Gene: ENSG00000078140 (Homo sapiens)

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Gene Identifier
ENSG00000078140
Transcript Identifier
ENST00000261427
Gene Type
Coding gene
Location
4 : 39698328-39778434 : positive

Family Information

Homologous gene family
HOM02SEM000029
(475 genes in 26 species)
specific family
Orthologous gene family
ORTHO02SEM000122
(172 genes in 26 species)
specific family

Descriptions

gene_descr
ubiquitin-conjugating enzyme E2K

Identifiers

Type Value
pidENSP00000261427
HGNC4914
UniprotP61086
RefSeq_mRNANM_005339.4

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070936
IDA
Genome Projectprotein K48-linked ubiquitination
GO:0070936
IDA
Gene Ontologyprotein K48-linked ubiquitination1
GO:0070059
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0060340
IMP
Genome Projectpositive regulation of type I interferon-mediated signaling pathway
GO:0060340
IMP
Gene Ontologypositive regulation of type I interferon-mediated signaling pathway2
GO:0043161
IBA
Genome Projectproteasome-mediated ubiquitin-dependent protein catabolic process
GO:0035458
IMP
Genome Projectcellular response to interferon-beta
GO:0035458
IMP
Gene Ontologycellular response to interferon-beta2
GO:0032434
IEA
Genome Projectregulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0016567
TAS
Genome Projectprotein ubiquitination
GO:0016567
TAS
Gene Ontologyprotein ubiquitination
GO:0010994
IDA
Genome Projectfree ubiquitin chain polymerization
GO:0010994
IDA
Gene Ontologyfree ubiquitin chain polymerization2
GO:0010800
IDA
Genome Projectpositive regulation of peptidyl-threonine phosphorylation
GO:0010800
IDA
Gene Ontologypositive regulation of peptidyl-threonine phosphorylation2
GO:0006511
TAS
Genome Projectubiquitin-dependent protein catabolic process
GO:0006511
TAS
Gene Ontologyubiquitin-dependent protein catabolic process3
GO:0010243
IEA
PLAZA Integrative Orthologyresponse to organonitrogen compound YDR177W
GO:0071702
IEA
PLAZA Integrative Orthologyorganic substance transport YGR133W
GO:0017038
IEA
PLAZA Integrative Orthologyprotein import YGR133W
GO:0030433
IEA
PLAZA Integrative Orthologyubiquitin-dependent ERAD pathway YDR177W
GO:0051234
IEA
PLAZA Integrative Orthologyestablishment of localization YGR133W
GO:0006625
IEA
PLAZA Integrative Orthologyprotein targeting to peroxisome YGR133W
GO:0072594
IEA
PLAZA Integrative Orthologyestablishment of protein localization to organelle YGR133W
GO:0042886
IEA
PLAZA Integrative Orthologyamide transport YGR133W
GO:0007049
IEA
PLAZA Integrative Orthologycell cycle FBgn0015321
GO:0006513
IEA
PLAZA Integrative Orthologyprotein monoubiquitination YGR133W
GO:0044743
IEA
PLAZA Integrative Orthologyprotein transmembrane import into intracellular organelle YGR133W
GO:1901698
IEA
PLAZA Integrative Orthologyresponse to nitrogen compound YDR177W
GO:0006996
IEA
PLAZA Integrative Orthologyorganelle organization YGR133W
GO:0043574
IEA
PLAZA Integrative Orthologyperoxisomal transport YGR133W
GO:0071705
IEA
PLAZA Integrative Orthologynitrogen compound transport YGR133W
GO:0055085
IEA
PLAZA Integrative Orthologytransmembrane transport YGR133W
GO:0036503
IEA
PLAZA Integrative OrthologyERAD pathway YDR177W
GO:0051865
IEA
PLAZA Integrative Orthologyprotein autoubiquitination YGR133W
GO:0033036
IEA
PLAZA Integrative Orthologymacromolecule localization YGR133W
GO:0007031
IEA
PLAZA Integrative Orthologyperoxisome organization YGR133W
GO:0015833
IEA
PLAZA Integrative Orthologypeptide transport YGR133W
GO:0034613
IEA
PLAZA Integrative Orthologycellular protein localization YGR133W
GO:0033365
IEA
PLAZA Integrative Orthologyprotein localization to organelle YGR133W
GO:0016562
IEA
PLAZA Integrative Orthologyprotein import into peroxisome matrix, receptor recycling YGR133W
GO:0015919
IEA
PLAZA Integrative Orthologyperoxisomal membrane transport YGR133W
GO:0006605
IEA
PLAZA Integrative Orthologyprotein targeting YGR133W
GO:0051179
IEA
PLAZA Integrative Orthologylocalization YGR133W
GO:0045184
IEA
PLAZA Integrative Orthologyestablishment of protein localization YGR133W
GO:0006810
IEA
PLAZA Integrative Orthologytransport YGR133W
GO:0001881
IEA
PLAZA Integrative Orthologyreceptor recycling YGR133W
GO:0043112
IEA
PLAZA Integrative Orthologyreceptor metabolic process YGR133W
GO:0065002
IEA
PLAZA Integrative Orthologyintracellular protein transmembrane transport YGR133W
GO:0016558
IEA
PLAZA Integrative Orthologyprotein import into peroxisome matrix YGR133W
GO:0046907
IEA
PLAZA Integrative Orthologyintracellular transport YGR133W
GO:0071806
IEA
PLAZA Integrative Orthologyprotein transmembrane transport YGR133W
GO:0051649
IEA
PLAZA Integrative Orthologyestablishment of localization in cell YGR133W
GO:0051726
IEA
PLAZA Integrative Orthologyregulation of cell cycle FBgn0015321
GO:0072663
IEA
PLAZA Integrative Orthologyestablishment of protein localization to peroxisome YGR133W
GO:0072662
IEA
PLAZA Integrative Orthologyprotein localization to peroxisome YGR133W
GO:0016050
IEA
PLAZA Integrative Orthologyvesicle organization YDR177W
GO:0051641
IEA
PLAZA Integrative Orthologycellular localization YGR133W
GO:0006886
IEA
PLAZA Integrative Orthologyintracellular protein transport YGR133W
GO:0008104
IEA
PLAZA Integrative Orthologyprotein localization YGR133W
GO:0070727
IEA
PLAZA Integrative Orthologycellular macromolecule localization YGR133W
GO:0015031
IEA
PLAZA Integrative Orthologyprotein transport YGR133W

