Gene: ENSG00000071575 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000071575
Transcript Identifier
ENST00000155926
Gene Type
Coding gene
Location
2 : 12718308-12740794 : positive

Family Information

Homologous gene family
HOM02SEM000001
(5917 genes in 26 species)
specific family
Orthologous gene family
ORTHO02SEM014057
(4 genes in 2 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
tribbles pseudokinase 2

Identifiers

Type Value
pidENSP00000155926
HGNC30809
UniprotQ92519
RefSeq_mRNANM_021643.3
EMBLAC009486
EMBLAK313237
EMBLAY245544
EMBLBC002637
EMBLCH471053
EMBLD87119

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006468
ISS
Genome Projectprotein phosphorylation
GO:0006468
ISS
Gene Ontologyprotein phosphorylation
GO:0045599
ISS
Genome Projectnegative regulation of fat cell differentiation
GO:0045599
ISS
Gene Ontologynegative regulation of fat cell differentiation1
GO:0045081
IMP
Genome Projectnegative regulation of interleukin-10 biosynthetic process
GO:0045081
IMP
Gene Ontologynegative regulation of interleukin-10 biosynthetic process2
GO:0043405
ISS, IBA
Genome Projectregulation of MAP kinase activity
GO:0043405
ISS
Gene Ontologyregulation of MAP kinase activity
GO:0032436
ISS, IBA
Genome Projectpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032436
ISS
Gene Ontologypositive regulation of proteasomal ubiquitin-dependent protein catabolic process3
GO:0006469
NAS
Genome Projectnegative regulation of protein kinase activity
GO:0006469
NAS
Gene Ontologynegative regulation of protein kinase activity4
GO:0010564
IEA
PLAZA Integrative Orthologyregulation of cell cycle process FBgn0028978
GO:0048598
IEA
PLAZA Integrative Orthologyembryonic morphogenesis FBgn0028978
GO:0071222
IEA
PLAZA Integrative Orthologycellular response to lipopolysaccharide ENSG00000173334
GO:0044271
IEA
PLAZA Integrative Orthologycellular nitrogen compound biosynthetic process ENSG00000173334
GO:0009617
IEA
PLAZA Integrative Orthologyresponse to bacterium ENSG00000173334
GO:0051235
IEA
PLAZA Integrative Orthologymaintenance of location FBgn0028978
GO:0048870
IEA
PLAZA Integrative Orthologycell motility ENSG00000173334
GO:0007049
IEA
PLAZA Integrative Orthologycell cycle FBgn0028978
GO:0042127
IEA
PLAZA Integrative Orthologyregulation of cell proliferation ENSG00000173334
GO:0006996
IEA
PLAZA Integrative Orthologyorganelle organization FBgn0028978
GO:1901698
IEA
PLAZA Integrative Orthologyresponse to nitrogen compound FBgn0028978
GO:0007167
IEA
PLAZA Integrative Orthologyenzyme linked receptor protein signaling pathway FBgn0028978
GO:1901699
IEA
PLAZA Integrative Orthologycellular response to nitrogen compound FBgn0028978
GO:0007166
IEA
PLAZA Integrative Orthologycell surface receptor signaling pathway ENSG00000173334
GO:0007169
IEA
PLAZA Integrative Orthologytransmembrane receptor protein tyrosine kinase signaling pathway FBgn0028978
GO:0006355
IEA
PLAZA Integrative Orthologyregulation of transcription, DNA-templated ENSG00000173334
GO:0031098
IEA
PLAZA Integrative Orthologystress-activated protein kinase signaling cascade ENSG00000173334
GO:0006351
IEA
PLAZA Integrative Orthologytranscription, DNA-templated ENSG00000173334
GO:0034645
IEA
PLAZA Integrative Orthologycellular macromolecule biosynthetic process ENSG00000173334
