Gene: ENSG00000069974 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000069974
Transcript Identifier
ENST00000569493
Gene Type
Coding gene
Location
15 : 55205507-55234934 : negative

Family Information

Homologous gene family
HOM02SEM000006
(1028 genes in 26 species)
specific family
Orthologous gene family
ORTHO02SEM013374
(4 genes in 3 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
RAB27A, member RAS oncogene family

Identifiers

Type Value
pidENSP00000456059
HGNC9766
UniprotP51159
UniprotA2RU94
RefSeq_mRNANM_183236.2
EMBLAF125393
EMBLAF154836
EMBLAF154837
EMBLAF154838
EMBLAF154839
EMBLAF154840
EMBLAF443871
EMBLAF498953
EMBLAK312836
EMBLBC107680
EMBLBC132800
EMBLBC136423
EMBLCH471082
EMBLCR536496
EMBLCR541693
EMBLU38654
EMBLU57094

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1990182
IMP
Genome Projectexosomal secretion
GO:1990182
IMP
Gene Ontologyexosomal secretion1
GO:1903435
IMP
Genome Projectpositive regulation of constitutive secretory pathway
GO:1903435
IMP
Gene Ontologypositive regulation of constitutive secretory pathway2
GO:1903428
IMP
Genome Projectpositive regulation of reactive oxygen species biosynthetic process
GO:1903428
IMP
Gene Ontologypositive regulation of reactive oxygen species biosynthetic process3
GO:1903307
IMP, IGI
Genome Projectpositive regulation of regulated secretory pathway
GO:1903307
IMP, IGI
Gene Ontologypositive regulation of regulated secretory pathway2
GO:0097278
IMP
Genome Projectcomplement-dependent cytotoxicity
GO:0097278
IMP
Gene Ontologycomplement-dependent cytotoxicity3
GO:0071985
IMP
Genome Projectmultivesicular body sorting pathway
GO:0071985
IMP
Gene Ontologymultivesicular body sorting pathway4
GO:0061024
TAS
Genome Projectmembrane organization
GO:0050766
IMP
Genome Projectpositive regulation of phagocytosis
GO:0050766
IMP
Gene Ontologypositive regulation of phagocytosis3
GO:0048489
TAS
Genome Projectsynaptic vesicle transport
GO:0048489
TAS
Gene Ontologysynaptic vesicle transport5
GO:0045921
IMP
Genome Projectpositive regulation of exocytosis
GO:0045921
IMP
Gene Ontologypositive regulation of exocytosis4
GO:0043320
IEA
Genome Projectnatural killer cell degranulation
GO:0043316
IEA
Genome Projectcytotoxic T cell degranulation
GO:0043312
TAS
Genome Projectneutrophil degranulation
GO:0043312
TAS
Gene Ontologyneutrophil degranulation
GO:0036257
IMP
Genome Projectmultivesicular body organization
GO:0036257
IMP
Gene Ontologymultivesicular body organization1
GO:0032402
IBA
Genome Projectmelanosome transport
GO:0032402
NAS
Gene Ontologymelanosome transport6
GO:0032400
IMP
Genome Projectmelanosome localization
GO:0032400
IMP
Gene Ontologymelanosome localization7
GO:0030318
IEA
Genome Projectmelanocyte differentiation
GO:0019882
IMP
Genome Projectantigen processing and presentation
GO:0019882
IMP
Gene Ontologyantigen processing and presentation8
GO:0010628
IMP
Genome Projectpositive regulation of gene expression
GO:0010628
IMP
Gene Ontologypositive regulation of gene expression1
GO:0007596
IEA
Genome Projectblood coagulation
GO:0006887
IDA
Genome Projectexocytosis
GO:0006887
IDA
Gene Ontologyexocytosis9
GO:0006605
IEA
Genome Projectprotein targeting
GO:0080090
IEA
PLAZA Integrative Orthologyregulation of primary metabolic process WBGene00000089
GO:0051239
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal process WBGene00000089
GO:0030431
IEA
PLAZA Integrative Orthologysleep FBgn0025382
GO:0017156
IEA
PLAZA Integrative Orthologycalcium ion regulated exocytosis WBGene00000089
GO:0051716
IEA
PLAZA Homology (enrichment)cellular response to stimulus HOM02SEM000006
GO:0006903
IEA
PLAZA Integrative Orthologyvesicle targeting WBGene00000089
GO:0031329
IEA
PLAZA Integrative Orthologyregulation of cellular catabolic process WBGene00000089
GO:0099022
IEA
PLAZA Integrative Orthologyvesicle tethering WBGene00000089
GO:1901575
