Gene: ENSG00000074047 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000074047
Transcript Identifier
ENST00000361492
Gene Type
Coding gene
Location
2 : 120797321-120990675 : positive

Family Information

Homologous gene family
HOM02SEM012860
(6 genes in 3 species)
specific family
Orthologous gene family
ORTHO02SEM012353
(5 genes in 3 species)
specific family

Descriptions

gene_descr
GLI family zinc finger 2

Identifiers

Type Value
pidENSP00000354586
HGNC4318
UniprotP10070
RefSeq_mRNANM_005270.4

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0090103
IEA
Genome Projectcochlea morphogenesis
GO:0071407
IEA
Genome Projectcellular response to organic cyclic compound
GO:0060831
IEA
Genome Projectsmoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0060603
IEA
Genome Projectmammary gland duct morphogenesis
GO:0060513
IEA
Genome Projectprostatic bud formation
GO:0060032
IEA
Genome Projectnotochord regression
GO:0048754
ISS
Genome Projectbranching morphogenesis of an epithelial tube
GO:0048754
ISS
Gene Ontologybranching morphogenesis of an epithelial tube
GO:0048666
ISS
Genome Projectneuron development
GO:0048666
ISS
Gene Ontologyneuron development
GO:0048589
ISS
Genome Projectdevelopmental growth
GO:0048589
ISS
Gene Ontologydevelopmental growth
GO:0048566
ISS
Genome Projectembryonic digestive tract development
GO:0048566
ISS
Gene Ontologyembryonic digestive tract development
GO:0045944
IDA
Genome Projectpositive regulation of transcription by RNA polymerase II
GO:0045944
IDA
Gene Ontologypositive regulation of transcription by RNA polymerase II1 2
GO:0045893
IDA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045893
IDA
Gene Ontologypositive regulation of transcription, DNA-templated3
GO:0045740
IDA
Genome Projectpositive regulation of DNA replication
GO:0045740
IDA
Gene Ontologypositive regulation of DNA replication1
GO:0045666
IEA
Genome Projectpositive regulation of neuron differentiation
GO:0043066
IEA
Genome Projectnegative regulation of apoptotic process
GO:0042733
IEA
Genome Projectembryonic digit morphogenesis
GO:0042475
ISS
Genome Projectodontogenesis of dentin-containing tooth
GO:0042475
ISS
Gene Ontologyodontogenesis of dentin-containing tooth
GO:0035295
ISS
Genome Projecttube development
GO:0035295
ISS
Gene Ontologytube development
GO:0033089
ISS
Genome Projectpositive regulation of T cell differentiation in thymus
GO:0033089
ISS
Gene Ontologypositive regulation of T cell differentiation in thymus
GO:0032331
IEA
Genome Projectnegative regulation of chondrocyte differentiation
GO:0030902
ISS
Genome Projecthindbrain development
GO:0030902
ISS
Gene Ontologyhindbrain development
GO:0030879
ISS
Genome Projectmammary gland development
GO:0030879
ISS
Gene Ontologymammary gland development
GO:0030324
ISS
Genome Projectlung development
GO:0030324
ISS
Gene Ontologylung development
GO:0021983
ISS
Genome Projectpituitary gland development
GO:0021983
ISS
Gene Ontologypituitary gland development
GO:0021965
ISS
Genome Projectspinal cord ventral commissure morphogenesis
GO:0021965
ISS
Gene Ontologyspinal cord ventral commissure morphogenesis
GO:0021938
IEA
Genome Projectsmoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021776
IEA
Genome Projectsmoothened signaling pathway involved in spinal cord motor neuron cell fate specification
GO:0021775
ISS
Genome Projectsmoothened signaling pathway involved in ventral spinal cord interneuron specification
GO:0021775
ISS
Gene Ontologysmoothened signaling pathway involved in ventral spinal cord interneuron specification
GO:0021696
ISS
Genome Projectcerebellar cortex morphogenesis
GO:0021696
ISS
Gene Ontologycerebellar cortex morphogenesis
GO:0021517
ISS
Genome Projectventral spinal cord development
GO:0021517
ISS
Gene Ontologyventral spinal cord development
GO:0021513
ISS
Genome Projectspinal cord dorsal/ventral patterning
GO:0021513
ISS
Gene Ontologyspinal cord dorsal/ventral patterning
GO:0021508
ISS
Genome Projectfloor plate formation
GO:0021508
ISS
Gene Ontologyfloor plate formation
GO:0009954
ISS
Genome Projectproximal/distal pattern formation
GO:0009954
ISS
Gene Ontologyproximal/distal pattern formation
GO:0009952
IEA
Genome Projectanterior/posterior pattern specification
GO:0009612
IEA
Genome Projectresponse to mechanical stimulus
GO:0008589
IEA
Genome Projectregulation of smoothened signaling pathway
GO:0008283
