation
GO:0030218
ISS
Gene Ontologyerythrocyte differentiation
GO:0030154
ISS
Genome Projectcell differentiation
GO:0030154
ISS
Gene Ontologycell differentiation
GO:0030041
NAS
Genome Projectactin filament polymerization
GO:0030041
NAS
Gene Ontologyactin filament polymerization2
GO:0022408
IEA
Genome Projectnegative regulation of cell-cell adhesion
GO:0019221
IDA
ISS
Genome Projectcytokine-mediated signaling pathway
GO:0019221
IDA
ISS
TAS
Gene Ontologycytokine-mediated signaling pathway5
GO:0018108
ISS
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0018108
ISS
Gene Ontologypeptidyl-tyrosine phosphorylation
GO:0016477
IBA
Genome Projectcell migration
GO:0014068
ISS
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0014068
ISS
Gene Ontologypositive regulation of phosphatidylinositol 3-kinase signaling
GO:0010811
IDA
Genome Projectpositive regulation of cell-substrate adhesion
GO:0010811
IDA
Gene Ontologypositive regulation of cell-substrate adhesion2
GO:0010667
IEA
Genome Projectnegative regulation of cardiac muscle cell apoptotic process
GO:0008631
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008285
ISS
Genome Projectnegative regulation of cell proliferation
GO:0008285
ISS
Gene Ontologynegative regulation of cell proliferation
GO:0007596
TAS
Genome Projectblood coagulation
GO:0007596
TAS
Gene Ontologyblood coagulation
GO:0007498
TAS
Genome Projectmesoderm development
GO:0007498
TAS
Gene Ontologymesoderm development6
GO:0007260
ISS, IBA
Genome Projecttyrosine phosphorylation of STAT protein
GO:0007260
ISS
Gene Ontologytyrosine phosphorylation of STAT protein
GO:0007259
TAS
Genome ProjectJAK-STAT cascade
GO:0007259
TAS
Gene OntologyJAK-STAT cascade7
GO:0007204
IEA
Genome Projectpositive regulation of cytosolic calcium ion concentration
GO:0007186
IEA
Genome ProjectG protein-coupled receptor signaling pathway
GO:0007167
ISS
Genome Projectenzyme linked receptor protein signaling pathway
GO:0007167
ISS
Gene Ontologyenzyme linked receptor protein signaling pathway
GO:0007165
ISS
Genome Projectsignal transduction
GO:0007165
ISS
Gene Ontologysignal transduction
GO:0006928
TAS
Genome Projectmovement of cell or subcellular component
GO:0006919
ISS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
ISS
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915
ISS
Genome Projectapoptotic process
GO:0006915
ISS
Gene Ontologyapoptotic process
GO:0006468
TAS
Genome Projectprotein phosphorylation
GO:0006468
TAS
Gene Ontologyprotein phosphorylation7
GO:0002250
IEA
Genome Projectadaptive immune response
GO:0000186
IEA
Genome Projectactivation of MAPKK activity
GO:0000165
TAS
Genome ProjectMAPK cascade
GO:0000165
TAS
Gene OntologyMAPK cascade
GO:0120162
ISS
Gene Ontologypositive regulation of cold-induced thermogenesis8
GO:0070757
TAS
Gene Ontologyinterleukin-35-mediated signaling pathway
GO:0070106
TAS
Gene Ontologyinterleukin-27-mediated signaling pathway
GO:0070102
TAS
Gene Ontologyinterleukin-6-mediated signaling pathway
GO:0046425
ISS
Gene Ontologyregulation of JAK-STAT cascade
GO:0045428
ISS
Gene Ontologyregulation of nitric oxide biosynthetic process
GO:0038155
TAS
Gene Ontologyinterleukin-23-mediated signaling pathway
GO:0009790
IEA
PLAZA Integrative Orthologyembryo development FBgn0004864
GO:0035166
IEA
PLAZA Integrative Orthologypost-embryonic hemopoiesis FBgn0004864
GO:0035167
IEA
PLAZA Integrative Orthologylarval lymph gland hemopoiesis FBgn0004864
GO:0035168
IEA
PLAZA Integrative Orthologylarval lymph gland hemocyte differentiation FBgn0004864