GO:0014910
IEA
PLAZA Integrative Orthologyregulation of smooth muscle cell migration ENSG00000173334
GO:0032101
IEA
PLAZA Integrative Orthologyregulation of response to external stimulus ENSG00000173334
GO:0034641
IEA
PLAZA Integrative Orthologycellular nitrogen compound metabolic process ENSG00000173334
GO:0033036
IEA
PLAZA Integrative Orthologymacromolecule localization FBgn0028978
GO:0014912
IEA
PLAZA Integrative Orthologynegative regulation of smooth muscle cell migration ENSG00000173334
GO:0033554
IEA
PLAZA Integrative Orthologycellular response to stress ENSG00000173334
GO:0032102
IEA
PLAZA Integrative Orthologynegative regulation of response to external stimulus ENSG00000173334
GO:0048585
IEA
PLAZA Integrative Orthologynegative regulation of response to stimulus ENSG00000173334
GO:0032868
IEA
PLAZA Integrative Orthologyresponse to insulin FBgn0028978
GO:0009968
IEA
PLAZA Integrative Orthologynegative regulation of signal transduction ENSG00000173334
GO:0009605
IEA
PLAZA Integrative Orthologyresponse to external stimulus ENSG00000173334
GO:0009607
IEA
PLAZA Integrative Orthologyresponse to biotic stimulus ENSG00000173334
GO:0032869
IEA
PLAZA Integrative Orthologycellular response to insulin stimulus FBgn0028978
GO:1903506
IEA
PLAZA Integrative Orthologyregulation of nucleic acid-templated transcription ENSG00000173334
GO:1902532
IEA
PLAZA Integrative Orthologynegative regulation of intracellular signal transduction FBgn0028978
GO:0048856
IEA
PLAZA Integrative Orthologyanatomical structure development FBgn0028978
GO:1900077
IEA
PLAZA Integrative Orthologynegative regulation of cellular response to insulin stimulus FBgn0028978
GO:0008361
IEA
PLAZA Integrative Orthologyregulation of cell size FBgn0028978
GO:0033043
IEA
PLAZA Integrative Orthologyregulation of organelle organization FBgn0028978
GO:0007275
IEA
PLAZA Integrative Orthologymulticellular organism development FBgn0028978
GO:1900076
IEA
PLAZA Integrative Orthologyregulation of cellular response to insulin stimulus FBgn0028978
GO:0043207
IEA
PLAZA Integrative Orthologyresponse to external biotic stimulus ENSG00000173334
GO:0031665
IEA
PLAZA Integrative Orthologynegative regulation of lipopolysaccharide-mediated signaling pathway ENSG00000173334
GO:0031664
IEA
PLAZA Integrative Orthologyregulation of lipopolysaccharide-mediated signaling pathway ENSG00000173334
GO:0030336
IEA
PLAZA Integrative Orthologynegative regulation of cell migration ENSG00000173334
GO:0019438
IEA
PLAZA Integrative Orthologyaromatic compound biosynthetic process ENSG00000173334
GO:0030334
IEA
PLAZA Integrative Orthologyregulation of cell migration ENSG00000173334
GO:0032870
IEA
PLAZA Integrative Orthologycellular response to hormone stimulus FBgn0028978
GO:0071840
IEA
PLAZA Integrative Orthologycellular component organization or biogenesis FBgn0028978
GO:0031663
IEA
PLAZA Integrative Orthologylipopolysaccharide-mediated signaling pathway ENSG00000173334
GO:0034654
IEA
PLAZA Integrative Orthologynucleobase-containing compound biosynthetic process ENSG00000173334
GO:0010467
IEA
PLAZA Integrative Orthologygene expression ENSG00000173334
GO:0016043
IEA
PLAZA Integrative Orthologycellular component organization FBgn0028978