IDA
Genome Projectcell proliferation
GO:0008283
IDA
Gene Ontologycell proliferation2
GO:0007507
ISS
Genome Projectheart development
GO:0007507
ISS
Gene Ontologyheart development
GO:0007442
ISS
Genome Projecthindgut morphogenesis
GO:0007442
ISS
Gene Ontologyhindgut morphogenesis
GO:0007418
ISS
Genome Projectventral midline development
GO:0007418
ISS
Gene Ontologyventral midline development
GO:0007411
ISS
Genome Projectaxon guidance
GO:0007411
ISS
Gene Ontologyaxon guidance
GO:0007389
ISS
Genome Projectpattern specification process
GO:0007389
ISS
Gene Ontologypattern specification process
GO:0007224
IDA
Genome Projectsmoothened signaling pathway
GO:0007224
IDA
Gene Ontologysmoothened signaling pathway2
GO:0006366
IEA
Genome Projecttranscription by RNA polymerase II
GO:0002076
ISS
Genome Projectosteoblast development
GO:0002076
ISS
Gene Ontologyosteoblast development
GO:0002062
IEA
Genome Projectchondrocyte differentiation
GO:0001822
ISS
Genome Projectkidney development
GO:0001822
ISS
Gene Ontologykidney development
GO:0001701
IEA
Genome Projectin utero embryonic development
GO:0001501
ISS
Genome Projectskeletal system development
GO:0001501
ISS
Gene Ontologyskeletal system development
GO:0000122
IMP
Genome Projectnegative regulation of transcription by RNA polymerase II
GO:0000122
IMP
Gene Ontologynegative regulation of transcription by RNA polymerase II2
GO:0010564
IEA
PLAZA Integrative Orthologyregulation of cell cycle process ENSG00000111087
GO:0045880
IEA
PLAZA Integrative Orthologypositive regulation of smoothened signaling pathway ENSG00000111087
GO:0048477
IEA
PLAZA Integrative Orthologyoogenesis FBgn0004859
GO:0048592
IEA
PLAZA Integrative Orthologyeye morphogenesis FBgn0004859
GO:0090090
IEA
PLAZA Integrative Orthologynegative regulation of canonical Wnt signaling pathway ENSG00000106571
GO:0022412
IEA
PLAZA Integrative Orthologycellular process involved in reproduction in multicellular organism FBgn0004859
GO:0007049
IEA
PLAZA Integrative Orthologycell cycle ENSG00000111087
GO:0007448
IEA
PLAZA Integrative Orthologyanterior/posterior pattern specification, imaginal disc FBgn0004859
GO:0007447
IEA
PLAZA Integrative Orthologyimaginal disc pattern formation FBgn0004859
GO:0198738
IEA
PLAZA Integrative Orthologycell-cell signaling by wnt ENSG00000106571
GO:0031929
IEA
PLAZA Integrative OrthologyTOR signaling FBgn0004859
GO:0007444
IEA
PLAZA Integrative Orthologyimaginal disc development FBgn0004859
GO:1900087
IEA
PLAZA Integrative Orthologypositive regulation of G1/S transition of mitotic cell cycle FBgn0004859
GO:0044703
IEA
PLAZA Integrative Orthologymulti-organism reproductive process FBgn0004859
GO:0038202
IEA
PLAZA Integrative OrthologyTORC1 signaling FBgn0004859
GO:0035215
IEA
PLAZA Integrative Orthologygenital disc development FBgn0004859
GO:0007281
IEA
PLAZA Integrative Orthologygerm cell development FBgn0004859
GO:0055025
IEA
PLAZA Integrative Orthologypositive regulation of cardiac muscle tissue development ENSG00000111087
GO:0035217
IEA
PLAZA Integrative Orthologylabial disc development FBgn0004859
GO:0060070
IEA
PLAZA Integrative Orthologycanonical Wnt signaling pathway ENSG00000106571
GO:0055024
IEA
PLAZA Integrative Orthologyregulation of cardiac muscle tissue development ENSG00000111087
GO:0048585
IEA
PLAZA Integrative Orthologynegative regulation of response to stimulus ENSG00000106571
GO:0000082
IEA
PLAZA Integrative OrthologyG1/S transition of mitotic cell cycle FBgn0004859
GO:0009968
IEA
PLAZA Integrative Orthologynegative regulation of signal transduction ENSG00000106571
GO:1902808
IEA
PLAZA Integrative Orthologypositive regulation of cell cycle G1/S phase transition ENSG00000111087
GO:0032504
IEA
PLAZA Integrative Orthologymulticellular organism reproduction FBgn0004859
GO:1902806
IEA
PLAZA Integrative Orthologyregulation of cell cycle G1/S phase transition ENSG00000111087
GO:0048100
IEA
PLAZA Integrative Orthologywing disc anterior/posterior pattern formation FBgn0004859
GO:0048584
IEA
PLAZA Integrative Orthologypositive regulation of response to stimulus ENSG00000111087
GO:0048738
IEA
PLAZA Integrative Orthologycardiac muscle tissue development ENSG00000111087
GO:0002385
IEA
PLAZA Integrative Orthologymucosal immune response FBgn0004859
GO:1902533
IEA
PLAZA Integrative Orthologypositive regulation of intracellular signal transduction FBgn0004859