GO:0035282
IEA
PLAZA Integrative Orthologysegmentation FBgn0004864
GO:1905269
IEA
PLAZA Integrative Orthologypositive regulation of chromatin organization FBgn0004864
GO:1901342
IEA
PLAZA Integrative Orthologyregulation of vasculature development ENSG00000162434
GO:0009791
IEA
PLAZA Integrative Orthologypost-embryonic development FBgn0004864
GO:0045765
IEA
PLAZA Integrative Orthologyregulation of angiogenesis ENSG00000162434
GO:0045766
IEA
PLAZA Integrative Orthologypositive regulation of angiogenesis ENSG00000162434
GO:0001944
IEA
PLAZA Integrative Orthologyvasculature development ENSG00000162434
GO:0030707
IEA
PLAZA Integrative Orthologyovarian follicle cell development FBgn0004864
GO:0006959
IEA
PLAZA Integrative Orthologyhumoral immune response FBgn0004864
GO:0007389
IEA
PLAZA Integrative Orthologypattern specification process FBgn0004864
GO:0042386
IEA
PLAZA Integrative Orthologyhemocyte differentiation FBgn0004864
GO:0042387
IEA
PLAZA Integrative Orthologyplasmatocyte differentiation FBgn0004864
GO:0002252
IEA
PLAZA Integrative Orthologyimmune effector process FBgn0004864
GO:0002009
IEA
PLAZA Integrative Orthologymorphogenesis of an epithelium FBgn0004864
GO:0150063
IEA
PLAZA Integrative Orthologyvisual system development FBgn0004864
GO:0007472
IEA
PLAZA Integrative Orthologywing disc morphogenesis FBgn0004864
GO:0007350
IEA
PLAZA Integrative Orthologyblastoderm segmentation FBgn0004864
GO:0009653
IEA
PLAZA Integrative Orthologyanatomical structure morphogenesis ENSG00000162434
GO:0060026
IEA
PLAZA Integrative Orthologyconvergent extension FBgn0004864
GO:0060027
IEA
PLAZA Integrative Orthologyconvergent extension involved in gastrulation FBgn0004864
GO:0007478
IEA
PLAZA Integrative Orthologyleg disc morphogenesis FBgn0004864
GO:0051301
IEA
PLAZA Integrative Orthologycell division FBgn0004864
GO:0010638
IEA
PLAZA Integrative Orthologypositive regulation of organelle organization FBgn0004864
GO:0031453
IEA
PLAZA Integrative Orthologypositive regulation of heterochromatin assembly FBgn0004864
GO:0010631
IEA
PLAZA Integrative Orthologyepithelial cell migration FBgn0004864
GO:1903670
IEA
PLAZA Integrative Orthologyregulation of sprouting angiogenesis ENSG00000162434
GO:0048707
IEA
PLAZA Integrative Orthologyinstar larval or pupal morphogenesis FBgn0004864
GO:1903672
IEA
PLAZA Integrative Orthologypositive regulation of sprouting angiogenesis ENSG00000162434
GO:0007481
IEA
PLAZA Integrative Orthologyhaltere disc morphogenesis FBgn0004864
GO:0007365
IEA
PLAZA Integrative Orthologyperiodic partitioning FBgn0004864
GO:0045317
IEA
PLAZA Integrative Orthologyequator specification FBgn0004864
GO:0045799
IEA
PLAZA Integrative Orthologypositive regulation of chromatin assembly or disassembly FBgn0004864
GO:0007369
IEA
PLAZA Integrative Orthologygastrulation FBgn0004864
GO:0046530
IEA
PLAZA Integrative Orthologyphotoreceptor cell differentiation FBgn0004864
GO:0072359
IEA
PLAZA Integrative Orthologycirculatory system development ENSG00000162434
GO:0098727
IEA
PLAZA Integrative Orthologymaintenance of cell number FBgn0004864
GO:0072358
IEA
PLAZA Integrative Orthologycardiovascular system development ENSG00000162434
GO:2000026
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal development ENSG00000162434
GO:0031445
IEA
PLAZA Integrative Orthologyregulation of heterochromatin assembly FBgn0004864
GO:0038114
IEA
PLAZA Integrative Orthologyinterleukin-21-mediated signaling pathway ENSG00000105639
GO:0007292
IEA
