Gene: ENSG00000049541 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000049541
Transcript Identifier
ENST00000055077
Gene Type
Coding gene
Location
7 : 74232106-74254383 : negative

Family Information

Homologous gene family
HOM02SEM000388
(90 genes in 26 species)
specific family
Orthologous gene family
ORTHO02SEM002638
(28 genes in 26 species)
specific family

Descriptions

gene_descr
replication factor C (activator 1) 2, 40kDa

Identifiers

Type Value
pidENSP00000055077
HGNC9970
UniprotP35250
RefSeq_mRNANM_181471.2
EMBLAB451243
EMBLAC005081
EMBLAF045555
EMBLAF483622
EMBLBC002813
EMBLCH471200
EMBLM87338

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1901796
TAS
Genome Projectregulation of signal transduction by p53 class mediator
GO:1900264
IDA
Genome Projectpositive regulation of DNA-directed DNA polymerase activity
GO:1900264
IDA
Gene Ontologypositive regulation of DNA-directed DNA polymerase activity1
GO:0070987
TAS
Genome Projecterror-free translesion synthesis
GO:0070987
TAS
Gene Ontologyerror-free translesion synthesis
GO:0042769
TAS
Genome ProjectDNA damage response, detection of DNA damage
GO:0042769
TAS
Gene OntologyDNA damage response, detection of DNA damage
GO:0042276
TAS
Genome Projecterror-prone translesion synthesis
GO:0042276
TAS
Gene Ontologyerror-prone translesion synthesis
GO:0033683
TAS
Genome Projectnucleotide-excision repair, DNA incision
GO:0033683
TAS
Gene Ontologynucleotide-excision repair, DNA incision
GO:0019985
TAS
Genome Projecttranslesion synthesis
GO:0019985
TAS
Gene Ontologytranslesion synthesis
GO:0006297
TAS
Genome Projectnucleotide-excision repair, DNA gap filling
GO:0006297
TAS
Gene Ontologynucleotide-excision repair, DNA gap filling
GO:0006296
TAS
Genome Projectnucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006296
TAS
Gene Ontologynucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006283
TAS
Genome Projecttranscription-coupled nucleotide-excision repair
GO:0006283
TAS
Gene Ontologytranscription-coupled nucleotide-excision repair
GO:0006260
TAS
Genome ProjectDNA replication
GO:0006260
TAS
Gene OntologyDNA replication
GO:0000722
TAS
Genome Projecttelomere maintenance via recombination
GO:0032201
TAS
Gene Ontologytelomere maintenance via semi-conservative replication
GO:0071103
IEA
PLAZA Integrative OrthologyDNA conformation change FBgn0260985
GO:0030154
IEA
PLAZA Integrative Orthologycell differentiation FBgn0260985
GO:0046331
IEA
PLAZA Integrative Orthologylateral inhibition FBgn0260985
GO:0045165
IEA
PLAZA Integrative Orthologycell fate commitment FBgn0260985
GO:0022412
IEA
PLAZA Integrative Orthologycellular process involved in reproduction in multicellular organism FBgn0260985
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction FBgn0260985
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process FBgn0260985
GO:0048869
IEA
PLAZA Integrative Orthologycellular developmental process FBgn0260985
GO:0006272
IEA
PLAZA Integrative Orthologyleading strand elongation YOL094C
GO:0022616
IEA
PLAZA Integrative OrthologyDNA strand elongation SPAC1687.03c
GO:0006271
IEA
PLAZA Integrative OrthologyDNA strand elongation involved in DNA replication SPAC1687.03c
GO:0031570
IEA
PLAZA Integrative OrthologyDNA integrity checkpoint FBgn0260985
GO:0044703
IEA
PLAZA Integrative Orthologymulti-organism reproductive process FBgn0260985
GO:0032501
IEA
PLAZA Integrative Orthologymulticellular organismal process FBgn0260985
GO:0140013
IEA
PLAZA Integrative Orthologymeiotic nuclear division FBgn0260985
GO:0051704
IEA
PLAZA Integrative Orthologymulti-organism process FBgn0260985
GO:0032502
IEA
PLAZA Integrative Orthologydevelopmental process FBgn0260985
GO:0071478
IEA
PLAZA Integrative Orthologycellular response to radiation SPAC1687.03c
GO:0140014
IEA
PLAZA Integrative Orthologymitotic nuclear division FBgn0260985
