Gene: ENSG00000070010 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000070010
Transcript Identifier
ENST00000263202
Gene Type
Coding gene
Location
22 : 19450670-19479085 : negative

Family Information

Homologous gene family
HOM02SEM001220
(44 genes in 25 species)
specific family
Orthologous gene family
ORTHO02SEM001298
(42 genes in 25 species)
specific family

Descriptions

gene_descr
ubiquitin fusion degradation 1 like (yeast)

Identifiers

Type Value
pidENSP00000263202
HGNC12520
UniprotQ92890
UniprotQ541A5
RefSeq_mRNANM_005659.6
EMBLAC000068
EMBLAC000087
EMBLAF141201
EMBLAJ239058
EMBLAK225877
EMBLAY101594
EMBLBC001049
EMBLBC005087
EMBLCH471176
EMBLCR456607
EMBLU64444

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0071712
IMP
Genome ProjectER-associated misfolded protein catabolic process
GO:0071712
IMP
Gene OntologyER-associated misfolded protein catabolic process1
GO:0070987
TAS
Genome Projecterror-free translesion synthesis
GO:0070987
TAS
Gene Ontologyerror-free translesion synthesis
GO:0043161
IEA
Genome Projectproteasome-mediated ubiquitin-dependent protein catabolic process
GO:0039536
IMP
Genome Projectnegative regulation of RIG-I signaling pathway
GO:0039536
IMP
Gene Ontologynegative regulation of RIG-I signaling pathway2
GO:0032480
IMP
Genome Projectnegative regulation of type I interferon production
GO:0032480
IMP
Gene Ontologynegative regulation of type I interferon production2
GO:0030970
IMP
Genome Projectretrograde protein transport, ER to cytosol
GO:0030970
IMP
Gene Ontologyretrograde protein transport, ER to cytosol3
GO:0016579
TAS
Genome Projectprotein deubiquitination
GO:0016579
TAS
Gene Ontologyprotein deubiquitination
GO:0006511
IMP
Genome Projectubiquitin-dependent protein catabolic process
GO:0006511
IMP
Gene Ontologyubiquitin-dependent protein catabolic process2
GO:0001501
TAS
Genome Projectskeletal system development
GO:0001501
TAS
Gene Ontologyskeletal system development4
GO:0030433
IEA
PLAZA Integrative Orthologyubiquitin-dependent ERAD pathway YGR048W
GO:0071501
IEA
PLAZA Integrative Orthologycellular response to sterol depletion SPBC16A3.09c
GO:0010605
IEA
PLAZA Integrative Orthologynegative regulation of macromolecule metabolic process YGR048W
GO:0070651
IEA
PLAZA Integrative Orthologynonfunctional rRNA decay YGR048W
GO:1990116
IEA
PLAZA Integrative Orthologyribosome-associated ubiquitin-dependent protein catabolic process YGR048W
GO:0010604
IEA
PLAZA Integrative Orthologypositive regulation of macromolecule metabolic process SPBC16A3.09c
GO:1903508
IEA
PLAZA Integrative Orthologypositive regulation of nucleic acid-templated transcription SPBC16A3.09c
GO:0044270
IEA
PLAZA Integrative Orthologycellular nitrogen compound catabolic process YGR048W
GO:0006357
IEA
PLAZA Integrative Orthologyregulation of transcription by RNA polymerase II SPBC16A3.09c
GO:0006991
IEA
PLAZA Integrative Orthologyresponse to sterol depletion SPBC16A3.09c
GO:0006355
IEA
PLAZA Integrative Orthologyregulation of transcription, DNA-templated SPBC16A3.09c
GO:0030162
IEA
PLAZA Integrative Orthologyregulation of proteolysis FBgn0036136
GO:0006351
IEA
PLAZA Integrative Orthologytranscription, DNA-templated SPBC16A3.09c
GO:0071629
IEA
PLAZA Integrative Orthologycytoplasm protein quality control by the ubiquitin-proteasome system YGR048W
GO:0051348
IEA
PLAZA Integrative Orthologynegative regulation of transferase activity YGR048W
GO:0010557
IEA
PLAZA Integrative Orthologypositive regulation of macromolecule biosynthetic process SPBC16A3.09c
GO:0010558
IEA
PLAZA Integrative Orthologynegative regulation of macromolecule biosynthetic process YGR048W
GO:2000058
IEA
PLAZA Integrative Orthologyregulation of ubiquitin-dependent protein catabolic process FBgn0036136
GO:0010556
IEA
PLAZA Integrative Orthologyregulation of macromolecule biosynthetic process SPBC16A3.09c
GO:0006984
IEA
PLAZA Integrative OrthologyER-nucleus signaling pathway SPBC16A3.09c
GO:1903506
IEA
PLAZA Integrative Orthologyregulation of nucleic acid-templated transcription SPBC16A3.09c
GO:0045862
IEA
PLAZA Integrative Orthologypositive regulation of proteolysis FBgn0036136
GO:2000060
IEA
PLAZA Integrative Orthologypositive regulation of ubiquitin-dependent protein catabolic process FBgn0036136
GO:0060341
IEA
PLAZA Integrative Orthologyregulation of cellular localization YGR048W