PLAZA Integrative Orthologyfemale gamete generation FBgn0004864
GO:0038113
IEA
PLAZA Integrative Orthologyinterleukin-9-mediated signaling pathway ENSG00000105639
GO:0060562
IEA
PLAZA Integrative Orthologyepithelial tube morphogenesis FBgn0004864
GO:2001252
IEA
PLAZA Integrative Orthologypositive regulation of chromosome organization FBgn0004864
GO:0038110
IEA
PLAZA Integrative Orthologyinterleukin-2-mediated signaling pathway ENSG00000105639
GO:0007297
IEA
PLAZA Integrative Orthologyovarian follicle cell migration FBgn0004864
GO:0038111
IEA
PLAZA Integrative Orthologyinterleukin-7-mediated signaling pathway ENSG00000105639
GO:0002040
IEA
PLAZA Integrative Orthologysprouting angiogenesis ENSG00000162434
GO:1904018
IEA
PLAZA Integrative Orthologypositive regulation of vasculature development ENSG00000162434
GO:0007298
IEA
PLAZA Integrative Orthologyborder follicle cell migration FBgn0004864
GO:0002164
IEA
PLAZA Integrative Orthologylarval development FBgn0004864
GO:0002165
IEA
PLAZA Integrative Orthologyinstar larval or pupal development FBgn0004864
GO:0007613
IEA
PLAZA Integrative Orthologymemory FBgn0004864
GO:0007610
IEA
PLAZA Integrative Orthologybehavior FBgn0004864
GO:0007611
IEA
PLAZA Integrative Orthologylearning or memory FBgn0004864
GO:0003006
IEA
PLAZA Integrative Orthologydevelopmental process involved in reproduction FBgn0004864
GO:0044087
IEA
PLAZA Integrative Orthologyregulation of cellular component biogenesis FBgn0004864
GO:0001745
IEA
PLAZA Integrative Orthologycompound eye morphogenesis FBgn0004864
GO:0048565
IEA
PLAZA Integrative Orthologydigestive tract development FBgn0004864
GO:0044089
IEA
PLAZA Integrative Orthologypositive regulation of cellular component biogenesis FBgn0004864
GO:0048563
IEA
PLAZA Integrative Orthologypost-embryonic animal organ morphogenesis FBgn0004864
GO:0051607
IEA
PLAZA Integrative Orthologydefense response to virus FBgn0004864
GO:0050877
IEA
PLAZA Integrative Orthologynervous system process FBgn0004864
GO:0019827
IEA
PLAZA Integrative Orthologystem cell population maintenance FBgn0004864
GO:0016318
IEA
PLAZA Integrative Orthologyommatidial rotation FBgn0004864
GO:0045610
IEA
PLAZA Integrative Orthologyregulation of hemocyte differentiation FBgn0004864
GO:0003382
IEA
PLAZA Integrative Orthologyepithelial cell morphogenesis FBgn0004864
GO:0048569
IEA
PLAZA Integrative Orthologypost-embryonic animal organ development FBgn0004864
GO:0003383
IEA
PLAZA Integrative Orthologyapical constriction FBgn0004864
GO:0007623
IEA
PLAZA Integrative Orthologycircadian rhythm FBgn0004864
GO:0007622
IEA
PLAZA Integrative Orthologyrhythmic behavior FBgn0004864
GO:0061525
IEA
PLAZA Integrative Orthologyhindgut development FBgn0004864
GO:0030855
IEA
PLAZA Integrative Orthologyepithelial cell differentiation FBgn0004864
GO:0007616
IEA
PLAZA Integrative Orthologylong-term memory FBgn0004864
GO:0001751
IEA
PLAZA Integrative Orthologycompound eye photoreceptor cell differentiation FBgn0004864
GO:0001754
IEA
PLAZA Integrative Orthologyeye photoreceptor cell differentiation FBgn0004864
GO:0019953
IEA
PLAZA Integrative Orthologysexual reproduction FBgn0004864
GO:0008360
IEA
PLAZA Integrative Orthologyregulation of cell shape FBgn0004864
GO:0070828
IEA
PLAZA Integrative Orthologyheterochromatin organization FBgn0004864
GO:0002260
IEA
PLAZA Integrative Orthologylymphocyte homeostasis ENSG00000105639
GO:0007276
IEA
PLAZA Integrative Orthologygamete generation FBgn0004864
GO:0071350
IEA
PLAZA Integrative Orthologycellular response to interleukin-15 ENSG00000105639
