Gene: ENSG00000087088 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000087088
Transcript Identifier
ENST00000293288
Gene Type
Coding gene
Location
19 : 48954929-48961097 : positive

Family Information

Homologous gene family
HOM02SEM001172
(44 genes in 24 species)
specific family

Descriptions

gene_descr
BCL2-associated X protein

Identifiers

Type Value
pidENSP00000293288
HGNC959
UniprotQ07812
RefSeq_mRNANM_004324.3

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2001244
IMP
Genome Projectpositive regulation of intrinsic apoptotic signaling pathway
GO:2001244
IMP
Gene Ontologypositive regulation of intrinsic apoptotic signaling pathway1 2 3
GO:2001241
IEA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001234
IEA
Genome Projectnegative regulation of apoptotic signaling pathway
GO:1990117
IDA
Genome ProjectB cell receptor apoptotic signaling pathway
GO:1990117
IDA
Gene OntologyB cell receptor apoptotic signaling pathway4
GO:1903896
TAS
Genome Projectpositive regulation of IRE1-mediated unfolded protein response
GO:1903896
TAS
Gene Ontologypositive regulation of IRE1-mediated unfolded protein response5
GO:1902512
IMP
Genome Projectpositive regulation of apoptotic DNA fragmentation
GO:1902512
IMP
Gene Ontologypositive regulation of apoptotic DNA fragmentation6
GO:1902445
IEA
Genome Projectregulation of mitochondrial membrane permeability involved in programmed necrotic cell death
GO:1902263
IEA
Genome Projectapoptotic process involved in embryonic digit morphogenesis
GO:1902262
IEA
Genome Projectapoptotic process involved in blood vessel morphogenesis
GO:1901030
TAS
Genome Projectpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901030
TAS
Gene Ontologypositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1900103
IMP
Genome Projectpositive regulation of endoplasmic reticulum unfolded protein response
GO:1900103
IMP
Gene Ontologypositive regulation of endoplasmic reticulum unfolded protein response7
GO:0097296
IEA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097193
IDA
Genome Projectintrinsic apoptotic signaling pathway
GO:0097193
IDA
Gene Ontologyintrinsic apoptotic signaling pathway8 9
GO:0097192
IEA
Genome Projectextrinsic apoptotic signaling pathway in absence of ligand
GO:0097191
IDA
Genome Projectextrinsic apoptotic signaling pathway
GO:0097191
IDA
Gene Ontologyextrinsic apoptotic signaling pathway4
GO:0097190
IDA
Genome Projectapoptotic signaling pathway
GO:0097190
IDA
Gene Ontologyapoptotic signaling pathway10
GO:0090200
IDA
Genome Projectpositive regulation of release of cytochrome c from mitochondria
GO:0090200
IDA, IMP
Gene Ontologypositive regulation of release of cytochrome c from mitochondria1 3
GO:0072332
IEA
Genome Projectintrinsic apoptotic signaling pathway by p53 class mediator
GO:0070584
IEA
Genome Projectmitochondrion morphogenesis
GO:0070242
IEA
Genome Projectthymocyte apoptotic process
GO:0070059
IMP
TAS
Genome Projectintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070059
IMP
TAS
Gene Ontologyintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress7 11
GO:0060068
IEA
Genome Projectvagina development
GO:0060058
IEA
Genome Projectpositive regulation of apoptotic process involved in mammary gland involution
GO:0060041
IEA
Genome Projectretina development in camera-type eye
GO:0060011
IEA
Genome ProjectSertoli cell proliferation
GO:0051881
IDA
Genome Projectregulation of mitochondrial membrane potential
GO:0051881
IDA
Gene Ontologyregulation of mitochondrial membrane potential12
GO:0051402
IEA
Genome Projectneuron apoptotic process
GO:0051281
IEA
Genome Projectpositive regulation of release of sequestered calcium ion into cytosol
GO:0051260
IDA
Genome Projectprotein homooligomerization
GO:0051260
IDA
Gene Ontologyprotein homooligomerization13 14
GO:0051259
IDA
Genome Projectprotein complex oligomerization
GO:0051259
IDA
Gene Ontologyprotein complex oligomerization15
GO:0048873
IEA
Genome Projecthomeostasis of number of cells within a tissue
GO:0048678
IEA
Genome Projectresponse to axon injury
GO:0048597
IEA
Genome Projectpost-embryonic camera-type eye morphogenesis
GO:0048515
IEA
Genome Projectspermatid differentiation
GO:0048147
IEA
Genome Projectnegative regulation of fibroblast proliferation
GO:0048087
IEA
Genome Projectpositive regulation of developmental pigmentation
GO:0046666
IEA
Genome Projectretinal cell programmed cell death
GO:0045136
IEA
Genome Projectdevelopment of secondary sexual characteristics
GO:0043653
IDA
Genome Projectmitochondrial fragmentation involved in apoptotic process
GO:0043653
IDA
Gene Ontologymitochondrial fragmentation involved in apoptotic process16
GO:0043525
IDA
Genome Projectpositive regulation of neuron apoptotic process
GO:0043525
IDA