GO:0010468
IEA
PLAZA Integrative Orthologyregulation of gene expression ENSG00000173334
GO:0042593
IEA
PLAZA Integrative Orthologyglucose homeostasis FBgn0028978
GO:0042592
IEA
PLAZA Integrative Orthologyhomeostatic process FBgn0028978
GO:0006928
IEA
PLAZA Integrative Orthologymovement of cell or subcellular component ENSG00000173334
GO:0032879
IEA
PLAZA Integrative Orthologyregulation of localization ENSG00000173334
GO:0051179
IEA
PLAZA Integrative Orthologylocalization ENSG00000173334
GO:0007346
IEA
PLAZA Integrative Orthologyregulation of mitotic cell cycle FBgn0028978
GO:0043434
IEA
PLAZA Integrative Orthologyresponse to peptide hormone FBgn0028978
GO:0006139
IEA
PLAZA Integrative Orthologynucleobase-containing compound metabolic process ENSG00000173334
GO:0043433
IEA
PLAZA Integrative Orthologynegative regulation of DNA-binding transcription factor activity ENSG00000173334
GO:0042221
IEA
PLAZA Integrative Orthologyresponse to chemical ENSG00000173334
GO:2001141
IEA
PLAZA Integrative Orthologyregulation of RNA biosynthetic process ENSG00000173334
GO:0090304
IEA
PLAZA Integrative Orthologynucleic acid metabolic process ENSG00000173334
GO:0070887
IEA
PLAZA Integrative Orthologycellular response to chemical stimulus ENSG00000173334
GO:0071219
IEA
PLAZA Integrative Orthologycellular response to molecule of bacterial origin ENSG00000173334
GO:0051726
IEA
PLAZA Integrative Orthologyregulation of cell cycle FBgn0028978
GO:0014812
IEA
PLAZA Integrative Orthologymuscle cell migration ENSG00000173334
GO:0071216
IEA
PLAZA Integrative Orthologycellular response to biotic stimulus ENSG00000173334
GO:0002832
IEA
PLAZA Integrative Orthologynegative regulation of response to biotic stimulus ENSG00000173334
GO:0048285
IEA
PLAZA Integrative Orthologyorganelle fission FBgn0028978
GO:0002831
IEA
PLAZA Integrative Orthologyregulation of response to biotic stimulus ENSG00000173334
GO:1901700
IEA
PLAZA Integrative Orthologyresponse to oxygen-containing compound ENSG00000173334
GO:1901701
IEA
PLAZA Integrative Orthologycellular response to oxygen-containing compound ENSG00000173334
GO:1903047
IEA
PLAZA Integrative Orthologymitotic cell cycle process FBgn0028978
GO:0010883
IEA
PLAZA Integrative Orthologyregulation of lipid storage FBgn0028978
GO:0010004
IEA
PLAZA Integrative Orthologygastrulation involving germ band extension FBgn0028978
GO:0010243
IEA
PLAZA Integrative Orthologyresponse to organonitrogen compound FBgn0028978
GO:0032535
IEA
PLAZA Integrative Orthologyregulation of cellular component size FBgn0028978
GO:0010888
IEA
PLAZA Integrative Orthologynegative regulation of lipid storage FBgn0028978
GO:0032496
IEA
PLAZA Integrative Orthologyresponse to lipopolysaccharide ENSG00000173334
GO:2000145
IEA
PLAZA Integrative Orthologyregulation of cell motility ENSG00000173334
GO:0032774
IEA
PLAZA Integrative OrthologyRNA biosynthetic process ENSG00000173334
GO:0033500
IEA
PLAZA Integrative Orthologycarbohydrate homeostasis FBgn0028978
GO:2000146
IEA
PLAZA Integrative Orthologynegative regulation of cell motility ENSG00000173334
GO:0010648
IEA
PLAZA Integrative Orthologynegative regulation of cell communication ENSG00000173334
GO:0051674
IEA
PLAZA Integrative Orthologylocalization of cell ENSG00000173334