GO:0050890
IEA
PLAZA Integrative Orthologycognition FBgn0004864
GO:0071355
IEA
PLAZA Integrative Orthologycellular response to interleukin-9 ENSG00000105639
GO:0048103
IEA
PLAZA Integrative Orthologysomatic stem cell division FBgn0004864
GO:0071352
IEA
PLAZA Integrative Orthologycellular response to interleukin-2 ENSG00000105639
GO:0071353
IEA
PLAZA Integrative Orthologycellular response to interleukin-4 ENSG00000105639
GO:0031497
IEA
PLAZA Integrative Orthologychromatin assembly FBgn0004864
GO:0071357
IEA
PLAZA Integrative Orthologycellular response to type I interferon ENSG00000105397
GO:0030048
IEA
PLAZA Integrative Orthologyactin filament-based movement FBgn0004864
GO:0007281
IEA
PLAZA Integrative Orthologygerm cell development FBgn0004864
GO:0007164
IEA
PLAZA Integrative Orthologyestablishment of tissue polarity FBgn0004864
GO:0035172
IEA
PLAZA Integrative Orthologyhemocyte proliferation FBgn0004864
GO:0035295
IEA
PLAZA Integrative Orthologytube development ENSG00000162434
GO:0007163
IEA
PLAZA Integrative Orthologyestablishment or maintenance of cell polarity FBgn0004864
GO:0060338
IEA
PLAZA Integrative Orthologyregulation of type I interferon-mediated signaling pathway ENSG00000105397
GO:0045995
IEA
PLAZA Integrative Orthologyregulation of embryonic development FBgn0004864
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process FBgn0004864
GO:0035171
IEA
PLAZA Integrative Orthologylamellocyte differentiation FBgn0004864
GO:0003002
IEA
PLAZA Integrative Orthologyregionalization FBgn0004864
GO:0060337
IEA
PLAZA Integrative Orthologytype I interferon signaling pathway ENSG00000105397
GO:0022412
IEA
PLAZA Integrative Orthologycellular process involved in reproduction in multicellular organism FBgn0004864
GO:0048592
IEA
PLAZA Integrative Orthologyeye morphogenesis FBgn0004864
GO:0030713
IEA
PLAZA Integrative Orthologyovarian follicle cell stalk formation FBgn0004864
GO:0048477
IEA
PLAZA Integrative Orthologyoogenesis FBgn0004864
GO:0048598
IEA
PLAZA Integrative Orthologyembryonic morphogenesis FBgn0004864
GO:0070252
IEA
PLAZA Integrative Orthologyactin-mediated cell contraction FBgn0004864
GO:0001736
IEA
PLAZA Integrative Orthologyestablishment of planar polarity FBgn0004864
GO:0035723
IEA
PLAZA Integrative Orthologyinterleukin-15-mediated signaling pathway ENSG00000105639
GO:0001738
IEA
PLAZA Integrative Orthologymorphogenesis of a polarized epithelium FBgn0004864
GO:0071103
IEA
PLAZA Integrative OrthologyDNA conformation change FBgn0004864
GO:0071104
IEA
PLAZA Integrative Orthologyresponse to interleukin-9 ENSG00000105639
GO:1902275
IEA
PLAZA Integrative Orthologyregulation of chromatin organization FBgn0004864
GO:0048514
IEA
PLAZA Integrative Orthologyblood vessel morphogenesis ENSG00000162434
GO:0007530
IEA
PLAZA Integrative Orthologysex determination FBgn0004864
GO:0048512
IEA
PLAZA Integrative Orthologycircadian behavior FBgn0004864
GO:0001672
IEA
PLAZA Integrative Orthologyregulation of chromatin assembly or disassembly FBgn0004864
GO:0006323
IEA
PLAZA Integrative OrthologyDNA packaging FBgn0004864
GO:0048880
IEA
PLAZA Integrative Orthologysensory system development FBgn0004864
GO:0001667
IEA
PLAZA Integrative Orthologyameboidal-type cell migration FBgn0004864
GO:0051128
IEA
PLAZA Integrative Orthologyregulation of cellular component organization FBgn0004864
GO:0000904
IEA
PLAZA Integrative Orthologycell morphogenesis involved in differentiation FBgn0004864
GO:0000902
IEA
PLAZA Integrative Orthologycell morphogenesis FBgn0004864
