Gene: ENSG00000095002 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000095002
Transcript Identifier
ENST00000233146
Gene Type
Coding gene
Location
2 : 47403192-47482949 : positive

Family Information

Homologous gene family
HOM02SEM000161
(159 genes in 26 species)
specific family
Orthologous gene family
ORTHO02SEM000252
(109 genes in 26 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
mutS homolog 2

Identifiers

Type Value
pidENSP00000233146
HGNC7325
UniprotP43246
RefSeq_mRNANM_000251.2

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0051096
IDA
Genome Projectpositive regulation of helicase activity
GO:0051096
IDA
Gene Ontologypositive regulation of helicase activity1
GO:0048304
IEA
Genome Projectpositive regulation of isotype switching to IgG isotypes
GO:0048298
IEA
Genome Projectpositive regulation of isotype switching to IgA isotypes
GO:0045910
IDA
ISS
Genome Projectnegative regulation of DNA recombination
GO:0045910
IDA
ISS
Gene Ontologynegative regulation of DNA recombination1
GO:0045190
ISS
Genome Projectisotype switching
GO:0045190
ISS
Gene Ontologyisotype switching
GO:0043570
IMP
Genome Projectmaintenance of DNA repeat elements
GO:0043570
IMP
Gene Ontologymaintenance of DNA repeat elements2
GO:0043524
ISS
Genome Projectnegative regulation of neuron apoptotic process
GO:0043524
ISS
Gene Ontologynegative regulation of neuron apoptotic process
GO:0042771
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0031573
IEA
Genome Projectintra-S DNA damage checkpoint
GO:0030183
ISS
Genome ProjectB cell differentiation
GO:0030183
ISS
Gene OntologyB cell differentiation
GO:0019724
ISS
Genome ProjectB cell mediated immunity
GO:0019724
ISS
Gene OntologyB cell mediated immunity
GO:0016447
ISS
Genome Projectsomatic recombination of immunoglobulin gene segments
GO:0016447
ISS
Gene Ontologysomatic recombination of immunoglobulin gene segments
GO:0016446
IEA
Genome Projectsomatic hypermutation of immunoglobulin genes
GO:0010224
ISS
Genome Projectresponse to UV-B
GO:0010224
ISS
Gene Ontologyresponse to UV-B
GO:0010165
ISS
Genome Projectresponse to X-ray
GO:0010165
ISS
Gene Ontologyresponse to X-ray
GO:0008584
ISS
Genome Projectmale gonad development
GO:0008584
ISS
Gene Ontologymale gonad development
GO:0008340
IEA
Genome Projectdetermination of adult lifespan
GO:0007281
IEA
Genome Projectgerm cell development
GO:0007050
IEA
Genome Projectcell cycle arrest
GO:0006302
IEA
Genome Projectdouble-strand break repair
GO:0006301
IDA
Genome Projectpostreplication repair
GO:0006301
IDA
Gene Ontologypostreplication repair3
GO:0006298
IDA, IGI
TAS
Genome Projectmismatch repair
GO:0006298
IDA, IGI
TAS
Gene Ontologymismatch repair3 4 5
GO:0006281
IDA
Genome ProjectDNA repair
GO:0006281
IDA
Gene OntologyDNA repair6
GO:0006119
IEA
Genome Projectoxidative phosphorylation
GO:0001701
IEA
Genome Projectin utero embryonic development
GO:0071168
IMP
Gene Ontologyprotein localization to chromatin7
GO:0010564
IEA
PLAZA Integrative Orthologyregulation of cell cycle process AT3G18524
GO:2000104
IEA
PLAZA Integrative Orthologynegative regulation of DNA-dependent DNA replication YDR097C
GO:0044271
IEA
PLAZA Integrative Orthologycellular nitrogen compound biosynthetic process YOL090W
GO:0006355
IEA
PLAZA Integrative Orthologyregulation of transcription, DNA-templated YOL090W
GO:1901576
IEA
PLAZA Integrative Orthologyorganic substance biosynthetic process YDR097C
GO:0022413
IEA
PLAZA Integrative Orthologyreproductive process in single-celled organism SPBC19G7.01c
GO:0006351
IEA
PLAZA Integrative Orthologytranscription, DNA-templated YOL090W
GO:0034645
IEA
PLAZA Integrative Orthologycellular macromolecule biosynthetic process YDR097C
GO:0097549
IEA
PLAZA Integrative Orthologychromatin organization involved in negative regulation of transcription YOL090W
GO:0010558
IEA
PLAZA Integrative Orthologynegative regulation of macromolecule biosynthetic process YDR097C
GO:0034401
IEA
PLAZA Integrative Orthologychromatin organization involved in regulation of transcription YOL090W
GO:0010556
IEA
PLAZA Integrative Orthologyregulation of macromolecule biosynthetic process YDR097C
GO:0032505
IEA
PLAZA Integrative Orthologyreproduction of a single-celled organism SPBC19G7.01c
GO:1903507
IEA
PLAZA Integrative Orthologynegative regulation of nucleic acid-templated transcription YOL090W
GO:1903506
IEA
PLAZA Integrative Orthologyregulation of nucleic acid-templated transcription YOL090W
GO:0006342
IEA
PLAZA Integrative Orthologychromatin silencing YOL090W
GO:0009058
IEA
PLAZA Integrative Orthologybiosynthetic process YDR097C
GO:0009059
IEA
PLAZA Integrative Orthologymacromolecule biosynthetic process YDR097C
GO:0033043
IEA
PLAZA Integrative Orthologyregulation of organelle organization AT3G18524
GO:0019438
IEA
PLAZA Integrative Orthologyaromatic compound biosynthetic process YOL090W
GO:0034654
IEA
PLAZA Integrative Orthologynucleobase-containing compound biosynthetic process YOL090W
GO:0010467
IEA
PLAZA Integrative Orthologygene expression YOL090W
GO:0010468
IEA
PLAZA Integrative Orthologyregulation of gene expression YOL090W
GO:0010629
IEA
PLAZA Integrative Orthologynegative regulation of gene expression YOL090W
GO:0009889
IEA
PLAZA Integrative Orthologyregulation of biosynthetic process YDR097C
GO:0044249
IEA
PLAZA Integrative Orthologycellular biosynthetic process YDR097C
GO:0008156
IEA
PLAZA Integrative Orthologynegative regulation of DNA replication YDR097C