GO:0006950
IEA
PLAZA Integrative Orthologyresponse to stress ENSG00000173334
GO:1901652
IEA
PLAZA Integrative Orthologyresponse to peptide FBgn0028978
GO:1901653
IEA
PLAZA Integrative Orthologycellular response to peptide FBgn0028978
GO:0007088
IEA
PLAZA Integrative Orthologyregulation of mitotic nuclear division FBgn0028978
GO:0045839
IEA
PLAZA Integrative Orthologynegative regulation of mitotic nuclear division FBgn0028978
GO:0016477
IEA
PLAZA Integrative Orthologycell migration ENSG00000173334
GO:0010876
IEA
PLAZA Integrative Orthologylipid localization FBgn0028978
GO:0051704
IEA
PLAZA Integrative Orthologymulti-organism process ENSG00000173334
GO:0033993
IEA
PLAZA Integrative Orthologyresponse to lipid ENSG00000173334
GO:0140014
IEA
PLAZA Integrative Orthologymitotic nuclear division FBgn0028978
GO:0000280
IEA
PLAZA Integrative Orthologynuclear division FBgn0028978
GO:0048662
IEA
PLAZA Integrative Orthologynegative regulation of smooth muscle cell proliferation ENSG00000173334
GO:0010639
IEA
PLAZA Integrative Orthologynegative regulation of organelle organization FBgn0028978
GO:0071396
IEA
PLAZA Integrative Orthologycellular response to lipid ENSG00000173334
GO:0045793
IEA
PLAZA Integrative Orthologypositive regulation of cell size FBgn0028978
GO:0071310
IEA
PLAZA Integrative Orthologycellular response to organic substance ENSG00000173334
GO:0018130
IEA
PLAZA Integrative Orthologyheterocycle biosynthetic process ENSG00000173334
GO:0051784
IEA
PLAZA Integrative Orthologynegative regulation of nuclear division FBgn0028978
GO:0043491
IEA
PLAZA Integrative Orthologyprotein kinase B signaling FBgn0028978
GO:0051783
IEA
PLAZA Integrative Orthologyregulation of nuclear division FBgn0028978
GO:0016070
IEA
PLAZA Integrative OrthologyRNA metabolic process ENSG00000173334
GO:0048660
IEA
PLAZA Integrative Orthologyregulation of smooth muscle cell proliferation ENSG00000173334
GO:0046483
IEA
PLAZA Integrative Orthologyheterocycle metabolic process ENSG00000173334
GO:0048659
IEA
PLAZA Integrative Orthologysmooth muscle cell proliferation ENSG00000173334
GO:0000278
IEA
PLAZA Integrative Orthologymitotic cell cycle FBgn0028978
GO:0051270
IEA
PLAZA Integrative Orthologyregulation of cellular component movement ENSG00000173334
GO:0009653
IEA
PLAZA Integrative Orthologyanatomical structure morphogenesis FBgn0028978
GO:0045786
IEA
PLAZA Integrative Orthologynegative regulation of cell cycle FBgn0028978
GO:0051271
IEA
PLAZA Integrative Orthologynegative regulation of cellular component movement ENSG00000173334
GO:0051707
IEA
PLAZA Integrative Orthologyresponse to other organism ENSG00000173334
GO:0008285
IEA
PLAZA Integrative Orthologynegative regulation of cell proliferation ENSG00000173334
GO:0008286
IEA
PLAZA Integrative Orthologyinsulin receptor signaling pathway FBgn0028978
GO:0040011
IEA
PLAZA Integrative Orthologylocomotion ENSG00000173334
GO:1901362
IEA
PLAZA Integrative Orthologyorganic cyclic compound biosynthetic process ENSG00000173334
GO:0040012
IEA
PLAZA Integrative Orthologyregulation of locomotion ENSG00000173334
GO:0040013
IEA
PLAZA Integrative Orthologynegative regulation of locomotion ENSG00000173334
GO:1901360
IEA
PLAZA Integrative Orthologyorganic cyclic compound metabolic process ENSG00000173334