GO:0034340
IEA
PLAZA Integrative Orthologyresponse to type I interferon ENSG00000105397
GO:0048646
IEA
PLAZA Integrative Orthologyanatomical structure formation involved in morphogenesis ENSG00000162434
GO:0006333
IEA
PLAZA Integrative Orthologychromatin assembly or disassembly FBgn0004864
GO:0007423
IEA
PLAZA Integrative Orthologysensory organ development FBgn0004864
GO:0007424
IEA
PLAZA Integrative Orthologyopen tracheal system development FBgn0004864
GO:0007538
IEA
PLAZA Integrative Orthologyprimary sex determination FBgn0004864
GO:0070672
IEA
PLAZA Integrative Orthologyresponse to interleukin-15 ENSG00000105639
GO:0070670
IEA
PLAZA Integrative Orthologyresponse to interleukin-4 ENSG00000105639
GO:0031507
IEA
PLAZA Integrative Orthologyheterochromatin assembly FBgn0004864
GO:0051130
IEA
PLAZA Integrative Orthologypositive regulation of cellular component organization FBgn0004864
GO:0060541
IEA
PLAZA Integrative Orthologyrespiratory system development FBgn0004864
GO:0002064
IEA
PLAZA Integrative Orthologyepithelial cell development FBgn0004864
GO:0002065
IEA
PLAZA Integrative Orthologycolumnar/cuboidal epithelial cell differentiation FBgn0004864
GO:0002066
IEA
PLAZA Integrative Orthologycolumnar/cuboidal epithelial cell development FBgn0004864
GO:0007626
IEA
PLAZA Integrative Orthologylocomotory behavior FBgn0004864
GO:0001525
IEA
PLAZA Integrative Orthologyangiogenesis ENSG00000162434
GO:0048542
IEA
PLAZA Integrative Orthologylymph gland development FBgn0004864
GO:0016476
IEA
PLAZA Integrative Orthologyregulation of embryonic cell shape FBgn0004864
GO:0035771
IEA
PLAZA Integrative Orthologyinterleukin-4-mediated signaling pathway ENSG00000105639
GO:0048546
IEA
PLAZA Integrative Orthologydigestive tract morphogenesis FBgn0004864
GO:0001654
IEA
PLAZA Integrative Orthologyeye development FBgn0004864
GO:0001776
IEA
PLAZA Integrative Orthologyleukocyte homeostasis ENSG00000105639
GO:0022604
IEA
PLAZA Integrative Orthologyregulation of cell morphogenesis FBgn0004864
GO:0007455
IEA
PLAZA Integrative Orthologyeye-antennal disc morphogenesis FBgn0004864
GO:0090132
IEA
PLAZA Integrative Orthologyepithelium migration FBgn0004864
GO:0022603
IEA
PLAZA Integrative Orthologyregulation of anatomical structure morphogenesis ENSG00000162434
GO:0090130
IEA
PLAZA Integrative Orthologytissue migration FBgn0004864
GO:0043029
IEA
PLAZA Integrative OrthologyT cell homeostasis ENSG00000105639
GO:0035239
IEA
PLAZA Integrative Orthologytube morphogenesis ENSG00000162434
GO:0055123
IEA
PLAZA Integrative Orthologydigestive system development FBgn0004864
GO:0017145
IEA
PLAZA Integrative Orthologystem cell division FBgn0004864
GO:0048609
IEA
PLAZA Integrative Orthologymulticellular organismal reproductive process FBgn0004864
GO:0048729
IEA
PLAZA Integrative Orthologytissue morphogenesis FBgn0004864
GO:0060031
IEA
PLAZA Integrative Orthologymediolateral intercalation FBgn0004864
GO:0009880
IEA
PLAZA Integrative Orthologyembryonic pattern specification FBgn0004864
GO:0009886
IEA
PLAZA Integrative Orthologypost-embryonic animal morphogenesis FBgn0004864
GO:0042067
IEA
PLAZA Integrative Orthologyestablishment of ommatidial planar polarity FBgn0004864
GO:0009887
IEA
PLAZA Integrative Orthologyanimal organ morphogenesis FBgn0004864
GO:0098542
IEA
PLAZA Integrative Orthologydefense response to other organism FBgn0004864
GO:0042074
IEA
PLAZA Integrative Orthologycell migration involved in gastrulation FBgn0004864
GO:0035220
IEA
PLAZA Integrative Orthologywing disc development FBgn0004864