GO:2001141
IEA
PLAZA Integrative Orthologyregulation of RNA biosynthetic process YOL090W
GO:0051447
IEA
PLAZA Integrative Orthologynegative regulation of meiotic cell cycle AT3G18524
GO:0030466
IEA
PLAZA Integrative Orthologychromatin silencing at silent mating-type cassette YOL090W
GO:0051321
IEA
PLAZA Integrative Orthologymeiotic cell cycle AT3G18524
GO:0048285
IEA
PLAZA Integrative Orthologyorganelle fission AT3G18524
GO:0051445
IEA
PLAZA Integrative Orthologyregulation of meiotic cell cycle AT3G18524
GO:0036297
IEA
PLAZA Integrative Orthologyinterstrand cross-link repair YDR097C
GO:1903046
IEA
PLAZA Integrative Orthologymeiotic cell cycle process AT3G18524
GO:0090329
IEA
PLAZA Integrative Orthologyregulation of DNA-dependent DNA replication YDR097C
GO:0010520
IEA
PLAZA Integrative Orthologyregulation of reciprocal meiotic recombination AT3G18524
GO:0031326
IEA
PLAZA Integrative Orthologyregulation of cellular biosynthetic process YDR097C
GO:0032774
IEA
PLAZA Integrative OrthologyRNA biosynthetic process YOL090W
GO:0045165
IEA
PLAZA Integrative Orthologycell fate commitment SPBC19G7.01c
GO:0031327
IEA
PLAZA Integrative Orthologynegative regulation of cellular biosynthetic process YDR097C
GO:0007127
IEA
PLAZA Integrative Orthologymeiosis I AT3G18524
GO:0040029
IEA
PLAZA Integrative Orthologyregulation of gene expression, epigenetic YOL090W
GO:0006312
IEA
PLAZA Integrative Orthologymitotic recombination SPBC19G7.01c
GO:0045835
IEA
PLAZA Integrative Orthologynegative regulation of meiotic nuclear division AT3G18524
GO:0006275
IEA
PLAZA Integrative Orthologyregulation of DNA replication YDR097C
GO:0006311
IEA
PLAZA Integrative Orthologymeiotic gene conversion YOL090W
GO:0040020
IEA
PLAZA Integrative Orthologyregulation of meiotic nuclear division AT3G18524
GO:0061982
IEA
PLAZA Integrative Orthologymeiosis I cell cycle process AT3G18524
GO:0016458
IEA
PLAZA Integrative Orthologygene silencing YOL090W
GO:0140013
IEA
PLAZA Integrative Orthologymeiotic nuclear division AT3G18524
GO:0000280
IEA
PLAZA Integrative Orthologynuclear division AT3G18524
GO:0010639
IEA
PLAZA Integrative Orthologynegative regulation of organelle organization AT3G18524
GO:0018130
IEA
PLAZA Integrative Orthologyheterocycle biosynthetic process YOL090W
GO:0051784
IEA
PLAZA Integrative Orthologynegative regulation of nuclear division AT3G18524
GO:0016070
IEA
PLAZA Integrative OrthologyRNA metabolic process YOL090W
GO:0051783
IEA
PLAZA Integrative Orthologyregulation of nuclear division AT3G18524
GO:0000710
IEA
PLAZA Integrative Orthologymeiotic mismatch repair YDR097C
GO:0009890
IEA
PLAZA Integrative Orthologynegative regulation of biosynthetic process YDR097C
GO:0006261
IEA
PLAZA Integrative OrthologyDNA-dependent DNA replication YDR097C
GO:0006260
IEA
PLAZA Integrative OrthologyDNA replication YDR097C
GO:1901362
IEA
PLAZA Integrative Orthologyorganic cyclic compound biosynthetic process YOL090W
GO:0097659
IEA
PLAZA Integrative Orthologynucleic acid-templated transcription YOL090W
GO:2000242
IEA
PLAZA Integrative Orthologynegative regulation of reproductive process AT3G18524
GO:0035825
IEA
PLAZA Integrative Orthologyhomologous recombination AT3G18524
GO:0035822
IEA
PLAZA Integrative Orthologygene conversion SPBC19G7.01c
GO:0051252
IEA
PLAZA Integrative Orthologyregulation of RNA metabolic process YOL090W
GO:0051253
IEA
PLAZA Integrative Orthologynegative regulation of RNA metabolic process YOL090W
GO:0010948
IEA
PLAZA Integrative Orthologynegative regulation of cell cycle process AT3G18524
GO:0060631
IEA
PLAZA Integrative Orthologyregulation of meiosis I AT3G18524
GO:0043111
IEA
PLAZA Integrative Orthologyreplication fork arrest YDR097C
GO:0006290
IEA
PLAZA Integrative Orthologypyrimidine dimer repair AT3G18524
GO:0045814
IEA
PLAZA Integrative Orthologynegative regulation of gene expression, epigenetic YOL090W
GO:0051128
IEA
PLAZA Integrative Orthologyregulation of cellular component organization AT3G18524
GO:0051129
IEA
PLAZA Integrative Orthologynegative regulation of cellular component organization AT3G18524
GO:2000112
IEA
PLAZA Integrative Orthologyregulation of cellular macromolecule biosynthetic process YDR097C
GO:2000113
IEA
PLAZA Integrative Orthologynegative regulation of cellular macromolecule biosynthetic process YDR097C
GO:0110029
IEA
PLAZA Integrative Orthologynegative regulation of meiosis I AT3G18524
GO:0045892
IEA
PLAZA Integrative Orthologynegative regulation of transcription, DNA-templated YOL090W
GO:0007534
IEA
PLAZA Integrative Orthologygene conversion at mating-type locus SPBC19G7.01c
GO:1902679
IEA
PLAZA Integrative Orthologynegative regulation of RNA biosynthetic process YOL090W
GO:0045128
IEA
PLAZA Integrative Orthologynegative regulation of reciprocal meiotic recombination AT3G18524
GO:0007533
IEA
PLAZA Integrative Orthologymating type switching SPBC19G7.01c
GO:0006325
IEA
PLAZA Integrative Orthologychromatin organization YOL090W
GO:0007530
IEA
PLAZA Integrative Orthologysex determination SPBC19G7.01c
GO:0000735
IEA
PLAZA Integrative Orthologyremoval of nonhomologous ends YOL090W
GO:0045005
IEA
PLAZA Integrative OrthologyDNA-dependent DNA replication maintenance of fidelity YDR097C
GO:0007531
IEA
PLAZA Integrative Orthologymating type determination SPBC19G7.01c
GO:2000241
IEA
PLAZA Integrative Orthologyregulation of reproductive process AT3G18524
GO:0007131
IEA
PLAZA Integrative Orthologyreciprocal meiotic recombination AT3G18524

