Gene: ENSG00000072694 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000072694
Transcript Identifier
ENST00000428605
Gene Type
Coding gene
Location
1 : 161663242-161677553 : positive

Family Information

Homologous gene family
HOM02SEM011738
(7 genes in 1 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
Fc fragment of IgG, low affinity IIb, receptor (CD32)

Identifiers

Type Value
pidENSP00000404329
HGNC3618
UniprotP31994

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0050776
TAS
Genome Projectregulation of immune response
GO:0050776
TAS
Gene Ontologyregulation of immune response
GO:0016032
IEA
Genome Projectviral process
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007165
TAS
Gene Ontologysignal transduction1
GO:0006955
TAS
Genome Projectimmune response
GO:0006955
TAS
Gene Ontologyimmune response1
GO:0045576
ISS
Gene Ontologymast cell activation2
GO:2001199
TAS
Gene Ontologynegative regulation of dendritic cell differentiation2
GO:1904646
ISS
Gene Ontologycellular response to amyloid-beta3
GO:1905898
ISS
Gene Ontologypositive regulation of response to endoplasmic reticulum stress3
GO:1902950
IGI
Gene Ontologyregulation of dendritic spine maintenance3
GO:1902564
TAS
Gene Ontologynegative regulation of neutrophil activation2
GO:1901216
ISS
Gene Ontologypositive regulation of neuron death3
GO:0090264
TAS
Gene Ontologyregulation of immune complex clearance by monocytes and macrophages2
GO:0071219
ISS
Gene Ontologycellular response to molecule of bacterial origin2
GO:0050869
TAS
Gene Ontologynegative regulation of B cell activation2
GO:0050777
ISS
Gene Ontologynegative regulation of immune response2
GO:0050766
ISS
Gene Ontologypositive regulation of phagocytosis2
GO:0050765
TAS
Gene Ontologynegative regulation of phagocytosis2
GO:0050710
TAS
Gene Ontologynegative regulation of cytokine secretion2
GO:0046330
ISS
Gene Ontologypositive regulation of JNK cascade3
GO:0045088
TAS
Gene Ontologyregulation of innate immune response2
GO:0043318
TAS
Gene Ontologynegative regulation of cytotoxic T cell degranulation2
GO:0043031
TAS
Gene Ontologynegative regulation of macrophage activation2
GO:0038096
IDA
Gene OntologyFc-gamma receptor signaling pathway involved in phagocytosis1
GO:0032693
ISS
Gene Ontologynegative regulation of interleukin-10 production2
GO:0030889
ISS
Gene Ontologynegative regulation of B cell proliferation2
GO:0019886
ISS
Gene Ontologyantigen processing and presentation of exogenous peptide antigen via MHC class II2
GO:0021549
ISS
Gene Ontologycerebellum development2
GO:0016064
ISS
Gene Ontologyimmunoglobulin mediated immune response2
GO:0010469
TAS
Gene Ontologyregulation of signaling receptor activity2
GO:0009617
ISS
Gene Ontologyresponse to bacterium2
GO:0006954
TAS
Gene Ontologyinflammatory response2
GO:0006952
ISS
Gene Ontologydefense response2
GO:0006911
ISS
Gene Ontologyphagocytosis, engulfment2
GO:0006898
IDA
Gene Ontologyreceptor-mediated endocytosis1
GO:0002924
ISS
Gene Ontologynegative regulation of humoral immune response mediated by circulating immunoglobulin2
GO:0002865
ISS
Gene Ontologynegative regulation of acute inflammatory response to antigenic stimulus2
GO:0002922
TAS
Gene Ontologypositive regulation of humoral immune response2
GO:0002819
TAS
Gene Ontologyregulation of adaptive immune response2
GO:0002638
ISS
Gene Ontologynegative regulation of immunoglobulin production2
GO:0002622
TAS
Gene Ontologyregulation of B cell antigen processing and presentation2
GO:0002605
TAS
Gene Ontologynegative regulation of dendritic cell antigen processing and presentation2
GO:0002316
TAS
Gene Ontologyfollicular B cell differentiation2
GO:0002436
TAS
Gene Ontologyimmune complex clearance by monocytes and macrophages2
GO:0002266
TAS
Gene Ontologyfollicular dendritic cell activation2
GO:0002313
TAS
Gene Ontologymature B cell differentiation involved in immune response2
GO:0001814
TAS
Gene Ontologynegative regulation of antibody-dependent cellular cytotoxicity2
GO:0001811
ISS
Gene Ontologynegative regulation of type I hypersensitivity2
GO:0002446
IEA
PLAZA Integrative Orthologyneutrophil mediated immunity ENSG00000143226
GO:0002275
IEA
PLAZA Integrative Orthologymyeloid cell activation involved in immune response ENSG00000143226
GO:0043312
IEA
PLAZA Integrative Orthologyneutrophil degranulation ENSG00000143226
GO:0002283
IEA
PLAZA Integrative Orthologyneutrophil activation involved in immune response ENSG00000143226