GO:0044092
IEA
PLAZA Integrative Orthologynegative regulation of molecular function YGR048W
GO:0051974
IEA
PLAZA Integrative Orthologynegative regulation of telomerase activity YGR048W
GO:1900180
IEA
PLAZA Integrative Orthologyregulation of protein localization to nucleus YGR048W
GO:1903050
IEA
PLAZA Integrative Orthologyregulation of proteolysis involved in cellular protein catabolic process FBgn0036136
GO:0051338
IEA
PLAZA Integrative Orthologyregulation of transferase activity YGR048W
GO:0035103
IEA
PLAZA Integrative Orthologysterol regulatory element binding protein cleavage SPBC16A3.09c
GO:0010467
IEA
PLAZA Integrative Orthologygene expression SPBC16A3.09c
GO:0034655
IEA
PLAZA Integrative Orthologynucleobase-containing compound catabolic process YGR048W
GO:0010468
IEA
PLAZA Integrative Orthologyregulation of gene expression SPBC16A3.09c
GO:0051053
IEA
PLAZA Integrative Orthologynegative regulation of DNA metabolic process YGR048W
GO:0010628
IEA
PLAZA Integrative Orthologypositive regulation of gene expression SPBC16A3.09c
GO:0032879
IEA
PLAZA Integrative Orthologyregulation of localization YGR048W
GO:0051972
IEA
PLAZA Integrative Orthologyregulation of telomerase activity YGR048W
GO:0009889
IEA
PLAZA Integrative Orthologyregulation of biosynthetic process SPBC16A3.09c
GO:0045732
IEA
PLAZA Integrative Orthologypositive regulation of protein catabolic process FBgn0036136
GO:0046700
IEA
PLAZA Integrative Orthologyheterocycle catabolic process YGR048W
GO:0034660
IEA
PLAZA Integrative OrthologyncRNA metabolic process YGR048W
GO:0034661
IEA
PLAZA Integrative OrthologyncRNA catabolic process YGR048W
GO:0032880
IEA
PLAZA Integrative Orthologyregulation of protein localization YGR048W
GO:1903052
IEA
PLAZA Integrative Orthologypositive regulation of proteolysis involved in cellular protein catabolic process FBgn0036136
GO:2001141
IEA
PLAZA Integrative Orthologyregulation of RNA biosynthetic process SPBC16A3.09c
GO:1900182
IEA
PLAZA Integrative Orthologypositive regulation of protein localization to nucleus YGR048W
GO:2000279
IEA
PLAZA Integrative Orthologynegative regulation of DNA biosynthetic process YGR048W
GO:0072665
IEA
PLAZA Integrative Orthologyprotein localization to vacuole YGR048W
GO:0051604
IEA
PLAZA Integrative Orthologyprotein maturation SPBC16A3.09c
GO:2000278
IEA
PLAZA Integrative Orthologyregulation of DNA biosynthetic process YGR048W
GO:0006401
IEA
PLAZA Integrative OrthologyRNA catabolic process YGR048W
GO:0051171
IEA
PLAZA Integrative Orthologyregulation of nitrogen compound metabolic process SPBC16A3.09c
GO:0051052
IEA
PLAZA Integrative Orthologyregulation of DNA metabolic process YGR048W
GO:0051173
IEA
PLAZA Integrative Orthologypositive regulation of nitrogen compound metabolic process SPBC16A3.09c
GO:0006366
IEA
PLAZA Integrative Orthologytranscription by RNA polymerase II SPBC16A3.09c
GO:0042176
IEA
PLAZA Integrative Orthologyregulation of protein catabolic process FBgn0036136
GO:0051172
IEA
PLAZA Integrative Orthologynegative regulation of nitrogen compound metabolic process YGR048W
GO:0061136
IEA
PLAZA Integrative Orthologyregulation of proteasomal protein catabolic process FBgn0036136
GO:0019439
IEA
PLAZA Integrative Orthologyaromatic compound catabolic process YGR048W
GO:0031324
IEA
PLAZA Integrative Orthologynegative regulation of cellular metabolic process YGR048W
GO:0031323
IEA
PLAZA Integrative Orthologyregulation of cellular metabolic process SPBC16A3.09c
GO:0080090
IEA
PLAZA Integrative Orthologyregulation of primary metabolic process SPBC16A3.09c
GO:0031326
IEA
PLAZA Integrative Orthologyregulation of cellular biosynthetic process SPBC16A3.09c
GO:0031325
IEA
PLAZA Integrative Orthologypositive regulation of cellular metabolic process SPBC16A3.09c
GO:0032774
IEA
PLAZA Integrative OrthologyRNA biosynthetic process SPBC16A3.09c
GO:0031328
IEA
PLAZA Integrative Orthologypositive regulation of cellular biosynthetic process SPBC16A3.09c
GO:0031327
IEA
PLAZA Integrative Orthologynegative regulation of cellular biosynthetic process YGR048W
GO:1903827
IEA
PLAZA Integrative Orthologyregulation of cellular protein localization YGR048W
GO:0032933
IEA
PLAZA Integrative OrthologySREBP signaling pathway SPBC16A3.09c
GO:0031329
IEA
PLAZA Integrative Orthologyregulation of cellular catabolic process FBgn0036136
GO:1903829
IEA