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0034450
IDA
Genome Projectubiquitin-ubiquitin ligase activity
GO:0034450
IDA
Gene Ontologyubiquitin-ubiquitin ligase activity4
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0031625
IPI
Gene Ontologyubiquitin protein ligase binding4 5 6
GO:0005524
IEA
Genome ProjectATP binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding7 8 9 10 11 12 13 14
GO:0004842
IDA
Genome Projectubiquitin-protein transferase activity
GO:0004842
IDA
Gene Ontologyubiquitin-protein transferase activity1
GO:0070628
IEA
PLAZA Integrative Orthologyproteasome binding YDR177W
GO:0044877
IEA
PLAZA Integrative Orthologyprotein-containing complex binding YDR177W

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0032433
IEA
Genome Projectfilopodium tip
GO:0005829
TAS
Genome Projectcytosol
GO:0005829
TAS
Gene Ontologycytosol
GO:0005737
IBA
Genome Projectcytoplasm
GO:0005634
IBA
Genome Projectnucleus
GO:0005777
IEA
PLAZA Integrative Orthologyperoxisome YGR133W
GO:1905368
IEA
PLAZA Integrative Orthologypeptidase complex YDR177W
GO:1905369
IEA
PLAZA Integrative Orthologyendopeptidase complex YDR177W
GO:1902494
IEA
PLAZA Integrative Orthologycatalytic complex YDR177W
GO:0032991
IEA
PLAZA Integrative Orthologyprotein-containing complex YDR177W
GO:0000502
IEA
PLAZA Integrative Orthologyproteasome complex YDR177W
GO:0042579
IEA
PLAZA Integrative Orthologymicrobody YGR133W

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000608Ubiquitin-conjugating enzyme E2
IPR009060UBA-like superfamily
IPR015940Ubiquitin-associated domain
IPR016135Ubiquitin-conjugating enzyme/RWD-like
IPR023313Ubiquitin-conjugating enzyme, active site

No MapMan annotations defined for this gene.
KeggID Description
K04649HIP2, UBC1; ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23]
No chloroplast target sequence found.