Gene: ENSG00000091106 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000091106
Transcript Identifier
ENST00000404025
Gene Type
Coding gene
Location
2 : 32224473-32256775 : negative

Family Information

Homologous gene family
HOM02SEM004016
(20 genes in 8 species)
specific family

Descriptions

gene_descr
NLR family, CARD domain containing 4

Identifiers

Type Value
pidENSP00000385090
HGNC16412
UniprotQ9NPP4

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0090307
IBA
Genome Projectmitotic spindle assembly
GO:1990001
IBA
Genome Projectinhibition of cysteine-type endopeptidase activity involved in apoptotic process
GO:0070269
ISS
Genome Projectpyroptosis
GO:0070269
ISS
Gene Ontologypyroptosis
GO:0051260
ISS
Genome Projectprotein homooligomerization
GO:0051260
ISS
Gene Ontologyprotein homooligomerization
GO:0051092
IDA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051092
IDA
Gene Ontologypositive regulation of NF-kappaB transcription factor activity1
GO:0050702
IDA
Genome Projectinterleukin-1 beta secretion
GO:0050702
IDA
Gene Ontologyinterleukin-1 beta secretion2
GO:0045087
IBA
Genome Projectinnate immune response
GO:0043065
IDA
Genome Projectpositive regulation of apoptotic process
GO:0043065
IDA
Gene Ontologypositive regulation of apoptotic process1
GO:0042981
TAS
Genome Projectregulation of apoptotic process
GO:0042981
TAS
Gene Ontologyregulation of apoptotic process
GO:0042742
IDA
Genome Projectdefense response to bacterium
GO:0042742
IDA
Gene Ontologydefense response to bacterium3
GO:0016567
IEA
Genome Projectprotein ubiquitination
GO:0016045
IDA
Genome Projectdetection of bacterium
GO:0016045
IDA
Gene Ontologydetection of bacterium3
GO:0009966
IBA
Genome Projectregulation of signal transduction
GO:0006954
ISS
Genome Projectinflammatory response
GO:0006954
ISS
Gene Ontologyinflammatory response
GO:0006919
IDA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
IDA
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process4
GO:0006915
IEA
Genome Projectapoptotic process
GO:0002218
ISS
Genome Projectactivation of innate immune response
GO:0002218
ISS
Gene Ontologyactivation of innate immune response

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0043027
IBA
Genome Projectcysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0042803
IDA
Genome Projectprotein homodimerization activity
GO:0042803
IDA
Gene Ontologyprotein homodimerization activity3
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042802
IPI
Gene Ontologyidentical protein binding5 6
GO:0005524
IDA
Genome ProjectATP binding
GO:0005524
IDA
Gene OntologyATP binding2
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding3 5 6 7 8 9
GO:0004842
IBA
Genome Projectubiquitin-protein transferase activity
GO:0000287
TAS
Genome Projectmagnesium ion binding
GO:0000287
TAS
Gene Ontologymagnesium ion binding2

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0072557
ISS, IBA
Genome ProjectIPAF inflammasome complex
GO:0072557
ISS
Gene OntologyIPAF inflammasome complex
GO:0005829
ISS
TAS
Genome Projectcytosol
GO:0005829
ISS
TAS
Gene Ontologycytosol
GO:0005634
IBA
Genome Projectnucleus
GO:0005622
NAS
Genome Projectintracellular

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001315CARD domain
IPR007111NACHT nucleoside triphosphatase
IPR011029Death-like domain superfamily
IPR027417P-loop containing nucleoside triphosphate hydrolase
IPR032675Leucine-rich repeat domain superfamily

No MapMan annotations defined for this gene.
KeggID Description
K12805NLRC4, CARD12; NLR family CARD domain-containing protein 4
No chloroplast target sequence found.