GO:0007276
IEA
PLAZA Integrative Orthologygamete generation FBgn0004859
GO:0044772
IEA
PLAZA Integrative Orthologymitotic cell cycle phase transition FBgn0004859
GO:1902531
IEA
PLAZA Integrative Orthologyregulation of intracellular signal transduction FBgn0004859
GO:0035222
IEA
PLAZA Integrative Orthologywing disc pattern formation FBgn0004859
GO:0035221
IEA
PLAZA Integrative Orthologygenital disc pattern formation FBgn0004859
GO:0035220
IEA
PLAZA Integrative Orthologywing disc development FBgn0004859
GO:0016202
IEA
PLAZA Integrative Orthologyregulation of striated muscle tissue development ENSG00000111087
GO:0035224
IEA
PLAZA Integrative Orthologygenital disc anterior/posterior pattern formation FBgn0004859
GO:0019953
IEA
PLAZA Integrative Orthologysexual reproduction FBgn0004859
GO:0055017
IEA
PLAZA Integrative Orthologycardiac muscle tissue growth ENSG00000111087
GO:2000045
IEA
PLAZA Integrative Orthologyregulation of G1/S transition of mitotic cell cycle FBgn0004859
GO:0030178
IEA
PLAZA Integrative Orthologynegative regulation of Wnt signaling pathway ENSG00000106571
GO:0044770
IEA
PLAZA Integrative Orthologycell cycle phase transition ENSG00000111087
GO:0014706
IEA
PLAZA Integrative Orthologystriated muscle tissue development ENSG00000111087
GO:0030858
IEA
PLAZA Integrative Orthologypositive regulation of epithelial cell differentiation FBgn0004859
GO:0030856
IEA
PLAZA Integrative Orthologyregulation of epithelial cell differentiation FBgn0004859
GO:0009913
IEA
PLAZA Integrative Orthologyepidermal cell differentiation ENSG00000111087
GO:0030855
IEA
PLAZA Integrative Orthologyepithelial cell differentiation ENSG00000111087
GO:0007346
IEA
PLAZA Integrative Orthologyregulation of mitotic cell cycle FBgn0004859
GO:0060038
IEA
PLAZA Integrative Orthologycardiac muscle cell proliferation ENSG00000111087
GO:0055023
IEA
PLAZA Integrative Orthologypositive regulation of cardiac muscle tissue growth ENSG00000111087
GO:0009880
IEA
PLAZA Integrative Orthologyembryonic pattern specification FBgn0004859
GO:0055021
IEA
PLAZA Integrative Orthologyregulation of cardiac muscle tissue growth ENSG00000111087
GO:0048609
IEA
PLAZA Integrative Orthologymulticellular organismal reproductive process FBgn0004859
GO:1904263
IEA
PLAZA Integrative Orthologypositive regulation of TORC1 signaling FBgn0004859
GO:0032006
IEA
PLAZA Integrative Orthologyregulation of TOR signaling FBgn0004859
GO:0032008
IEA
PLAZA Integrative Orthologypositive regulation of TOR signaling FBgn0004859
GO:0051726
IEA
PLAZA Integrative Orthologyregulation of cell cycle ENSG00000111087
GO:0016055
IEA
PLAZA Integrative OrthologyWnt signaling pathway ENSG00000106571
GO:0003007
IEA
PLAZA Integrative Orthologyheart morphogenesis FBgn0004859
GO:0045844
IEA
PLAZA Integrative Orthologypositive regulation of striated muscle tissue development ENSG00000111087
GO:0042335
IEA
PLAZA Integrative Orthologycuticle development FBgn0004859
GO:0008544
IEA
PLAZA Integrative Orthologyepidermis development ENSG00000111087
GO:0060043
IEA
PLAZA Integrative Orthologyregulation of cardiac muscle cell proliferation ENSG00000111087
GO:1903047
IEA
PLAZA Integrative Orthologymitotic cell cycle process FBgn0004859
GO:0060045
IEA
PLAZA Integrative Orthologypositive regulation of cardiac muscle cell proliferation ENSG00000111087
GO:0007292
IEA
PLAZA Integrative Orthologyfemale gamete generation FBgn0004859
GO:0030111
IEA
PLAZA Integrative Orthologyregulation of Wnt signaling pathway ENSG00000106571
GO:0010647
IEA
PLAZA Integrative Orthologypositive regulation of cell communication ENSG00000111087
GO:0060419
IEA
PLAZA Integrative Orthologyheart growth ENSG00000111087
GO:0010648
IEA
PLAZA Integrative Orthologynegative regulation of cell communication ENSG00000106571
GO:0007517
IEA
PLAZA Integrative Orthologymuscle organ development ENSG00000111087
GO:0001654
IEA
PLAZA Integrative Orthologyeye development FBgn0004859
GO:0007365
IEA
PLAZA Integrative Orthologyperiodic partitioning FBgn0004859
GO:0007367
IEA
PLAZA Integrative Orthologysegment polarity determination FBgn0004859
GO:0060537
IEA
PLAZA Integrative Orthologymuscle tissue development ENSG00000111087
GO:1903432
IEA
PLAZA Integrative Orthologyregulation of TORC1 signaling FBgn0004859
GO:0016358
IEA
PLAZA Integrative Orthologydendrite development FBgn0004859
GO:0035017
IEA
