Gene: ENSG00000070950 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000070950
Transcript Identifier
ENST00000264926
Gene Type
Coding gene
Location
3 : 8881357-8963385 : negative

Family Information

Homologous gene family
HOM02SEM014407
(6 genes in 6 species)
specific family

Descriptions

gene_descr
RAD18 E3 ubiquitin protein ligase

Identifiers

Type Value
pidENSP00000264926
HGNC18278
UniprotQ9NS91
RefSeq_mRNANM_020165.3
EMBLAB035274
EMBLAC008151
EMBLAC034186
EMBLAF169796
EMBLAK023075
EMBLAY004333
EMBLAY961989
EMBLBC001302

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0060548
IDA
Genome Projectnegative regulation of cell death
GO:0060548
IDA
Gene Ontologynegative regulation of cell death1
GO:0051984
IMP
Genome Projectpositive regulation of chromosome segregation
GO:0051984
IMP
Gene Ontologypositive regulation of chromosome segregation2
GO:0051865
IDA
Genome Projectprotein autoubiquitination
GO:0051865
IDA
Gene Ontologyprotein autoubiquitination3
GO:0042769
TAS
Genome ProjectDNA damage response, detection of DNA damage
GO:0042769
TAS
Gene OntologyDNA damage response, detection of DNA damage
GO:0016567
TAS
Genome Projectprotein ubiquitination
GO:0016567
TAS
Gene Ontologyprotein ubiquitination
GO:0009411
IBA
Genome Projectresponse to UV
GO:0006974
IDA
Genome Projectcellular response to DNA damage stimulus
GO:0006974
IDA
Gene Ontologycellular response to DNA damage stimulus1 2 3
GO:0006513
IBA
Genome Projectprotein monoubiquitination
GO:0006301
IBA
Genome Projectpostreplication repair
GO:0006281
NAS
Genome ProjectDNA repair
GO:0006281
NAS
Gene OntologyDNA repair4
GO:0035967
IEA
PLAZA Integrative Orthologycellular response to topologically incorrect protein SPBC1734.06
GO:0035966
IEA
PLAZA Integrative Orthologyresponse to topologically incorrect protein SPBC1734.06
GO:0006508
IEA
PLAZA Integrative Orthologyproteolysis SPBC1734.06
GO:0044271
IEA
PLAZA Integrative Orthologycellular nitrogen compound biosynthetic process YCR066W
GO:0006511
IEA
PLAZA Integrative Orthologyubiquitin-dependent protein catabolic process SPBC1734.06
GO:1901575
IEA
PLAZA Integrative Orthologyorganic substance catabolic process SPBC1734.06
GO:1901576
IEA
PLAZA Integrative Orthologyorganic substance biosynthetic process YCR066W
GO:0030163
IEA
PLAZA Integrative Orthologyprotein catabolic process SPBC1734.06
GO:0000209
IEA
PLAZA Integrative Orthologyprotein polyubiquitination SPBC1734.06
GO:0034645
IEA
PLAZA Integrative Orthologycellular macromolecule biosynthetic process YCR066W
GO:0070987
IEA
PLAZA Integrative Orthologyerror-free translesion synthesis YCR066W
GO:0051788
IEA
PLAZA Integrative Orthologyresponse to misfolded protein SPBC1734.06
GO:0019985
IEA
PLAZA Integrative Orthologytranslesion synthesis YCR066W
GO:0019941
IEA
PLAZA Integrative Orthologymodification-dependent protein catabolic process SPBC1734.06
GO:0033036
IEA
PLAZA Integrative Orthologymacromolecule localization SPBC1734.06
GO:0044265
IEA
PLAZA Integrative Orthologycellular macromolecule catabolic process SPBC1734.06
GO:0071630
IEA
PLAZA Integrative Orthologynuclear protein quality control by the ubiquitin-proteasome system SPBC1734.06
GO:0018130
IEA
PLAZA Integrative Orthologyheterocycle biosynthetic process YCR066W
GO:0071310
IEA
PLAZA Integrative Orthologycellular response to organic substance SPBC1734.06
GO:0009058
IEA
PLAZA Integrative Orthologybiosynthetic process YCR066W
GO:0044257
IEA
PLAZA Integrative Orthologycellular protein catabolic process SPBC1734.06
GO:0009059
IEA
PLAZA Integrative Orthologymacromolecule biosynthetic process YCR066W
GO:0042276
IEA
PLAZA Integrative Orthologyerror-prone translesion synthesis YCR066W
GO:0042275
IEA
PLAZA Integrative Orthologyerror-free postreplication DNA repair YCR066W
GO:1901565
IEA
PLAZA Integrative Orthologyorganonitrogen compound catabolic process SPBC1734.06
GO:1901362
IEA
PLAZA Integrative Orthologyorganic cyclic compound biosynthetic process YCR066W
GO:0009056
IEA
PLAZA Integrative Orthologycatabolic process SPBC1734.06
GO:1901044
IEA
PLAZA Integrative Orthologyprotein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process SPBC1734.06
GO:0009057
IEA
PLAZA Integrative Orthologymacromolecule catabolic process SPBC1734.06
GO:0019438
IEA
PLAZA Integrative Orthologyaromatic compound biosynthetic process YCR066W
GO:0034613
IEA
PLAZA Integrative Orthologycellular protein localization SPBC1734.06
GO:0031144
IEA
PLAZA Integrative Orthologyproteasome localization SPBC1734.06
GO:0033365
IEA
PLAZA Integrative Orthologyprotein localization to organelle SPBC1734.06
GO:0034654
IEA
PLAZA Integrative Orthologynucleobase-containing compound biosynthetic process YCR066W
GO:1990139
IEA
PLAZA Integrative Orthologyprotein localization to nuclear periphery SPBC1734.06
GO:0051179
IEA
PLAZA Integrative Orthologylocalization SPBC1734.06
GO:0043161
IEA
PLAZA Integrative Orthologyproteasome-mediated ubiquitin-dependent protein catabolic process SPBC1734.06
GO:0031503
IEA
PLAZA Integrative Orthologyprotein-containing complex localization SPBC1734.06
GO:0044248
IEA
PLAZA Integrative Orthologycellular catabolic process SPBC1734.06
GO:0043632
IEA
PLAZA Integrative Orthologymodification-dependent macromolecule catabolic process SPBC1734.06
GO:0044249
IEA
PLAZA Integrative Orthologycellular biosynthetic process YCR066W
GO:0042221
IEA
PLAZA Integrative Orthologyresponse to chemical SPBC1734.06
GO:0010033
IEA
PLAZA Integrative Orthologyresponse to organic substance SPBC1734.06
GO:0071218
IEA
PLAZA Integrative Orthologycellular response to misfolded protein SPBC1734.06
GO:0010498
IEA
PLAZA Integrative Orthologyproteasomal protein catabolic process SPBC1734.06
GO:0070887
IEA
PLAZA Integrative Orthologycellular response to chemical stimulus SPBC1734.06
GO:0051603
IEA
PLAZA Integrative Orthologyproteolysis involved in cellular protein catabolic process SPBC1734.06
GO:0034504
IEA
PLAZA Integrative Orthologyprotein localization to nucleus SPBC1734.06
GO:0071897
IEA
PLAZA Integrative OrthologyDNA biosynthetic process YCR066W
GO:1990920
IEA
PLAZA Integrative Orthologyproteasome localization to nuclear periphery SPBC1734.06
GO:0006515
IEA
PLAZA Integrative Orthologyprotein quality control for misfolded or incompletely synthesized proteins SPBC1734.06
GO:0051641
IEA
PLAZA Integrative Orthologycellular localization SPBC1734.06
GO:0034629
IEA
PLAZA Integrative Orthologycellular protein-containing complex localization SPBC1734.06
GO:0000731
IEA
PLAZA Integrative OrthologyDNA synthesis involved in DNA repair YCR066W
GO:0008104
IEA
PLAZA Integrative Orthologyprotein localization SPBC1734.06
GO:0036297
IEA
PLAZA Integrative Orthologyinterstrand cross-link repair SPBC1734.06
GO:0070727
IEA
PLAZA Integrative Orthologycellular macromolecule localization SPBC1734.06