PLAZA Integrative Orthologypositive regulation of cellular protein localization YGR048W
GO:0060255
IEA
PLAZA Integrative Orthologyregulation of macromolecule metabolic process SPBC16A3.09c
GO:0031331
IEA
PLAZA Integrative Orthologypositive regulation of cellular catabolic process FBgn0036136
GO:0032268
IEA
PLAZA Integrative Orthologyregulation of cellular protein metabolic process FBgn0036136
GO:0019222
IEA
PLAZA Integrative Orthologyregulation of metabolic process SPBC16A3.09c
GO:0016075
IEA
PLAZA Integrative OrthologyrRNA catabolic process YGR048W
GO:0016072
IEA
PLAZA Integrative OrthologyrRNA metabolic process YGR048W
GO:0016070
IEA
PLAZA Integrative OrthologyRNA metabolic process SPBC16A3.09c
GO:1901800
IEA
PLAZA Integrative Orthologypositive regulation of proteasomal protein catabolic process FBgn0036136
GO:0045944
IEA
PLAZA Integrative Orthologypositive regulation of transcription by RNA polymerase II SPBC16A3.09c
GO:0009894
IEA
PLAZA Integrative Orthologyregulation of catabolic process FBgn0036136
GO:0009896
IEA
PLAZA Integrative Orthologypositive regulation of catabolic process FBgn0036136
GO:0009890
IEA
PLAZA Integrative Orthologynegative regulation of biosynthetic process YGR048W
GO:0009891
IEA
PLAZA Integrative Orthologypositive regulation of biosynthetic process SPBC16A3.09c
GO:0009892
IEA
PLAZA Integrative Orthologynegative regulation of metabolic process YGR048W
GO:0009893
IEA
PLAZA Integrative Orthologypositive regulation of metabolic process SPBC16A3.09c
GO:1901361
IEA
PLAZA Integrative Orthologyorganic cyclic compound catabolic process YGR048W
GO:0019219
IEA
PLAZA Integrative Orthologyregulation of nucleobase-containing compound metabolic process SPBC16A3.09c
GO:0032270
IEA
PLAZA Integrative Orthologypositive regulation of cellular protein metabolic process FBgn0036136
GO:0032434
IEA
PLAZA Integrative Orthologyregulation of proteasomal ubiquitin-dependent protein catabolic process FBgn0036136
GO:0032436
IEA
PLAZA Integrative Orthologypositive regulation of proteasomal ubiquitin-dependent protein catabolic process FBgn0036136
GO:0097659
IEA
PLAZA Integrative Orthologynucleic acid-templated transcription SPBC16A3.09c
GO:0033365
IEA
PLAZA Integrative Orthologyprotein localization to organelle SPBC16A3.09c
GO:0016485
IEA
PLAZA Integrative Orthologyprotein processing SPBC16A3.09c
GO:0051252
IEA
PLAZA Integrative Orthologyregulation of RNA metabolic process SPBC16A3.09c
GO:0051254
IEA
PLAZA Integrative Orthologypositive regulation of RNA metabolic process SPBC16A3.09c
GO:0043086
IEA
PLAZA Integrative Orthologynegative regulation of catalytic activity YGR048W
GO:0065009
IEA
PLAZA Integrative Orthologyregulation of molecular function YGR048W
GO:0045934
IEA
PLAZA Integrative Orthologynegative regulation of nucleobase-containing compound metabolic process YGR048W
GO:0034067
IEA
PLAZA Integrative Orthologyprotein localization to Golgi apparatus SPBC16A3.09c
GO:0045935
IEA
PLAZA Integrative Orthologypositive regulation of nucleobase-containing compound metabolic process SPBC16A3.09c
GO:1902680
IEA
PLAZA Integrative Orthologypositive regulation of RNA biosynthetic process SPBC16A3.09c
GO:0034504
IEA
PLAZA Integrative Orthologyprotein localization to nucleus YGR048W
GO:2000112
IEA
PLAZA Integrative Orthologyregulation of cellular macromolecule biosynthetic process SPBC16A3.09c
GO:2000113
IEA
PLAZA Integrative Orthologynegative regulation of cellular macromolecule biosynthetic process YGR048W
GO:0050790
IEA
PLAZA Integrative Orthologyregulation of catalytic activity YGR048W
GO:0045893
IEA
PLAZA Integrative Orthologypositive regulation of transcription, DNA-templated SPBC16A3.09c
GO:0048522
IEA
PLAZA Integrative Orthologypositive regulation of cellular process SPBC16A3.09c
GO:0051247
IEA
PLAZA Integrative Orthologypositive regulation of protein metabolic process FBgn0036136
GO:0051246
IEA
PLAZA Integrative Orthologyregulation of protein metabolic process FBgn0036136
GO:1903364
IEA
PLAZA Integrative Orthologypositive regulation of cellular protein catabolic process FBgn0036136
GO:0009792
IEA
PLAZA Integrative Orthologyembryo development ending in birth or egg hatching WBGene00006733
GO:1903362
IEA
PLAZA Integrative Orthologyregulation of cellular protein catabolic process FBgn0036136
GO:0009790
IEA
PLAZA Integrative Orthologyembryo development WBGene00006733