PLAZA Integrative Orthologycuticle pattern formation FBgn0004859
GO:0051704
IEA
PLAZA Integrative Orthologymulti-organism process FBgn0004859
GO:0060828
IEA
PLAZA Integrative Orthologyregulation of canonical Wnt signaling pathway ENSG00000106571
GO:0048813
IEA
PLAZA Integrative Orthologydendrite morphogenesis FBgn0004859
GO:0000278
IEA
PLAZA Integrative Orthologymitotic cell cycle FBgn0004859
GO:0002066
IEA
PLAZA Integrative Orthologycolumnar/cuboidal epithelial cell development FBgn0004859
GO:0002065
IEA
PLAZA Integrative Orthologycolumnar/cuboidal epithelial cell differentiation FBgn0004859
GO:0002064
IEA
PLAZA Integrative Orthologyepithelial cell development FBgn0004859
GO:0045787
IEA
PLAZA Integrative Orthologypositive regulation of cell cycle ENSG00000111087
GO:0007350
IEA
PLAZA Integrative Orthologyblastoderm segmentation FBgn0004859
GO:0060421
IEA
PLAZA Integrative Orthologypositive regulation of heart growth ENSG00000111087
GO:0060420
IEA
PLAZA Integrative Orthologyregulation of heart growth ENSG00000111087
GO:0035265
IEA
PLAZA Integrative Orthologyorgan growth ENSG00000111087
GO:0033002
IEA
PLAZA Integrative Orthologymuscle cell proliferation ENSG00000111087
GO:0150063
IEA
PLAZA Integrative Orthologyvisual system development FBgn0004859
GO:0060914
IEA
PLAZA Integrative Orthologyheart formation FBgn0004859
GO:0023056
IEA
PLAZA Integrative Orthologypositive regulation of signaling ENSG00000111087
GO:0007424
IEA
PLAZA Integrative Orthologyopen tracheal system development FBgn0004859
GO:0023057
IEA
PLAZA Integrative Orthologynegative regulation of signaling ENSG00000106571
GO:0045931
IEA
PLAZA Integrative Orthologypositive regulation of mitotic cell cycle FBgn0004859
GO:0040008
IEA
PLAZA Integrative Orthologyregulation of growth ENSG00000111087
GO:0009967
IEA
PLAZA Integrative Orthologypositive regulation of signal transduction ENSG00000111087
GO:0044843
IEA
PLAZA Integrative Orthologycell cycle G1/S phase transition ENSG00000111087
GO:0046620
IEA
PLAZA Integrative Orthologyregulation of organ growth ENSG00000111087
GO:0002251
IEA
PLAZA Integrative Orthologyorgan or tissue specific immune response FBgn0004859
GO:0090068
IEA
PLAZA Integrative Orthologypositive regulation of cell cycle process ENSG00000111087
GO:0046622
IEA
PLAZA Integrative Orthologypositive regulation of organ growth ENSG00000111087
GO:1901992
IEA
PLAZA Integrative Orthologypositive regulation of mitotic cell cycle phase transition FBgn0004859
GO:1901990
IEA
PLAZA Integrative Orthologyregulation of mitotic cell cycle phase transition FBgn0004859
GO:0035277
IEA
PLAZA Integrative Orthologyspiracle morphogenesis, open tracheal system FBgn0004859
GO:0035556
IEA
PLAZA Integrative Orthologyintracellular signal transduction FBgn0004859
GO:0014855
IEA
PLAZA Integrative Orthologystriated muscle cell proliferation ENSG00000111087
GO:0030707
IEA
PLAZA Integrative Orthologyovarian follicle cell development FBgn0004859
GO:0061061
IEA
PLAZA Integrative Orthologymuscle structure development ENSG00000111087
GO:0006955
IEA
PLAZA Integrative Orthologyimmune response FBgn0004859
GO:0048880
IEA
PLAZA Integrative Orthologysensory system development FBgn0004859
GO:1901989
IEA
PLAZA Integrative Orthologypositive regulation of cell cycle phase transition ENSG00000111087
GO:0048638
IEA
PLAZA Integrative Orthologyregulation of developmental growth ENSG00000111087
GO:0048639
IEA
PLAZA Integrative Orthologypositive regulation of developmental growth ENSG00000111087
GO:1901987
IEA
PLAZA Integrative Orthologyregulation of cell cycle phase transition ENSG00000111087
GO:0048634
IEA
PLAZA Integrative Orthologyregulation of muscle organ development ENSG00000111087
GO:1901863
IEA
PLAZA Integrative Orthologypositive regulation of muscle tissue development ENSG00000111087
GO:1901861
IEA
PLAZA Integrative Orthologyregulation of muscle tissue development ENSG00000111087
GO:0043584
IEA
PLAZA Integrative Orthologynose development ENSG00000106571
GO:0048636
IEA
PLAZA Integrative Orthologypositive regulation of muscle organ development ENSG00000111087
GO:0022402
IEA
PLAZA Integrative Orthologycell cycle process ENSG00000111087
GO:0035282
IEA
PLAZA Integrative Orthologysegmentation FBgn0004859
GO:0043585
IEA
PLAZA Integrative Orthologynose morphogenesis ENSG00000106571
GO:0045927
IEA
PLAZA Integrative Orthologypositive regulation of growth ENSG00000111087

