Gene: ENSG00000064012 (Homo sapiens)

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Gene Identifier
ENSG00000064012
Transcript Identifier
ENST00000358485
Gene Type
Coding gene
Location
2 : 201258232-201286594 : positive

Family Information

Homologous gene family
HOM02SEM003735
(21 genes in 3 species)
specific family
Orthologous gene family
ORTHO02SEM008012
(10 genes in 3 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
caspase 8, apoptosis-related cysteine peptidase

Identifiers

Type Value
pidENSP00000351273
HGNC1509
UniprotQ14790
RefSeq_mRNANM_001080125.1

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1902042
TAS
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042
TAS
Gene Ontologynegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902041
TAS
Genome Projectregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902041
TAS
Gene Ontologyregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1900740
TAS
Genome Projectpositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1900740
TAS
Gene Ontologypositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0097296
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097296
TAS
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097202
IDA
Genome Projectactivation of cysteine-type endopeptidase activity
GO:0097202
IDA
Gene Ontologyactivation of cysteine-type endopeptidase activity1
GO:0097194
IMP
TAS
Genome Projectexecution phase of apoptosis
GO:0097194
IMP
TAS
Gene Ontologyexecution phase of apoptosis2
GO:0097191
IDA
Genome Projectextrinsic apoptotic signaling pathway
GO:0097191
IDA
Gene Ontologyextrinsic apoptotic signaling pathway3
GO:0097190
IMP
TAS
Genome Projectapoptotic signaling pathway
GO:0097190
IMP
TAS
Gene Ontologyapoptotic signaling pathway4
GO:0071550
TAS
Genome Projectdeath-inducing signaling complex assembly
GO:0071550
TAS
Gene Ontologydeath-inducing signaling complex assembly
GO:0071407
IEA
Genome Projectcellular response to organic cyclic compound
GO:0071260
IEP
Genome Projectcellular response to mechanical stimulus
GO:0071260
IEP
Gene Ontologycellular response to mechanical stimulus5
GO:0070423
TAS
Genome Projectnucleotide-binding oligomerization domain containing signaling pathway
GO:0070423
TAS
Gene Ontologynucleotide-binding oligomerization domain containing signaling pathway
GO:0060715
TAS
Genome Projectsyncytiotrophoblast cell differentiation involved in labyrinthine layer development
GO:0060715
TAS
Gene Ontologysyncytiotrophoblast cell differentiation involved in labyrinthine layer development6
GO:0060544
TAS
Genome Projectregulation of necroptotic process
GO:0060544
TAS
Gene Ontologyregulation of necroptotic process
GO:0051603
IMP
Genome Projectproteolysis involved in cellular protein catabolic process
GO:0051603
IMP
Gene Ontologyproteolysis involved in cellular protein catabolic process7
GO:0046677
IEA
Genome Projectresponse to antibiotic
GO:0045862
IDA
Genome Projectpositive regulation of proteolysis
GO:0045862
IDA
Gene Ontologypositive regulation of proteolysis1
GO:0045651
IMP
Genome Projectpositive regulation of macrophage differentiation
GO:0045651
IMP
Gene Ontologypositive regulation of macrophage differentiation8
GO:0045471
IEA
Genome Projectresponse to ethanol
GO:0043124
IMP
Genome Projectnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124
IMP
Gene Ontologynegative regulation of I-kappaB kinase/NF-kappaB signaling8
GO:0043123
IMP, IEP
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123
IMP, IEP
Gene Ontologypositive regulation of I-kappaB kinase/NF-kappaB signaling9 10
GO:0042113
TAS
Genome ProjectB cell activation
GO:0042113
TAS
Gene OntologyB cell activation6
GO:0042110
TAS
Genome ProjectT cell activation
GO:0042110
TAS
Gene OntologyT cell activation6
GO:0039650
TAS
Genome Projectsuppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process
GO:0039650
TAS
Gene Ontologysuppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process
GO:0036462
IDA
Genome ProjectTRAIL-activated apoptotic signaling pathway
GO:0036462
IDA
Gene OntologyTRAIL-activated apoptotic signaling pathway3
GO:0035666
TAS
Genome ProjectTRIF-dependent toll-like receptor signaling pathway
GO:0035666
TAS
Gene OntologyTRIF-dependent toll-like receptor signaling pathway
GO:0034612
IMP
Genome Projectresponse to tumor necrosis factor
GO:0034612
IMP
Gene Ontologyresponse to tumor necrosis factor7
GO:0032496
IEA
Genome Projectresponse to lipopolysaccharide
GO:0032355
IEA
Genome Projectresponse to estradiol
GO:0032025
IEA
Genome Projectresponse to cobalt ion
GO:0030225
TAS
Genome Projectmacrophage differentiation
GO:0030225
TAS
Gene Ontologymacrophage differentiation6
GO:0030101
TAS
Genome Projectnatural killer cell activation
GO:0030101
TAS
Gene Ontologynatural killer cell activation6
GO:0010803
TAS
Genome Projectregulation of tumor necrosis factor-mediated signaling pathway
GO:0010803
TAS
Gene Ontologyregulation of tumor necrosis factor-mediated signaling pathway
GO:0009409
IEA
Genome Projectresponse to cold
GO:0007166
TAS
Genome Projectcell surface receptor signaling pathway
GO:0007166
TAS
Gene Ontologycell surface receptor signaling pathway
GO:0006919
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
TAS
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915
IMP, IGI
Genome Projectapoptotic process
GO:0006915
IMP, IGI
Gene Ontologyapoptotic process11 12
GO:0006508
IDA
Genome Projectproteolysis
GO:0006508
IDA
Gene Ontologyproteolysis13
GO:0034138
TAS
Gene Ontologytoll-like receptor 3 signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0097200
IBA
Genome Projectcysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:0097199
IMP
Genome Projectcysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097199
IMP
Gene Ontologycysteine-type endopeptidase activity involved in apoptotic signaling pathway14 15
GO:0097153
IMP
Genome Projectcysteine-type endopeptidase activity involved in apoptotic process
GO:0097153
IMP
Gene Ontologycysteine-type endopeptidase activity involved in apoptotic process2
GO:0097110
IPI
Genome Projectscaffold protein binding
GO:0097110
IPI
Gene Ontologyscaffold protein binding3
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042802
IPI
Gene Ontologyidentical protein binding16 17
GO:0035877
IPI
Genome Projectdeath effector domain binding
GO:0035877
IPI
Gene Ontologydeath effector domain binding14
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0031625
IPI
Gene Ontologyubiquitin protein ligase binding18
GO:0008234
TAS
Genome Projectcysteine-type peptidase activity
GO:0008234
TAS
Gene Ontologycysteine-type peptidase activity19
GO:0008233
IDA, IMP
Genome Projectpeptidase activity
GO:0008233
IDA, IMP
Gene Ontologypeptidase activity8 20
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding3 8 10 13 17 18 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61
GO:0005164
IEA
Genome Projecttumor necrosis factor receptor binding
GO:0005123
IEA
Genome Projectdeath receptor binding
GO:0004197
IDA
TAS
Genome Projectcysteine-type endopeptidase activity
GO:0004197
IDA
TAS
Gene Ontologycysteine-type endopeptidase activity62 63
GO:0030234
IEA
PLAZA Integrative Orthologyenzyme regulator activity ENSG00000003402
GO:0008047
IEA
PLAZA Integrative Orthologyenzyme activator activity ENSG00000003402
GO:0002020
IEA
PLAZA Integrative Orthologyprotease binding ENSG00000003402
GO:0098772
IEA
PLAZA Integrative Orthologymolecular function regulator ENSG00000003402