GO:0000280
IEA
PLAZA Integrative Orthologynuclear division FBgn0260985
GO:0034644
IEA
PLAZA Integrative Orthologycellular response to UV SPAC1687.03c
GO:0016070
IEA
PLAZA Integrative OrthologyRNA metabolic process YOL094C
GO:0032504
IEA
PLAZA Integrative Orthologymulticellular organism reproduction FBgn0260985
GO:0000278
IEA
PLAZA Integrative Orthologymitotic cell cycle FBgn0260985
GO:0007276
IEA
PLAZA Integrative Orthologygamete generation FBgn0260985
GO:0009416
IEA
PLAZA Integrative Orthologyresponse to light stimulus SPAC1687.03c
GO:0009411
IEA
PLAZA Integrative Orthologyresponse to UV SPAC1687.03c
GO:0007399
IEA
PLAZA Integrative Orthologynervous system development FBgn0260985
GO:0048856
IEA
PLAZA Integrative Orthologyanatomical structure development FBgn0260985
GO:0045786
IEA
PLAZA Integrative Orthologynegative regulation of cell cycle FBgn0260985
GO:0007076
IEA
PLAZA Integrative Orthologymitotic chromosome condensation FBgn0260985
GO:0007275
IEA
PLAZA Integrative Orthologymulticellular organism development FBgn0260985
GO:0019953
IEA
PLAZA Integrative Orthologysexual reproduction FBgn0260985
GO:0016321
IEA
PLAZA Integrative Orthologyfemale meiosis chromosome segregation FBgn0260985
GO:0104004
IEA
PLAZA Integrative Orthologycellular response to environmental stimulus SPAC1687.03c
GO:0000070
IEA
PLAZA Integrative Orthologymitotic sister chromatid segregation FBgn0260985
GO:0048731
IEA
PLAZA Integrative Orthologysystem development FBgn0260985
GO:0000075
IEA
PLAZA Integrative Orthologycell cycle checkpoint FBgn0260985
GO:0000076
IEA
PLAZA Integrative OrthologyDNA replication checkpoint FBgn0260985
GO:0000077
IEA
PLAZA Integrative OrthologyDNA damage checkpoint FBgn0260985
GO:0071482
IEA
PLAZA Integrative Orthologycellular response to light stimulus SPAC1687.03c
GO:0048523
IEA
PLAZA Integrative Orthologynegative regulation of cellular process FBgn0260985
GO:0006298
IEA
PLAZA Integrative Orthologymismatch repair YOL094C
GO:0007267
IEA
PLAZA Integrative Orthologycell-cell signaling FBgn0260985
GO:0030261
IEA
PLAZA Integrative Orthologychromosome condensation FBgn0260985
GO:0007143
IEA
PLAZA Integrative Orthologyfemale meiotic nuclear division FBgn0260985
GO:0048609
IEA
PLAZA Integrative Orthologymulticellular organismal reproductive process FBgn0260985
GO:0070914
IEA
PLAZA Integrative OrthologyUV-damage excision repair SPAC1687.03c
GO:0007062
IEA
PLAZA Integrative Orthologysister chromatid cohesion YOL094C
GO:0051726
IEA
PLAZA Integrative Orthologyregulation of cell cycle FBgn0260985
GO:0098813
IEA
PLAZA Integrative Orthologynuclear chromosome segregation YOL094C
GO:0071214
IEA
PLAZA Integrative Orthologycellular response to abiotic stimulus SPAC1687.03c
GO:0045132
IEA
PLAZA Integrative Orthologymeiotic chromosome segregation FBgn0260985
GO:0048285
IEA
PLAZA Integrative Orthologyorganelle fission FBgn0260985
GO:0051321
IEA
PLAZA Integrative Orthologymeiotic cell cycle FBgn0260985
GO:0009628
IEA
PLAZA Integrative Orthologyresponse to abiotic stimulus SPAC1687.03c
GO:0006323
IEA
PLAZA Integrative OrthologyDNA packaging FBgn0260985
GO:0048519
IEA
PLAZA Integrative Orthologynegative regulation of biological process FBgn0260985
GO:0022008
IEA
PLAZA Integrative Orthologyneurogenesis FBgn0260985
GO:0045168
IEA
PLAZA Integrative Orthologycell-cell signaling involved in cell fate commitment FBgn0260985
GO:0007059
IEA
PLAZA Integrative Orthologychromosome segregation YOL094C
GO:0009314
IEA
PLAZA Integrative Orthologyresponse to radiation SPAC1687.03c
GO:1903047
IEA
PLAZA Integrative Orthologymitotic cell cycle process FBgn0260985
GO:1903046
IEA
PLAZA Integrative Orthologymeiotic cell cycle process FBgn0260985
GO:0000819
IEA
PLAZA Integrative Orthologysister chromatid segregation YOL094C
GO:0007292
IEA
PLAZA Integrative Orthologyfemale gamete generation FBgn0260985

