Gene: ENSG00000084207 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000084207
Transcript Identifier
ENST00000398606
Gene Type
Coding gene
Location
11 : 67583844-67586577 : positive

Family Information

Homologous gene family
HOM02SEM005541
(15 genes in 10 species)
specific family

Descriptions

gene_descr
glutathione S-transferase pi 1

Identifiers

Type Value
pidENSP00000381607
HGNC4638
UniprotP09211
UniprotV9HWE9
RefSeq_mRNANM_000852.3
EMBLCHEMBL3902
EMBLAY324387
EMBLBC010915
EMBLBT019949
EMBLBT019950
EMBLCH471076
EMBLCR450361
EMBLEU794620
EMBLM24485
EMBLU12472
EMBLU21689
EMBLU30897
EMBLU62589
EMBLX06547
EMBLX08058
EMBLX08094
EMBLX08095
EMBLX08096
EMBLX15480

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:2001237
IDA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway
GO:2001237
IDA
Gene Ontologynegative regulation of extrinsic apoptotic signaling pathway1
GO:1904706
IEA
Genome Projectnegative regulation of vascular smooth muscle cell proliferation
GO:1901687
TAS
Genome Projectglutathione derivative biosynthetic process
GO:1901687
TAS
Gene Ontologyglutathione derivative biosynthetic process
GO:0098869
IEA
Genome Projectcellular oxidant detoxification
GO:0071672
IEA
Genome Projectnegative regulation of smooth muscle cell chemotaxis
GO:0071638
IDA
Genome Projectnegative regulation of monocyte chemotactic protein-1 production
GO:0071638
IDA
Gene Ontologynegative regulation of monocyte chemotactic protein-1 production2
GO:0071460
IEA
Genome Projectcellular response to cell-matrix adhesion
GO:0071385
IEA
Genome Projectcellular response to glucocorticoid stimulus
GO:0071364
IEA
Genome Projectcellular response to epidermal growth factor stimulus
GO:0071222
ISS
Genome Projectcellular response to lipopolysaccharide
GO:0071222
ISS
Gene Ontologycellular response to lipopolysaccharide
GO:0070664
ISS
Genome Projectnegative regulation of leukocyte proliferation
GO:0070664
ISS
Gene Ontologynegative regulation of leukocyte proliferation
GO:0070373
IDA
Genome Projectnegative regulation of ERK1 and ERK2 cascade
GO:0070373
IDA
Gene Ontologynegative regulation of ERK1 and ERK2 cascade3
GO:0070372
ISS
Genome Projectregulation of ERK1 and ERK2 cascade
GO:0070372
ISS
Gene Ontologyregulation of ERK1 and ERK2 cascade
GO:0051771
IDA
Genome Projectnegative regulation of nitric-oxide synthase biosynthetic process
GO:0051771
IDA
Gene Ontologynegative regulation of nitric-oxide synthase biosynthetic process2
GO:0048147
ISS
Genome Projectnegative regulation of fibroblast proliferation
GO:0048147
ISS
Gene Ontologynegative regulation of fibroblast proliferation
GO:0045471
IEA
Genome Projectresponse to ethanol
GO:0043651
IDA
Genome Projectlinoleic acid metabolic process
GO:0043651
IDA
Gene Ontologylinoleic acid metabolic process4
GO:0043508
IDA
Genome Projectnegative regulation of JUN kinase activity
GO:0043508
IDA
Gene Ontologynegative regulation of JUN kinase activity1
GO:0043409
NAS
Genome Projectnegative regulation of MAPK cascade
GO:0043409
NAS
Gene Ontologynegative regulation of MAPK cascade2
GO:0043407
IDA
Genome Projectnegative regulation of MAP kinase activity
GO:0043407
IDA
Gene Ontologynegative regulation of MAP kinase activity3
GO:0043312
TAS
Genome Projectneutrophil degranulation
GO:0043312
TAS
Gene Ontologyneutrophil degranulation
GO:0043200
IEA
Genome Projectresponse to amino acid
GO:0043124
ISS
Genome Projectnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124
ISS
Gene Ontologynegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043066
TAS
Genome Projectnegative regulation of apoptotic process
GO:0043066
TAS
Gene Ontologynegative regulation of apoptotic process5
GO:0035732
NAS
Genome Projectnitric oxide storage
GO:0035732
NAS
Gene Ontologynitric oxide storage6
GO:0035726
ISS
Genome Projectcommon myeloid progenitor cell proliferation
GO:0035726
ISS
Gene Ontologycommon myeloid progenitor cell proliferation
GO:0034599
TAS
Genome Projectcellular response to oxidative stress
GO:0033591
IEA
Genome Projectresponse to L-ascorbic acid
GO:0032930
ISS
Genome Projectpositive regulation of superoxide anion generation
GO:0032930
ISS
Gene Ontologypositive regulation of superoxide anion generation
GO:0032873
ISS
Genome Projectnegative regulation of stress-activated MAPK cascade
GO:0032873
ISS
Gene Ontologynegative regulation of stress-activated MAPK cascade
GO:0032872
ISS
Genome Projectregulation of stress-activated MAPK cascade
GO:0032872
ISS
Gene Ontologyregulation of stress-activated MAPK cascade
GO:0032869
IEA
Genome Projectcellular response to insulin stimulus
GO:0032720
IDA
Genome Projectnegative regulation of tumor necrosis factor production
GO:0032720
IDA
Gene Ontologynegative regulation of tumor necrosis factor production2
GO:0032691
IDA
Genome Projectnegative regulation of interleukin-1 beta production
GO:0032691
IDA
Gene Ontologynegative regulation of interleukin-1 beta production2
GO:0032355
IEA
Genome Projectresponse to estradiol
GO:0031100
IEA
Genome Projectanimal organ regeneration
GO:0014003
IEA
Genome Projectoligodendrocyte development
GO:0010804
IC
Genome Projectnegative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010804
IC
Gene Ontologynegative regulation of tumor necrosis factor-mediated signaling pathway1
GO:0009890
IDA
Genome Projectnegative regulation of biosynthetic process
GO:0009890
IDA
Gene Ontologynegative regulation of biosynthetic process2
GO:0007417
TAS
Genome Projectcentral nervous system development
GO:0007417
TAS
Gene Ontologycentral nervous system development7
GO:0006805
IDA
Genome Projectxenobiotic metabolic process
GO:0006805
IDA
Gene Ontologyxenobiotic metabolic process8
GO:0006749
IDA
Genome Projectglutathione metabolic process
GO:0006749
IDA
Gene Ontologyglutathione metabolic process8
GO:0006469
IDA
Genome Projectnegative regulation of protein kinase activity
GO:0006469
IDA
Gene Ontologynegative regulation of protein kinase activity1
GO:0002674
NAS
Genome Projectnegative regulation of acute inflammatory response
GO:0002674
NAS
Gene Ontologynegative regulation of acute inflammatory response2
GO:0000302
ISS
Genome Projectresponse to reactive oxygen species
GO:0000302
ISS
Gene Ontologyresponse to reactive oxygen species