Gene Ontologypositive regulation of neuron apoptotic process17
GO:0043524
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0043497
IPI
Genome Projectregulation of protein heterodimerization activity
GO:0043497
IPI
Gene Ontologyregulation of protein heterodimerization activity18
GO:0043496
IDA
Genome Projectregulation of protein homodimerization activity
GO:0043496
IDA
Gene Ontologyregulation of protein homodimerization activity18
GO:0043065
IMP
Genome Projectpositive regulation of apoptotic process
GO:0043065
IDA, IMP
Gene Ontologypositive regulation of apoptotic process19 20
GO:0042981
TAS
Genome Projectregulation of apoptotic process
GO:0042981
TAS
Gene Ontologyregulation of apoptotic process
GO:0042475
IEA
Genome Projectodontogenesis of dentin-containing tooth
GO:0035234
IEA
Genome Projectectopic germ cell programmed cell death
GO:0034644
IEA
Genome Projectcellular response to UV
GO:0033599
IEA
Genome Projectregulation of mammary gland epithelial cell proliferation
GO:0033137
IEA
Genome Projectnegative regulation of peptidyl-serine phosphorylation
GO:0032976
IDA
Genome Projectrelease of matrix enzymes from mitochondria
GO:0032976
IDA
Gene Ontologyrelease of matrix enzymes from mitochondria12
GO:0032471
IEA
Genome Projectnegative regulation of endoplasmic reticulum calcium ion concentration
GO:0032469
TAS
Genome Projectendoplasmic reticulum calcium ion homeostasis
GO:0032469
TAS
Gene Ontologyendoplasmic reticulum calcium ion homeostasis21
GO:0032461
IDA
Genome Projectpositive regulation of protein oligomerization
GO:0032461
IDA
Gene Ontologypositive regulation of protein oligomerization22
GO:0032091
IDA
Genome Projectnegative regulation of protein binding
GO:0032091
IDA
Gene Ontologynegative regulation of protein binding23
GO:0021987
IEA
Genome Projectcerebral cortex development
GO:0021854
IEA
Genome Projecthypothalamus development
GO:0016032
IEA
Genome Projectviral process
GO:0010332
IEA
Genome Projectresponse to gamma radiation
GO:0010248
IDA
Genome Projectestablishment or maintenance of transmembrane electrochemical gradient
GO:0010248
IDA
Gene Ontologyestablishment or maintenance of transmembrane electrochemical gradient12
GO:0009651
IEA
Genome Projectresponse to salt stress
GO:0009636
IDA
Genome Projectresponse to toxic substance
GO:0009636
IDA
Gene Ontologyresponse to toxic substance24
GO:0009566
IEA
Genome Projectfertilization
GO:0008637
IDA
Genome Projectapoptotic mitochondrial changes
GO:0008637
IDA
Gene Ontologyapoptotic mitochondrial changes12
GO:0008635
IDA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0008635
IDA
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c4
GO:0008630
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage
GO:0008625
IC
Genome Projectextrinsic apoptotic signaling pathway via death domain receptors
GO:0008625
IC
Gene Ontologyextrinsic apoptotic signaling pathway via death domain receptors25
GO:0008053
IDA
Genome Projectmitochondrial fusion
GO:0008053
IDA
Gene Ontologymitochondrial fusion26
GO:0007281
IEA
Genome Projectgerm cell development
GO:0006977
TAS
Genome ProjectDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006977
TAS
Gene OntologyDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006919
IDA, IMP
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
IDA, IMP
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process6 27
GO:0006915
IDA, IMP
NAS
Genome Projectapoptotic process
GO:0006915
IDA, IMP
NAS
Gene Ontologyapoptotic process28 29 30
GO:0006808
IEA
Genome Projectregulation of nitrogen utilization
GO:0006687
IEA
Genome Projectglycosphingolipid metabolic process
GO:0002904
IEA
Genome Projectpositive regulation of B cell apoptotic process
GO:0002358
IEA
Genome ProjectB cell homeostatic proliferation
GO:0002352
IEA
Genome ProjectB cell negative selection
GO:0002262
IEA
Genome Projectmyeloid cell homeostasis
GO:0001974
IEA
Genome Projectblood vessel remodeling
GO:0001844
TAS
Genome Projectprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0001844
TAS
Gene Ontologyprotein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0001836
IDA
Genome Projectrelease of cytochrome c from mitochondria
GO:0001836
IDA
Gene Ontologyrelease of cytochrome c from mitochondria12 25 31
GO:0001822
IEA
Genome Projectkidney development
GO:0001783
IDA
Genome ProjectB cell apoptotic process
GO:0001783
IDA
Gene OntologyB cell apoptotic process4 10
GO:0001782
IEA
Genome ProjectB cell homeostasis
GO:0001777
IEA
Genome ProjectT cell homeostatic proliferation
GO:0001764
IEA
Genome Projectneuron migration
GO:0001541
IEA
Genome Projectovarian follicle development
GO:0034620
TAS
Gene Ontologycellular response to unfolded protein5
GO:0006367
TAS
Gene Ontologytranscription initiation from RNA polymerase II promoter