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0043531
IDA
Genome ProjectADP binding
GO:0043531
IDA
Gene OntologyADP binding8
GO:0032405
IDA
Genome ProjectMutLalpha complex binding
GO:0032405
IDA
Gene OntologyMutLalpha complex binding9
GO:0032357
IDA
Genome Projectoxidized purine DNA binding
GO:0032357
IDA
Gene Ontologyoxidized purine DNA binding10 11
GO:0032181
IDA
Genome Projectdinucleotide repeat insertion binding
GO:0032181
IDA
Gene Ontologydinucleotide repeat insertion binding6
GO:0032143
IDA
Genome Projectsingle thymine insertion binding
GO:0032143
IDA
Gene Ontologysingle thymine insertion binding6
GO:0032142
IDA
Genome Projectsingle guanine insertion binding
GO:0032142
IDA
Gene Ontologysingle guanine insertion binding6
GO:0032139
IDA
Genome Projectdinucleotide insertion or deletion binding
GO:0032139
IDA
Gene Ontologydinucleotide insertion or deletion binding6
GO:0032137
IDA, IMP
Genome Projectguanine/thymine mispair binding
GO:0032137
IDA, IMP
Gene Ontologyguanine/thymine mispair binding6 12 13
GO:0030983
IDA
Genome Projectmismatched DNA binding
GO:0030983
IDA
Gene Ontologymismatched DNA binding6 10 11
GO:0016887
IDA
Genome ProjectATPase activity
GO:0016887
IDA
Gene OntologyATPase activity9
GO:0005524
IDA
Genome ProjectATP binding
GO:0005524
IDA
Gene OntologyATP binding8
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding6 9 14 15 16 17 18 19 20 21 22 23 24 25 26 27
GO:0003697
IDA
Genome Projectsingle-stranded DNA binding
GO:0003697
IDA
Gene Ontologysingle-stranded DNA binding12
GO:0003690
IDA
Genome Projectdouble-stranded DNA binding
GO:0003690
IDA
Gene Ontologydouble-stranded DNA binding12
GO:0000400
IDA
Genome Projectfour-way junction DNA binding
GO:0000400
IDA
Gene Ontologyfour-way junction DNA binding28
GO:0000287
IDA
Genome Projectmagnesium ion binding
GO:0000287
IDA
Gene Ontologymagnesium ion binding9
GO:0042803
IDA
Genome Projectprotein homodimerization activity
GO:0042803
IDA
Gene Ontologyprotein homodimerization activity6
GO:0019901
IPI
Genome Projectprotein kinase binding
GO:0019901
IPI
Gene Ontologyprotein kinase binding18
GO:0019899
IPI
Genome Projectenzyme binding
GO:0019899
IPI
Gene Ontologyenzyme binding1 7 16 17 29 30 31 32
GO:0019237
IEA
Genome Projectcentromeric DNA binding
GO:0008022
IPI
Genome Projectprotein C-terminus binding
GO:0008022
IPI
Gene Ontologyprotein C-terminus binding33
GO:0003677
IDA
Genome ProjectDNA binding
GO:0003677
IDA
Gene OntologyDNA binding3
GO:0003682
IDA
Gene Ontologychromatin binding7
GO:0000403
IEA
PLAZA Integrative OrthologyY-form DNA binding YOL090W
GO:0000404
IEA
PLAZA Integrative Orthologyheteroduplex DNA loop binding YOL090W
GO:0000406
IEA
PLAZA Integrative Orthologydouble-strand/single-strand DNA junction binding YOL090W