GO:0033044
IEA
PLAZA Integrative Orthologyregulation of chromosome organization FBgn0004864
GO:0033043
IEA
PLAZA Integrative Orthologyregulation of organelle organization FBgn0004864
GO:0090596
IEA
PLAZA Integrative Orthologysensory organ morphogenesis FBgn0004864
GO:0042078
IEA
PLAZA Integrative Orthologygerm-line stem cell division FBgn0004864
GO:0007552
IEA
PLAZA Integrative Orthologymetamorphosis FBgn0004864
GO:0009615
IEA
PLAZA Integrative Orthologyresponse to virus FBgn0004864
GO:0048859
IEA
PLAZA Integrative Orthologyformation of anatomical boundary FBgn0004864
GO:0032504
IEA
PLAZA Integrative Orthologymulticellular organism reproduction FBgn0004864
GO:0006338
IEA
PLAZA Integrative Orthologychromatin remodeling FBgn0004864
GO:0032989
IEA
PLAZA Integrative Orthologycellular component morphogenesis FBgn0004864
GO:0001568
IEA
PLAZA Integrative Orthologyblood vessel development ENSG00000162434
GO:0098756
IEA
PLAZA Integrative Orthologyresponse to interleukin-21 ENSG00000105639
GO:0045475
IEA
PLAZA Integrative Orthologylocomotor rhythm FBgn0004864
GO:0035218
IEA
PLAZA Integrative Orthologyleg disc development FBgn0004864
GO:0098757
IEA
PLAZA Integrative Orthologycellular response to interleukin-21 ENSG00000105639
GO:0070669
IEA
PLAZA Integrative Orthologyresponse to interleukin-2 ENSG00000105639
GO:0035214
IEA
PLAZA Integrative Orthologyeye-antennal disc development FBgn0004864
GO:0035216
IEA
PLAZA Integrative Orthologyhaltere disc development FBgn0004864
GO:0044703
IEA
PLAZA Integrative Orthologymulti-organism reproductive process FBgn0004864
GO:0007560
IEA
PLAZA Integrative Orthologyimaginal disc morphogenesis FBgn0004864
GO:0007444
IEA
PLAZA Integrative Orthologyimaginal disc development FBgn0004864
GO:0007442
IEA
PLAZA Integrative Orthologyhindgut morphogenesis FBgn0004864
GO:0048749
IEA
PLAZA Integrative Orthologycompound eye development FBgn0004864
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction FBgn0004864
GO:0098760
IEA
PLAZA Integrative Orthologyresponse to interleukin-7 ENSG00000105639
GO:0098761
IEA
PLAZA Integrative Orthologycellular response to interleukin-7 ENSG00000105639
GO:0048511
IEA
PLAZA Integrative Orthologyrhythmic process FBgn0004864
GO:0010847
IEA
PLAZA Integrative Orthologyregulation of chromatin assembly FBgn0004864
GO:0035206
IEA
PLAZA Integrative Orthologyregulation of hemocyte proliferation FBgn0004864

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0051428
IEA
Genome Projectpeptide hormone receptor binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0043560
IEA
Genome Projectinsulin receptor substrate binding
GO:0043548
IEA
Genome Projectphosphatidylinositol 3-kinase binding
GO:0042393
IDA
Genome Projecthistone binding
GO:0042393
IDA
Gene Ontologyhistone binding4
GO:0042169
IPI
Genome ProjectSH2 domain binding
GO:0042169
IPI
Gene OntologySH2 domain binding9
GO:0035401
IDA
Genome Projecthistone kinase activity (H3-Y41 specific)
GO:0035401
IDA
Gene Ontologyhistone kinase activity (H3-Y41 specific)4
GO:0033130
IEA
Genome Projectacetylcholine receptor binding
GO:0031702
IEA
Genome Projecttype 1 angiotensin receptor binding
GO:0020037
IDA
Genome Projectheme binding
GO:0020037
IDA
Gene Ontologyheme binding10
GO:0019901
IDA
Genome Projectprotein kinase binding
GO:0019901
IDA
Gene Ontologyprotein kinase binding2
GO:0008022
IEA
Genome Projectprotein C-terminus binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding11 12 13 14 15 16 17 18 19 20 21 22 23 24
GO:0005143