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0019864
IEA
Genome ProjectIgG binding
GO:0019864
IDA
Gene OntologyIgG binding1
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding4 5 6 7 8 9 10
GO:0044877
IPI
Gene Ontologyprotein-containing complex binding3
GO:0019772
IDA
Gene Ontologylow-affinity IgG receptor activity1
GO:0001540
IPI
TAS
Gene Ontologyamyloid-beta binding3 11

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0005886
TAS
Genome Projectplasma membrane
GO:0005886
IDA
TAS
Gene Ontologyplasma membrane1
GO:0044297
ISS
Gene Ontologycell body2
GO:0043197
ISS
Gene Ontologydendritic spine2
GO:0009897
ISS
Gene Ontologyexternal side of plasma membrane2
GO:0005887
IDA
Gene Ontologyintegral component of plasma membrane3
GO:0098805
IEA
PLAZA Integrative Orthologywhole membrane ENSG00000143226
GO:0012505
IEA
PLAZA Integrative Orthologyendomembrane system ENSG00000143226
GO:0031982
IEA
PLAZA Integrative Orthologyvesicle ENSG00000143226
GO:0012506
IEA
PLAZA Integrative Orthologyvesicle membrane ENSG00000143226
GO:0098588
IEA
PLAZA Integrative Orthologybounding membrane of organelle ENSG00000143226
GO:0005737
IEA
PLAZA Integrative Orthologycytoplasm ENSG00000143226
GO:0005615
IEA
PLAZA Integrative Orthologyextracellular space ENSG00000143226
GO:0030659
IEA
PLAZA Integrative Orthologycytoplasmic vesicle membrane ENSG00000143226
GO:0005622
IEA
PLAZA Integrative Orthologyintracellular ENSG00000143226
GO:0044424
IEA
PLAZA Integrative Orthologyintracellular part ENSG00000143226
GO:0031090
IEA
PLAZA Integrative Orthologyorganelle membrane ENSG00000143226
GO:0044446
IEA
PLAZA Integrative Orthologyintracellular organelle part ENSG00000143226
GO:0044422
IEA
PLAZA Integrative Orthologyorganelle part ENSG00000143226
GO:0044444
IEA
PLAZA Integrative Orthologycytoplasmic part ENSG00000143226
GO:0044421
IEA
PLAZA Integrative Orthologyextracellular region part ENSG00000143226
GO:0030141
IEA
PLAZA Integrative Orthologysecretory granule ENSG00000143226
GO:0097708
IEA
PLAZA Integrative Orthologyintracellular vesicle ENSG00000143226
GO:0031410
IEA
PLAZA Integrative Orthologycytoplasmic vesicle ENSG00000143226
GO:0043230
IEA
PLAZA Integrative Orthologyextracellular organelle ENSG00000143226
GO:0099503
IEA
PLAZA Integrative Orthologysecretory vesicle ENSG00000143226
GO:0070062
IEA
PLAZA Integrative Orthologyextracellular exosome ENSG00000143226
GO:0030667
IEA
PLAZA Integrative Orthologysecretory granule membrane ENSG00000143226
GO:0043227
IEA
PLAZA Integrative Orthologymembrane-bounded organelle ENSG00000143226
GO:0005576
IEA
PLAZA Integrative Orthologyextracellular region ENSG00000143226
GO:0043226
IEA
PLAZA Integrative Orthologyorganelle ENSG00000143226
GO:0044433
IEA
PLAZA Integrative Orthologycytoplasmic vesicle part ENSG00000143226
GO:1903561
IEA
PLAZA Integrative Orthologyextracellular vesicle ENSG00000143226
GO:0043229
IEA
PLAZA Integrative Orthologyintracellular organelle ENSG00000143226

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003598Immunoglobulin subtype 2
IPR003599Immunoglobulin subtype
IPR007110Immunoglobulin-like domain
IPR013783Immunoglobulin-like fold

No MapMan annotations defined for this gene.
KeggID Description
K06472CD32a, FCGR2A; Fc fragment of IgG, low affinity IIa, receptor for (CD32)
K16824CD32c, FCGR2C; Fc fragment of IgG, low affinity IIc, receptor for (CD32)
K06463FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
K12560CD32b, FCGR2B; Fc fragment of IgG, low affinity IIb, receptor for (CD32)
No chloroplast target sequence found.