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0051117
IEA
Genome ProjectATPase binding
GO:0036435
IEA
Genome ProjectK48-linked polyubiquitin modification-dependent protein binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding5 6 7 8 9 10
GO:0005102
IEA
Genome Projectsignaling receptor binding
GO:0004843
TAS
Genome Projectthiol-dependent ubiquitin-specific protease activity
GO:0004843
TAS
Gene Ontologythiol-dependent ubiquitin-specific protease activity11
GO:0032183
IEA
PLAZA Integrative OrthologySUMO binding SPBC16A3.09c
GO:0032182
IEA
PLAZA Integrative Orthologyubiquitin-like protein binding SPBC16A3.09c
GO:0044877
IEA
PLAZA Integrative Orthologyprotein-containing complex binding WBGene00006733
GO:0043130
IEA
PLAZA Integrative Orthologyubiquitin binding YGR048W

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0036501
IPI
Genome ProjectUFD1-NPL4 complex
GO:0036501
IPI
Gene OntologyUFD1-NPL4 complex5
GO:0034098
IDA
ISS
Genome ProjectVCP-NPL4-UFD1 AAA ATPase complex
GO:0034098
IDA
ISS
Gene OntologyVCP-NPL4-UFD1 AAA ATPase complex2
GO:0005829
IEA
Genome Projectcytosol
GO:0005783
IDA
Genome Projectendoplasmic reticulum
GO:0005783
IDA
Gene Ontologyendoplasmic reticulum
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005654
TAS
Gene Ontologynucleoplasm
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
Gene Ontologynucleus12
GO:1990234
IEA
PLAZA Integrative Orthologytransferase complex YGR048W
GO:1990112
IEA
PLAZA Integrative OrthologyRQC complex YGR048W
GO:1902494
IEA
PLAZA Integrative Orthologycatalytic complex YGR048W
GO:0000151
IEA
PLAZA Integrative Orthologyubiquitin ligase complex YGR048W
GO:0000153
IEA
PLAZA Integrative Orthologycytoplasmic ubiquitin ligase complex YGR048W
GO:0000835
IEA
PLAZA Integrative OrthologyER ubiquitin ligase complex YGR048W
GO:0000836
IEA
PLAZA Integrative OrthologyHrd1p ubiquitin ligase complex YGR048W
GO:0000837
IEA
PLAZA Integrative OrthologyDoa10p ubiquitin ligase complex YGR048W
GO:0000839
IEA
PLAZA Integrative OrthologyHrd1p ubiquitin ligase ERAD-L complex YGR048W

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR004854Ubiquitin fusion degradation protein Ufd1-like

No MapMan annotations defined for this gene.
KeggID Description
K14016UFD1; ubiquitin fusion degradation protein 1
No chloroplast target sequence found.