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0043142
IDA
Genome Projectsingle-stranded DNA-dependent ATPase activity
GO:0043142
IDA
Gene Ontologysingle-stranded DNA-dependent ATPase activity1
GO:0003689
IDA
Genome ProjectDNA clamp loader activity
GO:0003689
IDA
Gene OntologyDNA clamp loader activity1
GO:0019899
IEA
Genome Projectenzyme binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding2 3 4
GO:0061860
IEA
PLAZA Integrative OrthologyDNA clamp unloader activity SPAC1687.03c

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0031390
IDA
Genome ProjectCtf18 RFC-like complex
GO:0031390
IDA
Gene OntologyCtf18 RFC-like complex1
GO:0005663
IDA
Genome ProjectDNA replication factor C complex
GO:0005663
IDA
Gene OntologyDNA replication factor C complex2
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005654
TAS
Gene Ontologynucleoplasm
GO:0044430
IEA
PLAZA Integrative Orthologycytoskeletal part FBgn0260985
GO:0005737
IEA
PLAZA Integrative Orthologycytoplasm SPAC1687.03c
GO:0005856
IEA
PLAZA Integrative Orthologycytoskeleton FBgn0260985
GO:1904949
IEA
PLAZA Integrative OrthologyATPase complex SPAC1687.03c
GO:0044454
IEA
PLAZA Integrative Orthologynuclear chromosome part SPAC1687.03c
GO:0031389
IEA
PLAZA Integrative OrthologyRad17 RFC-like complex YOL094C
GO:1902494
IEA
PLAZA Integrative Orthologycatalytic complex SPAC1687.03c
GO:0000790
IEA
PLAZA Integrative Orthologynuclear chromatin SPAC1687.03c
GO:0000785
IEA
PLAZA Integrative Orthologychromatin SPAC1687.03c
GO:0000228
IEA
PLAZA Integrative Orthologynuclear chromosome SPAC1687.03c
GO:0044444
IEA
PLAZA Integrative Orthologycytoplasmic part SPAC1687.03c
GO:0043596
IEA
PLAZA Integrative Orthologynuclear replication fork SPAC1687.03c
GO:0031391
IEA
PLAZA Integrative OrthologyElg1 RFC-like complex SPAC1687.03c
GO:0005829
IEA
PLAZA Integrative Orthologycytosol SPAC1687.03c
GO:0005875
IEA
PLAZA Integrative Orthologymicrotubule associated complex FBgn0260985
GO:0015630
IEA
PLAZA Integrative Orthologymicrotubule cytoskeleton FBgn0260985

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR003593AAA+ ATPase domain
IPR003959ATPase, AAA-type, core
IPR008921DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
IPR013748Replication factor C, C-terminal
IPR027417P-loop containing nucleoside triphosphate hydrolase

No MapMan annotations defined for this gene.
KeggID Description
K10755RFC2_4; replication factor C subunit 2/4
No chloroplast target sequence found.