ISS
Genome Projectinterleukin-12 receptor binding
GO:0005143
ISS
Gene Ontologyinterleukin-12 receptor binding
GO:0005131
ISS, IBA
Genome Projectgrowth hormone receptor binding
GO:0005131
ISS
Gene Ontologygrowth hormone receptor binding
GO:0005102
IPI
Genome Projectsignaling receptor binding
GO:0005102
IPI
Gene Ontologysignaling receptor binding25
GO:0005088
TAS
Genome ProjectRas guanyl-nucleotide exchange factor activity
GO:0005088
TAS
Gene OntologyRas guanyl-nucleotide exchange factor activity
GO:0004715
TAS
Genome Projectnon-membrane spanning protein tyrosine kinase activity
GO:0004715
TAS
Gene Ontologynon-membrane spanning protein tyrosine kinase activity
GO:0004713
EXP, IDA
ISS
TAS
Genome Projectprotein tyrosine kinase activity
GO:0004713
EXP, IDA
ISS
TAS
Gene Ontologyprotein tyrosine kinase activity26 27 28 29
GO:0004672
NAS
Genome Projectprotein kinase activity
GO:0004672
TAS
Gene Ontologyprotein kinase activity
GO:0042802
IPI
Gene Ontologyidentical protein binding30 31
GO:0019902
IEA
PLAZA Integrative Orthologyphosphatase binding ENSG00000105639
GO:0019903
IEA
PLAZA Integrative Orthologyprotein phosphatase binding ENSG00000105639
GO:0031625
IEA
PLAZA Integrative Orthologyubiquitin protein ligase binding ENSG00000162434
GO:0044389
IEA
PLAZA Integrative Orthologyubiquitin-like protein ligase binding ENSG00000162434

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0045121
ISS
Genome Projectmembrane raft
GO:0045121
ISS
Gene Ontologymembrane raft
GO:0031904
TAS
Genome Projectendosome lumen
GO:0031904
TAS
Gene Ontologyendosome lumen
GO:0031234
IBA
Genome Projectextrinsic component of cytoplasmic side of plasma membrane
GO:0016363
IEA
Genome Projectnuclear matrix
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0005925
IDA
Gene Ontologyfocal adhesion
GO:0005901
ISS
Genome Projectcaveola
GO:0005901
ISS
Gene Ontologycaveola
GO:0005886
IDA
Genome Projectplasma membrane
GO:0005886
IDA
Gene Ontologyplasma membrane
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0005829
TAS
Genome Projectcytosol
GO:0005829
TAS
Gene Ontologycytosol
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm32
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005654
IDA
TAS
Gene Ontologynucleoplasm
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus4 32
GO:0043230
IEA
PLAZA Integrative Orthologyextracellular organelle ENSG00000105397
GO:0070062
IEA
PLAZA Integrative Orthologyextracellular exosome ENSG00000105397
GO:0005615
IEA
PLAZA Integrative Orthologyextracellular space ENSG00000105397
GO:0044421
IEA
PLAZA Integrative Orthologyextracellular region part ENSG00000105397
GO:0005576
IEA
PLAZA Integrative Orthologyextracellular region ENSG00000105397
GO:1903561
IEA
PLAZA Integrative Orthologyextracellular vesicle ENSG00000105397

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000299FERM domain
IPR000719Protein kinase domain
IPR000980SH2 domain
IPR001245Serine-threonine/tyrosine-protein kinase, catalytic domain
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain superfamily
IPR011993PH-like domain superfamily
IPR014352FERM/acyl-CoA-binding protein superfamily
IPR016251Tyrosine-protein kinase, non-receptor Jak/Tyk2
IPR017441Protein kinase, ATP binding site
IPR019748FERM central domain
IPR019749Band 4.1 domain
IPR020635Tyrosine-protein kinase, catalytic domain
IPR020693Tyrosine-protein kinase, non-receptor Jak2

No MapMan annotations defined for this gene.
KeggID Description
K04447JAK2; Janus kinase 2
No chloroplast target sequence found.