GO:0019219
IEA
PLAZA Integrative Orthologyregulation of nucleobase-containing compound metabolic process ENSG00000173334
GO:0008283
IEA
PLAZA Integrative Orthologycell proliferation ENSG00000173334
GO:0051898
IEA
PLAZA Integrative Orthologynegative regulation of protein kinase B signaling FBgn0028978
GO:0033002
IEA
PLAZA Integrative Orthologymuscle cell proliferation ENSG00000173334
GO:0097659
IEA
PLAZA Integrative Orthologynucleic acid-templated transcription ENSG00000173334
GO:0009719
IEA
PLAZA Integrative Orthologyresponse to endogenous stimulus FBgn0028978
GO:0051252
IEA
PLAZA Integrative Orthologyregulation of RNA metabolic process ENSG00000173334
GO:0023057
IEA
PLAZA Integrative Orthologynegative regulation of signaling ENSG00000173334
GO:0014909
IEA
PLAZA Integrative Orthologysmooth muscle cell migration ENSG00000173334
GO:0010948
IEA
PLAZA Integrative Orthologynegative regulation of cell cycle process FBgn0028978
GO:0051896
IEA
PLAZA Integrative Orthologyregulation of protein kinase B signaling FBgn0028978
GO:0006725
IEA
PLAZA Integrative Orthologycellular aromatic compound metabolic process ENSG00000173334
GO:0046627
IEA
PLAZA Integrative Orthologynegative regulation of insulin receptor signaling pathway FBgn0028978
GO:0009725
IEA
PLAZA Integrative Orthologyresponse to hormone FBgn0028978
GO:0046626
IEA
PLAZA Integrative Orthologyregulation of insulin receptor signaling pathway FBgn0028978
GO:1905953
IEA
PLAZA Integrative Orthologynegative regulation of lipid localization FBgn0028978
GO:0090066
IEA
PLAZA Integrative Orthologyregulation of anatomical structure size FBgn0028978
GO:0048646
IEA
PLAZA Integrative Orthologyanatomical structure formation involved in morphogenesis FBgn0028978
GO:0045930
IEA
PLAZA Integrative Orthologynegative regulation of mitotic cell cycle FBgn0028978
GO:1905952
IEA
PLAZA Integrative Orthologyregulation of lipid localization FBgn0028978
GO:0010033
IEA
PLAZA Integrative Orthologyresponse to organic substance ENSG00000173334
GO:0065008
IEA
PLAZA Integrative Orthologyregulation of biological quality FBgn0028978
GO:0051128
IEA
PLAZA Integrative Orthologyregulation of cellular component organization FBgn0028978
GO:0051403
IEA
PLAZA Integrative Orthologystress-activated MAPK cascade ENSG00000173334
GO:0071417
IEA
PLAZA Integrative Orthologycellular response to organonitrogen compound FBgn0028978
GO:0051129
IEA
PLAZA Integrative Orthologynegative regulation of cellular component organization FBgn0028978
GO:2000112
IEA
PLAZA Integrative Orthologyregulation of cellular macromolecule biosynthetic process ENSG00000173334
GO:0071375
IEA
PLAZA Integrative Orthologycellular response to peptide hormone stimulus FBgn0028978
GO:0001703
IEA
PLAZA Integrative Orthologygastrulation with mouth forming first FBgn0028978
GO:0071495
IEA
PLAZA Integrative Orthologycellular response to endogenous stimulus FBgn0028978
GO:0002237
IEA
PLAZA Integrative Orthologyresponse to molecule of bacterial origin ENSG00000173334
GO:0051090
IEA
PLAZA Integrative Orthologyregulation of DNA-binding transcription factor activity ENSG00000173334
GO:0007254
IEA
PLAZA Integrative OrthologyJNK cascade ENSG00000173334
GO:0048878
IEA
PLAZA Integrative Orthologychemical homeostasis FBgn0028978