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0051434
IDA, IPI
Genome ProjectBH3 domain binding
GO:0051434
IDA, IPI
Gene OntologyBH3 domain binding2 31 32
GO:0051087
IEA
Genome Projectchaperone binding
GO:0046982
IPI
Genome Projectprotein heterodimerization activity
GO:0046982
IPI
Gene Ontologyprotein heterodimerization activity18
GO:0042803
IDA, IPI
Genome Projectprotein homodimerization activity
GO:0042803
IDA, IPI
Gene Ontologyprotein homodimerization activity18 33
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042802
IPI
Gene Ontologyidentical protein binding1 14 15 19 34 35 36 37 38 39 40 41 42 43
GO:0030544
IEA
Genome ProjectHsp70 protein binding
GO:0015267
IDA
Genome Projectchannel activity
GO:0015267
IDA
Gene Ontologychannel activity8
GO:0008289
IDA
Genome Projectlipid binding
GO:0008289
IDA
Gene Ontologylipid binding13
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding1 2 7 12 15 18 19 23 33 35 37 39 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83
GO:0097159
IEA
PLAZA Homology (enrichment)organic cyclic compound binding HOM02SEM001172
GO:1901363
IEA
PLAZA Homology (enrichment)heterocyclic compound binding HOM02SEM001172
GO:0003676
IEA
PLAZA Homology (enrichment)nucleic acid binding HOM02SEM001172

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0071944
IDA
Genome Projectcell periphery
GO:0071944
IDA
Gene Ontologycell periphery84
GO:0097144
IDA
Genome ProjectBAX complex
GO:0097144
IDA
Gene OntologyBAX complex14
GO:0097136
IDA
Genome ProjectBcl-2 family protein complex
GO:0097136
IDA
Gene OntologyBcl-2 family protein complex2
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0070062
Gene Ontologyextracellular exosome85
GO:0046930
IDA
Genome Projectpore complex
GO:0046930
IDA
Gene Ontologypore complex8
GO:0016020
IDA
Genome Projectmembrane
GO:0016020
Gene Ontologymembrane86
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005829
IDA
TAS
Gene Ontologycytosol14 27 32 52 87 88
GO:0005789
IDA
Genome Projectendoplasmic reticulum membrane
GO:0005789
IDA
Gene Ontologyendoplasmic reticulum membrane10
GO:0005783
IDA
Genome Projectendoplasmic reticulum
GO:0005783
IDA
Gene Ontologyendoplasmic reticulum10
GO:0005757
IDA
Genome Projectmitochondrial permeability transition pore complex
GO:0005757
IDA
Gene Ontologymitochondrial permeability transition pore complex12
GO:0005741
TAS
Genome Projectmitochondrial outer membrane
GO:0005741
IDA
TAS
Gene Ontologymitochondrial outer membrane89
GO:0005739
IDA
Genome Projectmitochondrion
GO:0005739
IDA
Gene Ontologymitochondrion14 25 27 32 87 88
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm89 90
GO:0005635
IDA
Genome Projectnuclear envelope
GO:0005635
IDA
Gene Ontologynuclear envelope52
GO:0005634
IDA, IMP
Genome Projectnucleus
GO:0005634
IDA, IMP
Gene Ontologynucleus52 87

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR002475Bcl2-like
IPR020717Apoptosis regulator, Bcl-2, BH1 motif, conserved site
IPR020726Apoptosis regulator, Bcl-2, BH2 motif, conserved site
IPR020728Apoptosis regulator, Bcl-2, BH3 motif, conserved site
IPR026298Blc2 family
IPR026304Apoptosis regulator BAX

No MapMan annotations defined for this gene.
KeggID Description
K02159BAX; apoptosis regulator BAX
No chloroplast target sequence found.