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0032302
IDA
Genome ProjectMutSbeta complex
GO:0032302
IDA
Gene OntologyMutSbeta complex6
GO:0032301
IDA
Genome ProjectMutSalpha complex
GO:0032301
IDA
Gene OntologyMutSalpha complex6 34
GO:0016020
IDA
Genome Projectmembrane
GO:0016020
Gene Ontologymembrane35
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005654
TAS
Gene Ontologynucleoplasm
GO:0000784
IDA
Genome Projectnuclear chromosome, telomeric region
GO:0000784
Gene Ontologynuclear chromosome, telomeric region36
GO:0005634
IDA
Gene Ontologynucleus7
GO:0005829
IEA
PLAZA Integrative Orthologycytosol SPCC285.16c
GO:0071944
IEA
PLAZA Integrative Orthologycell periphery AT3G18524
GO:0005737
IEA
PLAZA Integrative Orthologycytoplasm SPCC285.16c
GO:0005886
IEA
PLAZA Integrative Orthologyplasma membrane AT3G18524
GO:0044444
IEA
PLAZA Integrative Orthologycytoplasmic part SPCC285.16c

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000432DNA mismatch repair protein MutS, C-terminal
IPR007695DNA mismatch repair protein MutS-like, N-terminal
IPR007696DNA mismatch repair protein MutS, core
IPR007860DNA mismatch repair protein MutS, connector domain
IPR007861DNA mismatch repair protein MutS, clamp
IPR011184DNA mismatch repair Msh2-type
IPR016151DNA mismatch repair protein MutS, N-terminal
IPR027417P-loop containing nucleoside triphosphate hydrolase
IPR032642DNA mismatch repair protein Msh2

No MapMan annotations defined for this gene.
KeggID Description
K08735MSH2; DNA mismatch repair protein MSH2
No chloroplast target sequence found.