IEA
PLAZA Integrative Orthologyorganic substance catabolic process WBGene00000089
GO:0044267
IEA
PLAZA Integrative Orthologycellular protein metabolic process WBGene00000089
GO:0030163
IEA
PLAZA Integrative Orthologyprotein catabolic process WBGene00000089
GO:0007165
IEA
PLAZA Homology (enrichment)signal transduction HOM02SEM000006
GO:0090522
IEA
PLAZA Integrative Orthologyvesicle tethering involved in exocytosis WBGene00000089
GO:0031331
IEA
PLAZA Integrative Orthologypositive regulation of cellular catabolic process WBGene00000089
GO:0032268
IEA
PLAZA Integrative Orthologyregulation of cellular protein metabolic process WBGene00000089
GO:1990504
IEA
PLAZA Integrative Orthologydense core granule exocytosis WBGene00000089
GO:0044265
IEA
PLAZA Integrative Orthologycellular macromolecule catabolic process WBGene00000089
GO:0044260
IEA
PLAZA Integrative Orthologycellular macromolecule metabolic process WBGene00000089
GO:0044062
IEA
PLAZA Integrative Orthologyregulation of excretion WBGene00000089
GO:0002576
IEA
PLAZA Integrative Orthologyplatelet degranulation ENSG00000041353
GO:0044257
IEA
PLAZA Integrative Orthologycellular protein catabolic process WBGene00000089
GO:0009894
IEA
PLAZA Integrative Orthologyregulation of catabolic process WBGene00000089
GO:1901564
IEA
PLAZA Integrative Orthologyorganonitrogen compound metabolic process WBGene00000089
GO:0044057
IEA
PLAZA Integrative Orthologyregulation of system process WBGene00000089
GO:0009896
IEA
PLAZA Integrative Orthologypositive regulation of catabolic process WBGene00000089
GO:1901565
IEA
PLAZA Integrative Orthologyorganonitrogen compound catabolic process WBGene00000089
GO:0007154
IEA
PLAZA Homology (enrichment)cell communication HOM02SEM000006
GO:0009056
IEA
PLAZA Integrative Orthologycatabolic process WBGene00000089
GO:0009057
IEA
PLAZA Integrative Orthologymacromolecule catabolic process WBGene00000089
GO:0019538
IEA
PLAZA Integrative Orthologyprotein metabolic process WBGene00000089
GO:0032270
IEA
PLAZA Integrative Orthologypositive regulation of cellular protein metabolic process WBGene00000089
GO:0023052
IEA
PLAZA Homology (enrichment)signaling HOM02SEM000006
GO:0006807
IEA
PLAZA Integrative Orthologynitrogen compound metabolic process WBGene00000089
GO:0140029
IEA
PLAZA Integrative Orthologyexocytic process WBGene00000089
GO:0007588
IEA
PLAZA Integrative Orthologyexcretion WBGene00000089
GO:0044248
IEA
PLAZA Integrative Orthologycellular catabolic process WBGene00000089
GO:0045732
IEA
PLAZA Integrative Orthologypositive regulation of protein catabolic process WBGene00000089
GO:2000294
IEA
PLAZA Integrative Orthologypositive regulation of defecation WBGene00000089
GO:2000292
IEA
PLAZA Integrative Orthologyregulation of defecation WBGene00000089
GO:0030421
IEA
PLAZA Integrative Orthologydefecation WBGene00000089
GO:0051240
IEA
PLAZA Integrative Orthologypositive regulation of multicellular organismal process WBGene00000089
GO:0003008
IEA
PLAZA Integrative Orthologysystem process WBGene00000089
GO:0051247
IEA
PLAZA Integrative Orthologypositive regulation of protein metabolic process WBGene00000089
GO:0051246
IEA
PLAZA Integrative Orthologyregulation of protein metabolic process WBGene00000089
GO:0044238
IEA
PLAZA Integrative Orthologyprimary metabolic process WBGene00000089
GO:0051171
IEA
PLAZA Integrative Orthologyregulation of nitrogen compound metabolic process WBGene00000089
GO:0051173
IEA
PLAZA Integrative Orthologypositive regulation of nitrogen compound metabolic process WBGene00000089
GO:0042176
IEA
PLAZA Integrative Orthologyregulation of protein catabolic process WBGene00000089
GO:1903364
IEA
PLAZA Integrative Orthologypositive regulation of cellular protein catabolic process WBGene00000089
GO:1903362
IEA
PLAZA Integrative Orthologyregulation of cellular protein catabolic process WBGene00000089