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0097342
IDA
Genome Projectripoptosome
GO:0097342
IDA
Gene Ontologyripoptosome2
GO:0045121
IEA
Genome Projectmembrane raft
GO:0044297
IEA
Genome Projectcell body
GO:0043005
IEA
Genome Projectneuron projection
GO:0031265
IDA
Genome ProjectCD95 death-inducing signaling complex
GO:0031265
IDA
Gene OntologyCD95 death-inducing signaling complex14
GO:0031264
IDA
Genome Projectdeath-inducing signaling complex
GO:0031264
IDA
Gene Ontologydeath-inducing signaling complex4 51
GO:0005856
TAS
Genome Projectcytoskeleton
GO:0005856
TAS
Gene Ontologycytoskeleton64
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005829
IDA
TAS
Gene Ontologycytosol65
GO:0005741
TAS
Genome Projectmitochondrial outer membrane
GO:0005741
TAS
Gene Ontologymitochondrial outer membrane
GO:0005739
TAS
Genome Projectmitochondrion
GO:0005739
TAS
Gene Ontologymitochondrion64
GO:0005654
IDA
Genome Projectnucleoplasm
GO:0005654
IDA
Gene Ontologynucleoplasm

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001309Peptidase C14, p20 domain
IPR001875Death effector domain
IPR002138Peptidase C14, caspase non-catalytic subunit p10
IPR011029Death-like domain superfamily
IPR015917Peptidase C14A, caspase catalytic domain
IPR016129Peptidase family C14A, His active site
IPR029030Caspase-like domain superfamily
IPR033139Peptidase family C14A, cysteine active site

No MapMan annotations defined for this gene.
KeggID Description
K04398CASP8; caspase 8
No chloroplast target sequence found.