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1990841
IDA
Genome Projectpromoter-specific chromatin binding
GO:1990841
IDA
Gene Ontologypromoter-specific chromatin binding4
GO:0043565
IDA
Genome Projectsequence-specific DNA binding
GO:0043565
IDA
Gene Ontologysequence-specific DNA binding3 4 5
GO:0008270
IDA
Genome Projectzinc ion binding
GO:0008270
IDA
Gene Ontologyzinc ion binding6
GO:0008134
IPI
Genome Projecttranscription factor binding
GO:0008134
IPI
Gene Ontologytranscription factor binding4
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding7 8
GO:0003700
IDA
Genome ProjectDNA-binding transcription factor activity
GO:0003700
IDA
Gene OntologyDNA-binding transcription factor activity2
GO:0000978
IEA
Genome ProjectRNA polymerase II proximal promoter sequence-specific DNA binding
GO:0000981
ISA
NAS
Gene OntologyDNA-binding transcription factor activity, RNA polymerase II-specific9
GO:0035326
IEA
PLAZA Integrative Orthologyenhancer binding FBgn0004859
GO:0019899
IEA
PLAZA Integrative Orthologyenzyme binding ENSG00000106571
GO:0008013
IEA
PLAZA Integrative Orthologybeta-catenin binding ENSG00000106571
GO:0042803
IEA
PLAZA Integrative Orthologyprotein homodimerization activity FBgn0004859
GO:0042802
IEA
PLAZA Integrative Orthologyidentical protein binding FBgn0004859
GO:0036033
IEA
PLAZA Integrative Orthologymediator complex binding ENSG00000106571
GO:0044877
IEA
PLAZA Integrative Orthologyprotein-containing complex binding ENSG00000106571
GO:0001158
IEA
PLAZA Integrative Orthologyenhancer sequence-specific DNA binding FBgn0004859
GO:0046983
IEA
PLAZA Integrative Orthologyprotein dimerization activity FBgn0004859
GO:0042826
IEA
PLAZA Integrative Orthologyhistone deacetylase binding ENSG00000106571
GO:0035035
IEA
PLAZA Integrative Orthologyhistone acetyltransferase binding ENSG00000106571
GO:0000980
IEA
PLAZA Integrative OrthologyRNA polymerase II distal enhancer sequence-specific DNA binding FBgn0004859