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0031489
IEA
Genome Projectmyosin V binding
GO:0019904
IEA
Genome Projectprotein domain specific binding
GO:0019003
IDA
Genome ProjectGDP binding
GO:0019003
IDA
Gene OntologyGDP binding10
GO:0005525
IDA
ISS
Genome ProjectGTP binding
GO:0005525
IDA
ISS
Gene OntologyGTP binding11
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding2 9 12 13 14 15 16
GO:0003924
ISS
Genome ProjectGTPase activity
GO:0003924
ISS
Gene OntologyGTPase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0070382
IDA
Genome Projectexocytic vesicle
GO:0070382
IDA
Gene Ontologyexocytic vesicle9 17
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0070062
Gene Ontologyextracellular exosome18 19
GO:0045202
IEA
Genome Projectsynapse
GO:0042470
IDA
Genome Projectmelanosome
GO:0042470
IDA
Gene Ontologymelanosome6 20
GO:0035580
TAS
Genome Projectspecific granule lumen
GO:0035580
TAS
Gene Ontologyspecific granule lumen
GO:0033162
TAS
Genome Projectmelanosome membrane
GO:0033162
TAS
Gene Ontologymelanosome membrane
GO:0033093
IEA
Genome ProjectWeibel-Palade body
GO:0032585
IDA
Genome Projectmultivesicular body membrane
GO:0032585
IDA
Gene Ontologymultivesicular body membrane4
GO:0030667
IEA
Genome Projectsecretory granule membrane
GO:0030425
IDA
Genome Projectdendrite
GO:0030425
IDA
Gene Ontologydendrite20
GO:0030141
IBA
Genome Projectsecretory granule
GO:0016324
IEA
Genome Projectapical plasma membrane
GO:0005829
TAS
Genome Projectcytosol
GO:0005829
TAS
Gene Ontologycytosol
GO:0005794
IEA
Genome ProjectGolgi apparatus
GO:0005770
IDA
Genome Projectlate endosome
GO:0005770
IDA
Gene Ontologylate endosome17
GO:0005764
IDA
Genome Projectlysosome
GO:0005764
IDA
Gene Ontologylysosome14
GO:0005576
TAS
Genome Projectextracellular region
GO:0005576
TAS
Gene Ontologyextracellular region
GO:0001750
IEA
Genome Projectphotoreceptor outer segment
GO:0031088
IEA
PLAZA Integrative Orthologyplatelet dense granule membrane ENSG00000041353
GO:0098793
IEA
PLAZA Integrative Orthologypresynapse WBGene00000089
GO:0044456
IEA
PLAZA Integrative Orthologysynapse part WBGene00000089
GO:0031984
IEA
PLAZA Integrative Orthologyorganelle subcompartment ENSG00000041353
GO:0098791
IEA
PLAZA Integrative OrthologyGolgi subcompartment ENSG00000041353
GO:0030140
IEA
PLAZA Integrative Orthologytrans-Golgi network transport vesicle ENSG00000041353
GO:0042827
IEA
PLAZA Integrative Orthologyplatelet dense granule ENSG00000041353
GO:0005798
IEA
PLAZA Integrative OrthologyGolgi-associated vesicle ENSG00000041353
GO:0005795
IEA
PLAZA Integrative OrthologyGolgi stack ENSG00000041353
GO:0044431
IEA
PLAZA Integrative OrthologyGolgi apparatus part ENSG00000041353
GO:0008021
IEA
PLAZA Integrative Orthologysynaptic vesicle WBGene00000089

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001806Small GTPase
IPR005225Small GTP-binding protein domain
IPR027417P-loop containing nucleoside triphosphate hydrolase

No MapMan annotations defined for this gene.
KeggID Description
K07885RAB27A; Ras-related protein Rab-27A
No chloroplast target sequence found.