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070026
NAS
Genome Projectnitric oxide binding
GO:0070026
NAS
Gene Ontologynitric oxide binding9
GO:0043295
IEA
Genome Projectglutathione binding
GO:0035731
IDA
Genome Projectdinitrosyl-iron complex binding
GO:0035731
IDA
Gene Ontologydinitrosyl-iron complex binding9 10
GO:0035730
IDA
Genome ProjectS-nitrosoglutathione binding
GO:0035730
IDA
Gene OntologyS-nitrosoglutathione binding9
GO:0019207
ISS
Genome Projectkinase regulator activity
GO:0019207
ISS
Gene Ontologykinase regulator activity
GO:0008432
ISS
Genome ProjectJUN kinase binding
GO:0008432
ISS
Gene OntologyJUN kinase binding
GO:0008144
IEA
Genome Projectdrug binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding1 11 12 13 14
GO:0004602
IDA
Genome Projectglutathione peroxidase activity
GO:0004602
IDA
Gene Ontologyglutathione peroxidase activity4
GO:0004364
IDA
TAS
Genome Projectglutathione transferase activity
GO:0004364
IDA
TAS
Gene Ontologyglutathione transferase activity8

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1904813
TAS
Genome Projectficolin-1-rich granule lumen
GO:1904813
TAS
Gene Ontologyficolin-1-rich granule lumen
GO:0097057
IDA
Genome ProjectTRAF2-GSTP1 complex
GO:0097057
IDA
Gene OntologyTRAF2-GSTP1 complex1
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0070062
Gene Ontologyextracellular exosome15 16 17
GO:0034774
TAS
Genome Projectsecretory granule lumen
GO:0034774
TAS
Gene Ontologysecretory granule lumen
GO:0031982
IDA
Genome Projectvesicle
GO:0031982
Gene Ontologyvesicle18
GO:0005886
IEA
Genome Projectplasma membrane
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005829
IDA
TAS
Gene Ontologycytosol
GO:0005739
IDA
Genome Projectmitochondrion
GO:0005739
IDA
Gene Ontologymitochondrion
GO:0005737
TAS
Genome Projectcytoplasm
GO:0005737
TAS
Gene Ontologycytoplasm5
GO:0005634
IEA
Genome Projectnucleus
GO:0005622
IDA
Genome Projectintracellular
GO:0005615
IDA
Genome Projectextracellular space
GO:0005615
Gene Ontologyextracellular space19 20
GO:0005576
TAS
Genome Projectextracellular region
GO:0005576
TAS
Gene Ontologyextracellular region

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR003082Glutathione S-transferase, Pi class
IPR004045Glutathione S-transferase, N-terminal
IPR004046Glutathione S-transferase, C-terminal
IPR010987Glutathione S-transferase, C-terminal-like
IPR012336Thioredoxin-like fold

No MapMan annotations defined for this gene.
KeggID Description
K00799GST, gst; glutathione S-transferase [EC:2.5.1.18]
No chloroplast target sequence found.