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0061630
IBA
Genome Projectubiquitin protein ligase activity
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0043142
IBA
Genome Projectsingle-stranded DNA-dependent ATPase activity
GO:0042802
IDA
Genome Projectidentical protein binding
GO:0042802
IDA
Gene Ontologyidentical protein binding3
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0031625
IPI
Gene Ontologyubiquitin protein ligase binding5 6
GO:0031593
IDA
Genome Projectpolyubiquitin modification-dependent protein binding
GO:0031593
IDA
Gene Ontologypolyubiquitin modification-dependent protein binding7
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding1 2 8 9 10 11 12 13 14 15
GO:0003684
NAS
Genome Projectdamaged DNA binding
GO:0003684
NAS
Gene Ontologydamaged DNA binding4
GO:0000403
IDA
Genome ProjectY-form DNA binding
GO:0000403
IDA
Gene OntologyY-form DNA binding6
GO:0044877
IPI
Gene Ontologyprotein-containing complex binding2
GO:0046914
IEA
PLAZA Homology (enrichment)transition metal ion binding HOM02SEM014407
GO:0008270
IEA
PLAZA Homology (enrichment)zinc ion binding HOM02SEM014407
GO:0003697
IEA
PLAZA Integrative Orthologysingle-stranded DNA binding YCR066W

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0097505
IBA
Genome ProjectRad6-Rad18 complex
GO:0042405
IDA
Genome Projectnuclear inclusion body
GO:0042405
IDA
Gene Ontologynuclear inclusion body1
GO:0035861
IDA
Genome Projectsite of double-strand break
GO:0035861
IDA
Gene Ontologysite of double-strand break2
GO:0016604
IDA
Genome Projectnuclear body
GO:0016604
IDA
Gene Ontologynuclear body
GO:0005813
IDA
Genome Projectcentrosome
GO:0005813
IDA
Gene Ontologycentrosome16
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005657
IDA
Genome Projectreplication fork
GO:0005657
IDA
Gene Ontologyreplication fork6
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005654
IDA
TAS
Gene Ontologynucleoplasm
GO:0005634
IDA
NAS
Genome Projectnucleus
GO:0005634
IDA
NAS
Gene Ontologynucleus1 3 4 16
GO:0044454
IEA
PLAZA Integrative Orthologynuclear chromosome part SPBC1734.06
GO:0000790
IEA
PLAZA Integrative Orthologynuclear chromatin SPBC1734.06
GO:0000785
IEA
PLAZA Integrative Orthologychromatin SPBC1734.06
GO:0000228
IEA
PLAZA Integrative Orthologynuclear chromosome SPBC1734.06

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001841Zinc finger, RING-type
IPR003034SAP domain
IPR006642Zinc finger, Rad18-type putative
IPR013083Zinc finger, RING/FYVE/PHD-type
IPR017907Zinc finger, RING-type, conserved site

No MapMan annotations defined for this gene.
KeggID Description
K10627RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
No chloroplast target sequence found.