GO:0022402
IEA
PLAZA Integrative Orthologycell cycle process FBgn0028978
GO:0019915
IEA
PLAZA Integrative Orthologylipid storage FBgn0028978
GO:0007370
IEA
PLAZA Integrative Orthologyventral furrow formation FBgn0028978
GO:0043900
IEA
PLAZA Integrative Orthologyregulation of multi-organism process ENSG00000173334
GO:0009790
IEA
PLAZA Integrative Orthologyembryo development FBgn0028978
GO:0043901
IEA
PLAZA Integrative Orthologynegative regulation of multi-organism process ENSG00000173334

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004672
ISS
Genome Projectprotein kinase activity
GO:0004672
ISS
Gene Ontologyprotein kinase activity
GO:0000166
ISS
Genome Projectnucleotide binding
GO:0000166
ISS
Gene Ontologynucleotide binding
GO:0055106
ISS
Genome Projectubiquitin-protein transferase regulator activity
GO:0055106
ISS
Gene Ontologyubiquitin-protein transferase regulator activity3
GO:0031625
ISS
Genome Projectubiquitin protein ligase binding
GO:0031625
ISS
Gene Ontologyubiquitin protein ligase binding3
GO:0031434
IBA
Genome Projectmitogen-activated protein kinase kinase binding
GO:0008134
ISS
Genome Projecttranscription factor binding
GO:0008134
ISS
Gene Ontologytranscription factor binding1
GO:0004860
IEA
Genome Projectprotein kinase inhibitor activity
GO:0030554
IEA
PLAZA Integrative Orthologyadenyl nucleotide binding ENSG00000173334
GO:0017076
IEA
PLAZA Integrative Orthologypurine nucleotide binding ENSG00000173334
GO:0042803
IEA
PLAZA Integrative Orthologyprotein homodimerization activity FBgn0028978
GO:0042802
IEA
PLAZA Integrative Orthologyidentical protein binding FBgn0028978
GO:0005524
IEA
PLAZA Integrative OrthologyATP binding ENSG00000173334
GO:0043168
IEA
PLAZA Integrative Orthologyanion binding ENSG00000173334
GO:0043167
IEA
PLAZA Integrative Orthologyion binding ENSG00000173334
GO:0035639
IEA
PLAZA Integrative Orthologypurine ribonucleoside triphosphate binding ENSG00000173334
GO:0008144
IEA
PLAZA Integrative Orthologydrug binding ENSG00000173334
GO:0032555
IEA
PLAZA Integrative Orthologypurine ribonucleotide binding ENSG00000173334
GO:0032553
IEA
PLAZA Integrative Orthologyribonucleotide binding ENSG00000173334
GO:0032559
IEA
PLAZA Integrative Orthologyadenyl ribonucleotide binding ENSG00000173334
GO:0004674
IEA
PLAZA Integrative Orthologyprotein serine/threonine kinase activity FBgn0028978
GO:0046983
IEA
PLAZA Integrative Orthologyprotein dimerization activity FBgn0028978
GO:0046982
IEA
PLAZA Integrative Orthologyprotein heterodimerization activity FBgn0028978
GO:0097367
IEA
PLAZA Integrative Orthologycarbohydrate derivative binding ENSG00000173334

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0005737
ISS
Genome Projectcytoplasm
GO:0005737
ISS
Gene Ontologycytoplasm
GO:0005634
IBA
Genome Projectnucleus
GO:0005829
IEA
PLAZA Integrative Orthologycytosol FBgn0028978
GO:0044444
IEA
PLAZA Integrative Orthologycytoplasmic part FBgn0028978

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR011009Protein kinase-like domain superfamily
IPR024104Pseudokinase tribbles family/serine-threonine-protein kinase 40

No MapMan annotations defined for this gene.
KeggID Description
K08814TRIB1_2; tribbles homolog 1/2
No chloroplast target sequence found.