Gene: ENSG00000079999 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000079999
Transcript Identifier
ENST00000393623
Gene Type
Coding gene
Location
19 : 10486652-10500033 : negative

Family Information

Homologous gene family
HOM02SEM000524
(74 genes in 9 species)
specific family

Descriptions

gene_descr
kelch-like ECH-associated protein 1

Identifiers

Type Value
pidENSP00000377245
HGNC23177
UniprotQ14145
UniprotA0A024R7C0
RefSeq_mRNANM_012289.3
EMBLCHEMBL3038498
EMBLAC011461
EMBLAF361886
EMBLAF361888
EMBLAF361889
EMBLAF361890
EMBLAF361891
EMBLAF361892
EMBLAK056204
EMBLBC002417
EMBLBC002930
EMBLBC015945
EMBLBC021957
EMBLCH471106
EMBLD50922

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0071353
IEA
Genome Projectcellular response to interleukin-4
GO:0045604
IEA
Genome Projectregulation of epidermal cell differentiation
GO:0043687
TAS
Genome Projectpost-translational protein modification
GO:0043687
TAS
Gene Ontologypost-translational protein modification
GO:0043433
TAS
Genome Projectnegative regulation of DNA-binding transcription factor activity
GO:0043433
TAS
Gene Ontologynegative regulation of DNA-binding transcription factor activity1
GO:0042994
IBA
Genome Projectcytoplasmic sequestering of transcription factor
GO:0032436
TAS
Genome Projectpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032436
TAS
Gene Ontologypositive regulation of proteasomal ubiquitin-dependent protein catabolic process1
GO:0016579
TAS
Genome Projectprotein deubiquitination
GO:0016579
TAS
Gene Ontologyprotein deubiquitination
GO:0016567
IDA
IEA
Genome Projectprotein ubiquitination
GO:0016567
IDA
Gene Ontologyprotein ubiquitination2
GO:0010499
IDA
Genome Projectproteasomal ubiquitin-independent protein catabolic process
GO:0010499
IDA
Gene Ontologyproteasomal ubiquitin-independent protein catabolic process2
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0001701
IEA
Genome Projectin utero embryonic development
GO:0051865
IEA
PLAZA Integrative Orthologyprotein autoubiquitination FBgn0038475
GO:0006950
IEA
PLAZA Integrative Orthologyresponse to stress FBgn0038475
GO:0042127
IEA
PLAZA Integrative Orthologyregulation of cell proliferation ENSG00000184828
GO:0048523
IEA
PLAZA Integrative Orthologynegative regulation of cellular process ENSG00000184828
GO:0008285
IEA
PLAZA Integrative Orthologynegative regulation of cell proliferation ENSG00000184828
GO:0006979
IEA
PLAZA Integrative Orthologyresponse to oxidative stress FBgn0038475
GO:0008283
IEA
PLAZA Integrative Orthologycell proliferation ENSG00000184828

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004842
IBA
Genome Projectubiquitin-protein transferase activity
GO:0097718
IEA
Genome Projectdisordered domain specific binding
GO:0042803
IEA
Genome Projectprotein homodimerization activity
GO:0008134
IPI
Genome Projecttranscription factor binding
GO:0008134
IPI
Gene Ontologytranscription factor binding1
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding1 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0031463
IDA
Genome ProjectCul3-RING ubiquitin ligase complex
GO:0031463
IDA
Gene OntologyCul3-RING ubiquitin ligase complex2
GO:0030496
IDA
Genome Projectmidbody
GO:0030496
IDA
Gene Ontologymidbody24
GO:0005884
IEA
Genome Projectactin filament
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005829
IDA
TAS
Gene Ontologycytosol1
GO:0005815
IDA
Genome Projectmicrotubule organizing center
GO:0005815
IDA
Gene Ontologymicrotubule organizing center
GO:0005783
IEA
Genome Projectendoplasmic reticulum
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm7
GO:0005654
IDA
Genome Projectnucleoplasm
GO:0005654
IDA
Gene Ontologynucleoplasm
GO:0044427
IEA
PLAZA Integrative Orthologychromosomal part FBgn0038475
GO:0005694
IEA
PLAZA Integrative Orthologychromosome FBgn0038475
GO:0098687
IEA
PLAZA Integrative Orthologychromosomal region FBgn0038475
GO:0005703
IEA
PLAZA Integrative Orthologypolytene chromosome puff FBgn0038475
GO:0005700
IEA
PLAZA Integrative Orthologypolytene chromosome FBgn0038475

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000210BTB/POZ domain
IPR006652Kelch repeat type 1
IPR011333SKP1/BTB/POZ domain superfamily
IPR011705BTB/Kelch-associated
IPR015915Kelch-type beta propeller
IPR017096BTB-kelch protein
IPR030563Kelch-like ECH-associated protein 1

No MapMan annotations defined for this gene.
KeggID Description
K10456KLHL19, KEAP1, INRF2; kelch-like protein 19
No chloroplast target sequence found.