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0097546
TAS
Genome Projectciliary base
GO:0097546
TAS
Gene Ontologyciliary base
GO:0097542
TAS
Genome Projectciliary tip
GO:0097542
TAS
Gene Ontologyciliary tip
GO:0031514
IEA
Genome Projectmotile cilium
GO:0016607
IEA
Genome Projectnuclear speck
GO:0016020
IEA
Genome Projectmembrane
GO:0005930
IEA
Genome Projectaxoneme
GO:0005929
ISS
Genome Projectcilium
GO:0005929
ISS
Gene Ontologycilium
GO:0005829
TAS
Genome Projectcytosol
GO:0005829
TAS
Gene Ontologycytosol
GO:0005730
IDA
Genome Projectnucleolus
GO:0005730
IDA
Gene Ontologynucleolus
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005654
TAS
Gene Ontologynucleoplasm
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus4
GO:0032991
IEA
PLAZA Integrative Orthologyprotein-containing complex ENSG00000106571
GO:0016592
IEA
PLAZA Integrative Orthologymediator complex ENSG00000106571
GO:0035301
IEA
PLAZA Integrative OrthologyHedgehog signaling complex FBgn0004859

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR013087Zinc finger C2H2-type

No MapMan annotations defined for this gene.
KeggID Description
K16798GLI2; zinc finger protein GLI2
No chloroplast target sequence found.